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ShareScore release 0.9.0
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44 results for “untargeted metabolomics”
Untargeted Metabolomics for Primary Aldosteronism
ClinicalTrials.gov study NCT06076473. IPD Sharing: NO. Countries: 1. Publications: 0.
Dataset related to the article "Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid"
<p>This record contains raw data related to the article “Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid"</p> <p><strong>Abstract</strong></p> <p>Given to its ability to irreversibly acetylate the platelet cyclooxygenase-1 enzyme, acetylsalicylic acid (ASA) is successfully employed for the prevention of cardiovascular disease. Recently, an antitumoral effect of ASA in colorectal cancer has been increasingly documented. However, the molecular and metabolic mechanisms by which ASA exerts such effect is largely unknown. Using a new, untargeted liquid chromatography-mass spectrometry approach, we have analyzed urine samples from seven healthy participants that each ingested 100 mg of ASA once daily for 1 week. Of the 2007 features detected, 25 metabolites differing after ASA ingestion (nominal <em>p</em> < 0.05 and variable importance in projection (VIP) score > 1) were identified, and pathway analysis revealed low levels of glutamine and of metabolites involved in histidine and purine metabolisms. Likewise, consistent with an altered fatty acid <em>β</em>-oxidation process, a decrease in several short- and medium-chain acyl-carnitines was observed. An abnormal <em>β</em>-oxidation and a lower than normal glutamine availability suggests reduced synthesis of acetyl-Co-A, as they are events linked to one another and experimentally related to ASA antiproliferative effects. While giving an example of how untargeted metabolomics allows us to explore new clinical applications of drugs, the present data provide a direction to be pursued to test the therapeutic effects of ASA-e.g., the antitumoral effect-beyond cardiovascular protection.</p>
Met4DX: A mass spectrum-oriented computational framework for ion mobility-resolved untargeted metabolomics
<p>Supplementary data</p>
Untargeted metabolomics peak intensity on CIA mouse plasma
<p>Untargeted metabolomics with ultrahigh performance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) was done on plasma of collagen-induced arthritis (CIA) mouse model. Data keys and explanations are below.</p> <p>mouseID: Mouse ID for the current study</p> <p>Treatment: CIA or control</p> <p>Time: Time of sacrifice and sample collection</p> <p>Intensity: Metabolite peak intensity measured by UPLC-MS/MS</p> <p>CHEM_ID: Internal ID for metabolite</p> <p>SUPER_PATHWAY: The general biochemical class assigned to the identified biochemical (e.g. lipid, amino acid, carbohydrate, etc.) intended for sorting compounds by broad biochemical classes</p> <p>SUB_PATHWAY: A more specific biochemical class assigned to the identified biochemical (e.g. TCA cycle, monoacylglycerols, etc.) intended for grouping/sorting compounds by biochemical pathway/class</p> <p>The rest of the data keys includes metabolite identifiers in multiple public databases and analysis platform.</p> <p> </p> <p> </p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.