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10,561 results for “mechanics”
Data from: Mechanical fatigue in microtubules
<p><span>Mechanical failure of biological nanostructures due to sustained force application has been studied in great detail. In contrast, fatigue failure arising from repeated application of subcritical stresses has received little attention despite its prominent role in engineering and potentially biology. Here, taxol-stabilized microtubules are up to 256 times bent into sinusoidal shapes of varying wavelength and the frequency of breaking events are observed. These experiments allow the calculation of fatigue life parameters for microtubules. Repeated buckling due to 12.5% compression – equal to the compression level experienced by microtubules in contracting cardiomyocytes – results in failure after in average 5 million cycles, whereas at 20% compression failure occurs after in average one thousand cycles. The fatigue strength (Basquin) exponent B is estimated as -0.06. </span></p>
Data presented in Crustal structure and anisotropy measured by CHINArray and implications for complicated deformation mechanisms beneath the eastern Tibetan margin
<p>The dataset includes the raw waveforms and receiver functions presented in the paper Crustal structure and anisotropy measured by CHINArray and implications for complicated deformation mechanisms beneath the eastern Tibetan margin, submitted to JGR Solid Earth.</p><p>Contact: Zengsijia@cug.edu.cn</p><p> </p>
Elucidating the reaction mechanism of SO2 with Cu-CHA catalysts for NH3-SCR by X-ray absorption spectroscopy
<p>Dataset related to the article with the same title and authors:</p><p>https://pubs.rsc.org/en/content/articlelanding/2023/SC/D3SC03924B#fn1</p><p>dat files corresponding to the spectra reported in the article. See the article for the description of the procedures and of high and load loading catalysts</p><p> </p><p> </p>
Dataset for the publication titlted "A computational mechanics model for producing molecular assembly using molecularly woven pantographs" in the journal Cell Reports Physical Science, authored by Byeonghwa Goh and Joonmyung Choi.
<p>Dataset for the publication titlted "A computational mechanics model for producing molecular assembly using molecularly woven pantographs" in the journal Cell Reports Physical Science, authored by Byeonghwa Goh and Joonmyung Choi.</p>
Transcriptome analysis of Drosophila suzukii reveals molecular mechanisms conferring pyrethroid and spinosad resistance
<p class="MsoNormal"><em>Drosophila suzukii</em> possess a serrated ovipositor that enables them to lay eggs in soft-skinned, ripening fruits, making this insect<em> </em>a serious threat to berry production. Since its 2008 introduction into North America, growers have used insecticides as the primary approach for <em>D. suzukii</em> management, resulting in detections of insecticide resistance in this pest. This study sought to identify the molecular mechanisms conferring insecticide resistance in these resistant populations. We sequenced the transcriptomes of two pyrethroid- and two spinosad-resistant isogenic lines. In both pyrethroid-resistant lines and one spinosad-resistant line, we identified overexpression of metabolic genes that are implicated in resistance in other insect pests. In the other spinosad-resistant line, we observed an overexpression of cuticular genes that have been linked to resistance. Our findings enabled the development of molecular diagnostics that we used to confirm persistence of insecticide resistance in California. To validate these findings, we leveraged <em>D. melanogaster </em>mutants deficient in either metabolic or cuticular genes that were upregulated in resistant <em>D. suzukii </em>to demonstrate that these genes are involved in promoting resistance. This study is the first to characterize the molecular mechanisms of insecticide resistance in <em>D. suzukii</em> and provides insights into how current management practices can be optimized.</p> <p class="MsoNormal"> </p>
Data from: Mechanical morphotype switching as an adaptive response in Mycobacteria
<p><span>Invading microbes face a myriad of cidal mechanisms of phagocytes that inflict physical damage to microbial structures. How intracellular bacterial pathogens adapt to these stresses is not fully understood. Here, we report a new virulence mechanism by which changes to the mechanical stiffness of the mycobacterial cell surface confers refraction to killing during infection. Long-Term Time-Lapse Atomic Force Microscopy was used to reveal a process of "mechanical morphotype switching" in mycobacteria exposed to host intracellular stress. A "soft" mechanical morphotype switch enhances tolerance to intracellular macrophage stress, including cathelicidin. Both pharmacologic treatment, with bedaquiline, and a genetic mutant lacking <em>uvrA</em> modified the basal mechanical state of mycobacteria into a "soft" mechanical morphotype, enhancing survival in macrophages. Our study proposes microbial cell mechanical adaptation as a critical axis for surviving host-mediated stressors.</span></p>
Mechanical Comparison of Arrangement Strategies for Topological Interlocking Assemblies: Abaqus input files
<p>Topological Interlocking assemblies are arrangements of blocks kinematically constrained by a fixed frame, such that all rigid body motions of each block are constrained only by its permanent contact with other blocks and the frame. In the literature several blocks are introduced that can be arranged into different interlocking assemblies.<br><br>In this study we investigate the influence of arrangement on the overall structural behaviour of the resulting interlocking assemblies.<br>This is performed using the Versatile Block, as it can be arranged in three different doubly periodic ways given by wallpaper symmetries.<br><br>Our focus lies on the load transfer mechanisms from the assembly onto the frame.<br>For fast a priori evaluation of the assemblies we introduce a combinatorial model called Interlocking Flows.<br><br>To investigate our assemblies from a mechanical point of view we conduct several finite element studies. These reveal a strong influence of arrangement on the structural behaviour, for instance, an impact on both the point and amount of maximum deflection.<br>The results of the finite element analysis are in very good agreement with the predictions of the Interlocking Flow model.</p>
URB937 prevents the development of mechanical allodynia in rats with trigeminal neuralgia
<p>This dataset comprises the findings obtained in the study aimed at investigating the effects of URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in preventing and abolishing the trigeminal mechanical allodynia developed by rats subjected to chronic constriction injury of the infraorbital nerve (IoN-CCI).</p> <p> </p> <p>In vivo assessments performed in male Sprague-Dawley rats within the preventive and abrogative paradigm:</p> <p>- IoN-CCI model: following anaesthesia, the rat’s head was fixed in a stereotaxic frame and a mid-line scalp incision was made, exposing the skull and nasal bone. The edge of the orbit was dissected free, and the orbital contents were deflected with a cotton-tipped wooden rod to give access to the left IoN, which was loosely ligated with two chromic catgut ligatures (5-0) (2 mm apart). The scalp incision was closed us-ing silk sutures (5-0). In sham operated rats, the IoN was exposed using the same procedure, but the nerve was not ligated.</p> <p>- Prevention of mechanical allodynia: IoN-CCI animals were treated with URB937 (1mg/kg, i.p.) or vehicle (10% polyethylene glycol 200, 10% Tween 80 and saline) from day +1 after surgery and then every other day until day +25. The animals were tested with mechanical stimulation test (MST) the day before surgery (for baseline measurement) and on days +5, +12, +18 and +26 after surgery. Sham animals were treated with vehicle and subjected to the same procedure.</p> <p>- Abrogation of mechanical allodynia: IoN-CCI animals were subjected to chronic treatment with URB937 (1mg/kg, i.p.) or vehicle (10% polyethylene glycol 200, 10% Tween 80 and saline) after the complete development of allodynia. The animals underwent the MST the day before surgery (for baseline measurement) and on days +5, +12, +18 and +25 after surgery. On day +25, after MST, rats were treated with URB937 or vehicle and then daily until day +29 (5 total injections). On day +29, animals underwent MST 1 hour after URB937 or vehicle treatment. Sham animals were treated with vehicle and subjected to the same procedure.</p> <p>- Mechanical stimulation test (MST): a graded series of five Von Frey hairs (0.015 g, 0.127 g, 0.217 g, 0.745 g, and 2.150 g) were applied within the IoN territory, near the center of the vibrissal pad. Von Frey hairs were applied in an ascending order of intensity either ipsi- or contralaterally. For each rat, and at every designated time, a mean score for the five von Frey filaments was determined. The final MST responses of each rat are expressed as percentages to their baseline values.</p> <p>Ex vivo assessments performed on samples collected at the end of the last MST:</p> <p>- Gene expression analysis: mRNA expression levels of calcitonin gene-related peptide (CGRP), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta and IL-10 in the medulla, cervical spinal cord and trigeminal ganglion ipsilateral to IoN-CCI. mRNA levels were measured by rt-PCR. All samples were assayed in triplicate and gene expression levels were calculated according to the ΔΔCt method and expressed as relative quantification.</p> <p> </p> <p>RESULTS:</p> <p>URB937 significantly prevented the development of mechanical allodynia and the IoN-CCI-induced changes in mRNA expression levels of CGRP and cytokines in the evaluated areas. Similarly, treatment with URB937 after allodynia development significantly counteracted the IoN-CCI-induced changes in CGRP and cytokines gene expression; this was not associated with a significant abrogation of the mechanical allodynia.</p>
Data for "Ultimate molecular mechanical properties of polyolefin chains"
<p>LAMMPS input and data files, force field files, sample simulation outputs, and Jupyter notebooks used for the data analysis.</p>
Temporal variations of the multifaceted biodiversity and assembly mechanisms in lake fish assemblages
<p>Understanding long-term changes of fish diversity and community assembly rules is crucial for freshwater conservation. Growing evidence indicates that studying functional and phylogenetic diversity beyond purely taxonomic considerations can provide different but complementary information on community assembly. Here, the taxonomic, functional and phylogenetic β-diversity of fish communities, as well as the community assembly mechanisms were explored in five impounded lakes of the China's South-to-North Water Diversion Project (SNWDP) from the 1980s to the 2010s. We found that: 1) there was an obvious trend of species homogenization in the five impounded lakes, but the long-term transformations of different dimensional β-diversities were divergent; 2) water quality and land use variables have greater impacts in multi-dimensional β-diversity; and, 3) community assembly process in taxonomic and functional dimensions were dominated by random process in both periods, while shifted from limiting similarity to habitat filtering in the phylogenetic dimension. These results highlight that functional and phylogenetic diversity are important additional ecological indices for assessing patterns of fish diversity in lakes.</p>
Welcome in Mechanics Font
<p>The lettering "Welcome" represented by mechanically loaded or mechanically related objects. Can be used on title slides or other introductory media.</p>
Mechanical alphabet, TM1981 (Low res.)
Christopher Polhem (1661-1751) created the so-called mechanical alphabet in the years just before 1700. The wooden models illustrated the fundamentals of physics and mechanics and were intended to serve as an educational tool in teachings at the Laboratorium mechanicum established in 1697. After his death, the collection continued to serve as a didactic instrument and became part of the Swedish Royal Model Chamber. In 1925, the collection of 31 models was deposited at the newly established National Museum of Science and Technology. [TM1981](https://digitaltmuseum.se/021026544982/mekaniskt-alfabet-modell?aq=text%3A%22polhem%22+owner%3A%22S-TEK%22&i=23"tm1981") (TEKS0021248) Created in RealityCapture by Fredrik Olsson from 363 images in 02h:08m:42s. Please note: No post processing have been done, holes may occur in mesh. Read more about [Polhem]( https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
Mechanical alphabet, TM1360
Christopher Polhem (1661-1751) created the so-called mechanical alphabet in the years just before 1700. The wooden models illustrated the fundamentals of physics and mechanics and were intended to serve as an educational tool in teachings at the Laboratorium mechanicum established in 1697. After his death, the collection continued to serve as a didactic instrument and became part of the Swedish Royal Model Chamber. In 1925, the collection of 31 models was deposited at the newly established National Museum of Science and Technology. [TM1360](https://digitaltmuseum.se/021026544809/mekaniskt-alfabet-modell?i=32&aq=owner%3A%22S-TEK%22+text%3A%22polhem%22"tm1360") (TEKS0014705) Created by Fredrik Olsson in RealityCapture from 227 images. Read more about [Polhem]( https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
Mechanical alphabet, TM2002
Christopher Polhem (1661-1751) created the so-called mechanical alphabet in the years just before 1700. The wooden models illustrated the fundamentals of physics and mechanics and were intended to serve as an educational tool in teachings at the Laboratorium mechanicum established in 1697. After his death, the collection continued to serve as a didactic instrument and became part of the Swedish Royal Model Chamber. In 1925, the collection of 31 models was deposited at the newly established National Museum of Science and Technology. [TM2002](https://digitaltmuseum.se/021026545046/mekaniskt-alfabet-modell?i=16&aq=text%3A%22mekaniskt%22%2C%22alfabet%22"tm2002") (TEKS0021480) Created by Fredrik Olsson in RealityCapture from 237 images. Read more about [Polhem](https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
Christopher Polhem mechanical wooden modelTM1406
Christopher Polhem mechanical wooden model from the early 1700s This virtual artifact can be found in real life at the [Swedish National Museum of Science and Technology in Stockholm](https://sketchfab.com/Tekniskamuseet) Created in RealityCapture by Fredrik Olsson from 311 images in 01h:35m:23s. Please note: No post processing have been done, holes may occur in mesh Read more about [Polhem]( https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
Antikythera Mechanism Main Fragment (CT)
3D surface model based on the highest resolution CT scan of the main fragment of the Antikythera Mechanism after improvement of the corrupted scan as detailed in https://doi.org/10.1371/journal.pone.0207430. The Antikythera mechanism (an ancient greek astronomical calculator) originally made of bronze, was recovered from the sea after 2000 years, over this time it had corroded and become a calcified lump. This has changed the homogeneity of the original metal (if there was any in the first place) making it incredibly difficult to extract the mechanism from the CT scan to produce a 3D model. For this reason, some parts may appear 'missing'. # Front  # Back  Orignal CT data captured by X-Tek now owned by Nikon Metrology. Improved CT data available via https://doi.org/10.7910/DVN/UCXZWU. Images: https://en.wikipedia.org/wiki/Antikythera_mechanism Model Texture: https://www.3dxo.com/textures/5320_bronze Source: Objaverse 1.0 / Sketchfab
Christopher Polhem mechanical wooden modelTM1980
Christopher Polhem mechanical wooden model from the early 1700s This virtual artifact can be found in real life at the [Swedish National Museum of Science and Technology in Stockholm](https://sketchfab.com/Tekniskamuseet) Created in RealityCapture by Fredrik Olsson from 334 images in 00h:54m:31s. Please note: No post processing have been done, holes may occur in mesh Read more about [Polhem]( https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
Mechanical alphabet, TM1971 (Low res.)
Christopher Polhem (1661-1751) created the so-called mechanical alphabet in the years just before 1700. The wooden models illustrated the fundamentals of physics and mechanics and were intended to serve as an educational tool in teachings at the Laboratorium mechanicum established in 1697. After his death, the collection continued to serve as a didactic instrument and became part of the Swedish Royal Model Chamber. In 1925, the collection of 31 models was deposited at the newly established National Museum of Science and Technology. [TM1971](https://digitaltmuseum.se/021026493579/mekaniskt-alfabet-modell?aq=owner%3A%22S-TEK%22+text%3A%22polhem%22&i=16"tm1971") (TEKS0021139) Created in RealityCapture by Fredrik Olsson from 62 images in 00h:04m:23s. Please note: No post processing have been done, holes may occur in mesh. Read more about [Polhem](https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
Mechanical alphabet, TM1975 (Low res.)
Christopher Polhem (1661-1751) created the so-called mechanical alphabet in the years just before 1700. The wooden models illustrated the fundamentals of physics and mechanics and were intended to serve as an educational tool in teachings at the Laboratorium mechanicum established in 1697. After his death, the collection continued to serve as a didactic instrument and became part of the Swedish Royal Model Chamber. In 1925, the collection of 31 models was deposited at the newly established National Museum of Science and Technology. [TM1975](https://digitaltmuseum.se/021026544940/mekaniskt-alfabet-modell?aq=text%3A%22polhem%22+owner%3A%22S-TEK%22&i=34"tm1975") (TEKS0021182) Created in RealityCapture by Fredrik Olsson from 244 images in 01h:40m:20s. Please note: No post processing have been done, holes may occur in mesh. Read more about [Polhem]( https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
Mechanical alphabet, TM1997 (Low res.)
Christopher Polhem (1661-1751) created the so-called mechanical alphabet in the years just before 1700. The wooden models illustrated the fundamentals of physics and mechanics and were intended to serve as an educational tool in teachings at the Laboratorium mechanicum established in 1697. After his death, the collection continued to serve as a didactic instrument and became part of the Swedish Royal Model Chamber. In 1925, the collection of 31 models was deposited at the newly established National Museum of Science and Technology. [TM1997](https://digitaltmuseum.se/021026545025/mekaniskt-alfabet-modell?i=22&aq=owner%3A%22S-TEK%22+text%3A%22polhem%22"tm1997") (TEKS0021422) Created in RealityCapture by Fredrik Olsson from 317 images in 00h:56m:47s. Please note: No post processing have been done, holes may occur in mesh. Read more about [Polhem]( https://en.wikipedia.org/wiki/Christopher_Polhem"polhem") on Wikipedia. Source: Objaverse 1.0 / Sketchfab
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.