Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
71
datasets available to search
ShareScore release 0.9.0
Dataset results
71 results for “spike protein”
Profiling Spike Protein Antibody Response Post COVID-19 Booster
ClinicalTrials.gov study NCT05476822. IPD Sharing: Not stated. Countries: 0. Publications: 8.
Neonatal SARS-CoV-2 Anti-spike Protein Receptor-binding Domain Antibodies at Delivery
ClinicalTrials.gov study NCT05564884. IPD Sharing: NO. Countries: 1. Publications: 0.
Single-cell multi-modal profiling of proteins and chromatin accessibility using PHAGE-ATAC [Spike_mix_pbmcs]
GEO Series GSE172920. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models
GEO Series GSE223476. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Zeolitic Imidazolate Frameworks Activate Endosomal Toll-like Receptors and Potentiate Immunogenicity of SARS-CoV-2 Spike Protein Trimer
GEO Series GSE246178. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Augmenting SARS-CoV-2 vaccine induced spike protein-specific CD4+ T cell responses through IL-1β and its receptors.
GEO Series GSE206134. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in monocyte-derived macrophages
GEO Series GSE208320. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Cell Surface Protein mRNAs Show Differential Transcription in Pyramidal and Fast-Spiking Cells as Revealed by Single-Cell Sequencing
GEO Series GSE135060. Mus musculus. 84 samples. Type: Expression profiling by high throughput sequencing.
Highly efficient SARS-CoV-2 infection of human cardiomyocytes: spike protein-mediated cell fusion and its inhibition
GEO Series GSE184715. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Lung transcriptome profile of a severe COVID-19 mice model with SARS-CoV-2 spike protein and Poly (I:C)
GEO Series GSE216644. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
SARS-CoV-2 spike protein interacts with and activates TLR4
GEO Series GSE167480. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The Central Circadian Clock Protein CCA1 Regulates Seedling Growth and Spike Development in wheat (Triticum aestivum L.)
GEO Series GSE200426. Triticum aestivum. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The SARS-CoV-2 Spike protein modifies the transcriptional profile of human cardiac pericytes
GEO Series GSE218644. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Immunoblot test results for commercially available antibodies against SARS-CoV-2 spike protein and host proteins relevant to Coronavirus research.
<p>Attached is a description and results of the tested SARS-CoV-2 spike protein and host proteins.</p>
Structural basis of Omicron immune evasion: A comparative computational study of Spike protein-Antibody interaction
<p>The COVID-19 pandemic has caused more than 424 million infections and 5.9 million deaths so far. The vaccines used against SARS-COV-2 by now have been able to develop some neutralising antibodies in the vaccinated human population and slow down the infection rate. The effectiveness of the vaccines has been challenged by the emergence of the new strains with numerous mutations in the spike (S) protein of SARS-CoV-2. Since S protein is the major immunogenic protein of the virus and also contains Receptor Binding Domain (RBD) that interacts with the human Angiotensin-Converting Enzyme 2 (ACE2) receptors, any mutations in this region should affect the neutralisation potential of the antibodies leading to the immune evasion. Several variants of concern (VOC) of the virus have emerged so far. Among them, the most critical are Delta (B.1.617.2), and recently reported Omicron (B. 1.1.529) which have acquired a lot of mutations in the spike protein. We have mapped those mutations on the modelled RBD and evaluated the binding affinities of various human antibodies with it. Docking and molecular dynamics simulation studies have been used to explore the effect of the mutations on the structure of the RBD and the RBD-antibody interaction. The analysis shows that the mutations mostly at the interface of a nearby region lower the binding affinity of the antibody by ten to forty per cent, with a downfall in the number of interactions formed as a whole and therefore, it implies the generation of immune escape variants. Notable mutations and their effect was characterised by performing various analyses that explain the structural basis of antibody efficacy in Delta and a compromised neutralisation effect for the Omicron variant. Our results pave the way for robust vaccine design that can be effective for many variants.</p>
Safety and Immunogenicity of HDT-301 Targeting a SARS-CoV-2 Variant Spike Protein
ClinicalTrials.gov study NCT05132907. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Immunogenicity of Recombinant SARS-CoV-2 Spike Protein Vaccine (CHO Cell) for the Prevention of COVID-19
ClinicalTrials.gov study NCT05313022. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MVA-based SARS-CoV-2 vaccine candidates encoding different spike protein conformations induce distinct early transcriptional responses which may impact subsequent adaptive immunity
GEO Series GSE276544. Homo sapiens. 305 samples. Type: Expression profiling by high throughput sequencing.
SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2
GEO Series GSE241843. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2
GEO Series GSE147194. Homo sapiens. 10 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.