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5,826 results for “Randomized trial”
Efficacy of a multiple-component and multifactorial personalized fall prevention program in a mixed population of community-dwelling older adults with stroke, Parkinson's disease, or frailty compared to usual care: The PRE.C.I.S.A. Randomized Controlled Trial
<p>Raw data associated with the scientific publication 'Efficacy of a multiple-component and multifactorial personalized fall prevention program in a mixed population of community-dwelling older adults with stroke, Parkinson’s disease, or frailty compared to usual care: The PRE.C.I.S.A. Randomized Controlled Trial'.</p>
Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥60 vs <20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort
<p>Background: While numerous epidemiologic studies have found an association between higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and lower breast cancer risk, few have assessed this association for concentrations >40 ng/ml.</p> <p> </p> <p>Objective: To investigate the relationship between 25(OH)D concentration and breast cancer risk across a broad range of 25(OH)D concentrations among women aged 55 years and older.</p> <p> </p> <p>Methods: Analyses used pooled data from two randomized clinical trials (N=1129, N=2196) and a prospective cohort (N=1713) to examine a broad range of 25(OH)D concentrations. The outcome was diagnosis of breast cancer during the observation periods (median: 4.0 years). Three analyses were conducted: 1) Incidence rates were compared according to 25(OH)D concentration from <20 to ≥60 ng/ml (<50 to ≥150 nmol/L), 2) Kaplan-Meier plots were developed and 3) multivariate Cox regression was used to examine the association between 25(OH)D and breast cancer risk using multiple 25(OH)D measurements.</p> <p> </p> <p>Results: Within the pooled cohort (N=5038), 77 women were diagnosed with breast cancer (age-adjusted incidence: 512 cases per 100,000 person-years). Results were similar for the three analyses. First, comparing incidence rates, there was an 82% lower incidence rate of breast cancer for women with 25(OH)D concentrations ≥60 vs <20 ng/ml (Rate Ratio=0.18, <em>P</em>=0.006). Second, Kaplan-Meier curves for concentrations of <20, 20-39, 40-59 and ≥60 ng/ml were significantly different (<em>P</em>=0.02), with the highest proportion breast cancer-free in the ≥60 ng/ml group (99.3%) and the lowest proportion breast cancer-free in the <20 ng/ml group (96.8%). The proportion with breast cancer was 78% lower for ≥60 vs <20 ng/ml (<em>P</em>=0.02). Third, multivariate Cox regression revealed that women with 25(OH)D concentrations ≥60 ng/ml had an 80% lower risk of breast cancer than women with concentrations <20 ng/ml (HR=0.20, <em>P</em>=0.03), adjusting for age, BMI, smoking status, calcium supplement intake, and study of origin.</p> <p> </p> <p>Conclusions: Higher 25(OH)D concentrations were associated with a dose-response decrease in breast cancer risk with concentrations ≥60 ng/ml being most protective.</p>
Changes in School-day Step Counts during a Physical Activity for Lent Intervention: A Cluster Randomized Crossover Trial of the Savior's Sandals
<p>Excel data file of 187 participants in a Physical Activity for Lent program conducted in spring 2017 at 4 Catholic middle schools in San Diego, CA, USA. Includes daily physical activity step counts and questionnaire data for religiosity, physical activity enjoyment, and situational interest motivation.</p>
Effects of upper thoracic Mulligan mobilization on pain, range of motion and function in patients with mechanical neck pain: a randomized placebo-controlled trial
<p><span><span>Bu çalışmanın amacı mekanik boyun ağrısı olan bireylerde üst torasik bölgeye uygulanan Mulligan Ters Doğal Apofizeal Kaydırmaların (RNAGS) ağrı, hareket kısıtlılığı ve fonksiyon üzerindeki etkisini değerlendirmektir. Ocak 2021 ile Mayıs 2021 arasında yürütülen çalışmaya, sahte grup, fizyoterapi grubu ve Mulligan grubuna rastgele atanan 69 katılımcı dahil edildi. Tüm gruplara, paylaşımlı fizyoterapi müdahaleleri ve germe egzersizleri ile iki haftalık, 11 seanslık bir tedavi programı uygulandı. Mulligan grubuna Mulligan RNAGS tekniği ile ek mobilizasyon uygulandı. Sahte grup, standart altı Mulligan mobilizasyonu aldı. Sonuç ölçümleri arasında Hareket Aralığı (ROM), Görsel Analog Skala (VAS) ve Boyun Engellilik İndeksi (NDI) vardı. Gruplar arasında ölçümlerde hiçbir temel fark bulunamadı. Müdahaleden sonra, tüm gruplarda ROM artmış ve VAS ve NDI skorlarında azalma görüldü (p<0,001). Mulligan grubu diğer gruplara kıyasla VAS, ROM ve NDI'da önemli ölçüde daha fazla iyileşme gösterdi (p<0,001). Sham grubu fizyoterapi grubuna kıyasla NDI ve ekstansiyon ROM'da daha fazla iyileşme gösterdi (p<0,001). Üst torasik bölgedeki Mulligan RNAGS tekniği mekanik boyun ağrısında ağrı kesici, hareket aralığı ve işlevsellik açısından faydalı olduğu kanıtlandı. Uzun vadeli etkiler popülasyon bazlı çalışmalarla daha fazla araştırılmayı hak ediyor.</span></span></p>
Transcutaneous spinal cord stimulation enhances motor score and gait recovery in incomplete spinal cord injury. A double-blind randomized controlled trial
<p><strong><span>Background: </span></strong><span>Although transcutaneous spinal cord stimulation (tSCS) has been suggested as a safe and feasible intervention for gait rehabilitation, no studies have determined its effectiveness compared to sham stimulation.</span></p> <p><strong><span>Objective: </span></strong><span>To determine the effectiveness of tSCS combined with robotic-assisted gait training (RAGT) on lower limb muscle strength and walking function in incomplete spinal cord injury (iSCI) participants.</span></p> <p><strong><span>Methods: </span></strong><span>A randomized, double-blind, sham-controlled clinical trial was designed. Twenty-seven subacute iSCI participants were randomly allocated to tSCS or sham-tSCS group. The intervention consisted of 20 sessions of standard Lokomat walking training enhanced with tSCS. Primary outcomes were the lower extremity motor score (LEMS) and dynamometry. Secondary outcomes included the 10-Meter Walk Test (10MWT), the Timed Up and Go test (TUG), the 6-Minute Walk test (6MWT), the Spinal Cord Independence Measure III (SCIM III) and the Walking Index for Spinal Cord Injury II (WISCI-II). Assessments were performed before and after the intervention and at 1-month follow-up.</span></p> <p><strong><span>Results: </span></strong><span>Although no significant differences between groups were detected after the intervention, the tSCS group showed greater effects than the sham-tSCS group for LEMS (3.4 points; p=0.033), 10MWT (37.5s; p=0.030), TUG (47.7s; p=0.009), and WISCI-II (3.4 points; p=0.023) at the 1-month follow-up. Furthermore, the percentage of subjects who were able to walk at the follow-up was greater in the tSCS group (85.7%) compared to the sham group (43.1%; p=0.029).</span></p> <p><strong><span>Conclusions:</span></strong><span> The combination of standard RAGT with tSCS for 20 sessions was effective for LEMS and gait recovery in subacute iSCI participants after one month of follow-up.</span></p> <p><strong><span>Key words: </span></strong><span>Spinal cord injury; Transcutaneous spinal cord stimulation; Lokomat; Robotic-assisted gait training; Motor function; </span><span>Gait rehabilitation.</span></p>
Data From: ChatGPT versus expert feedback on clinical reasoning questions and their effect on learning: a randomized controlled trial
<p>Dataset Info</p> <p><strong>1) Immediate Test</strong><br>- The first row of the dataset identifies the columns.<br>- Column A represents the participants’ iDs.<br>- Column B represents the participants’ assigned group [0: Control (ExpertFeedback) 1: Intervention (ChatGPTFeedback)].<br>- Column C represents the genders of the participants (1: Female, 2: Male).<br>- Column D represents the first-year repetition status of the participants. (0: No, 1: Yes)<br>- Column E to H represent the scores in four different uncomplicated urinary tract infection (UTI) Key-Features Questions Items separately. <br>- Column I represents the total scores in uncomplicated UTI Key-Features Questions Items. <br>- Column J to M represent the scores in four different complicated UTI Key-Features Questions Items separately. <br>- Column N represents the total scores in complicated UTI Key-Features Questions Items. <br>- Column O to R represent the scores in four different pyelonephritis Key-Features Questions Items separately. <br>- Column S represents the total scores in pyelonephritis Key-Features Questions Items. <br>- Column T represents the total scores in immediate test. </p> <p><strong>2) Delayed Test</strong><br>- The first row of the dataset identifies the columns.<br>- Column A represents the participants iDs.<br>- Column B represents the participants’ assigned group [0: Control (ExpertFeedback) 1: Intervention (ChatGPTFeedback)].<br>- Column C represents the genders of the participants (1: Female, 2: Male).<br>- Column D represents the first-year repetition status of the participants. (0: No, 1: Yes)<br>- Column E to H represent the scores in four different uncomplicated urinary tract infection (UTI) Key-Features Questions Items separately. <br>- Column I represents the total scores in uncomplicated UTI Key-Features Questions Items. <br>- Column J to M represent the scores in four different complicated UTI Key-Features Questions Items separately. <br>- Column N represents the total scores in complicated UTI Key-Features Questions Items. <br>- Column O to R represent the scores in four different pyelonephritis Key-Features Questions Items separately. <br>- Column S represents the total scores in pyelonephritis Key-Features Questions Items. <br>- Column T represents the total scores in delayed test. </p> <p><strong>3) Pre-Intervention Survey on Critical Approach to AI</strong><br>- The first row of the dataset identifies the columns.<br>- Column A represents the participants iDs.<br>- Column B represents the participants’ assigned group [0: Control (ExpertFeedback) 1: Intervention (ChatGPTFeedback)].<br>- Column C represents the genders of the participants (1: Female, 2: Male).<br>- Column D represents the first-year repetition status of the participants (0: No, 1: Yes).<br>- Column E to J represent the responses of the participants to survey questions before the intervention. Each column is evaluated on a scale from 1 to 7. As it progresses from 1 to 7, the agreement status of participants to survey questions increases. (1: No agreement at all, 7: completely agree)</p> <p><strong>4) Post-Intervention Survey on Critical Approach to AI</strong><br>- The first row of the dataset identifies the columns.<br>- Column A represents the participants iDs.<br>- Column B represents the participants’ assigned group [0: Control (ExpertFeedback) 1: Intervention (ChatGPTFeedback)].<br>- Column C represents the genders of the participants (1: Female, 2: Male).<br>- Column D represents the first-year repetition status of the participants (0: No, 1: Yes).<br>- Column E to J represent the evaluation of the participants to survey questions after intervention. Each column is evaluated on a scale from 1 to 7. As it progresses from 1 to 7, the agreement status of participants to survey questions increases. (1: No agreement at all, 7: completely agree)</p>
Inter-Chemical Correlation results for the study: HHEARx2017-2121 (The Dynamics of Exposure, Phthalates and Asthma in a Randomized Trial (DEPART))
Title: The Dynamics of Exposure, Phthalates and Asthma in a Randomized Trial (DEPART) <br>Species: Homo sapiens <br>Number of samples: 281 <br>Number of named analytes: 30 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=41 <br>
Telerehabilitation program for COVID-19 survivors (TERECO) - Randomized controlled trial
<p><b>Objectives</b></p> <p>To investigate superiority of a telerehabilitation program for Covid-19 (TERECO) over no rehabilitation with regard to exercise capacity, lower-limb muscle strength (LMS), pulmonary function, health-related quality of life (HRQOL), and dyspnoea.</p> <p><b>Design</b></p> <p>Parallel-group randomised controlled-trial with 1:1 block-randomisation.</p> <p><b>Setting</b></p> <p>Three major hospitals from Jiangsu and Hubei provinces, China.</p> <p><b>Participants</b></p> <p>120 formerly hospitalised Covid-19 survivors with remaining dyspnoea complaints were randomised with 61 allocated to control and 59 to TERECO.</p> <p><b>Intervention</b></p> <p>Unsupervised home-based 6-week exercise program comprising breathing control and thoracic expansion, aerobic exercise, and LMS exercise, delivered via smartphone, and remotely monitored with heart rate telemetry.</p> <p><b>Outcomes</b></p> <p>Primary outcome was 6-minute walking distance (6MWD) in metres. Secondary outcomes were squat time in seconds; pulmonary function assessed by spirometry; HRQOL measured with SF-12; and mMRC-dyspnoea. Outcomes were assessed at 6 weeks (post-treatment) and 28 weeks (follow-up).</p> <p><b>Results</b></p> <p>Adjusted between-group difference in change in 6MWD was 65.45 metres (95% CI 43.8, 87.1; p<0.001) at post-treatment and 68.62 metres (95% CI 46.39, 90.85; p<0.001) at follow-up. Treatment effects for LMS were 20.12 seconds (95% CI 12.34, 27.9; p<0.001) post-treatment and 22.23 seconds (95% CI 14.24, 30.21; p<0.001) at follow-up. No group differences were found for lung function except post-treatment MVV. Increase in SF-12 physical component was greater in the TERECO group with treatment effects estimated as 3.79 (95% CI 1.24, 6.35; p=0.004) at post-treatment and 2.69 (95% CI 0.06, 5.32; p=0.045) at follow-up.</p> <p><b>Conclusions</b></p> <p>This trial demonstrated superiority of TERECO over no rehabilitation for 6MWD, LMS, and physical HRQOL.</p> <p><b>Trial registration</b>: ChiCTR2000031834, URL: <a href="http://www.chictr.org.cn/showproj.aspx?proj=52216">http://www.chictr.org.cn/showproj.aspx?proj=52216</a></p>
Dataset for "Assessing muscle-related adverse events in randomized trials of statins"
<p>Contains our extraction sheets with additional notes/comments on methods used in our study.</p>
Evaluating the educational effectiveness of a structured, simulator-assisted, peer-led training on cardiovascular physical examination in third-year medical students: A randomized, controlled trial
<p class="AbstractCxSpFirst"><span><span><span><span><span><span><span><span><span><span><span><b>Background:</b> Previous research suggests that cardiac examination skills in undergraduate medical students frequently need improvement. There are different ways to enhance physical examination (PE) skills such as simulator-based training or peer-assisted learning (PAL). </span></span></span></span></span></span></span></span></span></span></span></p> <p class="AbstractCxSpMiddle"><span><span><span><span><span><span><span><span><span><span><span><b>Aim:</b> The aim of this study was to evaluate the effectiveness of a structured, simulator-assisted, peer-led training on cardiovascular PE.</span></span></span></span></span></span></span></span></span></span></span></p> <p class="AbstractCxSpMiddle"><span><span><span><span><span><span><span><span><span><span><span><b>Methods:</b> Participants were third-year medical students at Leipzig University Faculty of Medicine. Students were randomly assigned to an intervention group (IG) and a control group (CG). In addition to standard curricular training, IG received a peer-led, simulator-based training in cardiac PE. Participant performance in cardiac PE was assessed using a standardized checklist with a maximum of 25 points. Primary outcome was assessed via checklist point distribution.</span></span></span></span></span></span></span></span></span></span></span></p> <p class="AbstractCxSpMiddle"><span><span><span><span><span><span><span><span><span><span><span><b>Results:</b> 89 students were randomised to either CG (<i>n</i> = 43) or IG (<i>n</i> = 46) with 70 completing the study. Overall, IG students performed significantly better than CG students did (max. points: 25, IG M ± SD in IG was 17 ± 3, in CG 12 ± 4, p < .0001). Simple mistakes such as not using the stethoscope correctly were more frequent in CG students. Prior experience did not lead to a significant difference in performance. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Abstract"><span><span><span><span><span><span><span><span><span><span><span><b>Conclusions:</b> Structured, peer-led and simulator-assisted teaching sessions improve cardiac PE skills in this setting compared to control students that did not receive this training.</span></span></span></span></span></span></span></span></span></span></span></p>
The STARS phase 2 study: a randomized controlled trial of gaboxadol in Angelman syndrome
<p><b>Objective</b>: To evaluate safety and tolerability and exploratory efficacy endpoints for gaboxadol (OV101) compared with placebo in individuals with Angelman syndrome (AS).</p> <p><b>Methods</b>: Gaboxadol is a highly selective orthosteric agonist that activates γ-subunit–containing extrasynaptic γ-aminobutyric acid type A (GABA<sub>A</sub>) receptors. In a multicenter, double-blind, placebo-controlled, parallel-group trial, adolescent and adult individuals with a molecular diagnosis of AS were randomized (1:1:1) to 1 of 3 dosing regimens for a duration of 12 weeks: placebo morning dose and gaboxadol 15 mg evening dose (qd); gaboxadol 10 mg morning dose and 15 mg evening dose (bid); or placebo morning and evening dose. Safety and tolerability were monitored throughout the study. Prespecified exploratory efficacy endpoints included adapted Clinical Global Impression–Severity (CGI-S) and Clinical Global Impression–Improvement (CGI-I) scales which documented the clinical severity at baseline and change after treatment, respectively.</p> <p><b>Results</b>: Eighty-eight individuals were randomized. Of 87 individuals (aged 13–45 years) who received at least 1 dose of study drug, 78 (90%) completed the study. Most adverse events (AEs) were mild to moderate, and no life-threatening AEs were reported. Efficacy of gaboxadol, as measured by CGI-I improvement in an exploratory analysis, was observed in gaboxadol qd vs placebo (p = 0.0006).</p> <p><b>Conclusion</b>: After 12 weeks of treatment, gaboxadol was found to be generally well tolerated with a favorable safety profile. The efficacy as measured by the AS-adapted CGI-I scale warrants further studies.</p>
Effectiveness of community-based health education and home support program to reduce blood pressure among patients with uncontrolled hypertension in Nepal: A cluster-randomized trial
<p><b>Background: </b>Hypertension is a major global public health problem. Elevated blood pressure can cause cardiovascular and kidney diseases. We assessed the effectiveness of health education sessions and home support programs in reducing blood pressure among patients with uncontrolled hypertension in a suburban community of Nepal.</p> <p><b>Methods</b>: We conducted a community-based, open-level, parallel-group, cluster randomized controlled trial in Birendranagar municipality of Surkhet, Nepal. We randomly assigned four clusters (wards) into intervention and control arms. We provided four health education sessions, frequent home and usual care for intervention groups over six months. The participants of the control arm received only usual care from health facilities. The primary outcome of this study was the proportion of controlled systolic blood pressure (SBP). The analysis included all participants who completed follow-up at six months.</p> <p><b>Results</b>: 125 participants were assigned to either the intervention (n=63) or the control (n=62) group. Of them, 60 participants in each group completed six months follow-up. The proportion of controlled SBP was significantly higher among the intervention participants compared to the control (58.3% vs. 40%). Odds ratio of this was 2.1 with 95% CI: 1.01-4.35 (p=0.046) and that of controlled diastolic blood pressure (DBP) was 1.31 (0.63-2.72) (p=0.600). The mean change (follow-up minus baseline) in SBP was significantly higher in the intervention than in the usual care (-18.7 mmHg vs. -11.2 mmHg, p=0.041). Such mean change of DBP was also higher in the intervention (-10.95 mmHg vs. -5.53 mmHg, p=0.065). The knowledge score on hypertension improved by 2.38 (SD 2.4) in the intervention arm, which was significantly different from that of the control group, 0.13 (1.8) (p<0.001).</p> <p><b>Conclusions</b>: Multiple health education sessions complemented by frequent household visits by health volunteers can effectively improve knowledge on hypertension and reduce blood pressure among uncontrolled hypertensive patients at the community level in Nepal. </p> <p><b>Keywords:</b> Hypertension; Blood pressure; Systolic Blood Pressure; Diastolic Blood Pressure; Cardiovascular disease; Health Education; Home Support</p> <p><b>Trial Registration: </b>ClinicalTrial.gov: <span>NCT02981251</span></p>
Rethinking mental health care for migrants and refugees; a randomized controlled trial on the effectiveness of Value Based Counseling, a culturally-sensitive, strength-based psychological intervention
<p>The study’s minimal data set </p>
Efficacy of Kinesiotaping on functional outcomes, pain and edema in the early rehabilitation after total knee arthroplasty surgery: a randomized controlled trial
<p><strong>Objective </strong>The aim of our study was to verify whether the application of Kinesiotaping in addition to usual treatment was superior to usual treatment alone regarding functional outcome, pain and edema in the first 13 days after total knee arthroplasty (TKA) surgery.</p> <p><strong>Design</strong> Open-label, parallel two-groups, Randomized controlled trial.</p> <p><strong>Setting </strong>Galeazzi hospital, Milan.</p> <p><strong>Participants </strong>Inpatients, aged between 50 and 85 years old, waiting TKA were invited to voluntarily participate to the trial. The study sample (n=71) was 42.3% men and the mean age was 68.1 (±9) years. A 1:1 ratio randomization list, to allocate the patient either to a Kinesiotaping Group (KT) or to a control (CON) group.</p> <p><strong>Interventions </strong>KT and CON groups received the same volume of standard post-TKA rehabilitation. KT was additionally treated with lymphatic correction applications of Kinesiotaping (Kinesio® Tex Classic, Mogliano Veneto, IT) on day 3rd (± 1) and 7th (± 1) post-surgery (2 applications during the rehabilitation period). Each application lasted 4-5 days before removal. KT was removed before patients discharge</p> <p><strong>Main Outcome Measure(s)</strong> 1) Circumference at knee level; 2) VAS for pain; 3) 10 Meter Walking Test; 4) Timed Up and Go Test; 5) passive knee range of motion; 6) body composition; 7) Functional Independence Measure; 8) Modified Barthel Index. Data were collected at T0 (before surgery), T1 (3±1 days after surgery), T2 (7±1 days after surgery), T3 (13±1 days after surgery)</p> <p><strong>Results </strong>No inter-group differences were found between KT and CON at T0, T1, T2 and T3. An effect of time was observed for all outcome measures.</p> <p><strong>Conclusions </strong>No superiority of Kinesiotaping was observed compared to usual rehabilitation treatment. Based on these results, the use of Kinesiotaping applied in the early stages of rehabilitation after TKA is not recommended.</p>
Effectiveness of Using 2D Atlas and 3D PDF as a Teaching Tool in Anatomy Lectures in Initial Learner Medical Students: A Randomized Controlled Trial
<p><strong>Dataset Info</strong></p> <p><strong>1) Immediate Test</strong></p> <p># The first row of the dataset identifies the columns.<br> # The first column represents the participant ids.<br> # The second column represents the participants' assigned group.<br> # The third column represents represents the genders of participants (1: Female, 2: Male)<br> # The fourth column represents the years of participants' in their six-year-long medical schools (1: Year-1 students, 2: Year-2 students).<br> # The fifth column represents participants' repeating year status. (0: No, 1: Yes)<br> # The sixth to the fifteenth columns (liver_q1_max2points to liver_q10_max2points) represent the scores in the first to tenth questions of the liver test. Maximum points of the questions can be seen on the first row of the relevant column.<br> # The sixteenth column (livertotalscore_max20points) represents the total score in the liver test.<br> # The seventeenth to the thirty fifth columns (genitalia_q1_max3points to genitalia_q19_max2points) represent the scores in the first to nineteenth questions of the genitalia test. Maximum points of the questions can be seen on the first row of the relevant column.<br> # The thirty sixth column (genitaliatotalscore_max40points) represents the total score in the genitalia test.</p> <p> </p> <p><strong>2) Delayed Test</strong></p> <p># The first row of the dataset identifies the columns.<br> # The first column represents the participant ids.<br> # The second column represents the participants' assigned group.<br> # The third column represents represents the genders of participants (1: Female, 2: Male)<br> # The fourth column represents the years of participants' in their six-year-long medical schools (1: Year-1 students, 2: Year-2 students).<br> # The fifth column represents participants' repeating year status. (0: No, 1: Yes)<br> # The sixth to the fifteenth columns (liver_q1_max2points to liver_q10_max2points) represent the scores in the first to tenth questions of the liver test. Maximum points of the questions can be seen on the first row of the relevant column.<br> # The sixteenth column (livertotalscore_max20points) represents the total score in the liver test.<br> # The seventeenth to the thirty fifth columns (genitalia_q1_max3points to genitalia_q19_max2points) represent the scores in the first to nineteenth questions of the genitalia test. Maximum points of the questions can be seen on the first row of the relevant column.<br> # The thirty sixth column (genitaliatotalscore_max40points) represents the total score in the genitalia test.</p>
Safety and immunogenicity of heterologous booster immunization with Ad5-nCoV after three-dose priming with inactivated SARS-CoV-2 vaccine in Chinese adults: a randomized, double-blind, parallel-controlled trial
<p>Data on safety and immunity of heterologous booster (fourth dose) after three-dose priming with inactivated SARS-CoV-2 vaccine are limited in Chinese adults. Here, we evaluate the safety and immunogenicity of immunization with Ad5-nCoV in a randomized, double-blind, parallel-controlled phase 4 clinical trial in Zhejiang, China (NCT05373030). Participants aged 18-80 years (100 participants per group) who have administered three doses of inactivated SARS-CoV-2 vaccine ≥ 6-month earlier were enrolled and randomized at 1:1 into two groups, then administered intramuscular Ad5-nCoV or different inactivated SARS-CoV-2 vaccine (CoronaVac or Covilo) respectively. All observed adverse reactions were predictable and manageable. Ad5-nCoV elicited significantly higher RBD-specific IgG levels, with a GMC of 2924.0 on day 14 post-booster, 7.8-fold that of the inactivated vaccine. Pseudovirus-neutralizing antibodies to Omicron BA.4/5 showed a similar pattern, with GMT of 228.9 in the Ad5-nCoV group and 65.5 in the inactivated vaccine group. The Ad5-nCoV booster-maintained a high antibody levels on day 90, with seroconversion of 71.4%, while the inactivated vaccine group was 5.2%, closed to pre-booster levels. In summary, a fourth Ad5-nCoV vaccination following three-dose inactivated SARS-CoV-2 vaccination is immunogenic, tolerable, and more efficient than inactivated SARS-CoV-2 vaccine. Ad5-nCoV elicits a stronger humoral response against Omicron BA.4/5 and maintains antibody levels for longer than homologous boosting.</p>
Data from: Identifying and overcoming breastfeeding challenges using two-way short message service, a randomized controlled trial
<p>Breastfeeding challenges, such as pain and perception of insufficient milk supply, prevent many women from exclusively breastfeeding their babies for the six-month duration recommended by the World Health Organization. Mobile health strategies may help women identify and overcome breastfeeding challenges. This study evaluated a two-way short message service (SMS) intervention that delivered breastfeeding messages to women in Kiambu County, Kenya, and its impact on rates of exclusive breastfeeding and breastfeeding behavior at 1, 4, and 6 months post-delivery. Women in the control group received a general package of messages containing postnatal information; women in the intervention group received these messages, plus messages related to breastfeeding and surveys which offered more information about breastfeeding challenges. Both groups of women had access to a help desk agent who responded to questions via SMS.</p> <p>There was no significant difference in the rate of exclusive breastfeeding between the intervention and control at any time point (p=.861). Women in the intervention group were more likely to report experiencing breastfeeding challenges such as pain and perceived insufficient milk supply than those in the control group (32% vs. 24%, p=0.00). Of the women in the intervention group who reported experiencing breastfeeding challenges, 70% of them found a resolution to their challenge, and 23% of them resolved their challenges using SMS. SMS may help women in low-resource settings to identify and overcome their breastfeeding challenges.</p>
Leukocyte- and Platelet-Rich Fibrin in endoscopic endonasal skull base reconstruction: study protocol for a multicenter prospective, parallel-group, single-blinded randomized controlled non-inferiority trial.
<p>Instruction video on how to prepare Leukocyte- and Platelet-Rich Fibrin for endoscopic endonasal skull base reconstruction reinforcement. </p>
Inflammatory and metabolic biomarker assessment in a randomized presurgical trial of curcumin and anthocyanin supplements in patients with colorectal adenomas
<p>Supplementary Figures of the manuscript entitled: Inflammatory and metabolic biomarker assessment in a randomized presurgical trial of curcumin and anthocyanin supplements in patients with colorectal adenomas.</p> <p>Supplementary Figure S1. Univariate analysis of IL-10 changes by BMI</p> <p>Supplementary Figure S2. Univariate analysis of leptin changes by dietary anthocyanin intake</p> <p>Supplementary Figure S3. Mixed models analysis of post-intervention IGFBP-3 by colorectal cancer family history</p> <p>Supplementary Figure S4. Mixed models analysis of adiponectin by treatment arm</p>
CONSORT Checklist for The assessment of educational and supportive care to the infertile females undergoes In Vitro Fertilization procedure by clinical pharmacist: A Randomized Clinical Trial
<p>CONSORT Checklist for The assessment of educational and supportive care to the infertile females undergoes In Vitro Fertilization procedure by clinical pharmacist: A Randomized Clinical Trial</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.