Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
79
datasets available to search
ShareScore release 0.9.0
Dataset results
79 results for “positive interactions”
Data from: Antagonistic biotic interactions mitigate the positive effects of warming on wood decomposition
Open the record for dataset details and reuse information.
Data from: Invasion-mediated effects on marine trophic interactions in a changing climate: positive feedbacks favour kelp persistence
The interactive effects of ocean warming and invasive species are complex and remain a source of uncertainty for projecting future ecological change. Climate-mediated change to trophic interactions can have pervasive ecological consequences, but the role of invasion in mediating trophic effects is largely unstudied. Using manipulative experiments in replicated outdoor mesocosms, we reveal how near-future ocean warming and macrophyte invasion scenarios interactively impact gastropod grazing intensity and preference for consumption of foundation macroalgae (Ecklonia radiata and Sargassum vestitum). Elevated water temperature increased consumption of both macroalgae through greater grazing intensity. Given the documented decline of kelp (E. radiata) growth at higher water temperatures, enhanced grazing could contribute to the shift from kelp-dominated to Sargasssum-dominated reefs that is occurring at the low-latitude margins of kelp distribution. However, presence of a native invader (Caulerpa filiformis) was related to low consumption by the herbivores on dominant kelp at warmer temperatures. Thus, antagonistic effects between climate change and a range expanding species can favour kelp persistence in a warmer future. Introduction of species should, therefore, not automatically be considered unfavourable under climate change scenarios. Climatic changes are increasing the need for effective management actions to address the interactive effects of multiple stressors and their ecological consequences, rather than single threats in isolation.
Datasets of positive and negative miRNA-target interactions
<p>MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally via base-pairing with complementary sequences on messenger RNAs (mRNAs). Computational approaches that predict miRNA target interactions (MTIs) facilitate the process of narrowing down potential targets for experimental validation. The availability of new datasets of high-throughput, direct MTIs has led to the development of machine learning (ML) based methods for MTI prediction. To train an ML algorithm, there is a need to supply entries from all class labels (i.e., positive and negative). Currently, no high-throughput assays exist for capturing negative examples, hindering effective classifier construction. Therefore, current ML approaches must rely on artificially generated negative examples for training. Moreover, the lack of uniform standards for generating such data leads to biased results and hampers comparisons between studies. We investigated the impact of different methods to generate negative data on the classification of true MTIs. The study relies on training ML models on a fixed positive dataset in combination with different negative datasets and evaluating their intra- and cross-dataset performance. As a result, we were able to examine each method independently and evaluate ML models’ sensitivity to the methodologies utilized in negative data generation.</p> <p>This data includes all the negative datasets generated by the different methods and the positive data that was used (folder Data.zip).<br>In addition, we uploaded all the train and test files that we used to train and test the models (folder Train_Test_files.zip).</p>
Aromatase Inhibitor Therapy With or Without Fulvestrant for the Treatment of HR Positive Metastatic Breast Cancer With an ERS1 Activating Mutation, the INTERACT Study
ClinicalTrials.gov study NCT04256941. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase I Open-Label Study of the Safety, Tolerance, and Pharmacokinetic Interactions of Combination Didanosine and Ribavirin in HIV-Positive Individuals
ClinicalTrials.gov study NCT00000772. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate Corrected QT Interval and Drug-Drug Interaction of Trastuzumab on Carboplatin in the Presence of Docetaxel in Patients With HER2-Positive Metastatic or Locally Advanced Inoperable
ClinicalTrials.gov study NCT00927589. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Coevolution between positive reciprocity, punishment, and partner switching in repeated interactions
Open the record for dataset details and reuse information.
Data from: Invasion-mediated effects on marine trophic interactions in a changing climate: positive feedbacks favour kelp persistence
Open the record for dataset details and reuse information.
EZH1/SUZ12 complex positively regulates the transcription of NF-κB target genes via interaction with UXT
GEO Series GSE75217. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
AR interacts with GATA3 to induce a luminal epithelial phenotype in breast cancer through regulation of lineage-restricted genes [ER-positive_cell_line_GATA3_ChIP-seq]
GEO Series GSE178253. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
AR interacts with GATA3 to induce a luminal epithelial phenotype in breast cancer through regulation of lineage-restricted genes [ER-positive cell line RNA-seq]
GEO Series GSE176005. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C
GEO Series GSE205000. Homo sapiens. 31 samples. Type: Other; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions [ChIP-seq]
GEO Series GSE79518. Mus musculus. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Spt6-Spn1 interaction is required for RNA Polymerase II association and precise nucleosome positioning along transcribed genes
GEO Series GSE284959. Saccharomyces cerevisiae. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo
GEO Series GSE15188. Escherichia coli; Saccharomyces cerevisiae. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
AR interacts with GATA3 to induce a luminal epithelial phenotype in breast cancer through regulation of lineage-restricted genes [ER-positive_PDX_GATA3_ChIP-seq]
GEO Series GSE178254. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions.
GEO Series GSE79520. Mus musculus. 40 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
A Study To Evaluate The Difference In iPad-Based Cognitive Video Game (Akili Interactive's Project: EVO) Performance In Amyloid-Positive Versus Amyloid-Negative Healthy Elderly Volunteers
ClinicalTrials.gov study NCT02265718. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase I, Multi-center, Open Label, Drug-drug Interaction Study to Assess the Effect of Ceritinib on the Pharmacokinetics of Warfarin and Midazolam in Patients With ALK-positive Advanced Tumors
ClinicalTrials.gov study NCT02422589. IPD Sharing: NO. Countries: 4. Publications: 0.
Oregon Supplement: Supporting Sustainable Positive Interactions in the Child Welfare System: The R3 Supervisor Strategy
ClinicalTrials.gov study NCT05475457. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.