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75 results for “sphingolipids”
Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m)
<p>Recent studies on Andean children indicate a prevalence of dyslipidemia and hypertension compared to dwellers at lower altitudes, suggesting that despite similar food intake and daily activities, they undergo different metabolic adaptations. In the present study, the sphingolipid pattern was investigated in serum of 7 underweight (UW), 30 normal weight (NW), 13 overweight (OW), and 9 obese (O) Andean children by liquid chromatography-mass spectrometry (LC-MS). Results indicate that levels of Ceramides (Cers) and sphingomyelins (SMs) correlate positively with biochemical parameters (except for Cers and Vitamin D, which correlate negatively), whereas sphingosine-1-phosphate (S1P) correlates negatively. Correlation results and LC-MS data identify the axis high density lipoprotein-cholesterol (HDL-C), Cers, and S1P as related to hypoxia adaptation. Specifically UW children are characterized by increased levels of S1P compared to O and lower levels of Cers compared to NW children. Furthermore, O children show lower levels of S1P and similar levels of Cers and SMs as NW. In conclusion, our results indicate that S1P is the primary target of hypoxia adaptation in Andean children, and its levels are associated with hypoxia tolerance. Furthermore, S1P can act as marker of increased risk of metabolic syndrome and cardiac dysfunction in young Andeans living at altitude</p>
Evaluation of Sphingolipids as Predictive Biomarkers of Immune Checkpoint Inhibitor Response in Melanoma Patients
ClinicalTrials.gov study NCT03627026. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sphingolipids in Asthma Pathogenesis
ClinicalTrials.gov study NCT06539221. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT03654352. IPD Sharing: NO. Countries: 1. Publications: 0.
Role of Sphingolipids in Pulmonary Edema
ClinicalTrials.gov study NCT01162161. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phospholipid and Sphingolipid Composition of High-density Lipoproteins (HDL) in Obese Non-diabetic Patients With Metabolic Syndrome
ClinicalTrials.gov study NCT02851602. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ATAC-seq and RNA-seq of cord blood cells in cytokine-rich ex vivo culture conditions following sphingolipid modulation
GEO Series GSE125214. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Aortic gene expression profiles show how APOA-I levels modulate infammation, lysosomal activity and sphingolipid metabolism in murine atherosclerosis
GEO Series GSE163657. Mus musculus. 35 samples. Type: Expression profiling by high throughput sequencing.
Ichthyosis associated with sphingosine 1-phosphate lyase insufficiency syndrome is due to aberrant calcium and sphingolipid regulation
GEO Series GSE207499. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity
GEO Series GSE199904. Saccharomyces cerevisiae. 42 samples. Type: Expression profiling by high throughput sequencing.
SMPD4 mediated sphingolipid metabolism regulates brain and primary cilia development
GEO Series GSE250472. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of the transcriptional profile of sphingolipid-related genes KD astrocytes during EAE in NOD mice.
GEO Series GSE139531. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling reveals an upregulation of genes related to Sphingolipid metabolism and Oxidative phosphorilation in HRas and NRas double-KO mice (DKO), which die because of a severe respira
GEO Series GSE130415. Mus musculus. 17 samples. Type: Expression profiling by array.
Critical Role of Sphingolipid Pathway Components in Murine Radiation-Induced Lung Injury: Protection by Sphingosine-1-Phosphate Analogues
GEO Series GSE25295. Mus musculus. 25 samples. Type: Expression profiling by array.
Fig. 1 in BiP-overexpressing soybean plants display accelerated hypersensitivity response (HR) affecting the SA-dependent sphingolipid and flavonoid pathways
Fig. 1. Symptoms of the soybean leaves from the transgenic overexpressing BiP (C9) and untransformed (WT) genotypes submitted to inoculation by P. syringae pv. tomato. In (A) Leaves from plants after 8 and 36 hai (hour after inoculation) and in (B) after 15 and 30 dai (day after inoculation).
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling of cytotoxic lymphocytes
GEO Series GSE10631. Homo sapiens. 44 samples. Type: Expression profiling by array.
Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate asthmatic airway hyperreactivity
GEO Series GSE203418. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism
GEO Series GSE271335. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis
GEO Series GSE189056. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Altering sphingolipid metabolism attenuates cell death and inflammatory response after myocardial infarction
GEO Series GSE138201. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
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