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60 results for “spontaneous activity”
A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage change
<p>Mice respond to a cage change (CC) with altered activity, disrupted sleep and increased anxiety. A bi-weekly cage change is, therefore, preferred over a shorter CC interval and is currently the prevailing routine for Individually ventilated cages (IVCs). However, the build-up of ammonia (NH3) during this period is a potential threat to the animal health and the literature holds conflicting reports leaving this issue unresolved. We have therefor examined longitudinally in-cage activity, animal health and the build-up of ammonia across the cage floor with female and male C57BL/6 mice housed four per IVC changed every other week. We used a multicentre design with a standardised husbandry enabling us to tease-out features that replicated across sites from those that were site-specific.</p> <p>CC induce a marked increase in activity, especially during daytime (~50%) when the animals rest. A reduction in density from four to two mice did not alter this response. This burst was followed by a gradual decrease till the next cage change. Female but not male mice preferred to have the latrine in the front of the cage. Male mice allocate more of the activity to the latrine free part of the cage floor already the day after a CC. A behaviour that progressed through the CC cycle but was not impacted by the type of bedding used. Reducing housing density to two mice abolished this behaviour. Female mice used the entire cage floor the first week while during the second week activity in the latrine area decreased.</p> <p>Measurement of NH3 ppm across the cage floor revealed x3 higher values for the latrine area compared with the opposite area. NH3 ppm increases from 0-1 ppm to reach ≤25 ppm in the latrine free area and 50-100 ppm in the latrine area at the end of a cycle. As expected in-cage bacterial load covaried with in-cage NH3 ppm.</p> <p>Histopathological analysis revealed no changes to the upper airways covarying with recorded NH3 ppm or bacterial load. We conclude that housing of four (or equivalent biomass) C57BL/6J mice for 10 weeks under the described conditions does not cause any overt discomfort to the animals.</p>
Modulatory Effects of Active Drugs on the Endocannabinoid System on Spontaneous and Induced Contractility of the Colon
ClinicalTrials.gov study NCT05760404. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Early PReserved SPONtaneous Breathing Activity in Mechanically Ventilated Patients With ARDS (PReSPON)
ClinicalTrials.gov study NCT04228471. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
STOP CSUA: phySical acTivity, mOod and sleeP in Chronic Spontaneous Urticaria and Angioedema
ClinicalTrials.gov study NCT05169645. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Study of Neuromuscular Electrical Stimulation to Increase Spontaneous Physical Activity in Obesity Patient
ClinicalTrials.gov study NCT02210585. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Correlation Between Brain Structure and Activity and Spontaneous Recovery of Motor Function Following Brain Ischemic Stroke
ClinicalTrials.gov study NCT05889429. IPD Sharing: NO. Countries: 1. Publications: 0.
Dose Escalation Trial Of Safety, Pharmacokinetic/Pharmacodynamic And Preliminary Clinical Activity of Briquilimab In Adult Patients With Chronic Spontaneous Urticaria (CSU)
ClinicalTrials.gov study NCT06162728. IPD Sharing: NO. Countries: 2. Publications: 0.
Physical Activity, Fertility, and Spontaneous Abortion in Danish Couples Trying to Conceive
ClinicalTrials.gov study NCT06705712. IPD Sharing: NO. Countries: 1. Publications: 0.
Increasing Spontaneous Non-exercise Activity (The Sitting Study)
ClinicalTrials.gov study NCT02809521. IPD Sharing: NO. Countries: 1. Publications: 0.
Feasibility Study of Platelet Activation and Inflammatory Response of Platelets in Hematopoietic Stem Cell Allograft Patients Post-transplant: Spontaneously and After Stimulation by an CMV Antigen
ClinicalTrials.gov study NCT03009708. IPD Sharing: NO. Countries: 1. Publications: 0.
Time,Self and Spontaneous Mental Activities in Patients With Psychotic Disorders
ClinicalTrials.gov study NCT02765880. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Spontaneous Breathing Activity on Atelectasis Formation During General Anaesthesia
ClinicalTrials.gov study NCT01073917. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Estrogen Drives Melanocortin Signaling to Increase Spontaneous Activity
GEO Series GSE181204. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage change
Open the record for dataset details and reuse information.
Constitutive Activation of NF-kB Inducing Kinase (NIK) in the Mesenchymal Lineage Drives Spontaneous Soft Tissue Sarcoma
GEO Series GSE158479. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma [aCGH_105k]
GEO Series GSE45478. Homo sapiens. 123 samples. Type: Genome variation profiling by array.
Spontaneous Elimination of Intraocular Tumors is Associated with IFNγ- and Fas/FasL-Dependent Activation of Macrophages
GEO Series GSE57101. Mus musculus. 4 samples. Type: Expression profiling by array.
Prolidase deficiency causes spontaneous T cell activation and lupus-like autoimmunity
GEO Series GSE221569. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Differential regulation of gene expression in neurons by spontaneous or sensory-driven activity and its dysregulation with aging
GEO Series GSE124343. Drosophila melanogaster. 31 samples. Type: Expression profiling by high throughput sequencing.
Spontaneous functional network activity in organoids resembles programmed early human brain development
GEO Series GSE113089. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.