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228
datasets available to search
ShareScore release 0.9.0
Dataset results
228 results for “model therapy”
Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies
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Data from: A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?
Background: The development of therapeutics is often characterized by promising animal research that fails to translate into clinical efficacy; this holds for the development of gene therapy in glioma. We tested the hypothesis that this is because of limitations in the internal and external validity of studies reporting the use of gene therapy in experimental glioma. Method: We systematically identified studies testing gene therapy in rodent glioma models by searching three online databases. The number of animals treated and median survival were extracted and studies graded using a quality checklist. We calculated median survival ratios and used random effects meta-analysis to estimate efficacy. We explored effects of study design and quality and searched for evidence of publication bias. Results: We identified 193 publications using gene therapy in experimental glioma, including 6,366 animals. Overall, gene therapy improved median survival by a factor of 1.60 (95% CI 1.53–1.67). Study quality was low and the type of gene therapy did not account for differences in outcome. Study design characteristics accounted for a significant proportion of between-study heterogeneity. We observed similar findings in a data subset limited to the most common gene therapy. Conclusion: As the dysregulation of key molecular pathways is characteristic of gliomas, gene therapy remains a promising treatment for glioma. Nevertheless, we have identified areas for improvement in conduct and reporting of studies, and we provide a basis for sample size calculations. Further work should focus on genes of interest in paradigms recapitulating human disease. This might improve the translation of such therapies into the clinic.
raw data - Comparison of High-Flow Nasal Cannula Oxygen and Conventional Oxygen Therapy in a Rat Model of Severe Carbon Monoxide Poisoning
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Feasibility of a Randomized Controlled Trial of Large Artificial Intelligence-Based Linguistic Models for Clinical Reasoning Training of Physical Therapy Students.
<p>Data collected for students who participated in the study</p>
Biopsychosocial Model-based Care Versus Routine Physical Therapy in Chronic Back Pain
ClinicalTrials.gov study NCT07280806. IPD Sharing: YES. Countries: 1. Publications: 0.
ML Decision Model for G-NEC Adjuvant Therapy
ClinicalTrials.gov study NCT06663852. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Constitution of ex Vivo Ovarian Tumor Models for the Validation of the Interest of Innovative Therapies and the Search for Tumor or Circulating Biomarkers Predictive of Treatment Response
ClinicalTrials.gov study NCT03831230. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Transtheoretical Model Group Therapy for Cocaine
ClinicalTrials.gov study NCT00178776. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study on the Effectiveness of Berlin Dissexuality Therapy as Part of the Model Project in Accordance With §65d SBG V
ClinicalTrials.gov study NCT06607042. IPD Sharing: NO. Countries: 0. Publications: 2.
Fascial Distortion Model Manual Therapy and Painful Shoulder Syndrome
ClinicalTrials.gov study NCT03521778. IPD Sharing: UNDECIDED. Countries: 0. Publications: 19.
Development of the Neuroimaging Biomarker-based Prediction Model of Anxiety-related Disorders: Effect of Mindfulness-based Cognitive Therapy Using Neuroscience on the Brain
ClinicalTrials.gov study NCT05911412. IPD Sharing: Not stated. Countries: 0. Publications: 23.
A Non-invasive Model to Predict Antiviral Therapy in Gray Zone of Chronic Hepatitis B
ClinicalTrials.gov study NCT06041022. IPD Sharing: NO. Countries: 0. Publications: 6.
The Effect of Patient Preference for Treatment Model in Internet Delivered Cognitive Behavior Therapy for Generalized Anxiety Disorder
ClinicalTrials.gov study NCT07201844. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Modelling the evolution of HIV-1 virulence in response to imperfect therapy and prophylaxis
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Data from: Bacterial competition and quorum-sensing signalling shapes the eco-evolutionary outcomes of model in vitro phage therapy
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Data from: An ultrasound image-based dynamic fusion modeling method for predicting the quantitative impact of in vivo liver motion on intraoperative HIFU therapies: investigations in a porcine model
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Data from: A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?
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Data from: Quantification and comparison of anti-fibrotic therapies by polarized SRM and SHG-based morphometry in rat UUO model
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Transcriptomic changes associated with SIRT1-based therapy in a model of retinal neurodegeneration
GEO Series GSE275359. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Human-correlated genetic HCC models identify combination therapy for precision medicine
GEO Series GSE273806. Mus musculus. 187 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.