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4,004 results for “In vivo”
Supplementary material 1 from: Mahmod AI, Oqal M, Khalid AM, Afifi FU, Talib WH (2024) Phytochemical analysis, antioxidant, and antitumor activity of Ligustrum ovalifolium leaves grown in Jordan: an in vitro and in vivo study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e111517
Ligustrum ovalifolium leaves ethyl acetate extract LCMS results
Figure 3 from: Mahmod AI, Oqal M, Khalid AM, Afifi FU, Talib WH (2024) Phytochemical analysis, antioxidant, and antitumor activity of Ligustrum ovalifolium leaves grown in Jordan: an in vitro and in vivo study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e111517
Figure 3 L. ovalifolium ethyl acetate extract effect on tumor size and cure percentage. Compared to the control group, treating tumor-bearing mice with L. ovalifolium has reduced tumor size and improved the cure percentage. (n=9 per group).
Figure 3 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 3 A plot of change in average tumor size (mm3) vs. time in (days) of treatment iEMT6/P (p < 0.05) compared to the control group
Figure 5 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 5 Effect of C. iphionoides treatment on serum levels of (A) Creatinine and (B) ALT, AST. Serum creatinine level is expressed in mg/dL, and concentrations of ALT and AST are expressed by IU/L. Mice were treated with (60 mg/kg/ day) of essential oil. Results are expressed as means (bars) ± SEM (lines). ALT, alanine transaminase; AST, aspartate transaminase.
Figure 2 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 2 Antiproliferative activity of essential oil of C. iphionoides on MDA-MB- 231, T47, A549, EMT6, Vero cell lines
Figure 3 from: Theodorea CF, Nurkolis F, Idrus E, Yusuf TW, Vivo CD, Subali D, Taslim NA, Nugraha AP (2024) Physicochemical characterization of novel toothpaste from Caulerpa racemosa and Thunnus fish bone: Antibacterial potency against colonization of selected cariogenic-periodontal bacteria. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e118021
Figure 3 Possible mechanism of combined C. racemosa and Thunnus fish bone flour toothpaste to cariogenic & periodontal bacteria. This figure is an original figure produced by the author(s) for this article.
Figure 2 from: Theodorea CF, Nurkolis F, Idrus E, Yusuf TW, Vivo CD, Subali D, Taslim NA, Nugraha AP (2024) Physicochemical characterization of novel toothpaste from Caulerpa racemosa and Thunnus fish bone: Antibacterial potency against colonization of selected cariogenic-periodontal bacteria. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e118021
Figure 2 Antibacterial activity towards the colonization of cariogenic & periodontal bacterias. ns= Not Significant (p>0.05), *=0.0294, **=0.0026, ****<0.0001.
Figure 4 from: AlNaimat S, Abu-Odeh A, Talib WH (2024) Anticancer and antioxidant activities of essential oils of Chiliadenus iphionoides from Jordan: in vitro and in vivo study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e116195
Figure 4 Effect of C. iphionoides essential oil on tumor size and cure percentage. Treatment with C. iphionoides essential oil reduced tumor size and increased cure percentage compared to the negative control. (N = 9 mice) in each group.
Figure 2 from: Mahmod AI, Oqal M, Khalid AM, Afifi FU, Talib WH (2024) Phytochemical analysis, antioxidant, and antitumor activity of Ligustrum ovalifolium leaves grown in Jordan: an in vitro and in vivo study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e111517
Figure 2 A plot verifying the changes in average tumor size (mm³) vs time (days) of treatment with L. ovalifolium ethyl acetate extract in Balb/C mice inoculated with the EMT6/P cell line.
Supplementary material 1 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Supplementary information
Figure 9 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Figure 9 Comparative ex-vivo permeation analysis shows a statistically significant difference between PHCl-NEG and PHCl gel.
Figure 7 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Figure 7 The rheological relationships of PHCl-loaded nanoemulgel (PHCl-NEG) between: A. Viscosity and shear rate; B. Shear rate and shear stress.
Figure A3 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Figure A3 Photographic pictures displaying PHCl-NEG: A. Consistency and physical appearance; B. Rheological behavior measurement.
IE-Map: A novel in-vivo atlas and template of the human inner ear
<p>Brain atlases and templates are core tools in scientific research with increasing importance also in clinical applications. Advances in neuroimaging now allowed us to expand the atlas domain to the vestibular and auditory organ, the inner ear. In this study, we present IE-Map, an in-vivo template and atlas of the human labyrinth derived from multi-modal high-resolution magnetic resonance imaging (MRI) data, in a fully non-invasive manner without any contrast agent or radiation. We reconstructed a common template from 126 inner ears (63 normal subjects) and annotated it with 94 established landmarks and semi-automatic segmentations of all relevant macroscopic vestibular and auditory substructures. We validated the atlas by comparing MRI templates to a novel CT/micro-CT atlas, which we reconstructed from 21 publicly available post-mortem images of the bony labyrinth. Templates in MRI and micro-CT have a high overlap, and several key anatomical measures of the bony labyrinth in IE-Map are in line with micro-CT literature of the inner ear. A quantitative substructural analysis based on the new template, revealed a correlation of labyrinth parameters with total intracranial volume. No effects of gender or laterality were found. We provide the validated templates, atlas segmentations, surface meshes and landmark annotations as open-access material, to provide neuroscience researchers and clinicians in neurology, neurosurgery, and otorhinolaryngology with a widely applicable tool for computational neuro-otology.</p>
Figure 5 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 5 Histological analysis of the adrenal gland. A. Adrenal gland of control group; B. Adrenal gland of 100 mg chrysin-treated group.
Figure 2 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 2 The expression of target genes in the ovary of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating ΔCt and relative fold gene expression. * P ≤ 0.05. 3β-HSD, 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase.
Figure 1 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 1 The expression of target genes in the adrenal gland of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating ΔCt and relative fold gene expression. * P ≤ 0.05, ** P ≤ 0.01. CYP17A1, cytochrome P450 family 17 subfamily A member 1; P450scc, cholesterol side-chain cleavage enzyme; 3β-HSD, 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase.
Figure 7 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 7 Histological analysis of the adrenal gland medulla. A. Adrenal medulla of control group; B. Adrenal medulla of 100 mg chrysin-treated group.
Figure 4 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 4 Effect of chrysin on adrenal gland histology. Stained section of the control adrenal cortex showing a thin capsule (C) with underlying zona glomerulosa (G) arranged in oval or curved clusters. Zona fasciculata cells (F) are arranged in parallel cords while cells of zona reticularis (R) with anastomosing cords (H & E stain).
Figure 3 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 3 The expression of estrogen receptor-α (ERα) in the uterus of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating of ΔCt and relative fold gene expression.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.