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339 results for “secondary study”
A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
ClinicalTrials.gov study NCT05019521. IPD Sharing: Not stated. Countries: 13. Publications: 1.
Extension Study of Etelcalcetide in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease (CKD) on Hemodialysis
ClinicalTrials.gov study NCT01785875. IPD Sharing: Not stated. Countries: 17. Publications: 2.
A Safety and Efficacy Study to Assess OZURDEX® in Patients With Macular Oedema Secondary to Retinal Vein Occlusion (RVO)
ClinicalTrials.gov study NCT01571557. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration
ClinicalTrials.gov study NCT03525600. IPD Sharing: Not stated. Countries: 15. Publications: 5.
A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization
ClinicalTrials.gov study NCT03250377. IPD Sharing: NO. Countries: 2. Publications: 1.
A Pilot Study of Ruxolitinib in Secondary Hemophagocytic Syndrome
ClinicalTrials.gov study NCT02400463. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Dialysis-Dependent Chronic Kidney Disease (DD-CKD)
ClinicalTrials.gov study NCT03054350. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Dose-Finding Study of Vadadustat in Japanese Subjects With Anemia Secondary to Non-Dialysis Dependent Chronic Kidney Disease (NDD-CKD)
ClinicalTrials.gov study NCT03054337. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Dataset for paper: Research Artifacts in Secondary Studies: A Systematic Mapping in Software Engineering
Open the record for dataset details and reuse information.
Common Reasons for Conflicts and Common Conflict Resolution Techniques Used: Findings of 8 Years of Secondary and Primary Research Studies
<p>The paper, a summary of 8 years of research (2015-2023) on conflict management, presents the common reasons for conflicts and common conflict resolution techniques used by employees at all levels in an organization based on secondary research and also an empirical investigation. The Macro Objective of the Research is to Generalize the Reasons for Conflicts and Conflict Resolution Techniques Used at Employee, Manager and Top Management Level using Author’s Previous 3 Secondary Research Studies and Current Primary Research Study by finding the Top-3 Common Reasons for Conflicts and Top-3 Common Conflict Resolution Techniques Used at all levels of Employees. The 3 different secondary research studies are conducted (2015-2023) at Employee level, Manager Level, Top Management Level to identify Top-5 Reasons for Conflicts and Top-5 Conflict Resolution Techniques used by Employees, Managers and Top Management Respectively. Top-5 items are identified based on reference count (number of citations) in literature in each of these research works. Later on, in 4th Paper (2023) Common Top-3 Reasons for Conflicts, Common Top-3 Conflict Resolution Techniques are Identified based on the 3 published secondary research works. This current work is primary study conducted on 68 respondents; and Primary Research Findings are Compared with Secondary Research findings; further top-3 common reasons for conflicts and top-3 conflict resolution techniques used are identified at all levels of employees in an organization. Overall, the paper presents the Top-3 common reasons for conflicts among employees, project managers, and top management; and top-3 common conflict resolution techniques used by employees, project managers and top management. Based on Secondary & Primary Research Studies, the Top-3 common reasons for conflicts identified are Resources, Value Differences, Personality Differences; and Top-3 conflict resolution techniques used are Avoidance, Compromise, Confrontation/Problem Solving at all levels of employees. </p>
Dataset : Micromolar concentration affinity study on a benchtop NMR spectrometer with secondary 13C labeled hyperpolarized ligands
<p><strong>Data of the dDNP decays for 13C drug screening</strong></p> <p><strong>Drug discovery Data recap</strong></p> <p> </p> <p><strong>Samples</strong></p> <p>Sample 2 : 44mM of Ac-L30 (N-Acetyl [1-<sup>13</sup>C]-6 amino-2-naphthoic acid) in 60/30/10 DMSO/D2O/H2O with 25 mM Tempol</p> <p>Sample 4 (in fact sample 3 in Topspin and according to OC figures) : 44mM of Ac-L08 (N-Acetyl [1-<sup>13</sup>C]-glycine) in 60/30/10 DMSO/D2O/H2O with 25 mM Tempol</p> <p> </p> <p><strong>Dissolution Ac-L30 </strong></p> <p><em>Sample : 600 µM Sample 2 without and with 2 µM HSA</em></p> <p><em>Topspin Folder : 20210414-DrugScreening</em></p> <ul> <li>Dissolution fragment : 1</li> <ul> <li>D1 5 sec</li> <li>Int between 167.2 - 168.3 ppm</li> <li>General model:</li> <li> val(t) = a*(exp(-(t)/T)+d)</li> <li> Coefficients (with 95% confidence bounds):</li> <li> T = 11.88 (10.84, 12.91)</li> <li> a = 1.017 (0.967, 1.066)</li> <li> d = 0.0005482 (-0.006744, 0.007841)</li> </ul> <li>TE : 2</li> <ul> <li>polarization to be computed</li> </ul> </ul> <ul> <li>Dissolution fragment + HSA : 3</li> <ul> <li>D1 5 sec</li> <li>Integration between 167.9 - 168.1 ppm</li> <li>General model:</li> <li> val(t) = a*(exp(-(t)/T)+d)</li> <li> Coefficients (with 95% confidence bounds):</li> <li> T = 6.339 (5.57, 7.109)</li> <li> a = 1.027 (0.9665, 1.088)</li> <li> d = -0.007015 (-0.01521, 0.001185)</li> </ul> <li>TE : 4</li> <ul> <li>polarization to be computed</li> </ul> </ul> <ul> <ul> <li>Code used to plot : Ac-L30.m</li> </ul> </ul> <p> </p> <p><strong>Dissolution Ac-L30 </strong></p> <p><em>Sample : 600 µM Sample 4 without and with 2 µM HSA</em></p> <p><em>Topspin Folder : 20210414-DrugScreening</em></p> <ul> <li>Dissolution fragment : 5</li> <ul> <li>D1 2,5 sec</li> <li>Int between 168.6 - 169 ppm</li> <li>General model:</li> <li> val(t) = a*(exp(-(t)/T)+d)</li> <li> Coefficients (with 95% confidence bounds):</li> <li> T = 29.25 (29.05, 29.46)</li> <li> a = 1.019 (1.015, 1.023)</li> <li> d = -0.001389 (-0.002239, -0.0005388)</li> </ul> <li>TE : 6</li> <ul> <li>polarization to be computed</li> </ul> </ul> <ul> <li>Dissolution fragment + HSA : 11</li> <ul> <li>D1 2,5 sec</li> <li>Integration between 168.6 - 169 ppm</li> <li>General model:</li> <li> val(t) = a*(exp(-(t)/T)+d)</li> <li> Coefficients (with 95% confidence bounds):</li> <li> T = 29.73 (29.57, 29.88)</li> <li> a = 0.9938 (0.9905, 0.9971)</li> <li> d = -0.0003466 (-0.0007762, 8.314e-05)</li> </ul> <li>TE : 12</li> <ul> <li>polarization to be computed</li> </ul> </ul> <ul> <ul> <li>Code used to plot : Ac-L08.m</li> </ul> </ul>
FIGURE. Variable positions in the ITS2 secondary structure of some Coelastrella sensu lato species. The ITS2 model of Coelastrella striolata strain CAUP H 3602 (JX513881) was used to map sequence differences. Variable positions of analyzed strains (GenBank numbers can be found in Table 3, 4 are given next to the main structure and are marked in bold. Hemi- Compensatory Base Changes in conservative regions are circled and Compensatory Base Change is contoured. Sequences of strains with GenBank numbers JX513879 (C. aeroterrestrica), JX513882 (C. terrestris), JX513884 (C. rubescens), MH176120 (C. rubescens var. oocystiformis), JX513880 (C. multistriata), JX513887 (C. oocystiformis) were used as representatives of Coelastrella species. The strains analyzed in this study are underlined. in Morphological and phylogenetic relations of members of the genus Coelastrella (Scenedesmaceae, Chlorophyta) from the Ural and Khentii Mountains (Russia, Mongolia)
FIGURE. Variable positions in the ITS2 secondary structure of some Coelastrella sensu lato species. The ITS2 model of Coelastrella striolata strain CAUP H 3602 (JX513881) was used to map sequence differences. Variable positions of analyzed strains (GenBank numbers can be found in Table 3, 4 are given next to the main structure and are marked in bold. Hemi- Compensatory Base Changes in conservative regions are circled and Compensatory Base Change is contoured. Sequences of strains with GenBank numbers JX513879 (C. aeroterrestrica), JX513882 (C. terrestris), JX513884 (C. rubescens), MH176120 (C. rubescens var. oocystiformis), JX513880 (C. multistriata), JX513887 (C. oocystiformis) were used as representatives of Coelastrella species. The strains analyzed in this study are underlined.
Bracing adults with chronic low back pain secondary to severe scoliosis: six months results of a prospective pilot study.
<p>Dataset from the paper: Bracing adults with chronic low back pain secondary to severe scoliosis: six months results of a prospective pilot study. Eur Spine J. 2021 Oct;30(10):2962-2966. doi: 10.1007/s00586-021-06808-1. Epub 2021 Mar 17. PMID: 33733328.</p> <p>Abstract</p> <p><strong>Purpose: </strong>Adult scoliosis is sometimes associated with back pain and severe curves can progress over time. Despite scoliosis has been estimated to affect up to 68% of the population over 60, there is scant literature about conservative treatment for adult scoliosis. Recently, we tested a new brace designed to alleviate pain for adult patients with chronic pain secondary to scoliosis. The study aims to test the efficacy of a prefabricated brace in reducing pain in adult scoliosis patients.</p> <p><strong>Methods: </strong>Twenty adults (age 67.8 ± 10.5, curve 61.9 ± 12.6° Cobb) with chronic low back pain (cLBP) secondary to Idiopathic Scoliosis (IS) were included. Patients were evaluated at baseline immediately before starting with the brace and after 6 months. Outcome measures were GRS, Oswestry Disability Index (ODI), Roland Morris Questionnaire (RM), COMI. The paired t test, ANOVA and Wilcoxon tests were used for statistical analysis RESULTS: At six months, worst pain, leg pain and back pain were significantly improved: from 7.15 to 5.60, from 5.65 to 4.35 and from 6.55 to 5.25 (p < 0.05). Sixty-five percent of patients achieved the minimal clinically important difference of 2 points for worst pain and leg pain, 55% for back pain. RM and COMI improved (p < 0.05), no differences for ODI.</p> <p><strong>Conclusion: </strong>The prefabricated brace showed a significant improvement at 6 months of worst, leg and back pain in most patients in a group of adult women with IS and cLBP. The quality of life didn't change in a clinically significant way even if the patients reported satisfaction with the treatment. Trial registration number and date of registration: ClinicalTrials.gov Identifier: <a href="http://clinicaltrials.gov/show/NCT02643290">NCT02643290</a>, December 31, 2015.</p>
FIGURE 36. The secondary structures for 22 in Contribution to the knowledge of Chinese Gryllacrididae (Orthoptera) V: Further study on the Chinese Capnogryllacris and comment on the phylogenetic relationships of the Gryllacrididae
FIGURE 36. The secondary structures for 22 tRNA genes of the Capnogryllacris nigromarginata hainanensis ssp. nov..
FIGURE 35. The secondary structures for 22 in Contribution to the knowledge of Chinese Gryllacrididae (Orthoptera) V: Further study on the Chinese Capnogryllacris and comment on the phylogenetic relationships of the Gryllacrididae
FIGURE 35. The secondary structures for 22 tRNA genes of the Capnogryllacris nigromarginata rectispina ssp. nov..
FIGURE 34. The secondary structures for 22 in Contribution to the knowledge of Chinese Gryllacrididae (Orthoptera) V: Further study on the Chinese Capnogryllacris and comment on the phylogenetic relationships of the Gryllacrididae
FIGURE 34. The secondary structures for 22 tRNA genes of the Capnogryllacris nigromarginata nigromarginata.
FIGURE 32. The secondary structures for 22 in Contribution to the knowledge of Chinese Gryllacrididae (Orthoptera) V: Further study on the Chinese Capnogryllacris and comment on the phylogenetic relationships of the Gryllacrididae
FIGURE 32. The secondary structures for 22 tRNA genes of the Capnogryllacris erythrocephala maculatis ssp. nov..
FIGURE 6. The secondary structures for 22 in Study on the Chinese Subfamily Anostostomatinae (Orthoptera: Anostostomatidae IV: One new recorded species Anabropsis (Apteranabropsis) tonkinensis Rehn, 1906
FIGURE 6. The secondary structures for 22 tRNA genes of Anabropsis (Apteranabropsis) tonkinensis (XZ262) mitogenome.
FIGURE 7. The secondary structures for 22 in Study on the Chinese Subfamily Anostostomatinae (Orthoptera: Anostostomatidae IV: One new recorded species Anabropsis (Apteranabropsis) tonkinensis Rehn, 1906
FIGURE 7. The secondary structures for 22 tRNA genes of Anabropsis (Apteranabropsis) tonkinensis (XZ335) mitogenome.
Supplemental material for: Clinical and neuroimaging outcomes of direct endovascular thrombectomy vs. bridging therapy in large vessel occlusion patients: a secondary analysis of SELECT cohort study
<p><b>Objective:</b> To evaluate the comparative safety and efficacy of direct endovascular thrombectomy(dEVT) compared to bridging therapy(BT:IV-tPA+EVT) and assess if BT potential benefit relates to stroke severity, size and initial presentation to EVT vs. non-EVT center.</p> <p><b>Methods:</b> In a prospective multicenter cohort-study of imaging selection for endovascular thrombectomy[SELECT], anterior-circulation large vessel occlusion (LVO) patients presenting to EVT-capable centers within 4.5hours from last-known-well were stratified into BT vs. dEVT.<b><i> </i></b>The primary outcome was 90-day functional independence[modified Rankin Scale(mRS)=0-2]. Secondary outcomes included a shift across 90-day mRS grades, mortality, symptomatic intracranial hemorrhage. We also performed subgroup-analyses according to initial presentation to EVT-capable center (direct versus transfer), stroke severity and baseline infarct core volume.</p> <p><b>Results:</b> We identified 226 LVOs (54%:men, mean age:65.6±14.6years, median NIHSS-score: 17, 28% received dEVT). Median time from arrival to groin-puncture did not differ in BT-patients when presenting directly[dEVT:1.43 (IQR=1.13-1.90) hours vs. BT:1.58(IQR=1.27-2.02)hours,p=0.40] or transferred to EVT-capable centers[dEVT:1.17 (IQR: 0.90-1.48) hours vs. BT:1.27 (IQR: 0.97-1.87) hours,p=0.24]. BT was associated with higher odds of 90-day functional independence (57% vs. 44%,aOR=2.02,95%CI:1.01-4.03,p=0.046) and functional improvement (adjusted cOR=2.06,95%CI:1.18-3.60,p=0.011), and lower likelihood of 90-day mortality (11% vs. 23%,aOR: 0.20,95%CI:0.07-0.58,p=0.003). No differences in any other outcomes were detected. In subgroup-analyses, BT patients with baseline NIHSS-scores<15 had higher functional independence likelihood compared to dEVT (aOR=4.87,95%CI:1.56-15.18,p=0.006); this association was not evident for patients with NIHSS-scores≥15 (aOR=1.05,95%CI:0.40-2.74,p=0.92). Similarly, functional outcomes improvements with BT were detected in patients with core volume strata (Ischemic core <50cc: aOR: 2.10, 95% CI:1.02-4.33, p=0.044 vs ischemic core ≥50cc: aOR: 0.41,95% CI:0.01-16.02,p=0.64) and transfer status (transferred: aOR: 2.21,95% CI:0.93-9.65,p=0.29 vs direct to EVT center: aOR:1.84,95%CI:0.80-4.23,p=0.15). </p> <p><b>Conclusions:</b> Bridging therapy appears to be associated with better clinical outcomes, especially with milder NIHSS-scores, smaller presentation core volumes and those who were "dripped and shipped".</p> <p><b>Classification of Evidence: </b>This study provides Class III evidence that for patients with ischemic stroke from anterior-circulation LVO within 4.5 hours from last-known-well, bridging therapy compared to direct endovascular thrombectomy leads to better 90-day functional outcomes.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.