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55 results for “total marrow irradiation”
A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantatio
ClinicalTrials.gov study NCT05201183. IPD Sharing: NO. Countries: 1. Publications: 0.
Busulfan, Etoposide, and Total-Body Irradiation in Treating Patients Undergoing Donor Stem Cell or Bone Marrow Transplant for Advanced Hematologic Cancer
ClinicalTrials.gov study NCT00534430. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Total-Body Irradiation, Busulfan, and Interferon Alfa Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Multiple Myeloma
ClinicalTrials.gov study NCT00003195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome
ClinicalTrials.gov study NCT05139004. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Standard-of-Care Reduced-Intensity Conditioning (RIC) With 200 Versus 400 cGy of Total Body Irradiation (TBI) in Patients With Acute Leukemia Undergoing First Allogeneic Blood or Marrow Transplantatio
ClinicalTrials.gov study NCT06803745. IPD Sharing: NO. Countries: 1. Publications: 0.
Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Hematological Cancer That Has Not Responded to Treat
ClinicalTrials.gov study NCT00800150. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT00002961. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Gene expression profile at single cell level of Lineage- Sca1+ c-Kit+ cells (LSKs) from the bone marrow of normal C57BL/6J mice with or without 5.0 Gy total body irradiation.
GEO Series GSE221907. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Automatic Planning of the Lower-Extremities for Total Marrow Irradiation Using Volumetric Modulated Arc Therapy"
<p>This record contains raw data related to article "Automatic Planning of the Lower-Extremities for Total Marrow Irradiation Using Volumetric Modulated Arc Therapy"</p> <p><strong>Abstract</strong></p> <p><strong>Purpose</strong>: Total marrow (and lymphoid) irradiation (TMI-TMLI) is limited by the couch travel range of modern linacs, which forces to split the treatment delivery into two plans with opposite orientations: a head-first supine upper-body plan, and a feet-first supine lower-extremities plan. A specific field junction is thus needed to obtain adequate target coverage in the overlap region of the two plans. In this study, an automatic procedure was developed for field junction creation and lower-extremities plan optimization.</p> <p><strong>Methods</strong>: Ten patients treated with TMI-TMLI at our institution were selected retrospectively. The planning of the lower-extremities was performed automatically. Target volume parameters (CTV_J-V<sub>98%</sub>>98%) at the junction region and several dose statistics (D<sub>98%</sub>, D<sub>mean</sub>, and D<sub>2%</sub>) were compared between automatic and manual plans. The Modulation Complexity Score (MCS) was used to assess plan complexity.</p> <p><strong>Results</strong>: The automatic procedure required 60-90 minutes, depending on the case. All automatic plans achieved clinically acceptable dosimetric results (CTV_J-V<sub>98%</sub>>98%), with significant differences found at the junction region, where D<sub>mean </sub>and D<sub>2% </sub>increased on average by 2.4% (p<0.03) and 3.0% (p<0.02), respectively. Similar plan complexity was observed (median MCS=0.12). Since March 2022 the automatic procedure has been introduced in our clinic, reducing the TMI-TMLI simulation-to-delivery schedule by 2 days.</p> <p><strong>Conclusions</strong>: The developed procedure allowed to streamline the treatment planning of TMI-TMLI, increasing efficiency and standardization, preventing human errors, while maintaining the dosimetric plan quality and complexity of manual plans. Automated strategies can simplify the future adoption and clinical implementation of TMI-TMLI treatments in new centers.</p> <p> </p>
Dataset related to article "Internal Guidelines for Reducing Lymph Node Contour Variability in Total Marrow and Lymph Node Irradiation "
<p>This record contains raw data related to article “Internal Guidelines for Reducing Lymph Node Contour Variability in Total Marrow and Lymph Node Irradiation"</p> <p><strong>Background: </strong> The total marrow and lymph node irradiation (TMLI) target includes the bones, spleen, and lymph node chains, with the latter being the most challenging structures to contour. We evaluated the impact of introducing internal contour guidelines to reduce the inter- and intraobserver lymph node delineation variability in TMLI treatments.</p> <p><strong>Methods: </strong> A total of 10 patients were randomly selected from our database of 104 TMLI patients so as to evaluate the guidelines' efficacy. The lymph node clinical target volume (CTV_LN) was recontoured according to the guidelines (CTV_LN_GL_RO1) and compared to the historical guidelines (CTV_LN_Old). Both topological (i.e., Dice similarity coefficient (DSC)) and dosimetric (i.e., V95 (the volume receiving 95% of the prescription dose) metrics were calculated for all paired contours.</p> <p><strong>Results: </strong> The mean DSCs were 0.82 ± 0.09, 0.97 ± 0.01, and 0.98 ± 0.02, respectively, for CTV_LN_Old vs. CTV_LN_GL_RO1, and between the inter- and intraobserver contours following the guidelines. Correspondingly, the mean CTV_LN-V95 dose differences were 4.8 ± 4.7%, 0.03 ± 0.5%, and 0.1 ± 0.1%.</p> <p><strong>Conclusions: </strong> The guidelines reduced the CTV_LN contour variability. The high target coverage agreement revealed that historical CTV-to-planning-target-volume margins were safe, even if a relatively low DSC was observed.</p>
Mouse bone marrow stromal cells: before or after total body irradiation
GEO Series GSE72235. Mus musculus. 2 samples. Type: Expression profiling by array.
Dataset related to article "Impact of the Extremities Positioning on the Set-Up Reproducibility for the Total Marrow Irradiation Treatment"
<p>Abstract</p><p>Total marrow (lymph node) irradiation (TMI/TMLI) delivery requires more time than standard radiotherapy treatments. The patient's extremities, through the joints, can experience large movements. The reproducibility of TMI/TMLI patients' extremities was evaluated to find the best positioning and reduce unwanted movements. Eighty TMI/TMLI patients were selected (2013-2022). During treatment, a cone-beam computed tomography (CBCT) was performed for each isocenter to reposition the patient. CBCT-CT pairs were evaluated considering: (i) online vector shift (OVS) that matched the two series; (ii) residual vector shift (RVS) to reposition the patient's extremities; (iii) qualitative agreement (range 1-5). Patients were subdivided into (i) arms either leaning on the frame or above the body; (ii) with or without a personal cushion for foot positioning. The Mann-Whitney test was considered (p < 0.05 significant). Six-hundred-twenty-nine CBCTs were analyzed. The median OVS was 4.0 mm, with only 1.6% of cases ranked < 3, and 24% of RVS > 10 mm. Arms leaning on the frame had significantly smaller RVS than above the body (median: 8.0 mm/6.0 mm, p < 0.05). Using a personal cushion for the feet significantly improved the RVS than without cushions (median: 8.5 mm/1.8 mm, p < 0.01). The role and experience of the radiotherapy team are fundamental to optimizing the TMI/TMLI patient setup.</p><p> </p>
Dataset related to article "Evaluation of plan complexity and dosimetric plan quality of total marrow and lymphoid irradiation using volumetric modulated arc therapy"
<p>This record contains raw data related to article "Evaluation of plan complexity and dosimetric plan quality of total marrow and lymphoid irradiation using volumetric modulated arc therapy"</p><p> Abstract</p><p>Purpose: To assess the impact of the planner's experience and optimization algorithm on the plan quality and complexity of total marrow and lymphoid irradiation (TMLI) delivered by means of volumetric modulated arc therapy (VMAT) over 2010-2022 at our institute.</p><p>Methods: Eighty-two consecutive TMLI plans were considered. Three complexity indices were computed to characterize the plans in terms of leaf gap size, irregularity of beam apertures, and modulation complexity. Dosimetric points of the target volume (D2%) and organs at risk (OAR) (Dmean) were automatically extracted to combine them with plan complexity and obtain a global quality score (GQS). The analysis was stratified based on the different optimization algorithms used over the years, including a knowledge-based (KB) model. Patient-specific quality assurance (QA) using Portal Dosimetry was performed retrospectively, and the gamma agreement index (GAI) was investigated in conjunction with plan complexity.</p><p>Results: Plan complexity significantly reduced over the years (r = -0.50, p < 0.01). Significant differences in plan complexity and plan dosimetric quality among the different algorithms were observed. Moreover, the KB model allowed to achieve significantly better dosimetric results to the OARs. The plan quality remained similar or even improved during the years and when moving to a newer algorithm, with GQS increasing from 0.019 ± 0.002 to 0.025 ± 0.003 (p < 0.01). The significant correlation between GQS and time (r = 0.33, p = 0.01) indicated that the planner's experience was relevant to improve the plan quality of TMLI plans. Significant correlations between the GAI and the complexity metrics (r = -0.71, p < 0.01) were also found.</p><p>Conclusion: Both the planner's experience and algorithm version are crucial to achieve an optimal plan quality in TMLI plans. Thus, the impact of the optimization algorithm should be carefully evaluated when a new algorithm is introduced and in system upgrades. Knowledge-based strategies can be useful to increase standardization and improve plan quality of TMLI treatments</p>
Dataset related to article "Deep learning and atlas-based models to streamline the segmentation workflow of Total Marrow and Lymphoid Irradiation"
<p>This record contains raw data related to article “Deep learning and atlas-based models to streamline the segmentation workflow of Total Marrow and Lymphoid Irradiation"</p> <p>Abstract:</p> <p><strong>Purpose: </strong>To improve the workflow of Total Marrow and Lymphoid Irradiation (TMLI) by enhancing the delineation of organs-at-risk (OARs) and clinical target volume (CTV) using deep learning (DL) and atlas-based (AB) segmentation models.</p> <p><strong>Materials and Methods:</strong> Ninety-five TMLI plans optimized in our institute were analyzed. Two commercial DL software were tested for segmenting 18 OARs. An AB model for lymph node CTV (CTV_LN) delineation was built using 20 TMLI patients. The AB model was evaluated on 20 independent patients and a semi-automatic approach was tested by correcting the automatic contours. The generated OARs and CTV_LN contours were compared to manual contours in terms of topological agreement, dose statistics, and time workload. A clinical decision tree was developed to define a specific contouring strategy for each OAR.</p> <p><strong>Results: </strong>The two DL models achieved a median Dice Similarity Coefficient (DSC) of 0.84 [0.73;0.92] and 0.84 [0.77;0.93] across the OARs. The absolute median dose (Dmedian) difference between manual and the two DL models was 2% [1%;5%] and 1% [0.2%;1%]. The AB model achieved a median DSC of 0.70 [0.66;0.74] for CTV_LN delineation, increasing to 0.94 [0.94;0.95] after manual revision, with minimal Dmedian differences. Since September 2022, our institution has implemented DL and AB models for all TMLI patients, reducing from 5 to 2 hours the time required to complete the entire segmentation process.</p> <p><strong>Conclusion: </strong>DL models can streamline the TMLI contouring process of OARs. Manual revision is still necessary for lymph node delineation using AB models.</p> <p> </p> <p><strong>Statements & Declarations</strong></p> <p><strong>Funding:</strong> This work was funded by the Italian Ministry of Health, grant AuToMI (GR-2019-12370739).</p> <p><strong>Competing Interests:</strong> The authors have no conflict of interests to disclose.</p> <p><strong>Author Contributions:</strong> All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by D.D., N.L., L.C., R.C.B., D.L., and P.M. The first draft of the manuscript was written by D.D. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.</p> <p><strong>Ethics approval:</strong> The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Ethics Committee of IRCCS Humanitas Research Hospital (ID 2928, 26 January 2021). ClinicalTrials.gov identifier: NCT04976205.</p> <p><strong>Consent to participate: </strong>Informed consent was obtained from all individual participants included in the study.</p>
Expression data from LT-HSCs from bone marrow non-irradiated, 8Gy CDR and 8Gy FLASH total body irradiated mice
GEO Series GSE54526. Mus musculus. 3 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.