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Dataset results
640 results for “Peripheral neuropathy”
A Genome Wide Association Study Reveals Genetic Predisposition for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma by Variation in the PREP1-CBS locus.
GEO Series GSE65777. Homo sapiens. 469 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
Schwann cell-specific ablation of Beclin 1 impairs peripheral myelination and leads to a progressive motor and sensory neuropathy
GEO Series GSE247435. Mus musculus. 16 samples. Type: Expression profiling by array.
Longitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathy
GEO Series GSE185084. Mus musculus. 120 samples. Type: Expression profiling by high throughput sequencing.
mouse sciatic nerve profile of CMT1A peripheral neuropathy model, caused by PMP22 overexpression
GEO Series GSE1962. Mus musculus. 2 samples. Type: Expression profiling by SAGE.
Disease mechanisms in peripheral neuropathies due to altered Pmp22 gene dosage or a Pmp22 point mutation
GEO Series GSE1947. Mus musculus. 21 samples. Type: Expression profiling by array.
Diabetic peripheral neuropathy is associated with changes in the frequency and function of circulating Natural Killer cells: results of a pilot study in patients with diabetic foot.
<p><strong><span>Background: </span></strong><span>Diabetic critical limb-threatening ischemia (CLTI) is a severe vascular disease with a high incidence of amputation and death. Circulating inflammatory markers may represent early diagnostic and prognostic tools. We previously showed that patients with diabetes mellitus and CLTI bear low abundance and impaired functionality of pro-angiogenic CD34<sup>+</sup> hematopoietic stem and progenitor cells (HSPCs) and high frequency of natural killer cells (NKs). However, no study assessed the frequency, phenotype, and function of NKs in the early stage of CLTI characterized by neuropathy.<strong> Methods: </strong>We enrolled 177 subjects sorted into 5 groups reflecting CLTI progression: 1) non-diabetic healthy controls (n=25), diabetic patients 2) without neurovascular complications (n=27), 3) with peripheral neuropathy (n=39), 4) with peripheral neuropathy and foot lesions (n=42), 5) with peripheral neuroischemia and foot lesions (n=44). We assessed the frequency of circulating B-, CD4<sup>+,</sup> and CD8<sup>+</sup> T-cells, NKs, and CD34<sup>+</sup>HSPCs, by a flow cytometry (FC)-based diagnostic kit. We investigated by FC the frequency of circulating NK subpopulations in donors with diabetic neuropathy (n=16) and controls (n=16). We characterized FACS-sorted circulating NKs secretome by antibody membrane arrays and we tested its pro-angiogenic potential<em> in vitro</em> and <em>in vivo</em> in <em>Hirudo verbana</em>.<strong> Results: </strong>Using age and sex-adjusted logistic multivariate models, we observed a decrease in CD34<sup>+</sup>HSPCs in all diabetic groups compared to control. Interestingly, NK frequency was increased in diabetic patients with neuropathy. Although the frequency of angiogenic NKs was similar in all groups, functionally, NKs from patients with diabetic neuropathy showed impaired degranulation <em>in vitro</em>, and reduced angiogenic ability <em>in vitro </em>and <em>in vivo</em>. Neuropathic NKs showed downregulation of angiogenic factors (IL-8, PDGF-B) and upregulation of factors related to monocyte/macrophage migration, effectively recruiting macrophages <em>in vivo</em>.<strong> Conclusion:</strong> By a routine laboratory test, we identified a specific cellular signature for patients with diabetes mellitus and peripheral neuropathy that includes low CD34<sup>+</sup>HSPCs and high NK frequency. Moreover, we show for the first time a functional impairment of NKs in neuropathic patients. If confirmed in larger cohorts, FACS detection of the circulating anti-angiogenic NK cell populations could be used for the early diagnosis of diabetic CLTI, a still unmet clinical need.</span></p>
Rood's Approach and Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients
ClinicalTrials.gov study NCT05882396. IPD Sharing: NO. Countries: 0. Publications: 0.
Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus
ClinicalTrials.gov study NCT03031834. IPD Sharing: NO. Countries: 0. Publications: 0.
Peripheral Analgesia in Painful Diabetic Neuropathy
ClinicalTrials.gov study NCT03354806. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN).
ClinicalTrials.gov study NCT00501202. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Phase II Clinical Study of AC591 in Preventing Oxaliplatin-Induced Peripheral Neuropathy
ClinicalTrials.gov study NCT06722950. IPD Sharing: NO. Countries: 0. Publications: 0.
Home-Based Neurofeedback Program in Treating Participants With Chemotherapy-Induced Peripheral Neuropathy
ClinicalTrials.gov study NCT03436680. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Use of Repetitive Transcranial Magnetic Stimulation in Cancer Patients With Chemotherapy-Induced Peripheral Neuropathy
ClinicalTrials.gov study NCT04107272. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effect of Rotating Magnetic Therapy on Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT03983200. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Vit D and Peripheral Neuropathy in Taxane Naive Patients
ClinicalTrials.gov study NCT05852496. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Multicenter, Randomized, Double-blind Phase II Trial to Evaluate GM1 Prevention of Peripheral Neuropathy in Patients With Breast Cancer
ClinicalTrials.gov study NCT05802342. IPD Sharing: NO. Countries: 0. Publications: 0.
Assessing Functional Impairments in Patients With Chemotherapy-Induced Peripheral Neuropathy
ClinicalTrials.gov study NCT07315334. IPD Sharing: NO. Countries: 0. Publications: 0.
Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer Undergoing Chemoth
ClinicalTrials.gov study NCT01492920. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Traditional Chinese Medicine Hand-Foot Soak for Chemotherapy-Induced Peripheral Neuropathy and Hand-Foot Syndrome
ClinicalTrials.gov study NCT07375446. IPD Sharing: YES. Countries: 0. Publications: 0.
The Effect of Piracetam on Diabetic Peripheral Neuropathy Patients
ClinicalTrials.gov study NCT06479629. IPD Sharing: NO. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.