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ShareScore release 0.7.1
Dataset results
67 results for “potassium channel”
Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events [Figure 2 mRNA data]
GEO Series GSE146664. Homo sapiens. 16 samples. Type: Other.
Potassium channel-driven bioelectric signaling affects the metastatic potential of triple negative breast cancer
GEO Series GSE171150. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Estrogen-Related Receptor γ (ERRγ) Regulates Oxygen-Dependent Expression of Voltage-gated Potassium (K+) Channels and Tissue Kallikrein during Human Trophoblast Differentiation
GEO Series GSE46463. Homo sapiens. 9 samples. Type: Expression profiling by array.
Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development [scRNA-Seq]
GEO Series GSE282936. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma
GEO Series GSE231577. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
KCNQ POTASSIUM CHANNELS MODULATE WNT ACTIVITY IN GASTRO-OESOPHAGEAL ADENOCARCINOMAS
GEO Series GSE242782. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis.
GEO Series GSE260669. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide screening of HNF1b binding sites identifies transcriptional regulation of the Kir4.1/Kir5.1 potassium channel
GEO Series GSE77397. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of potassium and chloride channels in eccrine sweat glands
GEO Series GSE73715. Mus musculus. 20 samples. Type: Expression profiling by array.
Diversely evolved xibalbin variants from remipede venom inhibit 3 potassium channels and activate PKA-II and Erk1/2 signalling
<p><span><strong>Background:</strong> </span><span>The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede <em>Xibalbanus tulumensis</em>, an underwater cave-dwelling crustacean, is the only crustacean for which a venom system has been described. Its venom contains several xibalbin peptides that have an inhibitor cysteine knot (ICK) scaffold.</span></p> <p><strong><span>Result:</span></strong><span><strong> </strong>Our screenings revealed that all tested xibalbin variants particularly inhibit potassium channels. Xib<sub>1</sub> and xib<sub>13</sub>, with their eight-cysteine domain similar to spider knottins also inhibit voltage-gated sodium channels. No activity was noted on calcium channels. Expanding the functional testing we demonstrate that xib<sub>1</sub> and xib<sub>13</sub> increase PKA-II and Erk1/2 sensitization signaling in nociceptive neurons, which may initiate pain sensitization. Our phylogenetic analysis suggests that xib<sub>13</sub> either originates from the common ancestor of pancrustaceans or earlier while xib<sub>1</sub> is more restricted to remipedes. The ten-cysteine scaffolded xib<sub>2</sub> emerged from xib<sub>1</sub>, a result that is supported by our phylogenetic and machine learning-based analyses.</span></p> <p><strong><span>Conclusions</span></strong><span><strong>: </strong>Our functional characterization of synthesized variants of xib<sub>1</sub>, xib<sub>2</sub>, and xib<sub>13</sub> elucidates their potential as inhibitors of potassium channels in mammalian systems. The specific interaction of xib<sub>2</sub> with Kv1.6 channels, which are relevant to treating variants of epilepsy, shows potential for further studies. At higher concentrations, xib1 and xib13 activate the kinases PKA-II and ERK1/2 in mammalian sensory neurons, suggesting pain sensitization and potential applications related to pain research and therapy. While tested insect channels suggest that all probably act as neurotoxins, the biological function of xib<sub>1</sub>, xib<sub>2,</sub> and xib<sub>13</sub> requires further elucidation. A novel finding on their evolutionary origin is the apparent emergence of </span><em><span>X. tulumensis</span></em><span>-specific xib<sub>2</sub> from xib<sub>1</sub>. Our study is an important cornerstone for future studies to untangle the origin and function of these enigmatic proteins as important components of remipede but also other pancrustacean and arthropod venoms.</span></p>
alignment of potassium channels sequences
<p>This aligment (MAFFT) was used to perform a phylogenetic analysis (PhyML) to determine the position of the potassium channel sequences of Oopsacas minuta.</p>
A Natural History Study of Participants With Potassium Sodium-Activated Channel Subfamily T Member 1 (KCNT1)-Related Epilepsy
ClinicalTrials.gov study NCT04924153. IPD Sharing: YES. Countries: 1. Publications: 0.
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.
ClinicalTrials.gov study NCT05565001. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies
ClinicalTrials.gov study NCT03954691. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Mexartan Potassium Tablets (AZL-M) and Calcium Channel Blockers (CCB) in the Treatment of Adults With Essential Hypertension in Chinese Population: a National Multicenter, Prosp
ClinicalTrials.gov study NCT05947448. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity
GEO Series GSE104052. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target
GEO Series GSE70647. Drosophila melanogaster. 4 samples. Type: Expression profiling by array.
Induction of potassium channel regulator KCNE4 in the submandibular lymph nodes of a melanoma metastasis model
GEO Series GSE197190. Mus musculus. 6 samples. Type: Expression profiling by array.
Effect of estradiol on thermoregulatory responses in ovariectomized rats administered ostruthin, a TWIK-related potassium channel agonist
GEO Series GSE278704. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target
GEO Series GSE70576. Homo sapiens. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.