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2,532 results for “at present”
HLApollo: Towards designing improved cancer immunotherapy targets with a superior peptide-MHC-I presentation model
<p><strong>Based on the success of cancer immunotherapy, personalized cancer vaccines have recently emerged as the vanguard of oncology treatment. Because antigen presentation on MHC class I (MHC-I) is key to the adaptive immune response to cancerous cells, it is critical to have highly predictive computational methods to model which peptides are presented on MHC-I. Here, we introduce HLApollo, a transformer-based model with end-to-end treatment of MHC-I sequence, deconvolution of multi-allelic data, and ligand-flanking sequences. We develop negative-set switching, a novel training strategy that greatly reduces overfitting, which is key to HLApollo’s performance, leading to increases of 20.19% and 4.1% in average precision (AP) vs. next best model on MHC-I presentation and immunogenicity, respectively. Incorporating protein features derived from protein language models yielded further gains and reduced the need for gene expression measurements. We achieve excellent pan-allelic generalization, and create a framework for estimating performance on untrained alleles. This guides the clinical use of HLApollo, where rare alleles may be observed – particularly for individuals from underrepresented ancestries. Our work uses all facets of available MHC-I data to develop a highly accurate MHC-I presentation predictor that meaningfully improves immunogenicity prediction and allelic coverage, important for clinical applications of personalized neoantigen vaccines.</strong></p>
Fig.1 in Floristic Structure Of Mountain Plants Collection And The Present Situation In Botanical Garden Of Siauliai University
Fig.1. The number of mountain plants genus and species in collection 2003 – 2008.
Wind Value: First Conference 2022, LCSA of a Pedestrian Bridge made from Wind Blades, Angie Nagle (Paul Leahy presented), Video
<p>Video of 12 mins 46 seconds, on Life Cycle Sustainability Assessment (LCSA) of a Pedestrian Bridge made from Discarded Wind Blades, written by Angie Nagle and presented by Paul Leahy, her supervisor.</p>
Dataset (Global C-responses for CSES and CSES+Swarm+Obs database) presented in the recently submitted AGU manuscript "Electrical conductivity of mantle transition zone and water content revealed by the magnetic data of China Seismo-electromagnetic Satellite".
<p>Dataset (Global C-responses for CSES and CSES+Swarm+Obs database) presented in the recently submitted AGU manuscript "Electrical conductivity of mantle transition zone and water content revealed by the magnetic data of China Seismo-electromagnetic Satellite".</p>
Supplementary File 8; The full data set used for the analysis presented herein
Open the record for dataset details and reuse information.
Fig. 10 in The Bezzi Diptera collection at the Museo di Storia Naturale di Milano: a list of the named genera and species, with their present status
Fig. 10 - Occurrence of genera with n species / Numero di generi con n specie.
Fig. 6 in The Bezzi Diptera collection at the Museo di Storia Naturale di Milano: a list of the named genera and species, with their present status
Fig. 6 - The third cabinet of Bezzi's collection. / Il terzo armadio della collezione Bezzi.
Fig. 8 - A in The Bezzi Diptera collection at the Museo di Storia Naturale di Milano: a list of the named genera and species, with their present status
Fig. 8 - A crowded box (box # 317). / Una scatola affollata (n. 317).
Fig. 1 in Past, present and future of host‾parasite co-extinctions
Fig. 1. Cumulative number of documented species extinctions according to IUCN (2014).
A comparison of the present growth pace of the United States infrastructure with the needs of the next decade (2025-2050)
<p><span>The US population relies on crumbling infrastructural facilities needing continual upkeep. As economic activity accelerates with purchasing power projected at more than $34.102 trillion (about $100,000 per person) compared to $16.7 trillion (about $51,000 per person) today, with the US population experiencing rapid growth with a projected population of over 438 million by 2050 compared to 350 million today, infrastructural development will be significantly affected. This study considers how human interactions and recent developments (the Covid-19 outbreak and the development of artificial intelligence) will bring about change in the future demand for infrastructure in the US by 2045.</span></p>
Data presented in "Laser cooled YbF molecules for measuring the electron's electric dipole moment"
<p>Data underlying figure 2, 3 and 4 of the paper</p>
Outgrowth of transferred tumors expressing libraries of PresentER minigenes in immunocompetent and immunodeficient mice
<p>Minigene sequencing of RMA/S tumors grown in RAG deficient mice, harvested and then transferred and grown in WT or RAG mice. "Pool 13" are wild type peptide minigenes. "Pool 18" are mutant peptide minigenes.</p>
Outgrowth of tumors expressing libraries of PresentER minigenes in vaccinated or unvaccinated immunocompetent mice
<p>Minigene sequencing of RMA/S tumors expressing libraries of PresentER peptide antigen minigenes after 17 days of growth in immunocompetent mice that were either vaccinated or nonvaccinated. "Pool 13" are wild type peptide minigenes. "Pool 18" are mutant peptide minigenes.</p>
Raw Experimental Data for work presented in 'Precise Localization of Multiple Noncooperative Objects in a Disordered Cavity by Wave Front Shaping'
<p>This is the raw experimental data for the work presented in 'Precise Localization of Multiple Noncooperative Objects in a Disordered Cavity by Wave Front Shaping', to be published in Physical Review Letters.</p> <p> </p> <p>https://journals.aps.org/prl/accepted/b307fY31A5a13c5579fc4252303f8b2e5e024fc00</p> <p> </p> <p>See the README file for an explanation of the data.</p> <p> </p> <p> </p>
Raw Experimental Data for work presented in 'Leveraging Chaos for Wave-Based Analog Computation: Demonstration with Indoor Wireless Communication Signals'
<p>This is the raw experimental data for the work presented in 'Leveraging Chaos for Wave-Based Analog Computation: Demonstration with Indoor Wireless Communication Signals', to be published in Physical Review X.</p> <p> </p> <p>https://journals.aps.org/prx/accepted/dc07aKdcFa91ea06d2949139dac733fa62ce1c02c</p> <p> </p> <p>See the README files and sample pieces of codes for an explanation of the data.</p>
Raw Experimental Data for work presented in 'Optimally diverse communication channels in disordered environments with tuned randomness'
<p>This is the raw experimental data for the work presented in 'Optimally diverse communication channels in disordered environments with tuned randomness', published in Nature Electronics.</p> <p> </p> <p><a href="https://doi.org/10.1038/s41928-018-0190-1">https://doi.org/10.1038/s41928-018-0190-1</a> </p> <p> </p> <p>See the README file for an explanation of the data.</p>
Genomes assemblies presented in Zhou et al., 2018, Current Biology 28, 2420–2428
<p>Snapshot of genome assemblies published as part of Zhou et al., 2018, Current Biology 28, 2420–2428. Please see <a href="http://dx.doi.org/10.1016/j.cub.2018.05.058">the paper</a> for full description and list of authors.</p>
ECSA EIE WG - presentations Philipp Schrögel & Christian Humm and Rick Hall
<p>This is a recording of two presentations that were given on 26.02.2019 at the meeting of the <a href="https://ecsa.citizen-science.net/empowerment-inclusiveness-equity">working group on "Empowerment, Inclusiveness and Equity"</a> co-chaired by Claudia Göbel, <a href="https://ecsa.citizen-science.net/">European Citizen Science Association</a>, and Michael Sogard, <a href="https://www.livingknowledge.org/">Living Knowledge Network</a>. The first presentation by Philipp Schrögel and his colleague Christian Humm, both Karlsruhe Institut of Technology – KIT, introduces their current research project "<a href="http://www.geistsoz.kit.edu/germanistik/2943.php">Citizen Science for all? Who is reached by science communication and citizen science? And who not?</a>" (<a href="http://wmk.itz.kit.edu/downloads/Science_for_all_Factsheet_English.pdf">factsheet in English</a>). The second presentation by Rick Hall, <a href="https://www.ignitefutures.org.uk/">Ignite!</a>, introduces the methodology used by Ignite! to engage young people with science and art.</p> <p> </p>
ECSA EIE WG - presentation Daniela Soleri
<p>This is a recording of the presentation "Equity and Citizen Science, Experiences Building the CSA Working Group" by Daniela Soleri. The presentation was given on 25.10.2018 at the meeting of the working group on "Empowerment, Inclusiveness and Equity" jointly organised by the European Citizen Science Association and Living Knowledge Network.</p>
Data presented in "Deep laser cooling and efficient magnetic compression of molecules"
<p>Experimental data presented in our paper "Deep laser cooling and efficient magnetic compression of molecules"</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.