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Figs 21–24. Culicoides insignis Lutz, 1913. 21–22 in Study of the immature stages of two species of the biting midge genus Culicoides (Diptera: Ceratopogonidae)
Figs 21–24. Culicoides insignis Lutz, 1913. 21–22 – male pupa; 23–24 – female pupa; 21, 23 – dorsal apotome; 22, 24 – ninth segment, ventral view. Scale bars: 0.05 mm. Abbreviations: DA-1-H, DA-2-H – dorsal apotomal sensilla; GL – genital lobe; TP – terminal process; D-5-IX, D-6-IX – campaniform sensilla of terminal process.
Figs 17–20. Culicoides insignis Lutz, 1913. 18 in Study of the immature stages of two species of the biting midge genus Culicoides (Diptera: Ceratopogonidae)
Figs 17–20. Culicoides insignis Lutz, 1913. 18 – male pupa; 17, 19–20 – female pupa; 17 – cephalothorax, ventral view; 18 – clypeal/labral sensilla and ocular sensilla; 19 – dorsal apotomal sensillum, cephalothoracic sensilla and respiratory organ; 20 – dorsal setae. Scale bars: 0.05 mm.Abbreviations: AN – antennae; CL-1-H, CL-2-H – clypeal/ labral sensilla; DA-1-H – dorsal apotomal sensillum; DL-1-H, DL-2-H, DL-3-H – dorsolateral cephalic sclerite sensilla; D-1-T, D-2-T, D-3-T, D-4-T, D-5-T – dorsal setae; O-1-H, O-2-H, O-3-H – ocular sensilla; P – pedicel; p – pores; RO – respiratory organ; SA-2-T – supraalar.
Figs 5–8. Culicoides bambusicola Lutz, 1913 in Study of the immature stages of two species of the biting midge genus Culicoides (Diptera: Ceratopogonidae)
Figs 5–8. Culicoides bambusicola Lutz, 1913, male pupa: 5 – cephalothoracic sensilla and respiratory organ; 6 – respiratory organ; 7 – anterolateral sensilla; 8 – clypeal/labral sensillum and ocular sensilla. Scale bars: 0.05 mm. Abbreviations: AL-1-T, AL-2-T, AL-3-T – anterolateral sensilla; AM-1-T – anteromedial sensillum; CL-1-H – clypeal/labral sensillum; DL-1-H, DL-2-H – dorsolateral cephalic sclerite sensilla; O-1-H, O-2-H, O-3-H – ocular sensilla; P – pedicel; p – pore; RO – respiratory organ.
Figure 12 in New information about the third stage larva and larval habitat of Microdon (Chymophila) bruchi Shannon, 1927 (Diptera, Syrphidae) from Argentina
Figure 12. Microdon (Chymophila) aurifacius Hull, 1937, holotype male, mesoscutum, lateral view.
Figure 9 in New information about the third stage larva and larval habitat of Microdon (Chymophila) bruchi Shannon, 1927 (Diptera, Syrphidae) from Argentina
Figure 9. Microdon (Chymophila) angulatus Hull, 1943, holotype male, hind leg.
Figure 11 in New information about the third stage larva and larval habitat of Microdon (Chymophila) bruchi Shannon, 1927 (Diptera, Syrphidae) from Argentina
Figure 11. Microdon (Chymophila) limbatus Wiedemann, 1830, holotype male, habitus.
Figure 10 in New information about the third stage larva and larval habitat of Microdon (Chymophila) bruchi Shannon, 1927 (Diptera, Syrphidae) from Argentina
Figure 10. Microdon (Chymophila) cyaneiventris (Macquart, 1846), syntype female, scutellum.
Supplementary material 2 from: Vimercati G, Davies SJ, Hui C, Measey J (2021) Cost-benefit evaluation of management strategies for an invasive amphibian with a stage-structured model. NeoBiota 70: 87-105. https://doi.org/10.3897/neobiota.70.72508
Supplementary material B
Supplementary material 1 from: Vimercati G, Davies SJ, Hui C, Measey J (2021) Cost-benefit evaluation of management strategies for an invasive amphibian with a stage-structured model. NeoBiota 70: 87-105. https://doi.org/10.3897/neobiota.70.72508
Supplementary material A
tomato RNAi, OE and WT fruit transcriptome at MG, Br and pink fruit stages-2
<p>tomato RNAi, OE and WT fruit transcriptome at MG, Br and pink fruit stages-2</p>
tomato RNAi, OE and WT fruit transcriptome at MG, Br and pink fruit stages-1
<p>tomato RNAi, OE and WT fruit transcriptome at MG, Br and pink fruit stages</p>
Data representing logical computations along four stages in the brain
<p>A key challenge in neuroimaging remains to understand where, when and now particularly how human brain networks compute over sensory inputs to achieve behavior. To study such dynamic algorithms from mass neural signals, we recorded the magnetoencephalographic (MEG) activity of participants who resolved the classic XOR, OR and AND functions as overt behavioral tasks (N = 10 participants/task, N-of-1 replications). Each function requires a different computation over the same inputs to produce the task- specific behavioral outputs. In each task, we found that source-localized MEG activity progresses through four computational stages identified within individual participants: (1) initial contra-lateral representation of each visual input in occipital cortex, (2) a joint linearly combined representation of both inputs in midline occipital cortex and right fusiform gyrus, followed by (3) nonlinear task-dependent input integration in temporal-parietal cortex and finally (4) behavioral response representation in post-central gyrus. We demonstrate the specific dynamics of each computation at the level of individual sources. The spatio-temporal patterns of the first two computations are similar across the three tasks; the last two computations are task specific. Our results therefore reveal where, when and how dynamic network algorithms perform different computations over the same inputs to produce different behaviors.</p>
Doryteuthis pealeii embyronic transcriptome individual stages 16-27 pooled and annotation
<p>Photoreception is a ubiquitous sensory ability found across the Metazoa, and photoreceptive organs are intricate and diverse in their structure. Although the morphology of the compound eye in Drosophila and the single-chambered eye in vertebrates have elaborated independently, the amount of conservation within the 'eye' gene regulatory network remains controversial, with few taxa studied. To better understand the evolution of photoreceptive organs, we established the cephalopod Doryteuthis pealeii as a lophotrochozoan model for eye development. Utilizing histological, transcriptomic and molecular assays, we characterize eye formation in Doryteuthis pealeii Through lineage tracing and gene expression analyses, we demonstrate that cells expressing Pax and Six genes incorporate into the lens, cornea and iris, and the eye placode is the sole source of retinal tissue. Functional assays demonstrate that Notch signaling is required for photoreceptor cell differentiation and retinal organization. This comparative approach places the canon of eye research in traditional models into perspective, highlighting complexity as a result of both conserved and convergent mechanisms.</p>
Characterization of Molting Process during the Different De-velopmental Stages of the Diamondback Moth Plutella xy-lostella
<p><strong>Supplementary Materials: </strong> Figure S1: The pre-ecdysis behavior of the larval-larval ecdysis of <em>P. xylostella</em> larva; Figure S2: The “peeled” prepupa of <em>P. xylostella</em> and the “eclosion hole” of on <em>P. xylostella</em> cocoon; Video S1: The hatching process of <em>P. xylostella</em> ; Video S2: The pre-ecdysis I behavior of larval-larval ecdysis of <em>P. xylostella</em>; Video S3: The pre-ecdysis II behavior of larval-larval ecdysis of <em>P. xylostella</em>; Video S4: The ecdysis behavior of larval-larval ecdysis of <em>P. xylostella</em>; Video S5: The cocooning behavior of larval-pupal metamorphosis of <em>P. xylostella</em>; Video S6: The pre-ecdysis I behavior of larval-pupal metamorphosis of <em>P. xylostella</em>; Video S7: The pre-ecdysis II behavior of larval-pupal metamorphosis of <em>P. xylostella</em>; Video S8: The ecdysis behavior of larval-pupal metamorphosis of <em>P. xylostella</em>; Video S9: The pre-eclosion behavior of <em>P. xylostella</em> pupa; Video S10: The intersegmental membrane of the abdomen of <em>P. xylostella</em> pupa inflates before eclosion; Video S11: The eclosion behavior of <em>P. xylostella</em>; Video S12: The stage II of the post-eclosion behavior of <em>P. xylostella</em> adult; Video S13: The stage III of the post-eclosion behavior of <em>P. xylostella</em> adult; Video S14: The stage IV of the post-eclosion behavior of <em>P. xylostella</em> adult.</p>
FIGURE 1 in Phenrica littoralis (Bechyné, 1955) (Coleoptera: Chrysomelidae) a potential candidate for the biological control of alligator weed, Alternanthera philoxeroides (Martius) Grisebach (Amaranthaceae): redescription of the adult, first description of immature stages, and biological notes
FIGURE 1. Phenrica littoralis (Bechyné), male, dorsal habitus.
Repurposing Domperidone in Secondary Progressive MS - A Simon 2-Stage Phase 2 Futility Trial - Table e1: Results of the binary logistic regression model
<p><b>Objective:</b> To assess whether treatment with the generic drug domperidone can reduce the progression of disability in secondary progressive multiple sclerosis (SPMS), we conducted a phase 2 futility trial following the Simon two-stage design.</p> <p><b>Methods:</b> We enrolled patients in an open-label, Simon two-stage, single-center, phase 2, single-arm futility trial at the Calgary MS Clinic if they met the following criteria: age 18 to 60 years, SPMS, screening EDSS score of 4.0 to 6.5 and screening T25FW of 9 seconds or more. Patients received domperidone 10mg QID for one year. The primary outcome was worsening of disability, defined as worsening of the T25FW performance by 20% or more at 12 months compared to at baseline. This trial is registered with ClinicalTrials.gov, number NCT02308137.</p> <p><b>Results:</b> Between February 13<sup>th</sup>, 2015 and January 3<sup>rd</sup>, 2020, 110 patients were screened, 81 received treatment, 64 completed follow-up, of whom 62 were analysed. The study did not meet its primary endpoint: 22 of 62 (35%) patients experienced significant worsening of disability, which is close to the expected proportion of 40%, and above the pre-defined futility threshold. Patients with higher prolactin levels during the study had a significantly lower risk of disability progression, which may warrant further investigation. Domperidone treatment was reasonably well tolerated, but adverse events occurred in 84% and serious adverse events in 15% of patients.</p> <p><b>Conclusions:</b> Domperidone treatment could not reject futility in reducing disability progression in SPMS. The Simon two-stage trial model may be a useful model for phase 2 studies in progressive MS.</p> <p><b>Classification of Evidence:</b> This study provides Class III evidence that in individuals with secondary progressive multiple sclerosis participating in a futility trial, domperidone treatment could not reject futility in reducing disability progression at 12 months.</p>
Fig. 7 in Eight Species Of Anuran Amphibians (Amphibia, Anura) Found In Ukraine: Comparative Morphology And Classification Of Larval Development Stages
Fig. 7. Stages characterizing the formation of a grown animals mouth and the end of metamorphosis: 25 — the angle of the mouth matches the nostril's vertical line (the stage of front limbs emergence); 26 — the angle of the mouth is located between the vertical lines of the nostril and the middle of the eye; 27 — the angle of the mouth matches the vertical line
Fig. 2 in Eight Species Of Anuran Amphibians (Amphibia, Anura) Found In Ukraine: Comparative Morphology And Classification Of Larval Development Stages
Fig. 2. Stages of fin development: 4 — the tail fin is developed but not yet transparent; 5 — the body of tail fin is transparent (at this stage operculum may cover the base of gills filaments).
Comparable early-stage decomposition but contrasting underlying drivers between surface and cave habitats along an elevational gradient
<p>The folder includes r script and the data files used to conduct the data analysis in this project: Comparable early-stage decomposition but contrasting underlying drivers between surface and cave habitats along an elevational gradient.</p>
Figure 1 in Toxicity of spiromesifen on different developmental stages of two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae)
Figure 1. The effectiveness (%) of spiromesifen on different stages of Tetranychus urticae – A. Eggs hatching ratio (2011); B. Eggs hatching ratio (2012); C. Immature stages (2011); D. Immature stages (2012); E. Adult (females,
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.