Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
663
datasets available to search
ShareScore release 0.9.0
Dataset results
663 results for “tumor targeting”
Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumors in dogs and identifies CYP26B1 as a potential new therapeutic target
GEO Series GSE196108. Canis lupus familiaris. 59 samples. Type: Expression profiling by high throughput sequencing.
The tumor associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma
GEO Series GSE190403. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Expression Profiles of MicroRNA, its genes and proteins targets and Stromal Genes in Aggressive Behavior Tumors from Young Patients with Breast Cancer.
GEO Series GSE77358. Homo sapiens. 42 samples. Type: Expression profiling by array.
Targeting dendritic cells with a PD-L1 based bispecific antibody rejuvenates specific anti-tumor T cells
GEO Series GSE214960. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Targeting PyMT oncogene to diverse mammary cell populations enhances tumor heterogeneity and generates rare breast cancer subtypes
GEO Series GSE40001. Mus musculus. 43 samples. Type: Expression profiling by array.
Targeting AEBP1 to mitigate pro-tumor activity of cancer-associated fibroblasts and increase therapeutic efficacy to anti-PD-1
GEO Series GSE301078. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Targeted transcriptome profiling of fresh paired normal and tumor tissue samples in glioblastoma patients
GEO Series GSE151352. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
TARGET: Kidney, Rhabdoid Tumor (RT)
Open the record for dataset details and reuse information.
TARGET: Kidney, Wilms Tumor (WT)
Open the record for dataset details and reuse information.
Dataset related to article "Targeted Mutational Analysis of Circulating Tumor DNA to Decipher Temporal Heterogeneity of High-Grade Serous Ovarian Cancer"
<p>This record contains raw data related to article<strong> "</strong>Targeted Mutational Analysis of Circulating Tumor DNA to Decipher Temporal Heterogeneity of High-Grade Serous Ovarian Cancer<strong>".</strong></p> <p>We have previously demonstrated that longitudinal untargeted analysis of plasma samples withdrawn from patients with high-grade serous ovarian cancer (HGS-EOC) can intercept the presence of molecular recurrence (TRm) earlier than the diagnosis of clinical recurrence (TRc). This finding opens a clinical important temporal window to acquire through plasma sample analysis a real-time picture of those emerging molecular lesions that will drive and sustain the growth of relapsed disease and ultimately will confer resistance. In this proof of principle study, the same genomic libraries obtained at the diagnosis (T0), TRm and TRc were further analyzed by targeted resequencing approach to sequence the coding region of a panel of 65 genes to provide longitudinal analysis of clonal evolution as a novel strategy to support clinical decisions for the second-line treatment. Experiments were performed on plasma and tumor tissues withdrawn on a selection of previously analyzed cohorts of cases (i.e., 33 matched primary and synchronous lesions and 43 plasma samples from 18 patients). At T0, the median concordance of mutations shared by each tumor tissue biopsy and its matched plasma sample was 2.27%. This finding confirms the limit of a single tumor biopsy to be representative of the entire disease, while plasma analysis can recapitulate most of the main molecular lesions of the disease. A comparable scenario was observed during longitudinal analysis, where, with the exception of the <em>TP53</em> gene and germline mutations in <em>BRCA1/2</em> genes, no other gene shared the same locus specific gene mutation across T0, TRm and TRc time points. This high level of temporal heterogeneity has important implications for planning second-line treatment. For example, in three out of 13 cases, plasma ctDNA analysis at TRm or TRc reported acquired novel variants in the <em>TP53BP1</em> gene not present at T0. In particular, patient 21564, potentially eligible for PARP-inhibitor (PARPi) treatment at the time of diagnosis (<em>BRCA1</em> c.5182delA mutation), would unlikely respond to these drugs in second-line therapy due to the presence of eight distinct <em>TP53BP1</em> variants in plasma samples collected TRc. This study demonstrates that liquid biopsy provides a real-time molecular picture to intercept those actionable genetic vulnerabilities or drug resistance mechanisms that could be used to plan a more rational second-line treatment.</p>
RNA sequence analysis to compare Dll1+ mouse breast tumor cells with and without targeted radiation
GEO Series GSE172398. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Analysis Identifies B-Lymphocyte Kinase as a Therapeutic Target for Desmoplastic Small Round Cell Tumor Cancer Stem Cell-Like Cells [RNA-seq]
GEO Series GSE248761. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Targeting LRRC25 enhances antitumor immunity of tumor-associated macrophages through CD8+ T cells [scRNA-seq]
GEO Series GSE264446. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
EZH2 is a potential therapeutic target for H3K27M mutant paediatric gliomas [RNA-Seq mouse tumors]
GEO Series GSE85388. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
GEO Series GSE241952. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Rationalistic Modulation of Immune Mechanisms Synergizes the Anti-Tumor Effects of Targeted Radiation Therapy in Pre-clinical Models
GEO Series GSE294347. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Targeting PGLYRP1 promotes anti-tumor immunity while inhibiting autoimmunity
GEO Series GSE223896. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing.
mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors
GEO Series GSE252247. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumor
GEO Series GSE196058. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Targeting COPI elicits CD8+ T cell-mediated anti-tumor immunity in preclinical models of Intrahepatic Cholangiocarcinoma (RNA-seq)
GEO Series GSE273167. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.