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632
datasets available to search
ShareScore release 0.9.0
Dataset results
632 results for “Cartilage”
Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis
GEO Series GSE287861. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Comparison of Transcriptome Signatures between Meniscus and Articular Cartilage from Knees Undergoing Arthroscopic Partial Meniscectomy
GEO Series GSE66635. Homo sapiens. 24 samples. Type: Expression profiling by array.
Inhibiting Aberrant Interfacial Friction Regulates Cell Fate and Promotes Cartilage Regeneration
GEO Series GSE314689. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression data from growth plate cartilage of control and immobilized embryonic chickens
GEO Series GSE77412. Gallus gallus. 23 samples. Type: Expression profiling by array.
NG2/CSPG4 regulates cartilage degeneration during TMJ osteoarthritis
GEO Series GSE214077. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome-based screening of ion channels and transporters in a migratory chondroprogenitor cell line isolated from late-stage osteoarthritic cartilage
GEO Series GSE160886. Homo sapiens. 6 samples. Type: Expression profiling by array.
Dysregulated gene expression in human osteoarthritis cartilage
GEO Series GSE169077. Homo sapiens. 11 samples. Type: Expression profiling by array.
Computational modelling of the cellular interplay in Rheumatoid Arthritis. Deciphering the role of innate and adaptive immunity in cartilage destruction and bone erosion
<p>Immune dysregulation was first implicated in the pathogenesis of Rheumatoid Arthritis (RA) by the discovery of anti-immunoglobulin G (IgG) antibodies known as rheumatoid factors. However, concepts of how immune responses contribute to disease have evolved dramatically over the last 50 years. Many cells and their cytokines play critical roles in the development of RA. The synovial compartment is infiltrated by leukocytes and the synovial fluid is inundated with pro-inflammatory mediators that are produced to induce an inflammatory cascade, which is characterized by interactions of fibroblast-like synoviocytes with the cells of the innate immune system, including monocytes, macrophages, mast cells, dendritic cell as well as cells of adaptive immune system such as T cells and B cells. The fulminant stage contains hyperplastic synovium, cartilage damage, bone erosion, and systemic consequence.</p> <p>The objective of my project is to construct a computational model able to decipher the interplay between cells of the innate and adaptive immunity in RA, that eventually leads to bone and cartilage breakdown.</p> <p>To do so, we will start by creating separate maps for T cells, B cells, macrophages, fibroblasts, osteoblasts and osteoclasts. We will use different data mining tools, appropriate data bases such as KEGG (Kanehisa et al, 2000), REACTOME (Fabregat et al, 2018) as well as internal data generated within Sanofi. We will exploit the graph editor CellDesigner (Funahashi et al, 2003) and the platform Minerva (Gawron et al, 2016) for automatic annotation and reference of the cell specific maps. We will benefit greatly from a global, fully annotated RA specific map (Singh et al, 2018, Singh et al, 2020). This map features interactions implicated in RA coming from various cell types, but due to the extensive annotations the user can opt for cell specific interactions and extract the corresponding network. We are also going to use public datasets of expression data (microarrays, RNAseq, RNAseq single cell), data concerning metabolic pathways from MetaCyc and Sanofi’s proprietary datasets to enrich and expand existing pathway resources. These maps will be used to generate cell specific dynamic models using the tool CaSQ (Aghamiri et al, 2020). The next step is the creation of a multicellular model to understand how the different cells interact, contributing to the emergent behavior of the system. We will prioritize signature pathways for each cell type and combine them to build a logical model that will represent the intra- and intercellular relationships.</p> <p> </p>
Quantitative Ultrasonography (US) Evaluation on Femoral Condyle Cartilage
ClinicalTrials.gov study NCT00630604. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Expression of enzymes involved in gag synthesis and degradation in cartilage aging and arthritis
GEO Series GSE27350. Mus musculus; Homo sapiens. 3 samples. Type: Expression profiling by array.
Epiphyseal cartilage
GEO Series GSE17368. Homo sapiens. 9 samples. Type: Expression profiling by array.
Cartilage zone arrays
GEO Series GSE39797. Homo sapiens; Bos taurus. 18 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.