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7,920 results for “implications”
Implication of Folate Deficiency in CYP2U1 loss of function
<p>Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenic mechanisms remains sparse and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 gene, loss of which is known to be involved in a complex form of these diseases in Humans. We showed that this model partially recapitulated the clinical and biochemical phenotypes of patients. Using electron microscopy, lipidomic, and proteomic studies, we identified vitamin B2 as a substrate of the CYP2U1 enzyme, as well as coenzyme Q, neopterin, and interferon-alpha levels as putative biomarkers in mouse and in fluids obtained from the largest series of CYP2U1- mutated patients reported so far. We also confirmed brain calcifications as a potential biomarker in patients. Our results suggest that CYP2U1 deficiency disrupts mitochondrial function and impacts proper neurodevelopment, which could be prevented by folate supplementation in our mouse model, followed by a neurodegenerative process altering multiple neuronal and extra neuronal tissues.</p>
Data supplement for "Global agricultural trade and land system sustainability: implications for ecosystem carbon storage, biodiversity and human nutrition"
<p>This data supplements the publication "Global agricultural trade and land system sustainability: implications for ecosystem carbon storage, biodiversity and human nutrition" by Thomas Kastner, Abhishek Chaudhary, Simone Gingrich, Alexandra Marques, U. Martin Persson, Giorgio Bidoglio, Gaëtane Le Provost, Florian Schwarzmüller, available here:</p> <p><a href="https://doi.org/10.1016/j.oneear.2021.09.006">https://doi.org/10.1016/j.oneear.2021.09.006</a></p> <p>For details, please refer to that publication.</p>
Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis
<p>Genetic studies have identified ≥240 loci associated with risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mechanisms. Recent studies investigating mRNA expression in human pancreatic islets have yielded important insights into the molecular drivers of normal islet function and T2D pathophysiology. However, similar studies investigating microRNA (miRNA) expression remain limited. Here, we present data from 63 individuals, the largest sequencing-based analysis of miRNA expression in human islets to date. We characterize the genetic regulation of miRNA expression by decomposing the expression of highly heritable miRNAs into <em>cis</em>- and <em>trans</em>-acting genetic components and mapping <em>cis</em>-acting loci associated with miRNA expression (miRNA-eQTLs). We find (i) 84 heritable miRNAs, primarily regulated by <em>trans</em>-acting genetic effects, and (ii) 5 miRNA-eQTLs. We also use several different strategies to identify T2D-associated miRNAs. First, we colocalize miRNA-eQTLs with genetic loci associated with T2D and multiple glycemic traits, identifying one miRNA, miR-1908, that shares genetic signals for blood glucose and glycated hemoglobin (HbA1c). Next, we intersect miRNA seed regions and predicted target sites with credible set SNPs associated with T2D and glycemic traits and find 32 miRNAs that may have altered binding and function due to disrupted seed regions. Finally, we perform differential expression analysis and identify 14 miRNAs associated with T2D status—including miR-187-3p, miR-21-5p, miR-668, and miR-199b-5p—and 4 miRNAs associated with a polygenic score for HbA1c levels—miR-216a, miR-25, miR-30a-3p, and miR-30a-5p.</p>
Dataset for Link between Anisotropic Electrochemistry and Surface Transformations at Single Crystal Silicon Electrodes: Implications for Lithium Ion Batteries
<p>This dataset provides the raw data to the manuscript</p> <p>"<strong>Link between Anisotropic Electrochemistry and Surface Transformations at Single Crystal Silicon Electrodes: Implications for Lithium Ion Batteries"</strong></p> <p>Specifically, the following measurements are provided:</p> <ul> <li>Electrochemical measurements as cyclic voltammetry using scanning electrochemical cell microscopy for three different Si crystallographic orientations (100, 110, 311) in 1 M LiPF6 in ethylene carbonate - ethyl methyl carbonate ("SECCM/")</li> <li>Scanning electron microscopy and transmission electron microscopy imaging of pristine and cycled samples ("Images/")</li> </ul>
Spectral data associated to the publication: "Near-infrared reflectance spectroscopy of sublimating salty ice analogues. Implications for icy moons" by R. Cerubini et al. (Planetary and Space Science 211, 2022)
<p>This is the complete set of experimental NIR reflectance data collected by R. Cerubini and co-authors for the article "Near-infrared reflectance spectroscopy of sublimating salty ice analogues. Implications for icy moons" published in Planetary and Space Science 211 (2022). doi: https://doi.org/10.1016/j.pss.2021.105391.</p> <p>The article itself is published in open-access and provides the methodology for the spectral aquisitions, discussion of the errors and uncertainties, analysis of the spectra and implications for the composition of Solar System surfaces.</p> <p>The data are contained in ASCII files (columns separated by comma). The first column is the wavelength (in micrometers) and the other columns contain the reflectance data (in unit of reflectance factor). The different compositions are indicated in the filenames and correspond directly to the figures in the published paper.</p> <p> </p> <p> </p>
Datasets for Wohlfarth et al. (2023) An advanced thermal roughness model for airless planetary bodies - Implications for global variations of lunar hydration and mineralogical mapping of Mercury with the MERTIS spectrometer
<p>This document describes the datasets and modeling results presented and discussed in our full research article.<br> <br> Wohlfarth, K., Wöhler, C., Hiesinger, H., Helbert, J. 2023, An advanced thermal roughness model for airless planetary bodies - Implications for global variations of lunar hydration and mineralogical mapping of Mercury with the MERTIS spectrometer, Astronomy and Astrophysics, 672<br> <br> <a href="https://doi.org/10.1051/0004-6361/202245343">https://doi.org/10.1051/0004-6361/202245343</a><br> <br> We provide several visualization scripts that read and display the results for convenience. Access to the original MATLAB® code for the thermal model implementation is available upon request (<a href="mailto:kay.wohlfarth@tu-dortmund.de">kay.wohlfarth@tu-dortmund.de</a>).<br> <br> More info in Dataproducts.pdf</p>
Delphi Study: Exploring the Implications of Large Language Models on the Science System
<p><strong>Sample description:</strong> Our target audience consisted of researchers working in the fields of science, technology, and society with a specific interest in Large Language Models (LLMs).</p> <p><strong>Collection method: </strong>Participants were recruited through the professional and personal networks of the authors, as well as the Alexander von Humboldt Institute (HIIG), using a combination of generic emails via LimeSurvey and personal contacts.</p> <p><strong>Description. </strong>The aim of this study was to explore the impact of large language models, specifically ChatGPT, on scholarly practice and academic writing, targeting researchers and experts in the fields of artificial intelligence, science, and technology who publish their research and scientific work. The two-stage Delphi survey sought to identify and assess the potential opportunities and challenges associated with the use of ChatGPT in academic work and scientific writing, with a specific focus on research impact rather than university teaching. Phase 1 yielded 72 responses, while Phase 2 had 52 responses.</p> <p>To conduct our analysis, we developed two distinct codebooks (see Files ChatGPT Delphi Codebook Phase 1.csv and ChatGPT Delphi Codebook Phase 2.csv) for the Delphi study. The first codebook was created by examining approximately half of the responses, extracting relevant information, and generating codes through inductive reasoning. We then categorized and developed subcodes based on these initial codes, assigning them to each participant's answers using deductive reasoning. For example, when addressing the potential applications of ChatGPT and other language models (LLMs), we identified six subcategories with precise definitions and illustrative examples. The analysis in Phase 1 led to the formulation of ranking questions for Phase 2, focusing on determining the most frequently utilized applications of ChatGPT and other LLMs based on the established codes.</p> <p>During Phase 2, we introduced two additional open-ended questions to explore the impact of ChatGPT and LLMs on the scientific system and society, aiming to envision future scenarios. The analysis of these questions in the second codebook followed a similar approach to Phase 1, including inductive reasoning for code generation and deductive reasoning for assigning codes to the answers. We observed overlapping codes with the Phase 1 codebook and assigned them to the second codebook. Additionally, we noted a shift in the connotation of certain answers from neutral in Phase 1 to being perceived as either positive or negative consequences of ChatGPT and other LLMs. This observation prompted the bifurcation of specific codes to capture the nuanced perspectives. For instance, applications such as reducing administrative tasks initially seen as valuable aids for researchers were sometimes viewed as potential causes for job replacement, implying negative outcomes.</p> <p>For detailed information on the analytical approach employed, including references to these methodologies, please refer to the methodology chapter in the official publication.</p> <p><strong>Content</strong></p> <ol> <li> <p>Questionaire-ChatGPT-Delphi-Phase1-Limesurvey-Export.pdf – This file file is an exported version of the Phase 1 questionnaire from Limesurvey. It includes the description, socio demographic questions, content questions, and a request for participant naming.</p> </li> <li> <p>Questionaire-ChatGPT-Delphi-Phase2-Limesurvey-Export.pdf – This file file is an exported version of the Phase 2 questionnaire from Limesurvey. It includes the description, socio demographic questions, content questions, and a request for participant naming.</p> </li> <li> <p>ChatGPT Delphi - Results Phase 1.pdf – This file contains the responses and corresponding questions from Phase 1 of the Delphi study. The responses provided by the participants are in the form of open-ended answers. As part of this publication, we have ensured the anonymity of the participants.</p> </li> <li> <p>ChatGPT Delphi - Results Phase 2. pdf – This file contains the responses and corresponding questions from Phase 2 of the Delphi study. It encompasses the ranking answers provided by the participants, as well as two open-ended answers. To maintain anonymity consistently, all participants have been anonymized again in this publication of our results.</p> </li> <li> <p>ChatGPT Delphi Codebook Phase 1.pdf – This file contains the Phase 1 codebook, which presents the primary codes, their respective subcodes, detailed definitions, and noteworthy examples.</p> </li> <li> <p>ChatGPT Delphi Codebook Phase 2.pdf – This file contains the Phase 1 codebook, which provides a comprehensive overview of the primary codes within the given scenario. It includes their corresponding subcodes, detailed definitions, and notable examples to enhance understanding and interpretation.</p> </li> </ol>
Towards a mechanistic description of autoxidation chemistry: from precursors to atmospheric implications (data)
<p>The files contain the raw data from simulations of the plots for main manuscript figures 2 & 3. Any data not archived here (mainly ADCHEM simulations) can be provided upon request (contact: lukas.pichelstorfer@helsinki.fi)</p> <p>On the data naming, content and structure:</p> <p>file names are structured as <Facility/experiment type>_<experimental conditions>_<data_content>.dat</p> <p>"..._time.dat": contains all data output times during the simulation [s]</p> <p>"...T.dat": gas phase temperature during the simulation [K] for all output times (columns)</p> <p>"..._DIAMETER.dat" contains the diameters [nm] of all (100) size bins (lines) for each output time (columns);</p> <p>"...SPC_NAMES.dat": contains the chemical species names</p> <p>"...N_bins.dat": particle number concentration [1/m3] for each size bin (lines) and each output time (columns)</p> <p>"...conc.dat": contains the gas-phase concentrations [1/ccm] of chemical species for all output times (number of species * number of times)</p> <p>"mass_spec.dat": contains the particle phase mass ([µg/m3] for all chemical species -> lines) sum over 100 size bins and for all output times (columns)</p> <p>"FlowTube_autoAPRAM_composition.dat": composition C/H/O/N for each autoAPRAM-fw species</p> <p>"FlowTube_autoAPRAM_names.dat": autoAPRAM-fw species</p>
Spatial data sets of the paper Heinrich Stadial 1 continental sand dunes and Middle to Late Holocene paleosol sequences in SE Iberia: implications for human occupation and site formation processes
<p>Spatial data sets of the paper Heinrich Stadial 1 continental sand dunes and Middle to Late Holocene paleosol sequences in SE Iberia: implications for human occupation and site formation processes. This data set is composed by 3 shapefiles:</p> <ol> <li>Dune_field: Feature class polygon shapefile geometry representing the individual dunes identified in the Villena dune field.</li> <li>Sampled dunes: Shapefile of point geometry representing the location of the stratigraphic sequences of CC1, CC2 and CC3 sampled for texture, soil chemistry, OSL and radiocarbon dating. </li> <li>Sediment sourcing samples: Shapefile of point geometry representing the location of the reference samples of El Moron, El Arenal de la Virgen and Sierra del Castellar. </li> </ol> <p>The spatial reference system is EPSG 25830.</p>
FESOM-REcoM model data: A regime shift on Weddell Sea continental shelves with local and remote physical-biogeochemical implications is avoidable in a 2°C scenario
<p>This data set includes the minimal data necessary to reproduce the findings of Nissen et al. (2023). Output of model simulations with the global ocean biogeochemical model FESOM1.4-REcoM2 is provided. In particular, besides information on the model grid, the data set includes annual mean water mass properties (temperature, salinity, density, oxygen, pH) and freshwater fluxes from sea ice and ice shelves and decadal averages of air-sea CO2 fluxes and deep-ocean carbon accumulation rates. Model results are provided from 1980-2100 for the four emission scenarios SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5 (sorted from low emission to high emission).</p> <p>Please see README for more information on the individual files. </p> <p>Data set belongs to: </p> <p>Nissen, C., R. Timmermann, M. Hoppema, and J. Hauck, 2023: A regime shift on Weddell Sea continental shelves with local and remote physical-biogeochemical implications is avoidable in a 2°C scenario. <em>J. Climate</em>, <a href="https://doi.org/10.1175/JCLI-D-22-0926.1">https://doi.org/10.1175/JCLI-D-22-0926.1</a>, in press.</p>
Dataset for Nanoscale Growth Mechanisms of Gypsum: Implications for Environmental Control of Crystal Habits
<p>This dataset collected here has been used in the paper "Nanoscale Growth Mechanisms of Gypsum: Implications for Environmental Control of Crystal Habits".</p> <p>The files are in .dat format and each one corresponds to the images indicated in the file name.</p>
"Outgassing Composition of the Murchison Meteorite: Implications for Volatile Depletion of Planetesimals and Interior-Atmosphere Connections for Terrestrial Exoplanets" Data Repository
<p>This repository contains the data files, analysis Jupyter notebooks and figures from Thompson et al. 2023 "Outgassing Composition of the Murchison Meteorite: Implications for Volatile Depletion of Planetesimals and Interior-Atmosphere Connections for Terrestrial Exoplanets"</p>
User Study Data for Paper "A case study in designing trustworthy interactions: implications for socially assistive robotics"
<p>Experimental data collected for the user study described in Frontiers paper "A case study in designing trustworthy interactions: implications for socially assistive robotics" by Mengyu Zhong et al. Citation: <i>Zhong, Mengyu, et al. "A case study in designing trustworthy interactions: implications for socially assistive robotics." Frontiers in Computer Science 5.1152532 (2023). </i></p>
Data from: Species delimitation in endangered groundwater salamanders: implications for aquifer management and biodiversity conservation
Open the record for dataset details and reuse information.
Emerging fungal pathogen of an invasive grass: Implications for competition with native plant species
This data package includes data and code from an experiment testing the effects of a leaf spot fungal infection and competition from the invasive (to the U.S.) grass Microstegium vimineum on the performance of three native grass species: Dichanthelium clandestinum, Elymus virginicus, and Eragrostis spectabilis. The experiment was performed between June and September of 2019 in a greenhouse on the University of Florida campus in Gainesville, FL, USA. The leaf spot infection is caused by the fungal pathogen Bipolaris gigantea, which has recently emerged on populations of M. vimineum in the U.S. We tested the hypothesis that infection of B. gigantea would both directly and indirectly affect the native grass species by measuring the change in biomass of each species with and without pathogen inoculation (direct effects) and by measuring the effect of pathogen inoculation on M. vimineum competition through changes in native grass biomass across a density gradient of M. vimneum (indirect effects). The code includes statistical analyses and figures. The code was run using R (version 4.0.1).
FIG. 4 in A zooarchaeological study of Rangifer tarandus (Linnaeus, 1758) from the Croxton site in Brooks Range, Alaska, and implications for utility analysis
FIG. 4. — Split caribou (Rangifer tarandus (Linnaeus, 1758)) right metatarsal with impacts on opposing surfaces. After being split and discarded, the bone
FIG. 1 in A zooarchaeological study of Rangifer tarandus (Linnaeus, 1758) from the Croxton site in Brooks Range, Alaska, and implications for utility analysis
FIG. 1. — Map showing the locations of the Croxton archaeological site and the modern village of Anaktuvuk Pass along the north slope of the Brooks Mountain Range, Alaska, United States.
FIG. 6 in L'apport du registre paléogène d'Amazonie sur la diversification initiale des Caviomorpha (Hystricognathi, Rodentia): implications phylogénétiques, macroévolutives et paléobiogéographiques
FIG. 6. — Consensus strict de l'AG1 (Fig. 5) et indices de Bremer aux noeuds. Les taxons en gras sont les espèces découvertes dans le Paléogène de Contamana (Éocène et Oligocène) et à Tarapoto/Shapaja. Le code couleur est le même que celui de la Figure 3.
FIG. 3 in L'apport du registre paléogène d'Amazonie sur la diversification initiale des Caviomorpha (Hystricognathi, Rodentia): implications phylogénétiques, macroévolutives et paléobiogéographiques
FIG. 3. — Arbre de contrainte employé pour les AG1-AG9, basé sur des données moléculaires. Modifié d'après Upham & Patterson (2015: 77, fig. 3). Les quatre super-familles de caviomorphes sont différenciées par des couleurs: Cavioidea (rouge), Chinchilloidea (bleu), Erehizontoidea (orange) et Octodontoidea (violet).
FIG. 17 in Archaeochiapasidae n. fam., a new early Cenomanian brachyuran family from Chiapas, Mexico, new hypothesis on Lecythocaridae Schweitzer & Feldmann, 2009, and phylogenetic implications (Crustacea, Decapoda, Brachyura, Eubrachyura)
FIG. 17. — Retroplumidae Gill, 1894 (Retroplumoidea Gill, 1894). Costacopluma maroccana Ossó-Morales, Artal & Vega, 2010, Calcaires à slumps de Taghit Formation, late Campanian, Merija, Morocco: thoracic sternum and pleon. AO39, Private Collection Àlex Ossó. Photography by Àlex Ossó and courtesy of À. Ossó. Scale bar: 10 mm.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.