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470 results for “lifespan”
Trained network for classification of images from yeast cell lifespans - DetecDiv (id01)
<p>Trained network for classification of images from yeast cell lifespans.</p> <p>Related to the dataset: <a href="https://doi.org/10.5281/zenodo.5552642">doi.org/10.5281/zenodo.5552642</a></p> <p>Testset: <a href="https://doi.org/10.5281/zenodo.5866747">doi.org/10.5281/zenodo.5866747 </a></p> <p><strong>------------------------------------------</strong></p> <p><strong>Author(s)</strong>: Théo, ASPERT</p> <p><strong>Contact email</strong>: theo.aspert@gmail.com</p> <p><strong>Affiliation</strong>: IGBMC, Université de Strasbourg</p> <p><strong>Funding bodies</strong>: This work was supported by the Agence Nationale pour la Recherche, the grant ANR-10-LABX-0030-INRT, a French State fund managed by the Agence Nationale de la Recherche under the frame program Investissements d'Avenir ANR-10-IDEX-0002-02.</p>
Research data supporting article "Somatic mutation rates scale with lifespan across mammals"
<p>Data files supporting analyses described in the article "Somatic mutation rates scale with lifespan across mammals" (Cagan, Baez-Ortega et al., 2022).</p>
Data and code for: Dog lifespans and the evolution of ageing
<p>The basic tenets of the evolutionary theories of senescence are well supported. However, there has been little progress in determining the relative influences of mutation accumulation and life history optimisation. The causes of the well-established inverse relationship between lifespan and body size across dog breeds are used here to test these two classes of theories. The lifespan-body size relationship is confirmed for the first time after controlling for breed phylogeny. The lifespan-body size relationship cannot be explained by evolutionary responses to differences in extrinsic mortality, either of contemporary breeds or of breeds at their establishment. The development of breeds larger and smaller than ancestral grey wolves has occurred through changes in early growth rate. This may explain the increase in the minimum age-dependent mortality rate with breed body size and thus higher age-dependent mortality throughout adult life. The main cause of this mortality is cancer. These patterns are consistent with the optimisation of life history as described by the disposable soma theory of the evolution of ageing. The dog breed lifespan-body size relationship may be the result of the evolution of greater defence against cancer lagging behind the rapid increase in body size during recent breed establishment.</p>
Genetic sex determination, sex chromosome size and sex-specific lifespan across tetrapods
<p>Sex differences in lifespan are ubiquitous across the tree of life and exhibit broad taxonomic patterns that remain a puzzle, such as males living longer than females in birds and <em>vice</em> <em>versa</em> in mammals. The prevailing "unguarded-X" hypothesis explains sex differences in lifespan by differential expression of recessive mutations <span>o</span>n the X or Z chromosome of the heterogametic sex but has only received indirect support to date. An alternative hypothesis is that the accumulation of deleterious mutations and repetitive elements on the Y or W chromosome might lower the survival of the heterogametic sex ("toxic Y" hypothesis). Here, we use a new database to report lower survival of the heterogametic relative to the homogametic sex across 136 species of birds, mammals, reptiles and amphibians, as expected if sex chromosomes shape sex-specific lifespans, and consistent with previous findings. We also found that the relative sizes of both the X and the Y chromosomes in mammals (but not the Z or the W chromosomes in birds) are associated with sex differences in lifespan, as predicted by the "unguarded-X" and the "toxic Y". Furthermore, we report that the relative size of the Y is negatively associated with male lifespan in mammals, so that small Y size correlates with increased male lifespan. In theory, toxic Y effects are expected to be particularly strong in mammals, and we did not find similar effects in birds. Our results confirm the role of sex chromosomes in explaining sex differences in lifespan across tetrapods and further suggest that, at least in mammals, "toxic Y" effects may play an important part in this role.</p>
Convergent genomics of longevity in rockfishes highlights the genetics of human lifespan variation
<p>Longevity is a defining, heritable trait that varies dramatically between species. To resolve the genetic regulation of this trait, we have mined genomic variation in rockfishes, which range in longevity from 11 to over 205 years, along with the sea robin as an outgroup. We used the phylomapping methodology to target sequencing and assembly to conserved, functional loci, defined using available genomic resources from well-characterized species. These annotations are in the gtf. For analysis of coding elements, assembled contigs were trimmed to just the exons. Exons were concatenated and analyzed to generate gene trees with IQTree, fixed to match the species tree. Additional details of these assembly methods are available at DOI: <a href="https://doi.org/10.1038/s41559-019-0914-2">10.1038/s41559-019-0914-2</a> and <a href="https://doi.org/10.1126/sciadv.add2743">DOI: 10.1126/sciadv.add2743</a></p>
Data for: Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction
<p>In many organisms, dietary restriction (DR) leads to lifespan extension through the activation of cell protection and pro-longevity gene expression programs. In the nematode <em>C. elegans</em>, the DAF-16 transcription factor is a key aging regulator that governs the Insulin/IGF-1 signaling pathway and undergoes translocation from the cytoplasm to the nucleus of cells when animals are exposed to food limitation. However, how large is the influence of DR on DAF-16 activity, and its subsequent impact on lifespan has not been quantitatively determined. In this work, we assess the endogenous activity of DAF-16 under various DR regimes by coupling CRISPR/Cas9-enabled fluorescent tagging of DAF-16 with quantitative image analysis and machine learning. Our results indicate that DR regimes induce strong endogenous DAF-16 activity, although DAF-16 is less responsive in aged individuals. DAF-16 activity is in turn a robust predictor of mean lifespan in <em>C. elegans</em>, accounting for 78% of its variability under DR. Analysis of tissue-specific expression aided by a machine learning tissue classifier reveals that, under DR, the DAF-16 influence on lifespan extension mainly originates from the intestine and neurons. DR also drives DAF-16 activity in unexpected locations such as the germline and intestinal nucleoli.</p>
Ether lipid biosynthesis promotes lifespan extension and enables diverse prolongevity paradigms in Caenorhabditis elegans
<p class="MsoNormal">Biguanides, including the world's most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these findings, indicating favorable effects of metformin on longevity and on reducing the incidence and morbidity associated with aging-related diseases. Despite this promise, the full spectrum of molecular effectors responsible for these health benefits remains elusive. Through unbiased screening in <em>C. elegans</em>, we uncovered a role for genes necessary for ether lipid biosynthesis in the favorable effects of biguanides. We demonstrate that biguanides prompt lifespan extension by stimulating ether lipid biogenesis. Loss of the ether lipid biosynthetic machinery also mitigates lifespan extension attributable to dietary restriction, target of rapamycin (TOR) inhibition, and mitochondrial electron transport chain inhibition. A possible mechanistic explanation for this finding is that ether lipids are required for activation of longevity-promoting, metabolic stress defenses downstream of the conserved transcription factor <em>skn-1/</em>Nrf. In alignment with these findings, overexpression of a single, key, ether lipid biosynthetic enzyme, <em>fard-1</em>/FAR1, is sufficient to promote lifespan extension. These findings illuminate the ether lipid biosynthetic machinery as a novel therapeutic target to promote healthy aging.</p>
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study
ClinicalTrials.gov study NCT04080544. IPD Sharing: NO. Countries: 1. Publications: 15.
Raw data from: Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity
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Life history data for: High investment into reproduction is associated with reduced lifespan in dogs
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Data from: Disturbance history is a key driver of tree lifespan in temperate primary forests
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Data from: Differential effects of early life adversity on male and female rhesus macaque lifespan
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The evolution of lifespan and ageing in response to dietary macronutrients in male and female decorated crickets
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Data from: From circuits to lifespan: Translating mouse and human timelines with neuroimaging based tractography
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The role of fine‐root mass, specific root length and lifespan in tree performance: a whole‐tree exploration
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Data from: Maternal age effects on offspring lifespan and reproduction vary within a species
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Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans
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Data From: Dietary restriction extends lifespan across different temperatures in the fly
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Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila
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The effects of costly telomere maintenance on lifespan-reproductive tradeoffs in sand lizards
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.