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1,337
datasets available to search
ShareScore release 0.9.0
Dataset results
1,337 results for “Neuropathy”
Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by GHKL ATPase gene therapy
GEO Series GSE235918. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Fucoidan reduces NETs accumulation and alleviates chemotherapy-induced peripheral neuropathy
GEO Series GSE249275. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Modeling hypoxia induced neuropathies using a fast and scalable human motor neuron differentiation system
GEO Series GSE134737. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
A macrophage-mediated TNFa signaling axis within peripheral nerves is required for initiation of autoimmune peripheral neuropathy
GEO Series GSE180498. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Inflammatory neuropathy driven by a pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells [TCR-seq]
GEO Series GSE252647. Mus musculus. 3 samples. Type: Other.
αO-conotoxin GeXIVA[1,2] reduced neuropathic pain and changed gene expression in chronic oxaliplatin-induced neuropathy mice model
GEO Series GSE253183. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of sciatic nerves from rats with diabetic peripheral neuropathy
GEO Series GSE147732. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase is associated with Charcot-Marie-Tooth neuropathy
GEO Series GSE125311. Drosophila melanogaster. 17 samples. Type: Expression profiling by high throughput sequencing.
Istradefylline (KW6002) protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin anti-tumor effects [Kidney_Tumor]
GEO Series GSE179246. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes for Human Diabetic Neuropathy
GEO Series GSE148061. Homo sapiens. 130 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
DNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Gene Expression Array: C57Bl6J mice]
GEO Series GSE45700. Mus musculus. 9 samples. Type: Expression profiling by array.
DNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Bisulfite-Seq]
GEO Series GSE45343. Mus musculus. 24 samples. Type: Methylation profiling by high throughput sequencing.
Vascular dysfunction is the primary cause of symptom onset in a mouse model of oxaliplatin-induced peripheral neuropathy: comparison of gene expression in blood vessels from mouse brain and sciatic n
GEO Series GSE255096. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
The expression of mRNA and lncRNA in peripheral blood mononuclear cells (PBMCs) of diabetes mellitus, diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN) pati
GEO Series GSE185011. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing.
Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.
GEO Series GSE309119. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Establishment of human Leber’s hereditary optic neuropathy model using iPSC-derived retinal organoids
GEO Series GSE305550. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Neuropathy of the haematopoietic stem cell niche is essential for myeloproliferative neoplasms [RNA-seq]
GEO Series GSE55798. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes for Human Diabetic Neuropathy (RNA-Seq)
GEO Series GSE148059. Homo sapiens. 77 samples. Type: Expression profiling by high throughput sequencing.
Data from: Neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors
Objective: To explore the association of peripheral neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) use in cancer patients. Methods: Published data search up to November 2018 reporting peripheral neuropathy in cancer patients treated with VEGFR-TKIs was performed. The primary outcome was presence of peripheral neuropathy at the end of the trial. Random-effects meta-analysis was performed to estimate Relative Risk (RR) of individual treatment. Results: Thirty Randomized Clinical Trials (RCTs) including 12,490 cancer patients were included in this analysis. Eight studies compared VEGFR-TKIs with placebo and the remaining studies compared VEGFR-TKIs with the standard chemotherapeutic regimen. When compared against placebo VEGFR-TKIs were associated with a higher risk of peripheral neuropathy (RR=1.76, 95% CI 1.13-2.75, p-value 0.01). Similarly, a stronger association was noted for sensory neuropathy with VEGFR-TKIs monotherapy (RR = 1.61; 95% CI 1.09-2.37, p = 0.02). Risk of peripheral neuropathy with VEGFR-TKIs was higher even when they were compared against control (either placebo or standard chemotherapeutic agents); RR=1.08, 95% CI 1.01-1.15, p-value 0.03. High-grade neuropathy (RR 1.28, 95% CI 1.06-1.54, p-value <0.01) and high-grade sensory neuropathy (RR 1.38, 95% CI 1.09-1.74, p-value <0.01) were noted more frequently with VEGFR-TKIs treatment compared against control. Conclusions: VEGFR-TKIs therapy appeared to be associated with an increased risk of neuropathy.
Clinical outcomes in multifocal motor neuropathy: a combined cross-sectional and follow-up study
Objective <p>To assess the clinical course of multifocal motor neuropathy (MMN) in a large cohort of patients and to identify predictive factors of a progressive disease course.</p> Methods <p>Between May 2015 and February 2016, we collected clinical data from 100 patients with MMN of whom 60 had participated in a nationwide cross-sectional cohort study in 2007. We documented clinical characteristics using standardized questionnaires and performed a standardized neurological examination. We used multiple linear regression analysis to identify factors that correlated with worse outcome.</p> Results <p>We found that age of diagnosis (45.2 <i>vs.</i> 48.6 years, <i>p</i><0.02) significantly increased between 2007 and 2015-2016, whereas diagnostic delay decreased with 15 months. Seven out of ten outcome measures deteriorated over time (all <i>p</i><0.01). Patients who had a lower MRC sum score and absence of one or more reflexes at the baseline visit showed a greater functional loss at follow up (<i>p</i>=0.007 and <i>p</i>=0.016).</p> Conclusions <p>Our study shows that MMN is a progressive disease. Although 87% of patients received maintenance treatment, muscle strength, reflexes, vibration sense, and the Self-Evaluation Scale significantly deteriorated over time. Lower MRC sum score and absence of reflexes predicted a more progressive disease course.</p> Classification of evidence <p>This study provides Class II evidence that lower MRC sum score and the absence of reflexes predict a more progressive disease course in patients with MMN.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.