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33,754 results for “Enhancers”
Behavioral account of attended stream enhancement for neural tracking
<p>This dataset provides material and data associated with Huet, Micheyl, Parizet, Gaudrain (<strong>2021</strong>) "Behavioral account of attended stream enhances neural tracking", <em>Frontiers in Neuroscience</em>, <a href="https://doi.org/10.3389/fnins.2021.674112">doi: 10.3389/fnins.2021.674112</a>.</p> <p>The current version of the repository contains only the audio data (temporal envelopes) and behavioral data. The EEG data will be added as it is curated.</p>
BAF155 Methylation Drives Metastasis By Hijacking Super-enhancers and Subverting Anti-tumor Immunity
<p>Subunits of the chromatin remodeler SWI/SNF are the most frequently disrupted genes in cancer. However, how post-translational modifications (PTM) of SWI/SNF subunits elicit epigenetic dysfunction remains unknown. Arginine-methylation of BAF155 by coactivator-associated arginine methyltransferase 1 (CARM1) promotes triple negative breast cancer (TNBC) metastasis. Herein, we discovered the dual roles of methylated-BAF155 (me-BAF155) in promoting tumor metastasis: activation of super-enhanceraddicted oncogenes by recruiting BRD4, and repression of interferon / pathway genes to suppress host immune response. Pharmacological inhibition of CARM1 and BAF155 methylation not only abrogated the expression of an array of oncogenes, but also boosted host immune responses by enhancing the activity and tumor infiltration of cytotoxic T cells. Moreover, strong me-BAF155 staining was detected in circulating tumor cells from metastatic cancer patients. Despite low cytotoxicity, CARM1 inhibitors strongly inhibited TNBC cell migration in vitro, and growth and metastasis in vivo. These findings illustrate a unique mechanism of arginine methylation of a SWI/SNF subunit that drives epigenetic dysregulation, and establishes me-BAF155 as a therapeutic target to enhance immunotherapy efficacy.</p>
Enhancing research informatics core user satisfaction through agile practices
<p><strong>Objective:</strong> The Huntsman Cancer Institute (HCI) Research Informatics Shared Resource (RISR), a software and database development core facility, sought to address a lack of published operational best practices for research informatics cores. It aimed to use those insights to enhance effectiveness after an increase in team size from 20 to 31 full-time equivalents coincided with a reduction in user satisfaction.</p> <p><strong>Materials and Methods:</strong> RISR migrated from a water-scrum-fall model of software development to agile software development practices, which emphasize iteration and collaboration. RISR's agile implementation emphasizes the product owner role, which is responsible for user engagement and may be particularly valuable in software development that requires close engagement with users like in science.</p> <p><strong>Results: </strong>All RISR's software development teams implemented agile practices in early 2020. All project teams are led by a product owner who serves as the voice of the user on the development team. Annual user survey scores for service quality and turnaround time recorded nine months after implementation increased by 17% and 11%, respectively.</p> <p><strong>Discussion:</strong> RISR is illustrative of the increasing size of research informatics cores and the need to identify best practices for maintaining high effectiveness. Agile practices may address concerns about the fit of software engineering practices in science. The study had one time point after implementing agile practices and one site, limiting its generalizability.</p> <p><strong>Conclusion:</strong> Agile software development may substantially increase a research informatics core facility's effectiveness and should be studied further as a potential best practice for how such cores are operated.</p>
Research Space and DMPTool - Streamlining the research lifecycle and enhancing FAIR principles with a series of interoperable tools
<p>A video demonstration of the integration between the Electronic Lab Notebook, RSpace, and the DMPTool. Presented at the FORCE11 annual conference on December 7, 2021.</p>
Effects of enhanced productivity of resources shared by predators in a food-web module: Comparing results of a field experiment to predictions of mathematical models of intra-guild predation
<p>This dataset contains data from a field experiment described in the publication "Wise, D. H. & Farfan, M.A. (2021) Effects of enhanced productivity of resources shared by predators in a food-web module: Comparing results of a field experiment to predictions of mathematical models of intra-guild predation. Ecology and Evolution, 00: 1-11. <a href="https://doi.org/10.1002/ece3.8375">https://doi.org/10.1002/ece3.8375</a>".</p> <p>The field experiment compared the response to increased input of nutrients and energy (artificial detritus) to an empirical model of intra-guild predation (IGP) to the predictions of published, simple mathematical models of asymmetric IGP (a generalist IG Predator that feeds both on a specialist IG Prey and a Resource that it shares with the IG Prey). The empirical model was a food-web module created by pooling species abundances across many families in a community of soil micro-arthropods into three response variables: IG Predator (large predatory mites), IG Prey (small predatory mites) and a shared Resource (fungivorous mites and springtails). The pattern of change over time in densities of the three response variables (IG Predator, IG Prey and Resource) was compared to the predictions of mathematical models of IGP to determine if the feeding relationships in this community of soil micro-arthropods could be abstracted into a simple IGP module. Thus, we were testing the hypothesis that IGP is a dominant organizing principle in this community.</p> <p>Simple mathematical models predict that increased input of nutrients and energy to the shared Resource will increase the equilibrium density of Resource and IG Predator, but will decrease that of IG Prey. By the experiment's end, densities of fungivores (Resource) had increased ~1.5x (ratio of pooled fungivore densities in the High treatment to plots with no addition of detritus (None treatment); and IG Predator densities had increased ~4x. Contrary to the prediction of mathematical models, IG Prey had not decreased, but instead had increased ~1.5x. We discuss possible reasons for the failure of the empirical model to agree with IGP theory.</p>
Experimental evidence that novel land management interventions inspired by history enhance biodiversity
<p>To address biodiversity declines within semi-natural habitats, land-management must cater for diverse taxonomic groups. Integrating our understanding of the ecological requirements of priority (rare, scarce or threatened) species through 'biodiversity auditing', with that of the intensity and complexity of historical land-use, encourages novel forms of management. Experimental confirmation is needed to establish whether this enhances biodiversity conservation relative to routine management.</p> <p>Biodiversity auditing and historical land-use of dry-open terrestrial habitats in Breckland (Eastern England) both encourage management incorporating ground-disturbance and spatio-temporal variability. To test biodiversity conservation outcomes, we developed 40 4-ha management complexes over three successive winters, of which 20 were shallow-cultivated (rotovation) and 20 deep-cultivated (ploughing), stratified across 3,850-ha of closed-sward dry grassland and lowland heathland (collectively 'dry grassland'). Complexes comprised four 1-ha sub-treatments: repeat-cultivation, first-time-cultivation, one-year-old fallow and two-year-old fallow. We examined responses of vascular plants; spiders; true bugs; ground, rove and 'other' beetles; bees and wasps; ants; and true flies on treatment complexes and 21 4-ha untreated controls. Sampling gave 132,251 invertebrates from 877 species and 28,846 plant observations from 167 species.</p> <p>Resampling and rarefaction analyses showed shallow- and deep-cultivation both doubled priority species richness (pooling sub-treatments within complexes) compared to controls. Priority spider, ground beetle, other beetle, and true bug richness were greater on both treatments than controls. Responses were strongest for those priority dry-open-habitat associated invertebrates initially predicted (by biodiversity auditing) to benefit from heavy physical-disturbance.</p> <p>Assemblage composition (pooling non-priority and priority species) varied between sub-treatments for plants, ants, true bugs, spiders, ground, rove and other beetles; but only one-year-old fallowed deep-cultivation increased priority richness across multiple taxa.</p> <p>Treatments produced similar biodiversity responses across various dry grassland 'habitats' that differed in plant composition, allowing simplified management guidance.</p> <p><em>Synthesis and applications</em>. Our landscape-scale experiment confirmed the considerable biodiversity value of interventions inspired by history and informed by systematic multi-taxa analysis of ecological requirements across priority biota. Since assemblage composition varied between sub-treatments, providing heterogeneity in management will support the widest suite of species. Crucially, the intended recipients responded most strongly, suggesting biodiversity audits could successfully inform interventions within other systems.</p>
Automatic Detection of Photovoltaic from Sentinel-2 observations by an Enhanced U-Net method - DataSet
<p>Data Availability for <strong>Enhanced U-Net(E-UNET)</strong></p> <p>Thank you for your interest in our dataset.<br> <strong>Repository contents:</strong><br> <em>Sentinel-2 L2A product</em>: The tiles that we selected containing photovoltaic.<br> <em>ImageFusion_Result</em>: The image fusion results of ROI including photovoltaic which we intercepted from the Sentinel-2 data. It contains 10m resolution, 10m and 20m resolution, 10m, 20m and 60m resolution fusion results, and RGB 3-channels fusion results.<br> <em>Image</em>: The RGB images for the ROI containing photovoltaic.<br> <em>Label</em>: The manual annotations for the ROI containing photovoltaic.</p>
Tree water uptake enhances nitrogen acquisition in a fertilized boreal forest – but not under nitrogen poor conditions
<p><span>Understanding how plant water uptake interacts with acquisition of soil nitrogen (N) and other nutrients is fundamental for predicting plant responses to a changing environment, but it is an area where models disagree.</span></p> <p><span>We present a novel isotopic labelling approach which reveals spatial patterns of water and N uptake, and their interaction, by trees. The stable isotopes <sup>15</sup>N and <sup>2</sup>H were applied to a small area of the forest floor in stands with high and low soil N availability. Uptake by surrounding trees was measured. The sensitivity of N acquisition to water uptake was quantified by statistical modelling.</span></p> <p><span>Trees in the high-N stand acquired twice as much <sup>15</sup>N as in the low-N stand and around half of their N uptake was dependent on water uptake (<sup>2</sup>H enrichment). In contrast, in the low-N stand there was no positive effect of water uptake on N uptake. </span></p> <p><span>We conclude that tree N acquisition was only marginally dependent on water flux toward the root surface under low N conditions but under high-N conditions, the water-associated N uptake was substantial. The results suggest a fundamental shift in N acquisition strategy under high-N conditions. </span></p>
Fatal enhanced respiratory syncytial virus disease in toddlers
<p>In 1967, two toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (FIRSV) in the United States died from enhanced RSV disease (ERD), a severe form of illness resulting from aberrant priming of the antiviral immune response during vaccination. Up to 80% of immunized children subsequently exposed to wild-type virus were hospitalized. These events hampered RSV vaccine development for decades. In this manuscript, we provide a characterization of the clinical, immunopathological, and transcriptional signature of fatal human ERD, outlining novel evidence for safety evaluation of RSV vaccines and a framework for understanding disease enhancement for pathogens in general. These are the scanned histology slides from this study. </p>
Stanza Models for Morphologically enhanced Universal Dependencies for Korean (morphUD)
<p>Stanza (<a href="https://stanfordnlp.github.io/stanza/">Stanford NLP Group</a>) models for Morphologically enhanced Universal Dependencies for Korean (morphUD) including ko.vectors.xz files for morphUD and wordUD. </p> <p> </p> <p>Embedding files are generated with https://doi.org/10.5281/zenodo.5869738</p> <p> </p> <p>All files are listed in file.txt </p> <p> </p>
Data from: Neurofeedback facilitation enhances post-stroke gait and balance recovery: a randomized trial
<p><strong>Objective:</strong> To test the hypothesis that supplementary motor area (SMA) facilitation with functional near-infrared spectroscopy mediated neurofeedback (fNIRS-NFB) augments post-stroke gait and balance recovery using the 3-meter-Timed Up-and-Go (TUG) test, we conducted this two-center, double-blind, randomized controlled trial involving 54 Japanese patients.</p> <p><strong>Methods:</strong> Patients with subcortical stroke-induced mild-to-moderate gait disturbance more than 12 weeks from onset, underwent 6 sessions of SMA neurofeedback facilitation during gait- and balance-related motor imagery using fNIRS-NFB. Participants were randomly allocated to intervention (REAL: 28 patients) or placebo (SHAM: 26 patients) group. In the REAL group, the fNIRS signal contained participants' cortical activation information. Primary outcome was TUG improvement, 4 weeks post intervention.</p> <p><strong>Results: </strong>The REAL group showed greater improvement in the TUG test (12.84 ± 15.07 s, 95% CI: 7.00-18.68) than the SHAM group (5.51± 7.64 s, 95% CI: 2.43 – 8.60; group difference 7.33 s, 95% CI: 0.83 – 13.83; p = 0.028), even after adjusting for covariates (group × time interaction; F1.23,61.69 = 4.50, p = 0.030, partial η2 = 0.083). Only the REAL group showed significantly increased imagery-related SMA activation and enhancement of resting-state connectivity between SMA and ventrolateral premotor area. Adverse effects associated with fNIRS-mediated neurofeedback intervention were absent.</p> <p><strong>Conclusion:</strong> SMA facilitation during motor imagery using fNIRS neurofeedback may augment post-stroke gait and balance recovery by modulating the SMA and its related network.</p> <p><strong>Classification of Evidence:</strong> This study provides Class III evidence that for patients with gait disturbance from subcortical stroke, SMA neurofeedback facilitation improves TUG time. (UMIN000010723 at UMIN-CTR http://www.umin.ac.jp/english/)</p>
Multiple parasitoid species enhance top-down control, but parasitoid performance is context-dependent
<ol> <li>Ecological communities are composed of many species, forming complex networks of interactions. Current environmental changes are altering community composition. We thus need to identify which aspects of species interactions are primarily driven by community structure and which by species identity to predict changes in the functioning of communities. Yet, this partitioning of effects is challenging and thus rarely explored.</li> <li>Here we disentangled the influence of community structure and the identity of co-occurring species on the outcome of consumer-resource interactions using a host-parasitoid system.</li> <li>We used four community modules that are common in host-parasitoid communities to represent community structure (i.e., host-parasitoid, exploitative competition, alternative host, and a combination of both exploitative competition and alternative host). We assembled nine different species combinations per community module in a laboratory experiment using a pool of three <em>Drosophila </em>hosts and three larval parasitoid species. To investigate the potential mechanisms at play, we compared host suppression and parasitoid performance across community modules and species assemblages.</li> <li>We found that multiple parasitoid species enhanced host suppression due to sampling effect, weaker interspecific than intraspecific competition between parasitoids, and synergism. However, the effects of community structure on parasitoid performance were species-specific and dependent on the identity of co-occurring species. Consequently, multiple parasitoid species generally strengthen top down-control, but the performance of the parasitoids depends on the identity of either the co-occurring parasitoid species, the alternative host species, or both. </li> </ol>
Raw datasets and media accompanying the manuscript: Homogenous high enhancement surface-enhanced Raman scattering (SERS) substrates by simple hierarchical tuning of gold nanofoams
<p>Raw datasets and media accompanying the manuscript: Homogenous high enhancement surface-enhanced Raman scattering (SERS) substrates by simple hierarchical tuning of gold nanofoams</p>
Computational Data for Weaker interdomain interactions in FimH30 from multidrug-resistant Escherichia coli ST131 mediate longer lasting interactions with mannose and enhanced adhesin function
<p>Input files for the MD simulations and the resulting trajectories. A representative trajectory is provided for the R and T state of each allele. </p>
Dataset for "Spectroscopic investigation of faeces with surface-enhanced Raman scattering: a case study with coeliac patients on gluten-free diet"
<p>This dataset contains all the spectra and OTU table data used in the paper "Spectroscopic investigation of faeces with surface-enhanced Raman scattering: a case study with coeliac patients on gluten-free diet", plus the R code to import the TXT (ASCII) files into a dataset, preprocess data, analzye data and generate the figures shown in the paper.</p> <p>Spectral data are available in 2 different format:</p> <p>- the original TXT files (as generated from the Raman instrument, 1 file = 1 spectrum)</p> <p>- as RData file (an hyperSpec object including metadata), directly to be opened in R</p> <p>The OTU table is available either as a single XLSX file or as a RData file to be opened in R.</p> <p>The R code used to generate the figures is available as a single file "Rcode.R".</p>
Iron Nitride Nanoparticles for Enhanced Reductive Dechlorination of Trichloroethylene: DFT Calculations
<p>This dataset contains input and output files of density functional theory calculations on which the computational part of the peer-reviewed article "Iron Nitride Nanoparticles for Enhanced Reductive Dechlorination of Trichloroethylene" by M. Brumovský et al., doi 10.1021/acs.est.1c08282, is based. Please cite this article when using the dataset.</p> <p>The dataset includes:<br> * Fully relaxed unit cells of Fe, Fe4N, and FeS in the folder "Unit_cells"<br> * Structures and energies of adsorbed TCE and H2O molecules on the Fe(110), Fe4N(001), and FeS(001) surfaces in the folder "Adsorption_calculations"<br> * Transition state calculations of TCE chemisorption and the first dechlorination step on the Fe4N(001) surface, including frequency calculations of transitions states, in the folder "NEB_calculations_on_Fe4N"<br> * TCE homolytic bond dissociation energies calculated using VASP and TURBOMOLE in the folder "BDE_calculations"<br> * Energies of reactants, products, and transitions states calculated with the inclusion of the solvent effect in the folder "VASPsol_calculations"</p> <p>The final geometries and energies calculated using VASP are reported in the CONTCAR and OUTCAR files, respectively. Note that the POTCAR files are not allowed to be made publicly accessible. However, their description is given in the OUTCAR files. Please consult VASP/TURBOMOLE manual for more information regarding input and output files. </p> <p>Funding: This work was supported by the Austrian Science Fund (FWF) project M 2892-N and the University of Ostrava (IRP201826, SGS06/PrF/2021). The Vienna Scientific Cluster (Project No. 70544) and IT4 Innovations National Supercomputing Center (LM2015070) are gratefully acknowledged for providing computational resources. </p> <p>Terms of use: These data are provided "as is", without any warranty. The data are provided under the Creative Commons Attribution 4.0 International license.</p>
Radiomics and Artificial Intelligence Analysis with Textural Metrics Extracted by Contrast-Enhanced Mammography and Dynamic Contrast Magnetic Resonance Imaging to detect breast malignant Lesions
<p>We uploade the dataset of the manuscript "Radiomics and Artificial Intelligence Analysis with Textural Metrics Extracted by Contrast-Enhanced Mammography and Dynamic Contrast Magnetic Resonance Imaging to detect breast malignant Lesions" by Current Oncology.</p> <p> </p>
Dataset of paper "Mechanistic modelling of solar disinfection (SODIS) kinetics of Escherichia coli, enhanced with H2O2 – Part 1: The dark side of peroxide"
<p>Data of the experimental and predicted <em>E. coli </em>inactivation and H<sub>2</sub>O<sub>2</sub> profiles under dark conditions to study the effect of rising water temperature.</p>
Dataser of paper "Mechanistic modelling of solar disinfection (SODIS) kinetics of Escherichia coli, enhanced with H2O2 – Part 2: Shine on you, crazy peroxide"
<p>Data of the experimental and predicted <em>E. coli </em>inactivation and H<sub>2</sub>O<sub>2</sub> profiles under different conditions of UV radiation, water temperature and initial H<sub>2</sub>O<sub>2</sub> concentration.</p>
Photodegradation of plant litter cuticles enhances microbial decomposition by increasing uptake of non-rainfall moisture
<p>Litter decomposition plays a central role in carbon cycling in terrestrial ecosystems worldwide. In drylands, which cover 40% of the Earth's land surface, photodegradation and biotic decomposition driven by non-rainfall moisture are important mechanisms of litter decay, though studies have only recently begun examining interactions between these two processes. We describe a novel priming mechanism in which photodegradation and biotic decay of the cuticle of plant litter increases litter absorption of non-rainfall moisture (fog, dew, and water vapor), supporting greater microbial decomposition.</p> <p>We used several field experiments in a coastal fog desert and a series of in situ observations to demonstrate a relationship between solar radiation, cuticle integrity, water absorption rates, and mass loss.</p> <p>Experimentally attenuating solar radiation for 36 months slowed mass loss, reduced cuticle degradation, and decreased litter moisture uptake relative to litter under ambient sunlight controls. In a separate field experiment, removing the cuticle of recently senesced grass tillers increased mass loss four-fold over 6 months relative to controls. Tillers with degraded cuticles also absorbed 3.8 times more water following an overnight dew event than did those with intact cuticles. Finally, fungal growth was consistently greater on the sun-facing side of in situ tillers than on the shaded side, coincident with greater cuticle degradation.</p> <p>We present a conceptual model where the cuticle of plant litter acts as a water-resistant barrier that is first degraded by solar radiation and surficial microbes, increasing litter's ability to absorb enough water during non-rainfall moisture events to support substantial biotic decomposition inside the tissue. Considering how photodegradation and non-rainfall moisture are both substantial drivers of litter decomposition in drylands, understanding how they interact under realistic field conditions will help us better predict how these systems are responding to changing climate regimes.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.