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594
datasets available to search
ShareScore release 0.9.0
Dataset results
594 results for “mild cognitive impairment”
Parkinson's Disease With Mild Cognitive Impairment Treated With Nicotinic Agonist Drug
ClinicalTrials.gov study NCT04810104. IPD Sharing: NO. Countries: 0. Publications: 0.
MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairment
ClinicalTrials.gov study NCT06177028. IPD Sharing: YES. Countries: 0. Publications: 0.
Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment
ClinicalTrials.gov study NCT03855319. IPD Sharing: NO. Countries: 0. Publications: 0.
A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment
ClinicalTrials.gov study NCT00240695. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Phase II Study for Amyloid Binding Imaging Study of [18F]AV-45 in Patients With Mild Cognitive Impairment, Alzheimer's Disease and Healthy Volunteers
ClinicalTrials.gov study NCT01238458. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities
ClinicalTrials.gov study NCT03195816. IPD Sharing: NO. Countries: 0. Publications: 0.
Intervention Effect of Yizhi Baduanjin on Patients With Mild Cognitive Impairment
ClinicalTrials.gov study NCT05899777. IPD Sharing: NO. Countries: 0. Publications: 0.
Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment
ClinicalTrials.gov study NCT03545152. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Long noncoding RNA microarray profile in the plasma of mild cognitive impairment due to Alzheimer's disease
GEO Series GSE225304. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by array.
Comparative efficacy of nonpharmacological interventions over global cognition in people with mild cognitive impairment and dementia: a systematic review and Bayesian network meta-analysis
<p>This database contains information on 122 RCT which compared the effect of different nonpharmacological interventions over global cognition in dementia and mild cognitive impairment. </p>
NMR based clinical metabolomics study revealed aberrant proline biosynthesis and mitochondrial dysfunction in patients of mild cognitive impairment
<p>The prevalence of type-2 diabetes mellitus (T2DM) is tremendously increasing in older population because of several reasons and studies have shown that such old-age T2DM patients have 50-65% higher risk of developing cognitive impairment and its progression towards mild cognitive impairment (MCI). The studies claim that in the majority of MCI patients, the diabetes selectively involves the brain and the condition is now considered as a neuroendocrine disorder, even referred to as type 3 diabetes (T3D). Impaired glucose metabolism and mitochondrial dysfunction in neurodegenerative diseases, particularly in MCI, is compelling. Therefore, clinical interest is emerging to understand the role of mitochondria in T2DM and T3D which may provide important insights into pathogenesis of such chronic diseases and may indeed provide a target for improved patient care. The present study, therefore, aims to compare the serum metabolic profiles of MCI patients with age and sex matched T2DM patients with respect to normal control (NC) subjects. The results revealed that abnormal glutamate-to-glutamine cycling and proline metabolism in MCI patients. Compared to T2DM patients, the elevated circulatory proline levels in MCI patients hinted towards abnormal mitochondrial functioning underlying cognitive impairment.</p>
Dataset for "Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease"
<p>The dataset contains the numerical data described and analyzed in the paper "Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer’s Disease", Sighinolfi et al., J Alzheimers Dis, 2024, doi: 10.3233/JAD-231192.</p> <p>It consists of the measures, performed using the Morphologist software, of the morphological properties of brain sulci in 87 subjects, as described in the paper.</p> <p>If interested in the data, please contact the Corresponding Author: <br>Prof. Caterina Tonon<br>caterina.tonon@unibo.it</p>
microRNA microarray profile in the plasma of mild cognitive impairment due to Alzheimer's disease
GEO Series GSE147232. Homo sapiens; Rattus norvegicus; Mus musculus. 10 samples. Type: Non-coding RNA profiling by array.
Analysis of inflammatory predictors and differences in gene expression in patients with Cognitive Impairment Mild responders and non-responders to Neurostimulation: a randomized, double-blind clinical trial
<p>https://docs.google.com/spreadsheets/d/1jUrBFxUs57HBCj-y0NkID1kzdnsLPpr9/edit#gid=788062431</p> <p>Mild cognitive impairment (MCI) refers to the transition state between the cognitive changes of normal aging and early dementia, but it does not notably interfere with activities of daily living. MCI is believed to be a prodromal stage of dementia that causes severe cognitive dysfunction, so its identification for early intervention is considered an important therapeutic strategy.<br> In this context, non-pharmacological interventions, such as Transcranial Direct Current Stimulation (tDCS), which uses direct electrical currents to stimulate specific parts of the brain, have been used to clinically improve these patients. Biochemical processes have been linked to the pathogenesis of MCI and dementia, including chronic inflammation, dysregulation of membrane lipids, disruption of neurotransmitter pathways, and mutations in specific genes. Therefore, the general objective of this study is to evaluate the inflammatory and gene expression profile of patients with MCI, responders and non-responders to tDCS. This is a randomized, double-blind, sham-controlled clinical trial (ClinicalTrials.org: NCT04934423).<br> Neuropsychological tests and a sociodemographic and clinical questionnaire will be used to assess and characterize the subjects. Participants captured by the Laboratory of Studies in Aging and Neurosciences of the Federal University of Paraíba will be divided into 02 groups, each with 25 patients, totaling 50 volunteers: Active – participants who will receive real anodic current; Sham – participants who will receive simulated stimulation. Participants enrolled by eligibility criteria will be randomly allocated in a simple 1:1 ratio. The equipment parameters will be customized by Computational Modeling with the help of the Non-Invasive Brain Stimulation Simulation Program and the measurement of the head circumference. The electroencephalogram and the evaluation of polymorphisms of the genes Alpha synuclein and Neuroregulin, as well as the inflammatory mediators IL-6, Il-10 and TNF-α, will be considered as possible predictors of response. The project was evaluated by the Research Ethics Committee of the Federal University of Paraíba, obtaining the following CAAE registration: 40675220.0.0000.5188. It is expected to find improvements in the scores of general cognition and memory tests after the intervention protocol of neurostimulation with an individual dose in the group that will receive the active current, compared to the simulated neurostimulation group. As well as finding differences in the Inflammatory and Genetic profiles of those responders and non-responders to Neurostimulation.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.