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67 results for “pleiotropy”
Data from: The role of pleiotropy and linkage in genes affecting a sexual ornament and bone allocation in the chicken
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Data from: Mitochondrial genetic effects on reproductive success: signatures of positive intrasexual, but negative intersexual pleiotropy
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Data from: Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness
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Data from: Pleiotropy in the wild: the dormancy gene DOG1 exerts cascading control on life-cycles
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Data from: Environmental pleiotropy and population demography direct adaptation under antibiotic selection
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Data from: Antagonistic pleiotropy in species with separate sexes, and the maintenance of genetic variation in life-history traits and fitness
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Data from: Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics
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Data from: Environmentally induced changes in correlated responses to selection reveal variable pleiotropy across a complex genetic network
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Data from: Pleiotropy can be effectively estimated without counting phenotypes through the rank of genotype-phenotype map
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Data from: Morphological integration and pleiotropy in the adaptive body shape of the snail-feeding carabid beetle Damaster blaptoides
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Tuberous sclerosis complex renal lesion pleiotropy arises from multiple aberrant developmental processes
GEO Series GSE182632. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 2)
GEO Series GSE44964. Homo sapiens. 32 samples. Type: Expression profiling by array.
Conserved pleiotropy of an ancient plant homeobox gene uncovered by cis-regulatory dissection
GEO Series GSE164297. Solanum lycopersicum. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment
GEO Series GSE44966. Homo sapiens. 80 samples. Type: Expression profiling by array.
Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)
GEO Series GSE44956. Homo sapiens. 48 samples. Type: Expression profiling by array.
Data from: Pleiotropy and the low cost of individual traits promote cooperation
The evolution of cooperation is thought to be promoted by pleiotropy, whereby cooperative traits are co-regulated with traits that are important for personal fitness. However, this hypothesis faces a key challenge: what happens if mutation targets a cooperative trait specifically rather than the pleiotropic regulator? Here we explore this question with the bacterium Pseudomonas aeruginosa, which cooperatively digests complex proteins using elastase. We empirically measure and theoretically model the fate of two mutants – one missing the whole regulatory circuit behind elastase production and the other with only the elastase gene mutated – relative to the wild-type. We first show that, when elastase is needed, neither of the mutants can grow if the wild-type is absent. And, consistent with previous findings, we show that regulatory gene mutants can grow faster than the wild-type when there are no pleiotropic costs. However, we find that mutants only lacking elastase production do not outcompete the wild-type, because the individual cooperative trait has a low cost. We argue that the intrinsic architecture of molecular networks makes pleiotropy an effective way to stabilize cooperative evolution. While individual cooperative traits experience loss-of-function mutations, these mutations may result in weak benefits, and need not undermine the protection from pleiotropy.
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT04953494. IPD Sharing: NO. Countries: 1. Publications: 0.
Use of Pleiotropy to Model Genetic Interactions in a Population
GEO Series GSE34787. Saccharomyces cerevisiae. 96 samples. Type: Expression profiling by array.
A knockout mutation associated with juvenile paroxysmal dyskinesia in Markiesje dogs indicates SOD1 pleiotropy
GEO Series GSE166712. Canis lupus familiaris. 5 samples. Type: Genome variation profiling by high throughput sequencing.
Data from: The role of pleiotropy in the maintenance of sex in yeast
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.