Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
738
datasets available to search
ShareScore release 0.9.0
Dataset results
738 results for “Microsatellite”
Multi-omic colon organoid analysis highlight MSH4 as a marker of Lynch syndrome and microsatellite instability [methylation array]
GEO Series GSE210018. Homo sapiens. 58 samples. Type: Methylation profiling by array; Methylation profiling by genome tiling array.
Dipeptidase-1 knockout mice develop invasive tumors with features of microsatellite unstable colorectal cancer
GEO Series GSE290572. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Inflammatory Conditions Promote Resistance to Immune Checkpoint Inhibitors in High Microsatellite Instability Colorectal Cancer
GEO Series GSE179784. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ZSCAN4-binding motif - TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes
GEO Series GSE243628. Homo sapiens; Mus musculus. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
ETV6 Deficiency and Microsatellite Enhancers Drive Transcriptional Dysregulation in B-Lymphoblastic Leukemia: ChIP-Seq data
GEO Series GSE186941. Homo sapiens. 56 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis.
Accelerated Aging and Microsatellite Instability in Recessive Dystrophic Epidermolysis Bullosa-Associated Cutaneous Squamous Cell Carcinoma
GEO Series GSE236849. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Microsatellite expansion RNA visualization, elimination, and reversal of molecular pathology by RNA-targeting Cas9
GEO Series GSE100943. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Radiation Therapy Inhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial
GEO Series GSE179351. Homo sapiens. 54 samples. Type: Expression profiling by high throughput sequencing.
Cathepsin D-Mediated MHC-I Degradation Contributes to Immune Evasion in Microsatellite Stable Colorectal Cancer
GEO Series GSE306871. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
An FFPE-based prognostic signature to predict metastasis in stage I/II microsatellite stable colorectal cancer
GEO Series GSE81986. Homo sapiens. 573 samples. Type: Expression profiling by array.
Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability
GEO Series GSE195985. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
ZSCAN4-binding motif - TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes [RNA-Seq]
GEO Series GSE243627. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Impeding transcription of expanded microsatellite repeats by deactivated Cas9
GEO Series GSE103997. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage [RNA-seq]
GEO Series GSE140615. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage
GEO Series GSE140621. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Colorectal cancers with microsatellite instability display unique miRNA profiles
GEO Series GSE30454. Homo sapiens. 74 samples. Type: Non-coding RNA profiling by array.
A novel role for the EWS portion of EWS/FLI in binding GGAA-microsatellites required for oncogenic transformation in Ewing sarcoma [RNA-Seq]
GEO Series GSE94502. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Microsatellite matrix of Poa annua
<p>Comparative studies of invasive species in human-inhabited versus truly uninhabited habitats, particularly on their genetic structure, remain scarce. Sub-Antarctic islands provide an ideal system to study invasions in such contrasting environments as they represent semi-pristine conditions in highly remote areas that are accessible only through a small number of introduction routes. Here we studied the invasion genetics of annual bluegrass <i>Poa annua</i> on the Prince Edward Islands (PEI) that include the inhabited Marion Island and the uninhabited Prince Edward Island. We analysed variation at nuclear microsatellite loci and performed flow cytometry analyses to compare the genetic diversity and structure of this widespread invasive grass. We also used ecological niche models to estimate currently suitable habitat in these islands. We found high levels of genetic diversity and evidence for extensive admixture between genetically distinct groups of <i>P. annua</i> on Marion Island. In contrast, Prince Edward Island populations showed low levels of genetic diversity and no apparent admixture. Higher genetic diversity was apparent at the human entry points and around human settlements on both islands, suggesting that these areas received multiple introductions and acted as both initial introduction sites and secondary sources for invasive populations within the archipelago. Over 70 years of continuous human activity on Marion Island have led to the invasive spread of this species around human settlements and along footpaths, facilitating ongoing gene flow among geographically separated populations. In contrast, this was not the case for Prince Edward Island. The high levels of genetic variation, admixture, and habitat suitability in invasive <i>P. annua</i> facilitated by human actions, may increase the adaptive potential of the species, which could further enhance the species' invasiveness.</p>
Data from: A single multiplex of twelve microsatellite markers for the simultaneous study of the brown hare (Lepus europaeus) and the mountain hare (Lepus timidus)
The management of hunted species is challenging, as it must conciliate the conservation of species and their sustainable exploitation. Non-genetic tools are widely used in this context but they may present limitations notably when species can hybridize or when large-scale spatial monitoring is required to establish optimal management actions. This is why genetic tools have been more and more integrated in wildlife management practices. However, the markers proposed are often amplified in small multiplexes when larger ones could allow to better cope with the small quantities of DNA obtained with non-invasive sampling methods. Here, we propose a unique multiplex of 12 autosomal microsatellite markers for the study of two hare species that exist in sympatry in some areas in Europe and are hunted notably in France: the brown hare Lepus europaeus and the mountain hare L. timidus. We tested 17 markers previously used in these two species or other lagomorph species, from which 12 were included in this single multiplex. Diversity was between 4 and 30 alleles per locus totalling 126 alleles and we showed that these markers possess appropriate genetic resolution for individual and species identification for the populations under study. This multiplex panel represents the largest number of microsatellites amplified in one reaction proposed for these two hare species and provides a cost-effective and valuable tool for further hybridization studies and the management of hares.
Data from: Microsatellite and major histocompatibility complex variation in an endangered rattlesnake, the Eastern Massasauga (Sistrurus catenatus)
Genetic diversity is fundamental to maintaining the long-term viability of populations, yet reduced genetic variation is often associated with small, isolated populations. To examine the relationship between demography and genetic variation, variation at hypervariable loci (e.g., microsatellite DNA loci) is often measured. However, these loci are selectively neutral (or near neutral) and may not accurately reflect genomewide variation. Variation at functional trait loci, such as the major histocompatibility complex (MHC), can provide a better assessment of adaptive genetic variation in fragmented populations. We compared patterns of microsatellite and MHC variation across three Eastern Massasauga (Sistrurus catenatus) populations representing a gradient of demographic histories to assess the relative roles of natural selection and genetic drift. Using 454 deep amplicon sequencing, we identified 24 putatively functional MHC IIB exon 2 alleles belonging to a minimum of six loci. Analysis of synonymous and nonsynonymous substitution rates provided evidence of historical positive selection at the nucleotide level, and Tajima's D provided support for balancing selection in each population. As predicted, estimates of microsatellite allelic richness, observed, heterozygosity, and expected heterozygosity varied among populations in a pattern qualitatively consistent with demographic history and abundance. While MHC allelic richness at the population and individual levels revealed similar trends, MHC nucleotide diversity was unexpectedly high in the smallest population. Overall, these results suggest that genetic variation in the Eastern Massasauga populations in Illinois has been shaped by multiple evolutionary mechanisms. Thus, conservation efforts should consider both neutral and functional genetic variation when managing captive and wild Eastern Massasauga populations.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.