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1,183
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ShareScore release 0.9.0
Dataset results
1,183 results for “Insertion”
Alteration of genome folding via engineered transposon insertion
GEO Series GSE137376. Homo sapiens. 113 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Induction of a chromatin boundary in vivo upon insertion of a TAD border (ChIP-Seq)
GEO Series GSE166574. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genitourinary defects, anxiety and aggressive-like behavior and glucose metabolism disorders in Zmym2 mutant mice with inserted piggyBac transposon
GEO Series GSE305505. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
The 3’ UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions
GEO Series GSE252940. Staphylococcus aureus. 4 samples. Type: Other.
Systematic analysis of effects of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs
GEO Series GSE178080. Mus musculus. 23 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites
GEO Series GSE178440. Homo sapiens. 73 samples. Type: Other.
Development of an in vitro genotoxicity assay to detect retroviral vector-induced lymphoid insertional mutants
GEO Series GSE241160. Mus musculus. 149 samples. Type: Expression profiling by array.
Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity
GEO Series GSE48076. Trichoplusia ni. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Establishment and characterization of CRISPR/Cas9-mediated insertion of FLT3 ITD K562 cell line: Molecular insight of CD52 in leukemia
GEO Series GSE116727. Homo sapiens. 4 samples. Type: Expression profiling by array.
Natural genetic variation caused by small insertions and deletions in the human genome
GEO Series GSE27889. Homo sapiens. 170 samples. Type: Genome variation profiling by genome tiling array.
Systematic analysis of effects of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs [ChIP-seq]
GEO Series GSE178078. Mus musculus. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
NHEJ-mediated insertional mutagenesis reveals a novel target for enhancing fatty alcohols production in Yarrowia lipolytica
GEO Series GSE199895. Yarrowia lipolytica CLIB122. 6 samples. Type: Expression profiling by high throughput sequencing.
Dissecting the effects of sequence on transcription attenuation by the Restrictor complex [INSERT-Seq]
GEO Series GSE284377. Mus musculus. 18 samples. Type: Other.
Post-partum intrauterine device insertion
<p>Complete data set for PPIDU use post CS</p>
Data from: Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: a computational study
Amphiphilic, monolayer-protected gold nanoparticles (NPs) have been shown to enter cells via a non-endocytic, non-disruptive pathway that could be valuable for biomedical applications. The same NPs were also found to insert into a series of model cell membranes as a precursor to cellular uptake, but the insertion mechanism remains unclear. Previous simulations have demonstrated that an amphiphilic NP can insert into a single leaflet of a planar lipid bilayer, but in this configuration all charged end groups are localized to one side of the bilayer and it is unknown if further insertion is thermodynamically favorable. Here, we use atomistic molecular dynamics simulations to show that an amphiphilic NP can reach the bilayer midplane non-disruptively if charged ligands iteratively ``flip'' across the bilayer. Ligand flipping is a favorable process that relaxes bilayer curvature, decreases the nonpolar solvent-accessible surface area of the NP monolayer, and increases attractive ligand-lipid electrostatic interactions. Analysis of end group hydration further indicates that iterative ligand flipping can occur on experimentally relevant timescales. Supported by these results, we present a complete energy landscape for the non-disruptive insertion of amphiphilic NPs into lipid bilayers. These findings will help guide the design of NPs to enhance bilayer insertion and non-endocytic cellular uptake, and also provide physical insight into a possible pathway for the translocation of charged biomacromolecules.
Data from: Influence of needle-insertion depth on epidural spread and clinical outcomes in caudal epidural injections: a randomized clinical trial
Background: A caudal epidural steroid injection (CESI) is a commonly used method to improve symptoms of lumbosacral pain. We compared the achievement of successful epidurograms and patient-reported clinical outcomes following different needle-insertion depths during CESI. Methods: For the conventional method group, the needle was advanced into the sacral canal. For the alternative method group, the needle was positioned immediately after penetration of the sacrococcygeal ligament. Epidural filling patterns and vascular uptake during fluoroscopy were determined to verify successful epidural injection. Procedural pain scores were investigated immediately after the procedure. Pain scores and patient global impression of symptom change were evaluated at 1-month follow-up. Results: Assessments were completed by 127 patients (conventional method, n=64; alternative method, n=63). The incidence of intravascular injection was significantly lower in the alternative method group than in the conventional method group (3.2% vs 20.3%, P=0.005). Procedural pain during needle insertion was significantly lower in the alternative method group (3.7±1.3 vs 5.3±1.2, P<0.001). Epidural contrast filling patterns were similar in both groups. One-month follow-up pain scores and patient global impression of symptom change were comparable in both groups. Conclusion: Compared with the conventional method, the alternative method for CESI could achieve similar epidural spread and symptom improvement. The alternative technique exhibited clinical benefits of a lower rate of intravascular injection and less procedural pain.
The insertase YidC chaperones the polytopic membrane protein MelB inserting and folding simultaneously from both termini
<p>The deposited data sets contain data for the supplementary figures of the manuscript "The insertase YidC chaperones the polytopic membrane protein MelB inserting and folding simultaneously from both termini" by Blaimschein et al. published in Structure (2023).</p>
Determination of the best point of entry of percutaneous insertion of sacroiliac screws depending on patient positioning for surgery: a cadaveric study
<p>Supplemental file, including raw data analysed in the manucript titled <em>Determination of the best point of entry of percutaneous insertion of sacroiliac screws depending on patient positioning for surgery: a cadaveric study.</em></p>
Endothelial Cell Loss in Pseudophakic Patients Receiving a Paul Glaucoma Drainage Device With Its Tube Inserted in the Anterior Versus Posterior Chamber: a Randomized Controlled Trial
ClinicalTrials.gov study NCT05500469. IPD Sharing: NO. Countries: 1. Publications: 0.
Immersive Virtual Reality to Reduce Procedural Pain During IV Insertion in Children in the Emergency Department
ClinicalTrials.gov study NCT03435367. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.