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opencc-zeroJun 2024View details →

Dataset: BioRestorative Therapies, Inc. (BRTX) Stock Performance

This dataset provides historical stock market performance data for specific companies. It enables users to analyze and understand the past trends and fluctuations in stock prices over time. This information can be utilized for various purposes such as investment analysis, financial research, and market trend forecasting.

opencc-zeroJun 2024View details →

Dataset: Taysha Gene Therapies, Inc. (TSHA) Stock Performance

opencc-zeroJun 2024View details →

Dataset: Intra-Cellular Therapies, Inc. (ITCI) Stock Performance

opencc-by-4.0Jun 2024View details →

METADATA for results of irradiation-induced complex DNA damage measurements using plasmid pBR322 along a typical Proton Treatment Plan at the MedAustron proton and carbon beam therapy facility (energy 137–198 MeV and Linear Energy Transfer (LET) range 1–9 keV/μm), by means of Agarose Gel Electrophoresis and DNA fragmentation using Atomic Force Microscopy (AFM)

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opencc-by-4.0Jul 2024View details →

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

Here we report a novel suite of magnetogenetic tools, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. AAV-mediated delivery of a floxed nanobody-TRPV1 into the striatum of adenosine 2a receptor-cre driver mice resulted in motor freezing when placed in an MRI or adjacent to a transcranial magnetic stimulation (TMS) device. Functional imaging and fiber photometry both confirmed activation of the target region in response to the magnetic fields.  Expression of the same construct in the striatum of wild-type mice along with a second injection of an AAVretro expressing cre into the globus pallidus led to similar circuit specificity and motor responses. Finally, a mutation was generated to gate chloride and inhibit neuronal activity. Expression of this variant in subthalamic nucleus in PitX2-cre parkinsonian mice resulted in reduced local c-fos expression and motor rotational behavior. These data demonstrate that magnetogenetic constructs can bidirectionally regulate activity of specific neuronal circuits non-invasively in-vivo using clinically available devices.

Figure 4. (a) Therapy player software screen, where a) is the stimuli time, b) is the total therapy time, c) is the file path, d) displays the numeric values of each sequence of the therapy, e) shows the current value, and f) shows the current lag angle for zenith and azimuth values; (b) USB mechanism for conversion, where a) USB-UART converter, and b) USB-Zigbee converter.-Design of a Novel Servo-motorized Laser Device for Visual Pathways Diseases Therapy

Where tt time expended by the servomotors to point the laser to a given position and execute a laser beam sequence; tspin is the time that a servomotor needs to spin one degree; ttol is a given the tolerance time; θservo is the addition of degrees that both servos in a laser driver need to spin point the laser in a given position; tstimuli is the time expended in execute a laser beam, between 250 and 605 ms (Weiskrantz et al., 1991); T is the total time of all repetitions in a therapy, suggested between 20 and 60 minutes and N is the number of repetitions in a therapy.

Figure 3. (Top): Illustration of the therapy selection main menu. This enables the user to select one of three options for the therapy. Stimuli sequence selectors; (Bottom): (a) Short distance – complete visual field; (b) Short distance – macular; (c) Middle-long distance.-Design of a Novel Servo-motorized Laser Device for Visual Pathways Diseases Therapy

distance therapies for the prescribed time suggested by the ophthalmologist. Note that the complete visual field therapy stimulates different parts in the entire visual field whereas macular therapy stimulate only a small part of the visual field, only the first 10° of vision range. In contrast, middle-long distance therapies are not developed inside the device; instead the patient must sit watching a wall, where the stimuli will be presented. Figure 3 (Bottom) shows the sequence selectors for the three different cases. The therapist will choose a desired number of sequences according to the results of the examination to each patient; hence it is completely patient dependent. Once the therapist finishes the particular design of the stimuli sequence, the software automatically displays a window where he can save the customized patient-specific details for future use as a text file.

Figure 2. (a) Representation of laser servo-driver for inverse kinematics analysis; (b) Representation of the lag angle, B, of the internal servomechanism (magnified version of the chin-rest).-Design of a Novel Servo-motorized Laser Device for Visual Pathways Diseases Therapy

As the servo-driver will be attached in the chin-rest in a non-central area with respect to the semispherical structure shown in Figure 1(a), it is necessary to calculate a lag angle, according to the measurements from the chin-rest, see Figure 2(b). This was done using a hybrid formula based on the law of cosines,

Figure 1. (a) Part of the acrylic structure where the patient is enclosed to avoid external stimulus; (b) Chin rest, corresponding proportions and measurements.-Design of a Novel Servo-motorized Laser Device for Visual Pathways Diseases Therapy

The device consists mainly of an acrylic semi-spherical structure (Figure 1(a)) where visual stimuli will be shown, according to a pre-designed therapy. Four servomotors will drive the lasers, two inside the structure (short distances drive the lasers, two inside the structure (short distance therapies) and two outside (middle-long distance therapies). A chin-rest must be used to have a better line of sight fixation. A webcam with infrared light will catch the Purkinje-Sanson images to identify the sight line (Borah, 2006; Halswanter, 2011; Pambakian et al., 2000). LabVIEW software is used to control the device, including an audio stimulus along with an image-processing pipeline. Finally a microcontroller is used to control the servo movements, laser beams and buzzers.

Figure 3. Logoped 1.0 program-Modern Tools in Patient-Centred Speech Therapy for Romanian Language

The program was designed for the therapy of logoneurosis, while being equally useful for the therapeutic activities used in the treatment of dyslexic-dysgraphic disorders. Logoped 1.0 provides a vast lexical material, which is organised into several sections: exercises involving reading the syllables and the words, sentences reading, followed by phrase and text reading. The colourful design of the words and sentences, the attractive way in which they are displayed on the monitor, and the fact that it allows choosing the exercises level of difficulty render the reading activity much more attractive for the pupil (Tobolcea, 2001). Its functional schema is presented in figure 3.

Figure 4. The relationship between the functional blocks of the systemModern Tools in Patient-Centred Speech Therapy for Romanian Language

The project’s complexity results from the considerable number of research fields it presupposes: artificial intelligence (pattern recognition, learning expert systems), virtual reality, digital signal processing, digital electronic (VLSI), computer architecture, and psychology (assessment procedures and techniques, therapeutic instructions, validation experimental design). In order to assure an assisted therapy one considers the relationships between six functional blocks: patient, speech therapist, office monitor program, expert system, 3D model and patient monitor program. The information flow of the system is given in Figure 4. There is a close connection between the child, as a patient, and his speech therapist. All the other modules are designed so as to contribute to the therapeutic action of the teacher. The monitor program allows realising a complex assessment and collecting information about the child; equally, it provides the opportunity to periodically track the child’s therapy results. The child is provided instant audio feedback which allows him/her to check the audio recordings history. The home monitor program is designed so as to build a virtual interface between teacher and child in order to allow the patient to continue his therapy at home. This component is designed both for the personal computer, which is placed in the therapist’s office, and personal digital assistant (PDA) which is used at home for independent work.

Figure 9. A model that helps the diagnosis prediction-Modern Tools in Patient-Centred Speech Therapy for Romanian Language

We have already implemented many modules of Logo-DM, such as: data cleaning module, data transformation module, feature extraction module, data clustering module and a classification module for diagnosis prediction.  Figure 9 shows the model achieved using a decision tree built on complex examination data that aims to predict the patient’s diagnosis. Currently, we are testing the built models on new cases in order to estimate their quality.

Figure 8. The end-to-end operations in Logo-DM-Modern Tools in Patient-Centred Speech Therapy for Romanian Language

The useful data mining tasks for speech therapy fall into three categories: classification, clustering, and association rules. Classification places children with different speech impairments in predefined classes, and makes possible to track the characteristics of various groups. To model different classes we use many predictor variables (e.g. personal or familial anamnesis data or related to lifestyle). By clustering we group people with speech disorders on the basis of similarity of different features. This helps therapists to understand their patients. Clustering aims to find subsets of a predetermined segment, with homogeneous behavior towards various methods of therapy that can be effectively targeted by a specific therapy, but it is not based on the previous definition of groups (Danubianu, Tobolcea, & Pentiuc, 2009). Association rules aim to find out relationships between different data which seem to have no semantic dependence. The built patterns might be very useful to determine why a specific therapy program has been successful on a segment of patients with speech disorders, and on the other was ineffective. The Logo-DM system was designed to help the speech therapists to optimize the personalized therapy of dyslalia. To understand what kind of knowledge we could discover in TERAPERS’ dataset to improve speech therapy, we have to describe the collected data.

Figure .5 Architecture of the Terapers system-Modern Tools in Patient-Centred Speech Therapy for Romanian Language

Shown in Figure 5, the architecture of the Terapers system implies the existence of two main connected components: on the one hand, an intelligent system which is installed on the office computer of each speech therapist and, on the other, a mobile system which is used as a virtual friend in the therapy applied to the child (Danubianu et al., 2008). The intelligent system – which represents the fixed component of the system – is installed on each computer from the office of the speech therapist; it is made up of the following parts: • an information management module for children; • an expert system, able to produce inferences based on the data given by the assessment module; • a mouth virtual module which allows the display of all hidden movements that are likely to occur during speech; • a management module of the exercises uses, which allows creating or modifying the exercises, depending on the various therapy stages, as well as their organization into complex issues.

Supplemental Data from: Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

Supplemental Data for: Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. JAMA. 2015 (Paper available at: <a href="https://www.ncbi.nlm.nih.gov/pubmed/26305651">PubMed</a> <a href="https://jamanetwork.com/journals/jama/fullarticle/2429715">JAMA</a>) Authors:  Jeffery M. Klco, M.D., Ph.D.* Christopher A. Miller, Ph.D.*, Malachi Griffith, Ph.D., Allegra Petti, Ph.D., David H. Spencer, M.D., Ph.D., Shamika Ketkar-Kulkarni, M.S., Lukas D. Wartman, M.D., Matthew Christopher, M.D., Ph.D., Tamara L. Lamprecht, B.S., Nicole M. Helton, B.S., Eric J. Duncavage, M.D., Jacqueline E. Payton, M.D., Ph.D., Jack Baty, B.A., Sharon E. Heath, Obi L. Griffith, Ph.D., Dong Shen, Ph.D., Jasreet Hundal, M.S., Gue Su Chang, Ph.D., Robert Fulton, M.S., Michelle O'Laughlin, B.S., Catrina Fronick, B.S., Vincent Magrini, Ph.D., Ryan T. Demeter, B.E., David E. Larson, Ph.D., Shashikant Kulkarni, M.S., Ph.D., Bradley A. Ozenberger, Ph.D., John S. Welch, M.D., Ph.D., Matthew J. Walter, M.D., Timothy A. Graubert, M.D., Peter Westervelt, M.D., Ph.D., Jerald P. Radich, M.D., Daniel C. Link, M.D., Elaine R. Mardis, Ph.D., John F. DiPersio, M.D., Ph.D., Richard K. Wilson, Ph.D., and Timothy J. Ley

opencc-by-4.0Oct 2018View details →

Data supplement to: "Refractory depression - Mechanisms & Efficacy of Radically Open Dialectical Behaviour Therapy (RefraMED): findings of randomised trial on benefits and harms"

Data and code to support primary analyses reported in "Refractory depression – mechanisms and efficacy of radically open dialectical behaviour therapy (RefraMED): findings of a randomised trial on benefits and harms". British Journal of Psychiatry. doi: 10.1192/bjp.2019.53

opencc-by-4.0Sep 2024View details →

A comparative study of the effectivity of MSC-based, NP-based and combined therapies in an experimental model of NaIO3-induced retinal degeneration

<div>Background</div> <div>Mesenchymal stem cells (MSCs) are currently tested as one of the promising options for the therapy of retinal diseases, due to their immunomodulatory and neuroprotective abilities. However, there are several limitations associated with this type of treatment. Therefore, combinations of MSCs with other therapeutic agents are being considered. One of such approaches is represented by the application of MSCs with nanoparticles (NPs), which are widely used in medicine for their antimicrobial and immunomodulatory properties. Nevertheless, there is a possibility of negative effects of NPs on MSCs.</div> <div>Methods</div> <div>In this study, we tested the in vitro and in vivo effect of silver (Ag) NPs on the properties of MSCs in an experimental mouse model of chronic retinal degeneration induced by sodium iodate.</div> <div>Results</div> <div>The results showed that simultaneous intravitreal administration of MSCs with AgNPs had no effect on the survival of MSCs in the eye, but a less effective regulation of Iba-1 (activated microglia/macrophages) and interleukin-1β expression in the retinal tissue compared to MSCs or AgNP only treated groups was observed. However, all treated groups had decreased expression of the gene for galectin-3 compared to the untreated control. In addition, MSCs applied alone or in combination with AgNPs and sorted from the degenerated retina on day 7 after application had increased expression of genes for specific retinal markers, and for transforming growth factor-β and insulin-like growth factor-1 compared to untreated naïve MSCs. On the contrary, the increased expression of the gene for glial cell-derived growth factor was observed only in the MSCs combined with AgNPs. However, the application of MSCs with AgNPs triggered increased expression for the IL-6 gene in the CD45 cells separated from the retina.</div> <div>Conclusion</div> <div>Overall, the results show that the application of MSCs or AgNPs has an immunomodulatory effect in chronic retinal degeneration, but the combined application of MSCs and AgNPs could decrease the effects of a single therapy.</div>

opencc-by-4.0Nov 2024View details →

Quantitative results of the analysis of two types of bone particles corresponding to the work "A comprehensive analysis of two types of xenogeneic bone particles for use in maxillofacial bone regeneration therapies"

This dataset corresponds to the quantitative data generated in the work entitled "A comprehensive analysis of two types of xenogeneic bone particles for use in maxillofacial bone regeneration therapies". Regeneration of maxillofacial bone structures is challenging. One of the strategies applied to bone damage repair is the use of bone filler particles, and different types of these particles have been tested. In this work, we analyzed the regenerative potential of deproteinized bone particles (DP) and collagen-based bone particles (CP) to determine the potential of each biomaterial in bone repair. Results of the structural analysis using scanning electron microscopy and 3D scanning showed that DP and CP were structurally similar, and consisted of a heterogeneous mixture of bone particles of different sizes and shapes. Then, ex vivo analyses using morphological evaluation, LIVE & DEAD and quantification of DNA released to the medium demonstrated that CP and DP were highly biocompatible when used in direct and in indirect contact with human cells, at 24, 48 and 72h of follow-up. Then, when both particles were grafted for 2 months on Wistar rats in which a critical defect had been generated at the mandible bone. Results of the computed tomography analysis showed a significant reduction of the bone defect in the CP group, but not in the DP group, as compared with negative controls devoid of any bone particles. Histological analysis of the graft area revealed that both particles were biocompatible in vivo, and a regenerative tissue with collagen fibers and mineralized spots was found in CP and DP, with higher number of mineralized spots in DP. Histochemistry and immunohistochemistry analyses confirmed the presence of collagen, proteoglycans and osteocalcin at the regeneration area of CP and DP. In general, these results confirm the biocompatibility of both types of particles and that both were able to induce maxillofacial bone regeneration, especially in the case of CP. Future studies should determine their clinical usefulness in patients with cleft palate, mandibular damage and other maxillofacial applications.

openother-openDec 2022View details →

Design and Development of a Smartphone-Based Geolocalized Exposure Therapy Software for Anxiety Disorders: SyMptOMS-ET -- Reproducibility Package

R Notebook and datasets for the submitted paper "Towards a self-applied, mobile-based geolocated exposure therapy software for anxiety disorders: SyMptOMS-ET app" <blockquote> Alberto González-Pérez, Laura Diaz-Sanahuja, Miguel Matey-Sanz, Jorge Osma, Carlos Granell, Juana Bretón-López, Sven Casteleyn. Towards a self-applied, mobile-based geolocated exposure therapy software for anxiety disorders: SyMptOMS-ET app. <a href="https://journals.sagepub.com/home/dhj">Digital Health Journal</a> [Submitted] </blockquote> Experiments were conducted using the v1.2.0 version of the SyMptOMS-ET open-source app, which can be found <a href="https://github.com/GeoTecINIT/symptoms-mobile-app/releases/tag/v1.2.0">here</a>.