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Dataset results
814 results for “LPS”
Gene expression data from the hippocampus of mice treated with oleacein in an in vivo model of depression induced by lipopolysaccharide (LPS)-mediated inflammation.
GEO Series GSE263606. Mus musculus. 6 samples. Type: Expression profiling by array.
Cardiac endothelial in vivo responses to LPS
GEO Series GSE1042. Mus musculus. 4 samples. Type: Expression profiling by array.
JmjD2d-dependence of LPS-induced genes
GEO Series GSE32255. Mus musculus. 9 samples. Type: Expression profiling by array.
Hypothalamus response to LPS and restraint stress
GEO Series GSE367. Mus musculus. 12 samples. Type: Expression profiling by array.
Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably extraterrestrial infection may trigger potentially novel bionetworks different from the terrestrial equivalent which could only be probed by investigating the host-pathogen relationship with minimum terrestrial bias. Towards this objective we strategically engineered a cell culture module equipped with a feedback controlled semi-automated platform to expose human endothelial cells to lipopolysaccharide (LPS). The assay was carried out in the STS-135 space shuttle and a concurrent ground study constituted the baseline. Transcriptomic investigation revealed an immune blunting in microgravity; Lbp MyD88 and MD-2 failed to encode proteins responsible for early LPS uptake. Longer exposure results implied that there was a delayed response potentially ineffectual in preventing pathogens from opportunistically modulating the infection network. Lack of recruitment of growth factors and a debilitated apoptosome supported this potential explanation. Certain cytokines such as IL-6 and IL-8 surged in response to LPS insult in microgravity. Contrasting expressions of B2M TIMP-1 and VEGRs suggested impaired pro-survival adaptation and healing mechanisms. The susceptibility of oxidative stress and immune regulation to microgravity compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion despite a serious drawback attributed to the small sample size we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by uG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. We identified the CCM of Tissue Genesis Inc. HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41 EA 47 EA45 and EA155 that were exposed to LPS for 4 hours. Samples EA123 EA165 EA127 EA126 were exposed to LPS for 8Hrs. Samples EA33 EA 125 EA79 and EA 39 were controls in this experiment.
Transcriptome profile in RAW264.7 cells in response to LPS stimulation
GEO Series GSE86588. Mus musculus. 12 samples. Type: Expression profiling by array.
Gene expression profiles of primary myocardial cells treated with LPS and transfected siMETTL3 in rats
GEO Series GSE185636. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Real-time quantitative PCR analysis of differentiated U937 cells stimulated with LPS+IFNgamma
GEO Series GSE275490. Homo sapiens. 2 samples. Type: Expression profiling by RT-PCR.
Effect of depletion of TSPAN6 on Biliary Epithelial Cells with and without LPS stimulation mirroring liver disease.
GEO Series GSE317449. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiles of neonatal intestinal organoids under fibroblast coculture with or without LPS sitimulation and tryptophan metabolites intervention
GEO Series GSE279881. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
RNA-Sequencing of LPS-stimulated TLR4 HEK293 cells edited at an immune-response trans-eQTL locus
GEO Series GSE145486. Homo sapiens. 78 samples. Type: Expression profiling by high throughput sequencing.
Difference of gene expression between LPS-stimulated monocytes cultured in the presence NRBCs and those cultured in the absence of NRBCs
GEO Series GSE70146. Homo sapiens. 2 samples. Type: Expression profiling by array.
Modulation of LPS-stimulated BV2 microglial cells by Amauroderma rugosum hexane fraction (HF)
GEO Series GSE81435. Mus musculus. 8 samples. Type: Expression profiling by array.
Integrated lncRNAs and mRNAs sequencing reveals lncRNAs regulatory network associated with lung injury in LPS-induced septic shock rats
GEO Series GSE154653. Rattus norvegicus. 10 samples. Type: Expression profiling by array.
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury by suppressing the NLRP3 inflammasome
GEO Series GSE89311. Mus musculus. 8 samples. Type: Expression profiling by array.
3' RNA sequencing of the mouse cortex at P6 following MMS and/or LPS
GEO Series GSE157184. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
TLR4 signaling of LPS chemotypes
GEO Series GSE250546. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Profiling of Polyadenylated RNAs after Brg1/Smarca4 knock-down in murine bone marrow-derived macrophages after LPS or LPS plus Dex stimulation [RNA-seq]
GEO Series GSE186513. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Single Cell RNA sequencing of TLR9 ligand (CpG oligonucleotide) and TLR2/4 ligand (LPS)-treated mouse gingiva
GEO Series GSE201109. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Whole blood gene expression after stimulation with TLR2 ligands (chitin oligomers, Pam2, Pam3) and the TLR4-ligand LPS
GEO Series GSE103094. Homo sapiens. 23 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.