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235 results for “silica”
Occupational exposure to silica and risk of heart disease: a systematic review with meta-analysis
<p><b><span>Objective</span></b> To search for evidence of the relationship between occupational silica exposure and heart disease.</p> <p><b><span>Design</span></b> A systematic review and meta-analysis.</p> <p><b><span>Background</span></b> Growing evidences suggest a connection between occupational silica exposure and heart disease; however, the link between them is less clear.</p> <p><b><span>Data sources </span></b>PubMed, ScienceDirect, Springer and EMBASE were searched for articles published between 1 January 1995 and 20 June 2019. Articles that investigated the effects of occupational silica exposure on heart disease risk were considered.</p> <p><b><span>Study selection </span></b><span>We included c</span><span>ohort stud</span><span>ies</span>, including prospective, retrospective and retro-prospective studies.</p> <p><b><span>Data extraction and synthesis</span></b> We extracted data by using a piloted data collection form and conducted random-effects meta-analysis and exposure-response analyses. The meta-relative risk (meta-RR), a measure of the average ratio of heart disease rates for those with and without silica exposure, was used as an inverse variance-weighted average of relative risks from the individual studies. The Newcastle-Ottawa Quality assessment Scale about cohort studies was used for study quality assessment.</p> <p><b><span>Outcome measure</span></b> We calculated heart disease risks of pulmonary heart disease, ischaemic heart disease and other heart diseases.</p> <p><span><b><span>Results</span></b> Twenty cohort articles were included. Results suggest a significant increase of overall heart disease risk (meta-RR = 1.08, 95% CI = 1.03, 1.13). Stronger evidences of association with pulmonary heart disease were found through both categories of heart disease risk estimate (meta-RR = 1.24, 95% CI = 1.08, 1.43) and exposure-response analyses (meta-RR = 1.39, 95% CI = 1.19, 1.62). Moreover, our subgroup analyses revealed that the statistical heterogeneity among studies could be attributed mainly to the diversities of reference group, occupation and study quality score.</span></p> <p><b><span>Conclusions</span></b> Silica-exposed workers have increased risk of overall heart disease, especially pulmonary heart disease. While further research is needed to better clarify the relationship between occupational silica exposure and ischaemic heart disease.</p>
Data for "Heat treatment and fiber drawing effect on the matrix structure and fluorescence lifetime of Er- and Tm-doped silica optical fibers"
<p>Includes data for absorption and attenuation measurements and calculations, profiles of refractive index and concentrations, TEM images, XRD patters, and data for fluorescence decay curves presented in the graphs.</p>
Data from: Production of low-carbon amorphous precipitated silica and hydrated magnesium carbonate from olivine
<p>A novel process is reported that produces amorphous silica and nesquehonite (MgCO<sub>3</sub>.3H<sub>2</sub>O) from the magnesium silicate mineral olivine ((Mg,Fe)<sub>2</sub>.SiO<sub>4</sub>). The amorphous silica formed is a supplementary cementitious material (SCM) for use in concrete. The formation of nesquehonite sequesters carbon and means that the overall process is carbon negative. Nesquehonite can also be used to form low-carbon construction products such as bricks, blocks, and boards. This paper reports on key process optimisation studies. The potential for amorphous precipitated silica derived from olivine to produce carbon-negative concrete is discussed.</p>
DNA-silica nanolattices as mechanical metamaterials
<p>Mechanical metamaterials consist of intricate periodic structures made using additive manufacturing techniques. Yet, nanoscale (<10 nm) features cannot be directly printed using these fabrication techniques, although this is the size regime in which enhanced material properties appear. In addition, current additive manufacturing techniques cannot easily combine disparate materials (e.g., soft, biological polymers with hard ceramics) into structural motifs. Here, we show that DNA origami can be used to construct octahedral-based isotropic and anisotropic nanolattices. When coated with a thin silica layer, these nanolattices obtain strength and energy absorption competitive with the best additively manufactured nanolattices. The DNA nanolattices have strut 6 nm diameters and ~50 nm unit cells, which are two orders of magnitude smaller than lithography-based lattices. The silica coating is as thin as ~1.65 nm, which results in enhanced strength. Atom probe tomography confirms the nanoscale distribution of DNA and silica in the octahedral lattice geometry. Finite element modeling (FEM) reveals two dominant failure modes: buckling at lower coating thicknesses and tensile fracture at higher thicknesses. Molecular dynamics (MD) simulations reveal that the DNA delays failure by suppressing buckling within the lattice struts, while the nanoscale silica undergoes a surface buckling mode which contributes to increased strength at large strains.</p>
Cellular uptake of silica and gold nanoparticles induces early activation of nuclear receptor NR4A1
<p>The approval of new nanomedicines requires a deeper understanding of the interaction between cells and nanoparticles (NPs). Silica (SiO<sub>2</sub>) and gold (Au) NPs have shown great potential in biomedical applications, such as the delivery of therapeutic agents, diagnostics, and biosensors. NP-cell interaction and internalization can trigger several cellular responses, including gene expression regulation. The identification of differentially expressed genes in response to NP uptake contributes to a better understanding of the cellular processes involved, including potential side effects. We investigated gene regulation in human macrophages and lung epithelial cells after acute exposure to spherical 60 nm SiO<sub>2</sub> NPs. SiO<sub>2</sub> NPs uptake did not considerably affect gene expression in epithelial cells, whereas five genes were up-regulated in macrophages. These genes are principally related to inflammation, chemotaxis, and cell adhesion. NR4A1, an important modulator of inflammation in macrophages, was found to be up-regulated. The expression of this gene was increased upon 1 h of macrophage exposure to spherical 50 nm AuNPs and 200 nm spherical SiO<sub>2</sub> NPs. NR4A1 can thus be an important immediate regulator of inflammation provoked by NP uptake in macrophages.</p>
Data sets for "Formation of an Al-rich niccolite-type silica in subducted oceanic crust: implications for water transport to the deep lower mantle"
<p>This is the XRD and IR datasets for the article "Formation of an Al-rich niccolite-type silica in subducted oceanic crust: implications for water transport to the deep lower mantle" by Liu and Yuan et al.</p>
Formation of super-dense hydrogen monolayer on mesoporous silica
<p>Source data of all figures in the main text and in the supplementary information of the paper '<em>Formation of super-dense hydrogen monolayer on mesoporous silica</em>'.</p>
Synthesis and characterization of fluorescent silica nanoparticles DATASET
<p>The synthesis of fluorescent nanoparticles has many potential applications in bio-imaging for enhanced and safer cell marking. Herein, two Stöber synthesis pathways were explored to incorporate fluorescein and rhodamine B in silica nanoparticles. Their luminescence properties were studied and probed with fluorescence spectroscopy. Mixed results were obtained. Simultaneous synthesis of nanoparticles and addition of fluorescent molecules seems to be the more promising pathway.</p> <p> </p>
Data for "Nanoparticle doping and molten-core methods towards highly thulium-doped silica fibers for 0.79 μm-pumped 2 μm fiber lasers – a fluorescence lifetime study"
<p>Includes data for basic characterization of the fibers (concentration profiles from EMPA, refractive index profiles of the preforms and fibers, attenuation of the fibers), as well as the measured fluorescence decay curves.</p>
atlantis_silica_processed
<div> <div> <div>Reference:</div> <div> </div> </div> </div> <div> <div> <div>Spicer, V.; Krokhin, O. V.</div> <div>Peptide Retention Time Prediction in Hydrophilic Interaction Liquid Chromatography. Comparison of Separation Selectivity between Bare Silica and Bonded Stationary Phases. J. Chromatogr. A 2018, 1534, 75–84, DOI: [10.1016/j.chroma.2017.12.046](https://doi.org/10.1016/j.chroma.2017.12.046)</div> </div> </div> <div> </div> <div> <div> <div>All datasets were implemented and curated from:</div> <div> </div> </div> </div> <div> <div> <div>Ma, C.; Ren, Y.; Yang, J.; Ren, Z.; Yang, H.; Liu, S.</div> <div>Improved Peptide Retention Time Prediction in Liquid Chromatography through Deep Learning. Anal. Chem. 2018, 90 (18), 10881–10888. DOI: [10.1021/acs.analchem.8b02386](https://doi.org/10.1021/acs.analchem.8b02386)</div> </div> </div>
luna_silica_processed
<div> <div> <div>Reference:</div> <div> </div> </div> </div> <div> <div> <div>Spicer, V.; Krokhin, O. V.</div> <div>Peptide Retention Time Prediction in Hydrophilic Interaction Liquid Chromatography. Comparison of Separation Selectivity between Bare Silica and Bonded Stationary Phases. J. Chromatogr. A 2018, 1534, 75–84, DOI: [10.1016/j.chroma.2017.12.046](https://doi.org/10.1016/j.chroma.2017.12.046)</div> </div> </div> <div> </div> <div> <div> <div>All datasets were implemented and curated from:</div> <div> </div> </div> </div> <div> <div> <div>Ma, C.; Ren, Y.; Yang, J.; Ren, Z.; Yang, H.; Liu, S.</div> <div>Improved Peptide Retention Time Prediction in Liquid Chromatography through Deep Learning. Anal. Chem. 2018, 90 (18), 10881–10888. DOI: [10.1021/acs.analchem.8b02386](https://doi.org/10.1021/acs.analchem.8b02386)</div> </div> </div>
Experimental data generated on the study of partial intrusion and extrusion of C8-CH3 silica
<p>Open access to experimental data generated by the project <a href="https://www.electro-intrusion.eu/en">Electro-Intrusion</a> (101017858, Horizon 2020, European Union) along with the research on the stability of hydrophobic porous materials to be used in intrusion-extrusion applications. Research pertaining to Task 2.1 (WP2).</p> <p>Underlying data for the publication Paulo, G. et al. Partial Water Intrusion and Extrusion in Hydrophobic Nanopores for Thermomechanical Energy Dissipation. The Journal of Physical Chemistry C 2024, 128(29), 12036-12045. <a title="DOI URL" href="https://doi.org/10.1021/acs.jpcc.4c02900">https://doi.org/10.1021/acs.jpcc.4c02900</a>. Data related to Figures 2, 4 and 5 in the article.</p>
DFTB study of silica glass under pressure (figures/samples trajectories)
<p>This deposit contains:</p> <p>1) Configurations (XYZ format) for selected densities/pressures (~100 configurations) extracted from the corresponding DFTB trajectories.</p> <p>(see configs-2-deposit.zip). The file readme-configs-2-deposit.txt gives details on configuration file and corresponding box size, pressure and density.</p> <p>2) xmgrace source files of the manuscript's figures (file figures.zip). Each .agr file contains the XY data of the plotted quantities.</p>
Aerogel Spring-Back Correlates with Strain Recovery: Effect of Silica Concentration and Aging - Dataset
<p>Dataset corresponding to the scientific publication:</p> <p>Sivaraman, Deeptanshu, Shanyu Zhao, Subramaniam Iswar, Marco Lattuada, and Wim J. Malfait. "Aerogel Spring‐Back Correlates with Strain Recovery: Effect of Silica Concentration and Aging." <em>Advanced Engineering Materials</em> 23, no. 10 (2021): 2100376. <a href="https://doi.org/10.1002/adem.202100376">https://doi.org/10.1002/adem.202100376</a></p> <p>This project was funded by the Swiss National Science Foundation through grant 200021_179000 (W.J.M). S.I. acknowledges the Flemish agency “Agentschap Innoveren en Ondernemen” (VLAIO) for providing financial support of this research through subvention IWT 130668.</p>
Cellular uptake of silica particles influences EGFR signaling pathway and is affected in response to EGF
<p><strong>Background:</strong> The human epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is involved in several key cellular processes such as cell proliferation and differentiation, and it has been linked to the development and progression of various cancers (e.g. breast and lung). Researchers have attempted to improve current cancer-targeted therapies by conjugating molecules on the surface of (nano)particles to efficiently target and inhibit EGFR. However, very few in vitro studies have investigated the effect of particles per se on EGFR signaling and dynamics. Furthermore, the impact of concomitant exposure of particles and EGFR ligands, such as epidermal growth factor (EGF) on cellular uptake efficiency has received little attention. </p> <p><strong>Purpose: </strong>The purpose of this research was to determine the effects of silica (SiO2) particles on EGFR expression and intracellular signaling pathways in A549 lung epithelial cells, in the presence or absence of epidermal growth factor (EGF).</p> <p><strong>Results: </strong>We showed that A549 cells are able to internalize SiO<sub>2</sub> particles with core diameters of 130 nm and 1 µm without affecting cell proliferation or migration. However, both SiO<sub>2</sub> particles interfere with the EGFR signaling pathway by raising the endogenous levels of extracellular signal-regulated kinase (ERK) 1/2. Furthermore, both in the presence and absence of SiO<sub>2</sub> particles, the addition of EGF increased cell migration. EGF also stimulated cellular uptake of 130 nm SiO<sub>2</sub> particles but not 1 µm particles. The increased uptake is primarily associated with EGF-stimulated macropinocytosis.</p> <p><strong>Conclusion: </strong>This study shows that SiO<sub>2</sub> particle uptake interferes with cellular signaling pathways and can be boosted by concurrent exposure to the bioactive molecule EGF. SiO<sub>2</sub> particles, both alone and in combination with the ligand EGF, interfere with EGFR signaling pathway in a size-dependent manner.</p>
Data from: Docosahexaenoic acid intake suppresses acute silica-induced inflammation, autoantibody production, and autoimmune-related gene expression in lupus-prone mice
<p class="MsoNormal">Short-term repeated intranasal exposure crystalline silica (cSiO<sub>2</sub>), a known human autoimmune trigger, induces uncontrolled inflammation, upregulated IFN-stimulated gene expression, diverse autoantibody production, and glomerulonephritis in lupus-prone female NZBWF1 mice. Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid (DHA) prevents subchronic cSiO<sub>2</sub> triggering of these lupus hallmarks. To understand how this intervention impacts acute effects of cSiO<sub>2</sub>, we fed NZBWF1 mice control (CON) or DHA-containing diet, subjected them to a single acute intranasal instillation of 2.5 mg cSiO<sub>2</sub>, then compared pulmonary inflammatory/autoimmune responses and autoimmune-related gene expression in experimental cohorts terminated at 7 and 28 d post-instillation (PI). Acute cSiO<sub>2 </sub>exposure of CON-fed mice elicited decreased macrophage and increased neutrophil numbers at 7 d PI, whereas at 28 d PI, CON-fed mice treated with particle displayed elevated total cell, macrophage, neutrophil, and lymphocyte counts. In contrast, DHA-fed mice treated with cSiO<sub>2</sub> exhibited less macrophage loss at 7 d PI and reduced total cell, macrophage, and lymphocyte accumulation at 28 d PI. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) of lung sections suggested that cSiO<sub>2</sub> induced more robust cell death at 7 d PI in CON-fed than DHA-fed mice. Targeted multiplex ELISA of lung extracts showed that at 28 d PI, cSiO<sub>2</sub> induced higher concentrations of inflammation-associated cytokines (IL-1α, IL-6, and GM-CSF) and IFN-stimulated chemokines (CCL2, CCL3, CXCL10) in the CON-fed cohort than in the DHA-fed cohort. Autoantigen protein microarray of BALF collected at 28 d PI indicated that cSiO<sub>2</sub> induced higher autoantibody responses for representative nuclear, ribosomal, mitochondrial, and complement proteins in CON-fed mice than DHA-fed mice. Gene expression analyses with NanoString Autoimmune Gene Expression assay revealed greater cSiO<sub>2</sub>-triggered upregulation of genes associated with TLR activation, DNA signaling, proinflammatory cytokines, chemokines, type 1 and 2 IFN response signatures, lymphocyte trafficking, MHC class 1 antigen presentation, B and T cell activation at 7 and 28 d PI in CON-fed mice than those fed DHA. Ingenuity Pathway Analysis (IPA) further demonstrated that DHA supplementation quelled cSiO<sub>2</sub>-induced responses top upstream regulators of proinflammatory and IFN-regulated gene networks to observed in CON-fed mice. Altogether, this short-term model illustrated that DHA suppression of aberrant acute cSiO<sub>2</sub>-induced inflammation is linked to altered regulation of autoimmune-related gene expression in lupus-prone mice.</p>
Transcriptome data from silica-preserved leaf tissue reveals gene flow patterns in a Caribbean bromeliad
<p>Transcriptome sequencing is a cost-effective approach that allows researchers to study a broad range of questions. However, to preserve RNA for transcriptome sequencing, tissue is often kept under special conditions, such as immediate ultracold freezing. Here, we demonstrate that RNA can be obtained from six-month-old, field-collected samples stored in silica gel at room temperature. Using these transcriptomes, we explore the evolutionary relationships of the genus Pitcairnia (Bromeliaceae) in the Dominican Republic and infer barriers to gene flow.</p>
Data from: Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid
<p>Introduction: Workplace exposure to respirable crystalline silica (cSiO<sub>2</sub>) is associated with chronic inflammatory and autoimmune diseases. At the mechanistic level, cSiO<sub>2</sub> particles are quickly phagocytosed by resident alveolar macrophages (AMs) in the lung, causing a robust cycle of proinflammatory cytokine release, lysosomal rupture, mitochondrial toxicity, and immunogenic cell death if the particle is not efficiently cleared by the lung. We and others have demonstrated in bone marrow-derived and transformed macrophage models that supplementation with the ω-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) contributes to increased membrane phospholipid content of DHA and subsequent suppression of cSiO<sub>2</sub>-triggered inflammatory responses. However, mechanistic exploration of ω-3 PUFA effects in AMs is challenging due to reliance on short-lived primary AMs derived from lung lavage fluid.</p> <p>Methods: To address these limitations, we have employed a recently developed novel self-renewing AM model from C57BL/6 mice, fetal liver-derived alveolar-like macrophages (FLAMs), that is phenotypically representative of primary lung AM populations. We found that incubation of FLAMs with 25 µM DHA as ethanolic suspensions or as complexes with bovine serum albumin were equally effective at increasing ω-3 PUFA content of phospholipids at the expense of the ω-6 PUFA arachidonic acid (ARA) and the ω-9 monounsaturated fatty acid oleic acid. Based on these findings, FLAMs were treated with 25 µM DHA in EtOH or EtOH vehicle (VEH) for 24 h, with or without LPS for 2 h, and with or without cSiO<sub>2</sub> for 1.5 or 4 h then proinflammatory cytokine release, lysosomal membrane permeabilization, and mitochondrial depolarization assessed. In addition, oxylipin metabolites were measured using a targeted LC-MS lipidomics panel of 156 metabolites.</p> <p>Results: Regardless of whether FLAMs were LPS-primed, cSiO<sub>2</sub>-triggered lysosomal permeability, mitochondrial toxicity, and cell death were not impacted by DHA. LPS+cSiO<sub>2</sub> elicited marked IL-1α, IL-1β, and TNF-α release after 1.5 and 4 h of cSiO<sub>2</sub> exposure, which was significantly inhibited by DHA. In VEH-treated cells, cSiO<sub>2</sub> alone and LPS+cSiO2 induced synthesis of ARA-derived proinflammatory oxylipins including prostaglandins, leukotrienes, and thromboxanes that was suppressed by DHA. In addition, DHA promoted synthesis of pro-resolving DHA-derived oxylipins at the expense of ARA-derived oxylipins.</p> <p>Discussion: FLAMs were amenable to lipidome modulation by DHA, which suppressed cSiO<sub>2</sub>-triggered proinflammatory cytokine responses and ARA-derived oxylipins that potentially contribute to the particle's toxicity in the lung. FLAMs are a promising in vitro alternative to primary AMs for investigating interventions against toxicant-triggered inflammation and autoimmunity in the lung.</p>
Linear machine learning based force matching for amorphous silica: How close are the classical two-body potentials to ab initio calculations?
<p>Please later see our manuscript (in submission) for details.</p>
Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate
ClinicalTrials.gov study NCT04238429. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.