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54
datasets available to search
ShareScore release 0.9.0
Dataset results
54 results for “immunopathology”
Mitochondria–lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [microarray 2]
GEO Series GSE266628. Mus musculus. 10 samples. Type: Expression profiling by array.
Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19
GEO Series GSE195894. Homo sapiens. 6 samples. Type: Other.
Theiler’s Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses
GEO Series GSE120042. Mus musculus. 57 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Theiler’s Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses [array]
GEO Series GSE119860. Mus musculus. 27 samples. Type: Expression profiling by array.
Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells
GEO Series GSE106260. Homo sapiens. 52 samples. Type: Expression profiling by array.
ADAR1 mutation causes ZBP1-dependent immunopathology II
GEO Series GSE200986. Mus musculus. 6 samples. Type: Other.
Mitochondria–lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [scRNA-seq3]
GEO Series GSE263803. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
ADAR1 mutation causes ZBP1-dependent immunopathology I
GEO Series GSE200985. Mus musculus. 12 samples. Type: Other.
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19
GEO Series GSE193068. Homo sapiens. 25 samples. Type: Expression profiling by array.
Vaccine-Elicited CD4 T Cells Induce Immunopathology Following Chronic LCMV Infection
GEO Series GSE63825. Mus musculus. 7 samples. Type: Expression profiling by array.
Mitochondria-lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [bulk RNA-seq]
GEO Series GSE264047. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
IL-23 promotes immunopathology and prevents IL-13-dependent tissue repair by Ly6Clo monocytes in parasite-induced liver damage
GEO Series GSE73686. Mus musculus. 12 samples. Type: Expression profiling by array.
Multi scalar data integration reveals the immunopathological mechanisms associated with IgA nephropathy progression
<p>IgA nephropathy (IgAN), the most common primary mesangial proliferative glomerulonephritis (MsPGN), represents the main cause of renal failure, while the precise pathogenetic mechanisms have not been fully determined. In this study, we employed multi-module data integration and functional experiment to explore the pathogenic programs underlying IgAN progression. Protein profiling of 21 IgAN samples showing progression and 28 samples without progression revealed that protein CXCL12, complement C3, and macrophage markers MRC1, and CD163 were negatively correlated with estimated glomerular filtration rate (eGFR) value, and poor prognosis (30% eGFR decline). Analysis of the single-cell RNA-sequencing (scRNA-seq) revealed that IgAN macrophages expressed high levels of CXCR4, PDGFB, TREM2, TNF, and complement C3, while Monocle pseudotime analysis suggested that these cells derived from the differentiation of infiltrating blood monocytes. Cross-species intercellular crosstalk analysis in human IgAN and ddY-mice IgAN model revealed that mesangial cells (MCs) in IgAN expressed high levels of CXCL12, CSF1 and PDGFRB and interacted with macrophages via the CXCL12-CXCR4, PDGFB-PDGFRB, and ITGAX/ITGAM-C3 axes. Interestingly, analysis of anti-Thy1.1 MsPGN scRNA-seq atlas revealed an inflammatory MCs (iMCs) phenotype which expressed Pdgfrb, Cxcl12, Csf1, and Il34 was associated with MsPGN injury process. Functional experiments revealed that specific blockade of the Cxcl12-Cxcr4 pathway significantly attenuated inflammatory injury, fibrosis, and decline of renal function in the MsPGN model. This study provides new insights into IgAN progression and may aid in the refinement of IgAN diagnosis and the optimization of treatment strategies.</p>
Memory CD4 T cells help adaptive immunity with minimal immunopathology
GEO Series GSE92474. Mus musculus. 6 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.