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73 results for “structural disorder”
Data from: Functional diversity and structural disorder in the human ubiquitination pathway
The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several hundred E3 (ubiquitin ligase) enzymes. By collecting and analyzing E3 sequences from the KEGG BRITE database and literature, we assembled a coherent dataset of 563 human E3s and analyzed their various physical features. We found an increase in structural disorder of the system with multiple disorder predictors (IUPred – E1: 5.97%, E2: 17.74%, E3: 20.03%). E3s that can bind E2 and substrate simultaneously (single subunit E3, ssE3) have significantly higher disorder (22.98%) than E3s in which E2 binding (multi RING-finger, mRF, 0.62%), scaffolding (6.01%) and substrate binding (adaptor/substrate recognition subunits, 17.33%) functions are separated. In ssE3s, the disorder was localized in the substrate/adaptor binding domains, whereas the E2-binding RING/HECT-domains were structured. To demonstrate the involvement of disorder in E3 function, we applied normal modes and molecular dynamics analyses to show how a disordered and highly flexible linker in human CBL (an E3 that acts as a regulator of several tyrosine kinase-mediated signalling pathways) facilitates long-range conformational changes bringing substrate and E2-binding domains towards each other and thus assisting in ubiquitin transfer. E3s with multiple interaction partners (as evidenced by data in STRING) also possess elevated levels of disorder (hubs, 22.90% vs. non-hubs, 18.36%). Furthermore, a search in PDB uncovered 21 distinct human E3 interactions, in 7 of which the disordered region of E3s undergoes induced folding (or mutual induced folding) in the presence of the partner. In conclusion, our data highlights the primary role of structural disorder in the functions of E3 ligases that manifests itself in the substrate/adaptor binding functions as well as the mechanism of ubiquitin transfer by long-range conformational transitions.
Effect of metacognitive interpersonal therapy on brain structural connectivity in borderline personality disorder: results from the CLIMAMITHE study.
<p><span>Recently, we showed that Metacognitive Interpersonal Therapy (MIT) is effective in improving clinical symptoms in borderline personality disorder (BPD). Here, we investigated whether the effect of MIT on clinical features is associated to microstructural changes in brain circuits supporting core BPD symptoms.</span></p>
Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders
ClinicalTrials.gov study NCT05679297. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Structural Chromosome Rearrangements and Brain Disorders
ClinicalTrials.gov study NCT06072079. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy
ClinicalTrials.gov study NCT00474357. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Structural Connectivity as Imaging Endophenotypes of Autism Spectrum Disorders
ClinicalTrials.gov study NCT01513629. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Structured Physical Exercise in Short-term Inpatient Treatment of Substance Use Disorder
ClinicalTrials.gov study NCT04141202. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effects of Explosive Blast as Compared to Post-Traumatic Stress Disorder on Brain Function and Structure
ClinicalTrials.gov study NCT00631436. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treating Passive Structure Knowledge Deficits in School-Age Children With Developmental Language Disorder
ClinicalTrials.gov study NCT06932016. IPD Sharing: YES. Countries: 1. Publications: 0.
Combined Treatment for Patients With Comorbid Substance Use Disorders and Post-traumatic Stress Disorder (PTSD): an Integration of Cognitive-behavioral Treatment (CBT) and Trauma-focused Structured Wr
ClinicalTrials.gov study NCT00763542. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating Adapted Structured Clinical Management for People With a Diagnosis of Personality Disorder
ClinicalTrials.gov study NCT04207970. IPD Sharing: NO. Countries: 1. Publications: 0.
Structural and Functional Connectivity in Autism Spectrum Disorders
ClinicalTrials.gov study NCT00755430. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Full 3D Eye Modeling in the Diagnosis and Treatment of Lens Diseases With Eye Structures Disorders
ClinicalTrials.gov study NCT07321769. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
ClinicalTrials.gov study NCT03336918. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Structuring the Integration of Care Management Services For Medicaid Enrollees Recipients With Chronic Illness, Substance Abuse Problems and Possible Psychiatric Disorders
ClinicalTrials.gov study NCT00399373. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Comparison of Group Cognitive Behavioural Therapy (CBT) and Structured Activity Group for Adults With Attention Deficit Hyperactivity Disorder (ADHD)
ClinicalTrials.gov study NCT06604845. IPD Sharing: NO. Countries: 1. Publications: 0.
Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness
ClinicalTrials.gov study NCT06311838. IPD Sharing: YES. Countries: 1. Publications: 0.
Peripheral Inflammation and Brain Structural Alterations in Patients With Disorders of Consciousness.
ClinicalTrials.gov study NCT03908541. IPD Sharing: NO. Countries: 1. Publications: 0.
Does Nurse Semi Structured Interview Added to a rTMS Improve Patients With Major Depressive Disorder?
ClinicalTrials.gov study NCT03436823. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Functional diversity and structural disorder in the human ubiquitination pathway
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