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7,673 results for “inhibitor”
Figure 2. Flufenacet degradation 24 h in Flufenacet activity is affected by GST inhibitors in blackgrass (Alopecurus myosuroides) populations with reduced flufenacet sensitivity and higher expression levels of GSTs
Figure 2. Flufenacet degradation 24 h after treatment with different inhibitors in the sensitive Alopecurus myosuroides population Herbiseed-S (A) and population Kehdingen1 with reduced flufenacet efficacy (B). Different letters indicate significant differences in flufenacet degradation between treatments,and asterisks (*) indicate significant differences between the two populations for each treatment (P ≤ 0.05).
Figure 5 in Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors
Figure 5. Glufosinate enhances the activity of protoporphyrinogen oxidase (PPO) inhibitors in the field. Performance of glufosinate and PPO-inhibiting herbicides applied individually or in tank mix on Bassia scoparia. Gluf, glufosinate; flumi, flumioxazin; saflu, saflufenacil; pyraflu, pyraflufen; lact, lactofen; fome, fomesafen. Means followed by the same letter do not differ according to Tukey's test (P <0.05). Error bars represent the standard deviations of the means.
Figure 4 in Flufenacet activity is affected by GST inhibitors in blackgrass (Alopecurus myosuroides) populations with reduced flufenacet sensitivity and higher expression levels of GSTs
Figure 4. Expression of three tau-class glutathione transferases (GST1, GST2,GST3), two phi-class GSTs (GST4, GST5), and a theta-class isoform (GST6) differentially expressed in the sensitive Alopecurus myosuroides populations Herbiseed-S and Appel-S and the populations Kehdingen1 and Kehdingen2 with reduced flufenacet efficacy. Different letters indicate significant differences between populations (false discovery rate ≤ 0.05). TMM, trimmed mean of M values.
Figure 4 in Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors
Figure 4. Glufosinate + saflufenacil is toxic to glufosinate-resistant soybean due to a transient accumulation of glutamate and subsequent protoporphyrin accumulation. Visual injury (A) and protoporphyrin accumulation (B) in glufosinate-susceptible (red) and glufosinate-resistant (blue) soybean following glufosinate and saflufenacil treatments. Glufosinate (C) and glutamate (D) levels in glufosinate-susceptible (gray) and glufosinate-resistant (blue) soybean following glufosinate (280 g ha−1) treatment. Asterisks (*) indicate means are significantly different by t-test (P <0.05) between soybean varieties or time point. Error bars represent the standard deviations of the means. HAT, hours after treatment.
Figure 2 in Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors
Figure 2. Enhanced herbicidal activity with glufosinate and saflufenacil. Dose response for glufosinate (A) and saflufenacil (B) in Amaranthus palmeri. Isobole analysis for the combination between the two herbicides in different proportions (C). The graph shows the proportion of each herbicide to achieve 50% reduction in dry biomass (ED50). If no synergism had been observed for the two compounds, data points were expected to fall into the red dashed line (additive effect).The concave shape of the isobole curve indicates high levels of synergism between the two herbicides. Error bars represent the standard deviations of the means.
Figure 1 in Characterization of Acetolactate Synthase (ALS)-Inhibitor Resistance in Pennsylvania smartweed (PersicOriO pensylvOnicO)
Figure 1. Dose–response assay using four-parameter log logistic model for (A) bensulfuron-methyl, (B) imazethapyr, and (C) bispyribac-sodium herbicides in Persicaria pensylvanica resistant (R) and susceptible (S) biotypes. Each data point is a mean response of 30 plants (10 plants per replication).
Figure 2 in Characterization of Acetolactate Synthase (ALS)-Inhibitor Resistance in Pennsylvania smartweed (PersicOriO pensylvOnicO)
Figure 2. Two ALS gene mutations conferring ALS-inhibitor resistance in Persicaria pensylvanica. The underlined nucleotides (TCA and TCC) code for the amino acid serine instead of an alanine and proline at two different locations (122 and 197) of the ALS gene. R1, R2, and S refer to two resistant and one susceptible individuals, respectively.
Figure 1 in Flufenacet activity is affected by GST inhibitors in blackgrass (Alopecurus myosuroides) populations with reduced flufenacet sensitivity and higher expression levels of GSTs
Figure 1. Dose–response analysis of the fresh weight of four Alopecurus myosuroides populations treated with different dose rates of flufenacet estimated using a threeparameter log-logistic model (see Equation 1).
Figure 7 in Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors
Figure 7. Visual observation and the physiological basis of the synergistic effect between glufosinate and protoporphyrinogen oxidase (PPO) inhibitors on Amaranthus palmeri. Glutamate is the precursor for the biosynthesis of glutamine,arginine,proline,and chlorophyll.Inhibition of glutamine synthetase (GS) diverges the fate of glutamate into proline/arginine and chlorophyll biosynthetic pathways. Inhibition of both GS and PPO leads to increased protoporphyrin accumulation and subsequent formation of reactive oxygen species (ROS).
Figure 6 in Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors
Figure 6. Saflufenacil (Saflu) at 1 g ha−1 can overcome the lack of efficacy by glufosinate (Gluf) at 280 g ha−1 on Amaranthus palmeri under low temperature and humidity. Visual injury provided with glufosinate + saflufenacil compared with the two herbicides applied individually at high (A) and low (B) temperature and humidity.Means with the same letter do not differ according to Tukey's test (P <0.05). Error bars represent the standard deviations of the means.
Figure 3 in Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors
Figure 3. Glufosinate enhances the activity of protoporphyrinogen oxidase (PPO) inhibitors, but the mixture is not effective on PPO-resistant Amaranthus tuberculatus. Response of PPO-susceptible (A) and PPO-resistant (B) A. tuberculatus to glufosinate (Gluf) and lactofen (Lact). Visual injury (C), reactive oxygen species (ROS) (D), and protoporphyrin (E) in PPO-susceptible (gray) and PPO-resistant (blue) A. tuberculatus following herbicide treatments. Asterisks (*) indicate means are significantly different by t-test (P <0.05) between biotypes within each treatment. Error bars represent the standard deviations of the means.
Data Sets ''Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids''
<p>Data Sets for the paper ''Proton Pump Inhibitor Omeprazole Alters the Spiking Characteristics of Proteinoids''</p>
Figure 4 in Use of melatonin as an inhibitor of apoptotic process for cryopreservation of zebrafish (Danio rerio) embryos
Figure 4. Representative images of zebrafish (Danio rerio) embryos showing reactive oxygen species (ROS) formation (A-D) and DNA fragmentation (E-H) following vitrification for the control group and vitrified treatments with 0, 1 µM and 1 mM melatonin respectively. Arrows and arrow heads point to tissues affected in the body axis and those in close proximity to the yolk respectively.
Figure 3 in Use of melatonin as an inhibitor of apoptotic process for cryopreservation of zebrafish (Danio rerio) embryos
Figure 3. Percentage area of zebrafish (Danio rerio) embryos affected by reactive oxygen species (ROS) formation and DNA fragmentation after vitrification for the control group and vitrified treatments with 0, 1 µM and 1 mM melatonin respectively. Bars with different letter within the same assay were significantly different from one another (P <0.05).
Figure 2 in Use of melatonin as an inhibitor of apoptotic process for cryopreservation of zebrafish (Danio rerio) embryos
Figure 2. Bax, bcl-2 and caspase-3 mRNA expression levels in zebrafish (Danio rerio) embryos for the control group and vitrified treatments with 0, 1 µM and 1 mM melatonin respectively obtained by the 2-∆∆CT method. Boxes with same letter are not significantly different from one another (P> 0.05).
Figure 1 in Use of melatonin as an inhibitor of apoptotic process for cryopreservation of zebrafish (Danio rerio) embryos
Figure 1. Representative scanning electron micrographs of vitrified and non-vitrified zebrafish (Danio rerio) embryos. (A) Control group; (B-D) Vitrified with 0, 1 µM and 1 mM melatonin respectively. Arrows, arrow head and asterisk point to invaginations and perforations, rupture of the vitelline membrane and wrinkling of the epidermis respectively.
An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host
<p><span>Only a few bacteria are able to colonize the nuclei of eukaryotes and nearly all of these are known from protists. One bacterial clade, however, “<em>Candidatus</em> Endonucleobacter”, infects the nuclei of deep-sea mussels, where it replicates to ≥ 80,000 bacteria per nucleus and causes nuclei to swell to 50 times their original size. How these parasites are able to replicate so massively and avoid apoptosis is not known. </span><span>Dual RNA-seq transcriptomes of infected nuclei isolated using laser-capture microdissection revealed </span><span>that in contrast to previous assumptions, “</span><em><span>Ca. </span></em><span>Endonucleobacter” does not gain most of its nutrition from nuclear DNA or RNA. Instead, “<em>Ca.</em> Endonucleobacter” upregulated genes for importing sugars, lipids, amino acids and possibly mucin from its host, and digested these nutrients. “<em>Ca.</em> Endonucleobacter” likely prevents apoptosis of host cells by upregulating 7-13 inhibitors of apoptosis (IAPs), proteins previously only known from animals and a few invertebrate viruses. Comparative phylogenetic analyses revealed that “<em>Ca.</em> Endonucleobacter” acquired IAPs repeatedly through horizontal gene transfer (HGT) from their hosts in </span><span>convergent acquisition. HGT from eukaryotes to bacteria, although assumed to be rare, may be more common than currently recognized, particularly in bacteria that live in intimate associations with eukaryotic hosts.</span></p>
Research data supporting "A robust liposomal platform for direct colorimetric detection of sphingomyelinase enzyme and inhibitors"
<p>Raw research data supporting the publication: Holme, M. N. et al., ACS Nano, 2018, DOI: 10.1021/acsnano.8b03308.</p>
Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen synthase kinase-3β inhibitors
<p>The dataset related to the publication:</p> <p>Andreev et al. Design, Synthesis and Biological Evaluation of 7 Chloro-9H-pyrimido[4,5-b]indole-based Glycogen synthase kinase-3β inhibitors.<br> <br> The files include:</p> <p>1) Movies of the MD simulations of compounds 14b (<strong>Cmpd14b.mpg</strong>) and 24 (<strong>Cmpd24.mpg</strong>).</p> <p>2) Raw trajectory files of the Desmond MD simulations of the compounds 14b (<strong>14b.zip</strong>), 24 (<strong>24.zip</strong>) and 24 (3a<em>R</em>, 7a<em>S</em>) (<strong>24_3aR_7aS.zip</strong>) (contains out.cms and the full trj files).</p> <p>3) Output conformations of the QM Tautomer & Conformation Predictor of Maestro (Schrödinger, LLC, New York, NY, 2019) of the compounds<br> 14b (<strong>Cmpd14b_QMconftauto_output.mae</strong>; <strong>Cmpd14b_QMconftauto_output.sdf</strong>), <br> 24 (<strong>Cmpd24_QMconftauto_output.mae</strong>; <strong>Cmpd24_QMconftauto_output.sdf</strong>) and <br> 24 (3a<em>R</em>, 7a<em>S</em>) (<strong>Cmpd24_3aR_7aS_QMconftauto_output.mae</strong>; <strong>Cmpd24_3aR_7aS_QMconftauto_output.sdf</strong>)</p> <p>4) Jaguar pKa calculation (conformations) output-files for compounds 14b, 14c, 14d, 14e, 14f, 14g, 14h, 14i, 14j, 14k, 14l, 14m, 14n <strong>pKa.zip</strong> (contains conformation in .mae file and Final weighted pKa value in .out file).</p>
Antiviral activity of HIV-1 integrase strand-transfer inhibitors against mutants with integrase resistance-associated mutations and their frequency in treatment-naïve individuals
<p>The development of resistance to human immunodeficiency virus 1 (HIV-1) integrase strand-transfer inhibitors (INSTI) has been documented; however, knowledge of the impact of pre-existing integrase (IN) mutations on INSTI resistance (INSTI-R) is still evolving. The frequency of HIV-1 IN mutations in 2177 treatment-naïve subjects was investigated, along with the INSTI susceptibility of site-directed mutant viruses containing major and minor INSTI-R mutations. Total 6 of 39 minor INSTI-R mutations (M50I, S119P/G/T/R, and E157Q) were found in >1% of IN-treatment-naïve subjects with no impact on INSTI susceptibility. When each combined with major INSTI-R mutation, M50I, S119P, and E157Q led to decreased susceptibility to elvitegravir but remained sensitive to dolutegravir and bictegravir.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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