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856 results for “time course”
Time Course of a Misperception of Verticality and Its Characteristics in Post-stroke Participants
ClinicalTrials.gov study NCT05978596. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium
ClinicalTrials.gov study NCT01782820. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dataset: lhp1 FLC-Venus time course imaging – Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory
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Time course and diagnostic utility of NfL, tau, GFAp, and UCH-L1 in subacute and chronic TBI
<p><strong>Objective:</strong> To determine whether neurofilament light (NfL), glial fibrillary acidic protein (GFAP), tau, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) measured in serum relate to traumatic brain injury (TBI) diagnosis, injury severity, brain volume, and diffusion tensor imaging (DTI) measures of traumatic axonal injury (TAI) in patients with TBI.</p> <p><strong>Methods:</strong> Patients with TBI (n = 162) and controls (n = 68) were prospectively enrolled between 2011 and 2019. Patients with TBI also underwent serum, functional outcome, and imaging assessments at 30 (n=30), 90 (n=48), and 180 (n=59) days, and 1 (n=84), 2 (n=57), 3 (n=46), 4 (n = 38), and 5 (n = 29) years after injury.</p> <p><strong>Results:</strong> At enrollment, patients with TBI had increased serum NfL compared to controls (p < 0.0001). Serum NfL decreased over the course of 5 years but remained significantly elevated compared to controls. Serum NfL at 30 days distinguished patients with mild, moderate, and severe TBI from controls with an area under the receiver-operating characteristic curve (AUROC) of 0.84, 0.92, and 0.92, respectively. At enrollment, serum GFAP was elevated in patients with TBI compared to controls (p < 0.001). GFAP showed a biphasic release in serum, with levels decreasing during the first 6 months of injury but increasing over the subsequent study visits. The highest AUROC for GFAP was measured at 30 days, distinguishing patients with moderate and severe TBI from controls (both 0.89). Serum tau and UCH-L1 showed weak associations with TBI severity and neuroimaging measures. Longitudinally, serum NfL was the only bio- marker that was associated with the likely rate of MRI brain atrophy and DTI measures of progression of TAI.</p> <p><strong>Conclusions:</strong> Serum NfL shows greater diagnostic and prognostic utility than GFAP, tau, and UCH-L1 for subacute and chronic TBI.</p> <p><strong>Classification of evidence:</strong></p> <p>This study provides Class III evidence that serum NfL distinguishes patients with mild TBI from healthy controls.</p>
Time-course adaptive changes in hippocampal transcriptome and synaptic function induced by simulated microgravity associated with cognition
<p>Introduction: The investigation of cognitive function in microgravity, both short-term and long-term, remains largely descriptive. And the underlying mechanisms of the changes over time remain unclear. Methods: Behavioral tests, electrophysiological recording, and RNA sequencing were used to observe differences in behavior, synaptic plasticity, and gene expression. Results: Initially, we measured the performance of spatial cognition exposed to long-term simulated microgravity (SM). Both working memory and advanced cognitive abilities were enhanced. Somewhat surprisingly, the synaptic plasticity of the hippocampal CA3-CA1 synapse was impaired. To gain insight into the mechanism of changing regularity over time, transcriptome sequencing in the hippocampus was performed. The analysis identified 20 differentially expressed genes (DEGs) in the hippocampus after short-term modeling, 19 of which were up-regulated. Gene ontology (GO) analysis showed that these up-regulated genes were mainly enriched in synaptic-related processes, such as <em>Stxbp5l</em> and <em>Epha6</em>. This might be related to the enhancement of working memory performance under short-term SM exposure. Under exposure to long-term SM, 7 DEGs were identified in the hippocampus, all of which were up-regulated and related to oxidative stress and metabolism, such as <em>Depp1</em> and <em>Lrg1</em>. Compensatory effects occurred with increased modeling time. Discussion: To sum up, our current research indicates that the cognitive function under SM exposure is consistently maintained or potentially even being enhanced over both short and long durations. The underlying mechanisms are intricate and potentially linked to the differential expression of hippocampal-associated genes and alterations in synaptic function, with these effects being time-dependent. The present study will lay the experimental and theoretical foundation of the multi-level mechanism of cognitive function under space flight.</p>
Defining the Conjunctival Staining Method: Instillation Volume and Time Course to Assess Staining With Lissamine Green
ClinicalTrials.gov study NCT00768898. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate the Onset of Effect and Time Course of Change in Lung Function With Benralizumab in Severe, Uncontrolled Asthma Patients With Eosinophilic Inflammation
ClinicalTrials.gov study NCT02869438. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Characterisation of the Time-course Response of UV-induced Erythema
ClinicalTrials.gov study NCT04290273. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Time Course Evolution of Cardiac Output
ClinicalTrials.gov study NCT03694717. IPD Sharing: NO. Countries: 0. Publications: 1.
Time course and diagnostic utility of NfL, tau, GFAp, and UCH-L1 in subacute and chronic TBI
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Data from: The influence of real-time feedback on the quality of resuscitation: a prospective study comparing bystanders, paramedic course participants, and emergency physician trainee
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IMR90 radiation bystander time-course experiment 0.5Gy alpha particle
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the contribution of genome level changes in neighboring bystander cells to tissue and organ stress after irradiation. The timing of these changes is critical in the physiological context and these questions can only be answered by studying signaling and global transcriptomics in a chronological way. Here we present a strategy to identify different biologically important signaling modules that act in concert in the radiation and bystander responses. We used time series gene expression analysis of normal human fibroblast cells measured at 0.5 hour 1 hour 2 hours 4 hours 6 hours and 24 hours after exposure to radiation coupled with a novel clustering method targeted to short time series Feature Based Partitioning around medoids Algorithm (FBPA) to look for genes that were potentially co-regulated. This method uses biologically meaningful features of the expression profile and dimension augmentation to address the analysis of sparse data sets such as ours. We applied FBPA and Short Time series Expression Miner (STEM) to the same datasets and present the results of our comparisons using computational metrics as well as biological enrichment. Enrichment showed that gene expression in irradiated cells fell into broad categories of signal transduction cell cycle/cell death and inflammation/immunity; but only FBPA clustered functions well. In bystander cells the gene expression response was also broadly categorized into functions associated with cell communication and motility signal transduction and inflammation; but neither STEM nor FBPA separated biological functions as well as in irradiated samples. Network analysis revealed that p53 and NF-kappaB were central players in gene expression in both irradiated and bystander gene clusters. Analysis of individual clusters also suggested new regulators of gene expression in the radiation and bystander response that may act at the epigenetic level such as histone deacetylases (HDAC1 and HDAC2) and methylases (KDM5B) that can act as strong transcription repressors. Based on these results we propose a novel time series clustering method FBPA as a powerful approach that can be applied to sparse data sets (including genomic profiling data) where the choice of features selected for clustering and stringent statistical outcome analysis can augment our knowledge of the underlying cellular mechanisms in biological processes. There are 72 total samples 4 corresponding biological replicates of IMR90 cells that were not irradiated (control=C) irradiated (alpha=A) and bystander (B) cells were harvested at 0.5 hour 1 hour 2 hours 4 hours 6 hours and 24 hours after treatment
YDRseries2, Yeast desiccation / rehydration time course
GEO Series GSE1312. Saccharomyces cerevisiae. 21 samples. Type: Expression profiling by array.
Time course of mesenchymal breast cancer cells (MTΔECad) undergoing transdifferentiation into terminally differentiated adipocytes
GEO Series GSE89553. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Time course progression of BMP4-treated hESC gene expressions under 4 % and 20 % oxygen conditions.
GEO Series GSE10469. Homo sapiens. 12 samples. Type: Expression profiling by array.
Expression of 50-500nt ncRNAs in silkworm Bombyx mori: developmental time courses
GEO Series GSE22913. Bombyx mori. 5 samples. Type: Non-coding RNA profiling by array.
Time course of glucocortiocid receptor isoforms
GEO Series GSE6711. Homo sapiens. 60 samples. Type: Expression profiling by array.
Selectively targeting bromodomain and extraterminal proteins for degradation as a novel anti-glioblastoma strategy NA-seq (time course) May 15, 2018 approved TSV
GEO Series GSE99183. Homo sapiens. 49 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Time-course analysis of transcriptomic changes of mesothelial cells after stress exposure
GEO Series GSE149583. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
scATAC-seq of OT-1 CD8+ T cells from different time-course of Lm-OVA infected mice
GEO Series GSE241714. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.