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267
datasets available to search
ShareScore release 0.9.0
Dataset results
267 results for “target of selection”
Intracoronary Stenting and Antithrombotic Regimen: Lesion Platelet Adhesion as Selective Target of Endovenous Revacept
ClinicalTrials.gov study NCT03312855. IPD Sharing: NO. Countries: 1. Publications: 1.
Select Nutrient and Gene Variant Analysis in a Targeted Diet and Lifestyle Intervention Reduces Preterm Birth
ClinicalTrials.gov study NCT05436119. IPD Sharing: NO. Countries: 1. Publications: 1.
A Physical Therapy Program Targeting Lower Extremity Selective Motor Control in Children With Spastic Cerebral Palsy
ClinicalTrials.gov study NCT07310550. IPD Sharing: NO. Countries: 1. Publications: 1.
(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis
ClinicalTrials.gov study NCT03731260. IPD Sharing: Not stated. Countries: 13. Publications: 3.
Targeted Therapy Selection Based on Tumor Tissue Kinase Activity Profiles for Patients With Advanced Solid Malignancies, an Exploratory Study
ClinicalTrials.gov study NCT01190241. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluating a Targeted Selective Speech, Language, and Communication Intervention at Scale - Protocol for the 'Happy Talk' Cluster Randomised Controlled Trial.
ClinicalTrials.gov study NCT06460090. IPD Sharing: YES. Countries: 1. Publications: 3.
Data from: Targeted re-sequencing of five Douglas-fir provenances reveals population structure and putative target genes of positive selection
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Data from: Individual inversions or their combinations: which is the main selective target in a natural population of Drosophila subobscura?
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Data from: Defining the role of the MADS-box gene, Zea agamous like1, a target of selection during maize domestication
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Data from: Searching for the bull's-eye: agents and targets of selection vary among geographically disparate cyanogenesis clines in white clover (Trifolium repens L.)
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Data from: A gene with major phenotypic effects as a target for selection versus homogenizing gene flow
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Data from: Identifying targets of selection in mosaic genomes with machine learning: applications in Anopheles gambiae for detecting sites within locally adapted chromosomal inversions
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Demographic History and Genomic Targets of Positive Selection in Giant Gough Mice
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Secondary evolve and re-sequencing: an experimental confirmation of putative selection targets without phenotyping
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Data from: Energy expenditure and body size are targets of natural selection across a wide geographic range, in a terrestrial invertebrate
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Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes
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Data from: Sexual selection targets cetacean pelvic bones
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Supplementary material 2 from: Lang A, Dolek M, Lee MS, Freese-Hager A, Otto M (2020) Selection of non-target Lepidoptera species to test Bt maize effects in the laboratory: which species and how to breed them? BioRisk 15: 45-65. https://doi.org/10.3897/biorisk.15.59823
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Supplementary material 1 from: Lang A, Dolek M, Lee MS, Freese-Hager A, Otto M (2020) Selection of non-target Lepidoptera species to test Bt maize effects in the laboratory: which species and how to breed them? BioRisk 15: 45-65. https://doi.org/10.3897/biorisk.15.59823
Reference list: breeding and rearing Lepidoptera
Selection and exploitation of prevalent, tandemly repeated genomic targets for improved real-time PCR-based detection of Wuchereria bancrofti and Plasmodium falciparum in mosquitoes
<p><b>Background</b></p> <p>Optimization of polymerase chain reaction (PCR)-based diagnostics requires the careful selection of molecular targets that are both highly repetitive and pathogen-specific. Advances in both next-generation sequencing (NGS) technologies and bioinformatics-based analysis tools are facilitating this selection process, informing target choices and reducing labor. Once developed, such assays provide disease control and elimination programs with an additional set of tools capable of evaluating and monitoring intervention successes. The importance of such tools is heightened as intervention efforts approach their endpoints, as accurate and complete information is an essential component of the informed decision-making process. As global efforts for the control and elimination of both lymphatic filariasis and malaria continue to make significant gains, the benefits of diagnostics with improved analytical and clinical/field-based sensitivities and specificities will become increasingly apparent.</p> <p><b>Methodology/Principal Findings </b></p> <p>Coupling Illumina-based NGS with informatics approaches, we have successfully identified the tandemly repeated elements in both the <i>Wuchereria bancrofti </i>and <i>Plasmodium falciparum </i>genomes of putatively greatest copy number. Utilizing these sequences as quantitative real-time PCR (qPCR)-based targets, we have developed assays capable of exploiting the most abundant tandem repeats for both organisms. For the detection of <i>P. falciparum</i>, analysis and development resulted in an assay with improved analytical and field-based sensitivity vs. an established ribosomal sequence-targeting assay. Surprisingly, analysis of the <i>W. bancrofti </i>genome predicted a ribosomal sequence to be the genome's most abundant tandem repeat. While resulting cycle quantification values comparing a qPCR assay targeting this ribosomal sequence and a commonly targeted repetitive DNA sequence from the literature supported our finding that this ribosomal sequence was the most prevalent tandemly repeated target in the <i>W. bancrofti </i>genome, the resulting assay did not significantly improve detection sensitivity in conjunction with field sample testing. </p> <p><b>Conclusions/Significance </b></p> <p>Examination of pathogen genomes facilitates the development of PCR-based diagnostics targeting the most abundant and specific genomic elements. While in some instances currently available tools may deliver equal or superior performance, systematic analysis of potential targets provides confidence that the selected assays represent the most advantageous options available and that informed assay selection is occurring in the context of a particular study's objectives.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.