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55 results for “mammal genetics”
Panmixia in a sea ice-associated marine mammal: evaluating genetic structure of the Pacific walrus (Odobenus rosmarus divergens) at multiple spatial scales
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Both selection and drift drive the spatial pattern of adaptive genetic variation in a wild mammal
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Data from: Impacts of genetic correlation on the independent evolution of body mass and skeletal size in mammals
Mammals show a predictable scaling relationship between limb bone size and body mass. This relationship has a genetic basis which likely evolved via natural selection but it is unclear how much the genetic correlation between these traits in turn impacts their capacity to evolve independently. We selectively bred laboratory mice for increases in tibia length independent of body mass to test the hypothesis that a genetic correlation with body mass constrains evolutionary change in tibia length. Over 14 generations we produced mean tibia length increases of 11-12% while mean body mass was unchanged in selectively bred mice and random-bred controls. Using evolutionary scenarios with different selection and quantitative genetic parameters we also found that this genetic correlation impedes the rate of evolutionary change in both traits slowing increases in tibia length while preventing decreases in body mass despite the latter's negative effect on fitness. Overall results from this ongoing selection experiment suggest that parallel evolution of relatively longer hind limbs among rodents for example in the context of strong competition for resources and niche partitioning in heterogeneous environments may have occurred very rapidly on geological timescales in spite of the genetic correlation between tibia length and body mass.
Data from: A high quality pedigree and genetic markers both reveal inbreeding depression for quality but not survival in a cooperative mammal
Inbreeding depression, the reduced fitness of offspring of closely related parents, is commonplace in both captive and wild populations and has important consequences for conservation and mating system evolution. However, because of the difficulty of collecting pedigree and life history data from wild populations, relatively few studies have been able to compare inbreeding depression for traits at different points in the life cycle. Moreover, pedigrees give the expected proportion of the genome that is identical by descent (IBDg) whereas in theory with enough molecular markers realised IBDg can be quantified directly. We therefore investigated inbreeding depression for multiple life-history traits in a wild population of banded mongooses using pedigree-based inbreeding coefficients (fped) and standardised multilocus heterozygosity (sMLH) measured at 35-43 microsatellites. Within an information theoretic framework, we evaluated support for either fped or sMLH as inbreeding terms and used sequential regression to determine whether the residuals of sMLH on fped explain fitness variation above and beyond fped. We found no evidence of inbreeding depression for survival, either before or after nutritional independence. By contrast, inbreeding was negatively associated with two quality related traits, yearling body mass and annual male reproductive success. Yearling body mass was associated with fped but not sMLH, while male annual reproductive success was best explained by both fped and residual sMLH. Thus, our study not only uncovers variation in the extent to which different traits show inbreeding depression, but also reveals trait-specific differences in the ability of pedigrees and molecular markers to explain fitness variation and suggests that for certain traits genetic markers may capture variation in realised IBDg above and beyond the pedigree expectation.
Supplementary material 1 from: Birand A, Cassey P, Ross JV, Thomas PQ, Prowse TAA (2022) Scalability of genetic biocontrols for eradicating invasive alien mammals. NeoBiota 74: 93-103. https://doi.org/10.3897/neobiota.74.82394
Tables S1, S2
Data from: A high quality pedigree and genetic markers both reveal inbreeding depression for quality but not survival in a cooperative mammal
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Data from: Impacts of genetic correlation on the independent evolution of body mass and skeletal size in mammals
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Data from: Lack of genetic diversity across diverse immune genes in an endangered mammal, the Tasmanian devil (Sarcophilus harrisii)
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Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [PLACseq_Hybrid]
GEO Series GSE295850. Mus musculus. 9 samples. Type: Other.
Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [PLACseq_Fasted]
GEO Series GSE295853. Mus musculus. 14 samples. Type: Other.
Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [ChIP-seq_sq]
GEO Series GSE294477. Ictidomys tridecemlineatus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [snATACseq]
GEO Series GSE295866. Mus musculus. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [bulk ATACseq]
GEO Series GSE295855. Mus musculus. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [ChIP-seq_mm]
GEO Series GSE294476. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genomic Convergence in Hibernating Mammals Elucidates the Genetics of Metabolic Regulation in the Hypothalamus [snRNAseq]
GEO Series GSE295856. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.