Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7,327
datasets available to search
ShareScore release 0.9.0
Dataset results
7,327 results for “Pathway”
Data from: Diapause induction and relaxed selection on alternative developmental pathways in a butterfly
1. Seasonal phenotypic plasticity entails differential trait expression depending on the time of season. The facultative induction of winter diapause in temperate insects is a developmental switch mechanism often leading to differential expression in life history traits. However, when there is a latitudinal shift from a bivoltine to univoltine life cycle, selection for pathway-specific expression is disrupted, which may allow drift towards less optimal trait values within the non-selected pathway. 2. We use field- and experimental data from five Swedish populations of Pararge aegeria to investigate latitudinal variation in voltinism, local adaptation in the diapause switch, and footprints of selection on pathway-specific regulation of life history traits and sexual dimorphism in larval development. 3. Field data clearly illustrated how natural populations gradually shift from bivoltinism to univoltinism as latitude increases. This was supported experimentally as the decrease in direct development at higher latitudes was accompanied by increasing critical daylengths, suggesting local adaptation in the diapause switch. 4. The differential expression among developmental pathways in development time and growth rate was significantly less pronounced in univoltine populations. Univoltine populations showed no significant signs of protandry during larval development, suggesting that erosion of the direct development pathway under relaxed selection has led to the loss of its sex-specific modifications.
Data from: Diagnostic pathways and direct medical costs incurred by new adult pulmonary tuberculosis patients prior to anti-tuberculosis treatment – Tamil Nadu, India
Background: Tuberculosis (TB) patients face substantial delays prior to treatment initiation, and out of pocket (OOP) expenditures often surpass the economic productivity of the household. We evaluated the pre-diagnostic cost and health seeking behaviour of new adult pulmonary TB patients registered at Primary Health Centres (PHCs) in Vellore district, Tamil Nadu, India. Methods: This descriptive study, part of a randomised controlled trial conducted in three rural Tuberculosis Units from Dec 2012 to Dec 2015, collected data on number of health facilities, dates of visits prior to the initiation of anti-tuberculosis treatment, and direct OOP medical costs associated with TB diagnosis. Logistic regression analysis examined the factors associated with delays in treatment initiation and OOP expenditures. Results: Of 880 TB patients interviewed, 34.7% presented to public health facilities and 65% patients sought private health facilities as their first point of care. The average monthly individual income was $77.79 (SD 57.14). About 69% incurred some pre-treatment costs at an average of $39.74. Overall, patients experienced a median of 6 days (3-11 IQR) of time to treatment initiation and 21 days (10-30 IQR) of health systems delay. Age ≤ 40 years (aOR: 1.73; CI: 1.22 - 2.44), diabetes (aOR: 1.63; CI: 1.08 - 2.44) and first visit to a private health facility (aOR: 17.2; CI: 11.1 - 26.4) were associated with higher direct OOP medical costs, while age ≤ 40 years (aOR: 0.64; CI: 0.48 - 0.85) and first visit to private health facility (aOR: 1.79, CI: 1.34 - 2.39) were associated with health systems delay. Conclusion: The majority of rural TB patients registering at PHCs visited private health facilities first and incurred substantial direct OOP medical costs and delays prior to diagnosis and anti-tuberculosis treatment initiation. This study highlights the need for PHCs to be made as the preferred choice for first point of contact, to combat TB more efficiently.
Data from: Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk
Size at birth, postnatal weight gain, and adult risk for type 2 diabetes may reflect environmental exposures during developmental plasticity and may be mediated by epigenetics. Both low birth weight (BW), as a marker of fetal growth restraint, and high birth weight (BW), especially after gestational diabetes mellitus (GDM), have been linked to increased risk of adult type 2 diabetes. We assessed DNA methylation patterns using a bead chip in cord blood samples from infants of mothers with GDM (group 1) and infants with prenatal growth restraint indicated by rapid postnatal catch-up growth (group 2), compared with infants with normal postnatal growth (group 3). Seventy-five CpG loci were differentially methylated in groups 1 and 2 compared with the controls (group 3), representing 72 genes, many relevant to growth and diabetes. In replication studies using similar methodology, many of these differentially methylated regions were associated with levels of maternal glucose exposure below that defined by GDM [the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study] or were identified as changes observed after randomized periconceptional nutritional supplementation in a Gambian cohort characterized by maternal deprivation. These studies provide support for the concept that similar epigenetic modifications may underpin different prenatal exposures and potentially increase long-term risk for diseases such as type 2 diabetes.
Stiffness Regulates Breast Cancer Antitumor Immunity via COX2-FGF2 Pathway
<p>The code for spatial analysis done with subset of samples form publication: Bassiouni R, Idowu MO, Gibbs LD, Robila V, Grizzard PJ, Webb MG, Song J, Noriega A, Craig DW, Carpten JD. Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast Cancer. Cancer Res. 2023 Jan 4;83(1):34-48. doi: 10.1158/0008-5472.CAN-22-2682. PMID: 36283023; PMCID: PMC9812886.</p> <p> </p>
Pathways to national-scale adoption of enhanced geothermal power through experience-driven cost reductions: Supplementary Data
<p>Dataset containing inputs, results, and code referenced in "Pathways to national-scale adoption of enhanced geothermal power through experience-driven cost reductions."</p> <ul> <li>"Central_Cases.zip", "NoEGS.zip", "Policy_Sensitivities.zip", "EGS_Sensitivities_Learning.zip", "EGS_Sensitivities_Other.zip", "OtherTech_Sensitivities.zip", and "IRA_Repeal_Cases.zip" contain the full set of capacity expansion model results referenced in the paper</li> <li>"GenX_EGS_HalfTimeSeries.zip" contains the source code for the modified version of the GenX electricity system capacity expansion model used in this work</li> <li>"GenX_Input_Files.zip" contains the full set of GenX inputs used in this work, including customized run files that apply inter-planning-period linkages, conditional policies, and endogenous learning-by-doing, which may be used alongside the model source code to replicate the results</li> <li>"PowerGenome_Inputs_and_Processing.zip" contains the settings files used to create GenX inputs in the PowerGenome tool, as well as post-processing scripts used to modify certain technologies and implement 2-hourly resolution</li> <li>"Costing_and_Supply_Curves.zip" contains the source code for the EGS cost model used in this work, as well as input temperature-at-depth data from Aljubran and Horne (2024). Temperature-at-depth data from Blackwell et al. (2011) is available for purchase from the SMU Geothermal Laboratory.</li> <li>"EGS_GenX_Inputs.zip" contains other EGS performance data and scripts used to build final GenX inputs</li> </ul> <p> </p>
Dataset for Utilizing Pathway Dependency and Network Representation of Anticancer Drug Sensitivity for Drug Synergy Prediction
Open the record for dataset details and reuse information.
Dataset of "Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer"
Open the record for dataset details and reuse information.
Data from: Tryptophan and Cortisol modulate the Kynurenine and Serotonin transcriptional pathway in the kidney of Oncorhynchus kisutch
<p>Aquaculture fish are kept for long-periods in sea cages or tanks. Consequently, accumulated stress causes the fish to present serious problems with critical economic losses. Fish food has been supplemented to reduce the stress, using many compoment as amino acids such as tryptophan. This study aims to determine the transcriptional effect of tryptophan and cortisol on primary cell cultures of salmon head and posterior kidney. Our results indicate activation of the kynurenine pathway and serotonin activity when stimulated with tryptophan and cortisol. 95% of tryptophan is degraded by the kynurenine pathway, indicating the relevance of knowing how this pathway is activated and if stress levels associated with fish culture trigger its activation. Additionally, it is essential to know the consequence of increasing kynurenic acid "KYNA" levels in the short and long term, and even during the fish ontogeny.</p>
A hippocampo-cortical pathway detects changes in the validity of an action as a predictor of reward
<p>This repository contains the source files for all behavioural data.</p>
( R, S)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway
Open the record for dataset details and reuse information.
Data from: A novel triptolide analog downregulates NF-kB and induces mitochondrial apoptosis pathways in human pancreatic cancer
<p>Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, the 5-year survival rate stands at only 12%. Triptolides have potent anti-tumor activity against different types of cancers, including pancreatic cancer, however poor solubility and toxicity limit their translation into clinical use. We synthesized a novel pro-drug of triptolide, (E)-19-[(1'-benzoyloxy-1'-phenyl)-methylidene]-Triptolide (CK21), which was formulated into an emulsion for in vitro and in vivo testing in rats and mice, and using human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids. A time-course transcriptomic profiling of tumor organoids treated with CK21 in vitro was conducted to define its mechanism of action, as well as transcriptomic profiling at a single time point post-CK21 administration in vivo. Intravenous administration of emulsified CK21 resulted in the stable release of triptolide, and potent anti-proliferative effects on human pancreatic cancer cell lines and patient-derived pancreatic tumor organoids in vitro, and with minimal toxicity in vivo. Time course transcriptomic profiling of tumor organoids treated with CK21 in vitro revealed <10 differentially expressed genes (DEGs) at 3 h and ~8,000 DEGs at 12 h. Overall inhibition of general RNA transcription was observed, and Ingenuity pathway analysis together with functional cellular assays confirmed inhibition of the NF-κB pathway, increased oxidative phosphorylation and mitochondrial dysfunction, leading ultimately to increased reactive oxygen species (ROS) production, reduced B-cell-lymphoma protein 2 (BCL2) expression, and mitochondrial-mediated tumor cell apoptosis. CK21 is a novel pro-drug of triptolide that exerts potent anti-proliferative effects on human pancreatic tumors by inhibiting the NF-κB pathway, leading ultimately to mitochondrial-mediated tumor cell apoptosis.</p>
Paving the Way: Analysing Energy Transition Pathways and Green Hydrogen Exports in Developing Countries – The Case of Algeria. Supplementary Data
<p>Supplementary material for peer review</p><ul><li>Model Input</li><li>Model Results (LEAP/NEMO)</li></ul>
Tailoring the reaction pathway for control of size and composition of silver-gold alloy nanoparticles
<p>This is the raw data for the manuscript:</p> <p>Tailoring the reaction pathway for control of size and composition of silver-gold alloy nanoparticles<br><br>Abstract:<br><br>In this work, we focus on tuning both the particle size and chemical composition of bimetallic silver-gold alloy nanoparticles (NPs) by carefully controlling the reaction pathway. NP synthesis involves the control of the supersaturation profile in time and space. For the reaction-controlled case, this supersaturation profile is determined by a network of reactions leading to the build-up of the monomer concentration. Using a variety of characterization tools, we show how the process conditions influence the coupled reactions in the complex formation mechanism of silver-gold alloy NPs. Applying a simple mass balance allows for the independent control of size and chemical composition of these NPs, yielding particles with constant composition and varying size in the range of 20 to 40 nm. A series of constant sizes and varying chemical compositions in the range of 10 % to 100 % molar gold content is also possible. Our new methodology shows an example of how reaction networks can be tailored to achieve targeted NP properties and paves the way for better control in the synthesis of multicomponent NPs.</p> <p> </p> <p>All data are sorted according to their appearance in the figures of the main manuscript.</p>
Global terrestrial moisture recycling in Shared Socioeconomic Pathways
<p>Data generated for the preprint "Global terrestrial moisture recycling in Shared Socioeconomic Pathways" by Staal et al.:</p> <p>Staal, A., Meijer, P., Nyasulu, M.K., Tuinenburg, O.A. & Dekker, S.C. (preprint). Global terrestrial moisture recycling in Shared Socioeconomic Pathways. [link and info to be added later] </p> <p>Data are stored as netcdf files and zipped. The global files contain monthly global terrestrial precipitation recycling in mm/month. The basin files contain monthly basin precipitation recycling in mm/month. For SSPs 1-2.6, 2-4.5, 3-7.0, and 5-8.5 the monthly results are given for 2050-2059 and 2090-2099. For SSP2-4.5, also monthly results for 2015-2024 are provided. Please see Staal et al. for further details.</p>
Uncoupling of Behavioral and Metabolic Twenty-Four-Hour Rhythms in Reindeer (Current Biology, Meier et al. 2024): Metabolomics analysis tables: Annotation list, pathway analysis outputs, target list for targeted peak exstraction and MS/MS spectra of annotated features
<p><span>Metabolomics analysis tables: Annotation list, pathway analysis outputs, target list for targeted peak exstraction and MS/MS spectra of annotated features</span></p>
A singlet oxygen non-radical pathway for Rhodamine B dye degradation: Study on its stability, mechanism of degradation, and detoxification
<p><span>This study examined the degradation pathway of used face mask-derived carbon (UFMC) as a catalyst to activate peroxymonosulfate (PMS) without light sources and metal for Rhodamine B (RhB) dye degradation.</span><span> </span><span>The structural changes in the UFMC catalyst resulting from RhB degradation reduced its oxygen functionality and so reduced the rate of RhB dye degradation with each usage. </span><span>The structural changes of UFMC catalysts were confirmed by Fourier transform infrared, Raman, and X-ray photoelectron spectroscopy. The oxygen functionalities were involved in the generation of reactive oxygen species (ROS), in terms of singlet oxygen (<sup>1</sup>O<sub>2</sub>), which are involved in the RhB dye degradation mechanism. This was confirmed using paramagnetic resonance (EPR) spectroscopy and scavenging analyses. </span><span>Re-useability and stability investigations revealed the UFMC catalyst reached a minimum degradation percentage (38.8%) in the 5<sup>th</sup> cycle, confirming the complete utilization of UFMC functional groups for RhB dye degradation. </span><span>Finally, the ability to detoxify the RhB dye water was assessed using zebrafish (<em>Danio rerio) </em>with different RhB dye concentrations (2 to 6 mg/L), and 0 to 72 h of incubation at 26 °C and the<em> </em>yeast<em> </em>cells<em> (Saccharomyces cerevisiaetests)</em> harvested about 10<sup>7</sup> cells per mL for 24 h under shaking at 160 rpm at 30 °C. </span><span>Based on these results, the animal models were exposed to the RhB dye water, the significant changes in their growth were evident. However, treated with the RhB degraded water as a control, no developmental deformity was observed. This research employed the </span><span>UFM</span><span> derived carbon conveniently supported with PMS for dye removal application.</span></p>
PATHWAYS 2
Open the record for dataset details and reuse information.
PATHWAYS working version
Open the record for dataset details and reuse information.
PATHWAYS 2
Open the record for dataset details and reuse information.
Dataset for "Activation of the mPFC-NAc pathway reduces motor impulsivity but does not affect risk-related decision-making in innately high-impulsive male rats"
<p><span>Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders</span><span> (SUD) are characterized by exacerbated motor and risk-related impulsivities, which are associated with decreased cortical activity. In rodents, the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) have been separately implicated in impulsive behaviors, but studies on the specific role of the mPFC-NAc pathway in these behaviors are limited. Here, we investigated whether heightened impulsive behaviors are associated with reduced mPFC activity in rodents, and determined the involvement of the mPFC-NAc pathway in motor and risk-related impulsivities. We used the Roman High- (RHA) and Low-Avoidance (RLA) rat lines, which display divergent phenotypes in impulsivity. To investigate alterations in cortical activity in relation to impulsivity, regional brain glucose metabolism was measured using positron emission tomography and [<sup>18</sup>F]-fluorodeoxyglucose ([<sup>18</sup>F]FDG). Using chemogenetics, the activity of the mPFC-NAc pathway was either selectively activated in high-impulsive RHA rats or inhibited in low-impulsive RLA rats, and the effects of these manipulations on motor and risk-related impulsivity were concurrently assessed using the rat gambling task. We showed that basal [<sup>18</sup>F]FDG uptake was lower in the mPFC and NAc of RHA compared to RLA rats. Activation of the mPFC-NAc pathway in RHA rats reduced motor impulsivity, without affecting risk-related decision-making. Conversely, inhibition of the mPFC-NAc pathway had no effect in RLA rats. Our results suggest that the mPFC-NAc pathway controls motor impulsivity, but has limited involvement in risk-related decision-making. Our findings suggest that reducing fronto-striatal activity may help attenuate motor impulsivity in patients with impulse control dysregulation like ADHD or SUD.</span></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.