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163 results for “valproic acid”
Data from: Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy
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REMI-seq analysis of D. discoideum cells treated with Lithium or Valproic acid
<p>A critical aspect of toxicity evaluation is developmental and reproductive toxicity (DART) testing. Traditionally, DART testing has been conducted <i>in vivo</i> in mammalian model systems. New legislation aimed at reducing animal use and the prohibitive costs associated with DART testing, together with a need to understand the genetic pathways underlying developmental toxicity means there is a growing demand for alternative model systems for toxicity evaluation. Here we explore the potential of the eukaryotic social amoeba <i>Dictyostelium </i>discoideum, which is already widely used as a simple model system for cell and developmental biology, as a potential non-animal model for DART testing. We developed assays for high-throughput screening of toxicity during <i>D. discoideum </i>growth and development. This allowed the toxicity of a broad range of test compounds to be characterized, which revealed that <i>D. discoideum </i>can broadly predict mammalian toxicity. In addition, we show that this system can be used to perform functional genomic screens to compare the molecular modes of action of different compounds. For example, genome wide screens for mutations that affect lithium and valproic acid toxicity allowed common and unique biological targets and molecular processes mediating their toxicity to be identified. These studies illustrate that <i>D. discoideum </i>could<i> </i>represent a predictive non-animal model for DART testing due to its amenability to high throughput approaches and molecular genetic tractability.</p>
Effect of Valproic Acid Concentration on Photic Response
ClinicalTrials.gov study NCT00609245. IPD Sharing: NO. Countries: 1. Publications: 0.
Valproic Acid in Combination With FEC100 for Primary Therapy in Patients With Breast Cancer
ClinicalTrials.gov study NCT01010854. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Valproic Acid and Dihydroergotamine as Abortive Therapy in Pediatric Migraine
ClinicalTrials.gov study NCT03885154. IPD Sharing: NO. Countries: 1. Publications: 0.
Valproic Acid Use in Patients With Neurological Disorders
ClinicalTrials.gov study NCT05830981. IPD Sharing: NO. Countries: 0. Publications: 4.
Valproic Acid (Depakote ER) in Patients With Advanced Thyroid Cancer
ClinicalTrials.gov study NCT00525135. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients.
ClinicalTrials.gov study NCT00000629. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study
ClinicalTrials.gov study NCT01729598. IPD Sharing: YES. Countries: 1. Publications: 0.
Decitabine (DAC) w/ or w/o Valproic Acid (VPA) in Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)
ClinicalTrials.gov study NCT00414310. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Valproic Acid With Chemoradiotherapy for Pancreatic Cancer
ClinicalTrials.gov study NCT01333631. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Valproic Acid in Treating Patients With Progressive, Non-Metastatic Prostate Cancer
ClinicalTrials.gov study NCT00670046. IPD Sharing: NO. Countries: 1. Publications: 0.
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS
ClinicalTrials.gov study NCT00439673. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficiency Study of Valproic Acid In HAM/TSP
ClinicalTrials.gov study NCT00519181. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Comparing Compliance, Tolerability, Efficacy and Adverse Events in Bipolar Tients From Valproic Acid to Depakote ER
ClinicalTrials.gov study NCT00211250. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICU
ClinicalTrials.gov study NCT02343575. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Valproic Acid (VPA) vs Placebo to Shorten Time of Indwelling Pleural Catheter
ClinicalTrials.gov study NCT01900730. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Azacytidine With Valproic Acid Versus Ara-C in Acute Myeloid Leukemia (AML)/ Myelodysplastic Syndrome (MDS) Patients
ClinicalTrials.gov study NCT00382590. IPD Sharing: Not stated. Countries: 1. Publications: 0.
REMI-seq analysis of D. discoideum cells treated with Lithium or Valproic acid
Open the record for dataset details and reuse information.
Expression profiles of 7-day cultured HSPCs in the presence or absence of valproic acid and/or lithium
GEO Series GSE35291. Mus musculus. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.