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188 results for “swine”
Safety and Immunogenicity of Three Dosage Levels of Swine Influenza Vaccine in Children Ages 3 to <9 Years, Adolescents 9 to <18 Years, Adults 18 to <65 Years and Elderly 65 Years and Older.
ClinicalTrials.gov study NCT01855945. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Feral swine genotypes and metadata used for identifying translocations in the United States
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Mixed ancestry from wild and domestic lineages contributes to the rapid expansion of invasive feral swine
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Co-occurrence of antimicrobials and metals in swine manure as potential drivers of antimicrobial resistance in the environment
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Data from: Pilot-scale H2S and swine odor removal system using commercially available biochar
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Genomic regions associated with pseudorabies virus infection status in naturally infected feral swine (Sus scrofa)
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Ecological drivers of African swine fever virus persistence in wild boar populations: insight for control
Environmental sources of infection can play a primary role in shaping epidemiological dynamics, however the relative impact of environmental transmission on host-pathogen systems is rarely estimated. We developed and fit a spatially-explicit model of African swine fever virus (ASFV) in wild boar to estimate what proportion of carcass-based transmission is contributing to the low-level persistence of ASFV in Eastern European wild boar. Our model was developed based on ecological insight and data from field studies of ASFV and wild boar in Eastern Poland. We predicted that carcass-based transmission would play a substantial role in persistence, especially in low-density host populations where contact rates are low. By fitting the model to outbreak data using Approximate Bayesian Computation, we inferred that between 53 to 66% of transmission events were carcass-based – i.e., transmitted through contact of a live host with a contaminated carcass. Model fitting and sensitivity analyses showed that the frequency of carcass-based transmission increased with decreasing host density, suggesting that management policies should emphasize the removal of carcasses and consider how reductions in host densities may drive carcass-based transmission. Sensitivity analyses also demonstrated that carcass-based transmission is necessary for the autonomous persistence of ASFV under realistic parameters. Autonomous persistence through direct transmission alone required high host densities; otherwise re-introduction of virus periodically was required for persistence when direct transmission probabilities were moderately high. We quantify the relative role of different persistence mechanisms for a low-prevalence disease using readily collected ecological data and viral surveillance data. Understanding how the frequency of different transmission mechanisms vary across host densities can help identify optimal management strategies across changing ecological conditions.
Data from: Origins of the 2009 H1N1 influenza pandemic in swine in Mexico
Asia is considered an important source of influenza A virus (IAV) pandemics, owing to large, diverse viral reservoirs in poultry and swine. However, the zoonotic origins of the 2009 A/H1N1 influenza pandemic virus (pdmH1N1) remain unclear, due to conflicting evidence from swine and humans. There is strong evidence that the first human outbreak of pdmH1N1 occurred in Mexico in early 2009. However, no related swine viruses have been detected in Mexico or any part of the Americas, and to date the most closely related ancestor viruses were identified in Asian swine. Here, we use 58 new whole-genome sequences from IAVs collected in Mexican swine to establish that the swine virus responsible for the 2009 pandemic evolved in central Mexico. This finding highlights how the 2009 pandemic arose from a region not considered a pandemic risk, owing to an expansion of IAV diversity in swine resulting from long-distance live swine trade.
Data from: Effects of the selective stretch-activated channel blocker GsMtx4 on stretch-induced changes in refractoriness in isolated rat hearts and on ventricular premature beats and arrhythmias after coronary occlusion in swine
Mechanical factors may contribute to ischemic ventricular arrhythmias. GsMtx4 peptide, a selective stretch-activated channel blocker, inhibits stretch-induced atrial arrhythmias. We aimed to assess whether GsMtx4 protects against ventricular ectopy and arrhythmias following coronary occlusion in swine. First, the effects of 170-nM GsMtx4 on the changes in the effective refractory period (ERP) induced by left ventricular (LV) dilatation were assessed in 8 isolated rat hearts. Then, 44 anesthetized, open-chest pigs subjected to 50-min left anterior descending artery occlusion and 2-h reperfusion were blindly allocated to GsMtx4 (57 μg/kg iv. bolus and 3.8 μg/kg/min infusion, calculated to attain the above concentration in plasma) or saline, starting 5-min before occlusion and continuing until after reflow. In rat hearts, LV distension induced progressive reductions in ERP (35±2, 32±2, and 29±2 ms at 0, 20, and 40 mmHg of LV end-diastolic pressure, respectively, P<0.001) that were prevented by GsMTx4 (33±2, 33±2, and 32±2 ms, respectively, P=0.002 for the interaction with LV end-diastolic pressure). Pigs receiving GsMtx4 had similar number of ventricular premature beats during the ischemic period as control pigs (110±28 vs. 103±21, respectively, P=0.842). There were not significant differences among treated and untreated animals in the incidence of ventricular fibrillation (13.6 vs. 22.7%, respectively, P=0.696) or tachycardia (36.4 vs. 50.0%, P=0.361) or in the number of ventricular tachycardia episodes during the occlusion period (1.8±0.7 vs. 5.5±2.6, P=0.323). Thus, GsMtx4 administered under these conditions does not suppress ventricular ectopy following coronary occlusion in swine. Whether it might protect against malignant arrhythmias should be tested in studies powered for these outcomes.
BIOPEP-UWM: Calculations for top 20 abundant peptides from Cynara cardunculus swine blood hydrolysate FNF
<p>Calculations by BIOPEP (https://biochemia.uwm.edu.pl/biopep-uwm/) for top 20 abundant peptides from <em>Cynara cardunculus</em> swine blood hydrolysate FNF.</p>
Fig. 2 in Turicibacter bilis sp. nov., a novel bacterium isolated from the chicken eggshell and swine ileum
Fig. 2. Whole genome sequence phylogeny of MMM721T, ISU324, PIG517 and all publicly available genomes on the PATRIC genome database as of November 2020. The tree is rooted by Eggerthia catenaformis OT569. Only bootstrap values>50% are noted for branch nodes. The PATRIC genome IDs are noted in parentheses after the strain name.
Fig. 1 in Turicibacter bilis sp. nov., a novel bacterium isolated from the chicken eggshell and swine ileum
Fig. 1. (a) Transmission electron microscope image of MMM721T cells. Bar, 1 Μm. (b) Scanning electron microscope image of MMM721T cells. Bar, 2 Μm. Cells were cultured in BHIGL for 24 h at 42 °C prior to fixation and visualization.
Mortality data from an intensive swine production system
<p>The present data was generated in a study conducted to investigate the risk factors and causes of sow mortality. A post-mortem examination and microbiological investigation were conducted on 123 sows from a breeding herd with 15,000 dams located in Brazilian Midwest (Mato-Grosso State).</p>
The baseline immunological and hygienic status of pigs impact disease severity of African swine fever
<p>Primary data of manuscript</p>
Swine Flu (Influenza A H1N1) Follow on Vaccine Study
ClinicalTrials.gov study NCT01239537. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects 18 or More Years of Age
ClinicalTrials.gov study NCT00970177. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Immunogenicity, Tolerability and Safety of One or Two Doses of an Adjuvanted Swine-origin A H1N1 Influenza Vaccine in Healthy Subjects 18 or More Years of Age Both Vaccinated and Not Yet Vaccinated Ag
ClinicalTrials.gov study NCT00992212. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Single-blind, Dose-ranging Study of Novel Swine Influenza Virus Vaccine in Japanese Pediatric Subjects
ClinicalTrials.gov study NCT01000207. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immunogenicity, Safety and Tolerability of Two Doses of Adjuvanted and Non-adjuvanted Swine Origin A/H1N1 Monovalent Influenza Vaccine in Healthy Subjects From 6 Months to 17 Years of Age
ClinicalTrials.gov study NCT00971100. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Single-blind, Dose-ranging Study of Novel Swine Influenza Virus Vaccine in Japanese Adult Subjects
ClinicalTrials.gov study NCT00996138. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.