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92 results for “pedigrees”
The pedigree of the present family and the domain structure of keratin 2 and the mutation detected in the present patient
<p>Figure S1: The pedigree of the present family. Squares are males and circles females. Solid squares represent affected individuals (P, the proband)</p> <p>Figure S2: The domain structure of keratin 2 and the mutation detected in the present patient. The location of the mutation in this patient is indicated by the black arrow.</p>
Data from: Genomic pedigree reconstruction identifies predictors of mating and reproductive success in an invasive vertebrate
The persistence of an invasive species is influenced by its reproductive ecology, and a successful control program must operate on this premise. However, the reproductive ecology of invasive species may be enigmatic due to factors that also limit their management, such as cryptic coloration and behavior. We explored the mating and reproductive ecology of the invasive Brown Treesnake (BTS: <i>Boiga irregularis</i>) by reconstructing a multigenerational genomic pedigree based on 654 single nucleotide polymorphisms for a geographically-closed population established in 2004 on Guam (N=426). The pedigree allowed annual estimates of individual mating and reproductive success to be inferred for snakes in the study population over a 14-year period. We then employed generalized linear mixed models to gauge how well phenotypic and genomic data could predict sex-specific annual mating and reproductive success. Average snout-vent length (SVL), average body condition index (BCI), and trappability were significantly related to annual mating success for males, with average SVL also related to annual mating success for females. Male and female annual reproductive success were positively affected by SVL, BCI, and trappability. Surprisingly, the degree to which individuals were inbred had no effect on annual mating or reproductive success. When juxtaposed with current control methods, these results indicate that baited traps, a common interdiction tool, may target fecund BTS in some regards but not others. Our study emphasizes the importance of reproductive ecology as a focus for improving BTS control and promotes genomic pedigree reconstruction for such an endeavor in this invasive species and others.
Code and data for "Wild snapdragon plant pedigree sheds light on limited connectivity enhanced by higher migrant reproductive success in a fragmented landscape"
<p>Archive file containing all the code and data for producing results and the supplementary result of the MS entitled "Wild snapdragon plant pedigree sheds light on limited connectivity enhanced by higher migrant reproductive success in a fragmented landscape". See README.txt for files descriptions.</p>
Pedigree and phenotypic variables used for estimation of heritability of sand lizard badge size and condition
<p><span>Sexual selection on fitness-determining traits should theoretically erode genetic variance and lead to low heritability. However, many sexually selected traits maintain significant phenotypic and additive genetic variance, with explanations for this "lek paradox" including genic capture due to condition-dependence, and breaks on directional selection due to environmental sources of variance including maternal effects. Here we investigate genetic and environmental sources of variance in the intrasexually selected green badge of the sand lizard (<em>Lacerta agilis</em>). The badge functions as a cue to male fighting ability in this species, and male-male interactions determine mate acquisition. Using animal models on a pedigree including three generations of males measured over an extensive nine year field study, we partition phenotypic variance in both badge size and body condition into additive genetic, maternal, and permanent environmental effects experienced by an individual over its lifespan. Heritability of badge size was 0.33 with a significant estimate of underlying additive genetic variance. Body condition was strongly environmentally determined in this species and does not show either significant additive genetic variance or heritability. Neither badge size nor body condition were responsive to maternal effects. We propose that the lack of additive genetic variance and heritability of body condition makes it unlikely that genic capture mechanisms maintains additive genetic variance for badge size. That said, genic capture was originally proposed for male traits under female choice, not agonistic selection. If developmental pathways generating variance in body condition, and/or the covarying secondary sex trait, differ between inter- and intrasexual selection, or the rate at which their additive genetic variance or covariance is depleted, future work may show whether genic capture is largely restricted to intersexual selection processes.</span></p>
Exploratory Data Analysis for Disease Pedigrees and Cancer Genetics
ClinicalTrials.gov study NCT00339508. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Estimating relatedness and inbreeding using molecular markers and pedigrees: the effect of demographic history
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Data for: Machine learning for genomic and pedigree prediction in sugarcane
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Data from: A comparison of pedigree- and genetic-based measures for identifying inbreeding depression in the critically endangered Attwater’s Prairie-chicken
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Data from: Traces of Medieval migrations in a socially-stratified population from Northern Italy. Evidence from uniparental markers and deep-rooted pedigrees.
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Data from: Estimating quantitative genetic parameters in wild populations: a comparison of pedigree and genomic approaches
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Data from: Genomic pedigree reconstruction identifies predictors of mating and reproductive success in an invasive vertebrate
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Data from: Recovery of native genetic background in admixed Populations Using haplotypes, phenotypes, and pedigree information – using Cika cattle as a case breed
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Data from: The influence of nonrandom extra-pair paternity on heritability estimates derived from wild pedigrees
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Pedigree-based assessment of recent population connectivity in a threatened rattlesnake
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Data from: Relationship type affects the reliability of dispersal distance estimated using pedigree inferences in partially sampled populations: a case study involving invasive American mink in Scotland
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Pedigree and phenotypic variables used for estimation of heritability of sand lizard badge size and condition
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Data from: Pedigree error due to extra-pair reproduction substantially biases estimates of inbreeding depression
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Data from: Mechanisms of kin discrimination inferred from pedigrees and the spatial distribution of mates
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Data from: Pedigree-based inbreeding coefficient explains more variation in fitness than heterozygosity at 160 microsatellites in a wild bird population
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Data from: Genetic pedigree analysis of the pilot breeding program for the rediscovered Galapagos giant tortoise from Floreana island
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.