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395 results for “rat model”
A multivariate physiological model of vagus nerve signalling during metabolic challenges in anaesthetised rats for diabetes treatment
<p>Raw recordings that support the findings of the paper. In the intact recordings, there may be more than one recoridng corresponding to the same animal. For ligated recordings, odd numbers correspond to efferent and even numbers to afferent recordings.</p>
Datasets and code for "Phylogenetic modeling of enhancer shifts in mole-rats reveals regulatory changes associated with tissue-specific traits"
<p>This archive contains the code and datasets generated in the associated manuscript: "Phylogenetic modeling of enhancer shifts in mole-rats reveals regulatory changes associated with tissue-specific traits". We provide instructions, environments and scripts to reproduce the presented analyses.</p>
Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing
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Serum levels of tau protein increase according to the severity of the injury in DAI rat model
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Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity
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Data from: A novel technique to develop thoracic spinal laminectomy and a methodology to assess the functionality and welfare of the contusion SCI rat model
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Data from: A priori and a posteriori approaches for finding genes of evolutionary interest in non-model species: osmoregulatory genes in the kidney transcriptome of the desert rodent Dipodomys spectabilis (banner-tailed kangaroo rat)
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Figure 1 from: Kondeva-Burdina M, Krasteva I, Popov G, Manov V (2019) Neuroprotective and antioxidant activities of saponins' mixture from Astragalus glycyphylloides in a model of 6-hydroxydopamine-induced oxidative stress on isolated rat brain synaptosomes. Pharmacia 66(4): 233-236. https://doi.org/10.3897/pharmacia.66.e37997
Figure 1 Effects of PSM and S on synaptosomal viability in conditions of 6-OHDA-induced oxidative stress; ***P ≤ 0.001 vs control (non-treated synaptosomes); +P ≤ 0.05, ++P ≤ 0.01, +++P ≤ 0.001 vs6-OHDA.
Figure 2 from: Kondeva-Burdina M, Krasteva I, Popov G, Manov V (2019) Neuroprotective and antioxidant activities of saponins' mixture from Astragalus glycyphylloides in a model of 6-hydroxydopamine-induced oxidative stress on isolated rat brain synaptosomes. Pharmacia 66(4): 233-236. https://doi.org/10.3897/pharmacia.66.e37997
Figure 2 Effects of PSM and S on GSH level in conditions of 6-OHDA-induced oxidative stress ***P ≤ 0.001 vs control (non-treated synaptosomes); +P ≤ 0.05, ++P ≤ 0.01 vs6-OHDA.
Dataset related to article "Identification of a gut-microbiota signature linked to epileptogenesis in a rat model of acquired epilepsy"
<p>Five excel files containing data related to the article</p>
raw data - Comparison of High-Flow Nasal Cannula Oxygen and Conventional Oxygen Therapy in a Rat Model of Severe Carbon Monoxide Poisoning
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Dataset related to: Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis
<p><strong>Background/aim: </strong> Necrotizing crescentic glomerulonephritis (GN) associated with anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) is a devastating disease that quickly progresses to kidney failure. Current therapies are broadly immunosuppressive and associated with adverse effects. We wanted to set up a model that could be suitable for testing narrowly targeted therapies.</p> <p><strong>Methods: </strong> The model was constructed in male Wistar Kyoto rats through injections of human MPO (hMPO) and pertussis toxin, followed by a sub-nephritogenic dose of sheep anti-rat glomerular basement membrane (GBM) serum to boost the disease. Rats were monitored for 35 days. Rats given hMPO alone, saline, or human serum albumin with or without anti-GBM serum were also studied.</p> <p><strong>Results: </strong> Rats receiving hMPO developed circulating anti-hMPO and anti-rat MPO antibodies. Challenging hMPO-immunized rats with the anti-GBM serum led to more glomerular neutrophil infiltration and MPO release, and severe haematuria, heavy proteinuria, and higher blood urea nitrogen than hMPO alone. Pauci-immune GN developed with crescents, affecting 25% of glomeruli. The majority of crescents were fibrocellular. Necrotizing lesions and Bowman capsule ruptures were detected. Cells double positive for claudin-1 (a marker of parietal epithelial cells [PECs]) and neural cell adhesion molecule (NCAM; progenitor PECs) were present in crescents. Double staining for NCAM and Ki-67 established proliferative status of progenitor PECs. Podocyte damage was associated with endothelial and GBM changes by electron microscopy. Monocyte/macrophages and CD4+ and CD8+ T cells accumulated in glomeruli and the surrounding area and in the tubulointerstitium. Lung haemorrhage also manifested.</p> <p><strong>Conclusion: </strong> This model reflects histological lesions of human ANCA-associated rapidly progressive GN and may be useful for investigating new therapies.</p>
Dataset related to article "Evolution of brain injury and neurological dysfunction after cardiac arrest in the rat – a multimodal and comprehensive model."
<p>Excel file related to the article</p>
Application of adipose-derived stem cells combined with platelet-rich plasma in a rat rotator cuff repair model
<p>A controlled experimental study conducted on 48 Sprague-Dawley rats. The supraspinatus tendon was sectioned and repaired and was randomly allocated to two groups: application of PRP alone or PRP and ASCs. Biomechanical and histological analysis was performed at 3 days, 1, 2 and 4 weeks. <br> Results: There were no statistically significant differences in the biomechanical study. In the PRP group, load to failure at two weeks was 3.89 N ± 0.99 and in the ASCs group was 7.87 N ± 2.18 (p=0.05). Histological examination showed an increase in the presence of vessels at one and four weeks in the ASCs group (p=0.047). Collagen fibers were present in 25% of the repaired tissue in the ASCs group at one week and absent in the PRP group (p=0.047). Maximum differences in collagen concentration occurred at two weeks in favor of the ASCs group (p=0.059).<br> Conclusion: The use of ASCs does not improve the biomechanical properties of the repair. However, increased vascularity and collagen fibers type I were promising findings in the group treated with ASC.</p>
Altered Control of Breathing in a Rat Model of Allergic Lower Airway Inflammation
<p>This table shows summary data for all measurements made during normoxia and hypoxic exposures, pulmonary function tests, assessments of cytokines in bronchoalveolar lavage fluid and cytokines and IgE in serum, made in the study entitled "Altered Control of Breathing in a Rat Model of Allergic Lower Airway Inflammation".</p>
Altered Control of Breathing in a Rat Model of Allergic Lower Airway Inflammation
<p>These graphs represent supplemental data collected in conjunction with the manuscript entitled "Altered Control of Breathing in a Rat Model of Allergic Lower Airway Inflammation". </p>
Role of Hypoxic Secretome from Mesenchymal Stem Cells in Enhancing Tissue Repair: Regulatory Effects on HIF-1α, VEGF, and Fibroblast in a Sphincterotomy Rat Model
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Effects of warm ischemia and reperfusion in liver mouse and rat models - a systematic review and meta-analysis
<p>Systematic Review and meta-analysis</p>
Colon Data - Lipid MSI from Chronic Pain Model (Rat)
<p>Rat model of comorbid visceral pain. Colon tissues swiss-rolled in 2% gelatin. Cryosections at 12 um thickness. Norharmane matrix, negative ion mode lipid scans by MALDI-MSI at 50um spatial resolution. Converted from native file structure to the common file format, .imzML. Compressed zip folders contain both the .ibd and .imzML files.</p> <p>Data used in: Kasun Pathirage, Aman Virmani, Alison Scott, Richard Traub, Robert Ernst, Reza Ghodssi, Behtash Babadi, and Pamela Abshire. (2023). “Interpretable dimensionality reduction and classification of mass spectrometry imaging data in a visceral pain model via non-negative matrix factorization,” bioRxiv 2023.04.24.538180. doi: <a href="https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.org%2F10.1101%2F2023.04.24.538180&data=05%7C01%7CAscott1%40umaryland.edu%7Cc2a3f9b67a964db86c8a08db484f3b69%7C3dcdbc4a7e4c407b80f77fb6757182f2%7C0%7C0%7C638183279460394978%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=0yzFTOcsD9FiNnZK8R28EVKqKiW1MwydsF0LW0KzJgE%3D&reserved=0">https://doi.org/10.1101/2023.04.24.538180</a></p> <p> </p>
Data from: Evaluation of the novel avocado/soybean unsaponifiable Arthrocen to alter joint pain and inflammation in a rat model of osteoarthritis
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.