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663
datasets available to search
ShareScore release 0.9.0
Dataset results
663 results for “tumor targeting”
Identifying Genetic Targets in Gynecological Tumors
ClinicalTrials.gov study NCT07169396. IPD Sharing: NO. Countries: 1. Publications: 4.
Dual-targeting CLDN18.2 and PD-L1 CAR-T for Patients with CLDN18.2-positive Advanced Solid Tumors
ClinicalTrials.gov study NCT06084286. IPD Sharing: NO. Countries: 1. Publications: 2.
To Observe the Dual-target Chimeric Antigen Receptor T Cells in the Treatment of B Cell Hematologic Tumors
ClinicalTrials.gov study NCT05388695. IPD Sharing: NO. Countries: 1. Publications: 1.
Hormone Receptor Positive Disease Across Solid Tumor Types: A Phase I Study of Single-Agent Hormone Blockade and Combination Approaches With Targeted Agents to Provide Synergy and Overcome Resistance
ClinicalTrials.gov study NCT01197170. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors
ClinicalTrials.gov study NCT03565445. IPD Sharing: YES. Countries: 9. Publications: 1.
Toremifene in Desmoid Tumor: Prospective Clinical Trial and Identification of Potential Molecular Targets
ClinicalTrials.gov study NCT02353429. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molecular Targeted Agents
ClinicalTrials.gov study NCT02517892. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors
ClinicalTrials.gov study NCT03970382. IPD Sharing: NO. Countries: 1. Publications: 2.
First in Human Evaluation of Safety, Pharmacokinetics, and Clinical Activity of a Monoclonal Antibody Targeting Netrin 1 in Patients With Advanced/Metastatic Solid Tumors
ClinicalTrials.gov study NCT02977195. IPD Sharing: NO. Countries: 1. Publications: 2.
Targeted Therapy Selection Based on Tumor Tissue Kinase Activity Profiles for Patients With Advanced Solid Malignancies, an Exploratory Study
ClinicalTrials.gov study NCT01190241. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sequential Targeting of Cluster of Differentiation 52 (CD52) and Tumor Necrosis Factor (TNF) Allows Early Minimization Therapy in Kidney Transplantation
ClinicalTrials.gov study NCT02711202. IPD Sharing: NO. Countries: 0. Publications: 1.
ImmunoPET Targeting Trophoblast Cell-surface Antigen 2 (Trop-2) in Solid Tumors
ClinicalTrials.gov study NCT06188468. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Chimeric Antigen Receptor T Cells Targeting claudin18.2 in Solid Tumors.
ClinicalTrials.gov study NCT03874897. IPD Sharing: YES. Countries: 1. Publications: 6.
SHIVA02 - Evaluation of the Efficacy of Targeted Therapy Based on Tumor Molecular Profiling in Patients With Advanced Cancer Using Each Patient as Its Own Control (SHIVA02)
ClinicalTrials.gov study NCT03084757. IPD Sharing: YES. Countries: 1. Publications: 1.
CLDN18.2 Targeting PET Imaging in Patients With Gastrointestinal Tumors
ClinicalTrials.gov study NCT04883970. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: D quantification of tumor vasculature in lymphoma xenografts in NOD/SCID mice allows to detect differences among vascular-targeted therapies
Open the record for dataset details and reuse information.
Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells
<p>Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. This approach may still be limited by the presence of immunosuppressive myeloid populations. Here we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. Treatment of xenograft tumors resulted in PD-L1 dependent tumor growth inhibition. PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. The clinical study of PD-L1 CAR haNKs is warranted.</p>
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
<p>Single-cell RNA sequencing data of rat connectedTUM neurons from co-culture with GBStarter cells (Tetzlaff & Reyhan et. al., 2024)</p>
A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping
ClinicalTrials.gov study NCT02509598. IPD Sharing: NO. Countries: 1. Publications: 0.
Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)
ClinicalTrials.gov study NCT06357988. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.