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60
datasets available to search
ShareScore release 0.9.0
Dataset results
60 results for “nanobodies”
A Multicenter, Open-Label, Non-Randomized, Single-Arm Clinical Study of Nanobody CD5-CAR T Cell Therapy for Refractory/Relapsed T Lymphocyte Malignancies
ClinicalTrials.gov study NCT07070323. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nanobody-Based Anti-CD5 CAR-T for Relapsed/Refractory T-ALL/LBL
ClinicalTrials.gov study NCT06874946. IPD Sharing: NO. Countries: 1. Publications: 0.
Multiple Ascending Doses (MAD) of Anti-A Disintegrin and Metalloproteinase With Thrombospondin Motifs-5 (Anti-ADAMTS-5) Nanobody in Participants With Knee Osteoarthritis (OA)
ClinicalTrials.gov study NCT03583346. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CLDN18.2 Targeting Nanobody Probe for PET Imaging in Solid Tumors
ClinicalTrials.gov study NCT05436093. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment
GEO Series GSE223428. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Nanobody engineered and photosensitiser loaded bacterial outer membrane vesicles potentiate anti-tumor immunity and immunotherapy
GEO Series GSE272295. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Di- and trimeric biological switches made of nanobody-cytokine receptor fusion proteins simulate IL-23 signaling
GEO Series GSE101569. Mus musculus. 32 samples. Type: Expression profiling by array.
Engineered Nanobodies Targeting Endogenous Digoxin-like Substances Function as Novel Immune Checkpoints Inhibitors and Enhance Immunotherapy against Cancer Metastasis
GEO Series GSE308031. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Engineered Nanobodies Targeting Endogenous Digoxin-like Substances Function as Novel Immune Checkpoints Inhibitors and Enhance Immunotherapy against Cancer Metastasis
GEO Series GSE308027. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
LC-MS raw data for "A new generation of nanobody research tools using improved mass spectrometry-based discovery methods"
<p>This dataset contains LC-MS raw data for VHH identifications from the project "A new generation of nanobody research tools using improved mass spectrometry-based discovery methods." The descriptions of the raw data files are in Summary_Table_MS_RawData.pdf. Files are in the format of Thermo RAW in zip archives.</p>
Construction of Nanobody Library in Mammalian Cells by Linear-double-stranded DNA Based AND Gate Genetic Circuit
GEO Series GSE155159. Homo sapiens. 3 samples. Type: Other.
Temporal mapping of the anti-tumor effects of nanobody-based MSLN.CAR-T cell therapy in metastatic solid tumors [scRNA-Seq]
GEO Series GSE303224. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Effect of anti-TNF/IL-6 NANOBODY® VHH, Humira, Sylvant, TNF, IL6 and TNF+IL6 in RA-FLS/T cell cocultures
GEO Series GSE200291. Homo sapiens. 98 samples. Type: Expression profiling by high throughput sequencing.
Temporal mapping of the anti-tumor effects of nanobody-based MSLN.CAR-T cell therapy in metastatic solid tumors [total RNA-Seq]
GEO Series GSE303385. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
Additive efficacy of a novel bispecific anti-TNF/IL-6 NANOBODY compound in translational models of Rheumatoid Arthritis
GEO Series GSE200293. Homo sapiens; Mus musculus. 154 samples. Type: Expression profiling by high throughput sequencing.
Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies
GEO Series GSE143181. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing; Other.
Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies II
GEO Series GSE143179. Homo sapiens. 4 samples. Type: Other.
Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies I
GEO Series GSE142447. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
iMbody - a nanobody for i-Motif research
GEO Series GSE212765. Homo sapiens. 4 samples. Type: Other.
Dataset related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"
<p>This record contains raw data related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"</p><p> </p><p><strong>Rationale:</strong> Nanobodies (Nbs) have emerged as an elegant alternative to the use of conventional monoclonal antibodies in cancer therapy, but a detailed microscopic insight into the <i>in vivo</i> pharmacokinetics of different Nb formats in tumor-bearers is lacking. This is especially relevant for the recognition and targeting of pro-tumoral tumor-associated macrophages (TAMs), which may be located in less penetrable tumor regions. <strong>Methods:</strong> We employed anti-Macrophage Mannose Receptor (MMR) Nbs, in a monovalent (m) or bivalent (biv) format, to assess <i>in vivo</i> TAM targeting. Intravital and confocal microscopy were used to analyse the blood clearance rate and targeting kinetics of anti-MMR Nbs in tumor tissue, healthy muscle tissue and liver. Fluorescence Molecular Tomography was applied to confirm anti-MMR Nb accumulation in the primary tumor and in metastatic lesions. <strong>Results:</strong> Intravital microscopy demonstrated significant differences in the blood clearance rate and macrophage targeting kinetics of (m) and (biv)anti-MMR Nbs, both in tumoral and extra-tumoral tissue. Importantly, (m)anti-MMR Nbs are superior in reaching tissue macrophages, an advantage that is especially prominent in tumor tissue. The administration of a molar excess of unlabelled (biv)anti-MMR Nbs increased the (m)anti-MMR Nb bioavailability and impacted on its macrophage targeting kinetics, preventing their accumulation in extra-tumoral tissue (especially in the liver) but only partially influencing their interaction with TAMs. Finally, anti-MMR Nb administration not only allowed the visualization of TAMs in primary tumors, but also at a distant metastatic site. <strong>Conclusions:</strong> These data describe, for the first time, a microscopic analysis of (m) and (biv)anti-MMR Nb pharmacokinetics in tumor and healthy tissues. The concepts proposed in this study provide important knowledge for the future use of Nbs as diagnostic and therapeutic agents, especially for the targeting of tumor-infiltrating immune cells</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.