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3,255
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3,255 results for “Pancreatic Cancer”
NC-6004(Nanoplatin) and Gemcitabine to Treat Pancreatic Cancer in Asia
ClinicalTrials.gov study NCT00910741. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Ultrasound-assisted Treatment of Inoperable Pancreatic Cancer
ClinicalTrials.gov study NCT01674556. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of Mitazalimab in Combination With Chemotherapy in Pancreatic Cancer Patients
ClinicalTrials.gov study NCT04888312. IPD Sharing: NO. Countries: 3. Publications: 2.
Mesopancreas Study in Pancreatic Cancer
ClinicalTrials.gov study NCT05895214. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
PP2A complex disruptor SET prompts widespread hyper-transcription of growth-essential genes in the pancreatic cancer cells
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Data from: A novel triptolide analog downregulates NF-kB and induces mitochondrial apoptosis pathways in human pancreatic cancer
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Data from: Effect of pancreatic cancer-derived extracellular vesicles on bone marrow-derived macrophages
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Data from: Development and evaluation of a fluorescent antibody-drug conjugate for molecular imaging and targeted therapy of pancreatic cancer
Antibodies are widely available and cost-effective research tools in life science, and antibody conjugates are now extensively used for targeted therapy, immunohistochemical staining, or in vivo diagnostic imaging of cancer. Significant advances in site-specific antibody labeling technologies have enabled the production of highly characterized and homogenous conjugates for biomedical purposes, and some recent studies have utilized site-specific labeling to synthesize bifunctional antibody conjugates with both imaging and drug delivery properties. While these advances are important for the clinical safety and efficacy of such biologics, these techniques can also be difficult, expensive, and time-consuming. Furthermore, antibody-drug conjugates (ADCs) used for tumor treatment generally remain distinct from conjugates used for diagnosis. Thus, there exists a need to develop simple dual-labeling methods for efficient therapeutic and diagnostic evaluation of antibody conjugates in pre-clinical model systems. Here, we present a rapid and simple method utilizing commercially available reagents for synthesizing a dual-labeled fluorescent ADC. Further, we demonstrate the fluorescent ADC's utility for simultaneous targeted therapy and molecular imaging of cancer both in vitro and in vivo. Employing non-site-specific, amine-reactive chemistry, our novel biopharmaceutical theranostic is a monoclonal antibody specific for a carcinoembryonic antigen (CEA) biomarker conjugated to both paclitaxel and a near-infrared (NIR), polyethylene glycol modified (PEGylated) fluorophore (DyLight™ 680-4xPEG). Using in vitro systems, we demonstrate that this fluorescent ADC selectively binds a CEA-positive pancreatic cancer cell line (BxPC-3) in immunofluorescent staining and flow cytometry, exhibits efficient internalization kinetics, and is cytotoxic. Model studies using a xenograft of BxPC-3 cells in athymic mice also show the fluorescent ADC's efficacy in detecting tumors in vivo and inhibiting tumor growth more effectively than equimolar amounts of unconjugated drug. Overall, our results demonstrate that non-selective, amine-targeting chemistry is an effective dual-labeling method for synthesizing and evaluating a bifunctional fluorescent antibody-drug conjugate, allowing concurrent detection, monitoring and treatment of cancer.
Gene expression analysis of KRAS knockout pancreatic cancer cell line CFPAC1
<p>We used CRISPR to inactivate mutant KRAS in CFPAC1 (KRASG12V) pancreatic cancer cell lines. Gene expression analysis of KRAS intact vs. knockout cells identified sets of genes involved in protein synthesis, cell differentiation, and metabolic processes, while the expression of MAPK/ERK target genes remained unperturbed.</p>
OrganoIDNetData: A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models
<p>OrganoIDNetData encompasses 180 images with 34113 organoids of human and murine Pancreatic Ductal Adenocarcinoma co-cultured with immune cells.</p> <p><strong>For further information and to cite this dataset, please refer to:</strong></p> <p>Kulkarni, A., Ferreira, N., Scodellaro, R. <em>et al.</em> A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models. <em>Sci Data</em> <strong>11</strong>, 820 (2024). https://doi.org/10.1038/s41597-024-03631-3</p>
Spatially Resolved Transcriptomics Atlas of Matched Primary and Metastatic Pancreatic Cancer Reveal Principles of Ecological Adaptation
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Fig. 1 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 1. Structures of alkaloids isolated from R. spectabilis Engl.
Fig. 2. NOESY correlations for compound 1 and HMBC correlations for compound 2 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 2. NOESY correlations for compound 1 and HMBC correlations for compound 2.
Fig. 4 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 4. Electronic circular dichroism (ECD) spectra of 1 6, and 9 in EtOH.
Fig. 3 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 3. The key NOESY correlations of cyclohexenyl unit of 5 9.
Fig. 1 in Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line
Fig. 1. Structures of isolated compounds from B. rotunda.
Vorinostat Plus Radiation Therapy in Pancreatic Cancer
ClinicalTrials.gov study NCT00831493. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Medical Nutrition Therapy or Standard Care in Treating Patients With Lung Cancer, Pancreatic Cancer, or Stage III or Stage IV Prostate Cancer
ClinicalTrials.gov study NCT00769652. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Genetic Testing for Breast, Ovarian, Pancreatic, and Prostate Cancers
ClinicalTrials.gov study NCT04330716. IPD Sharing: YES. Countries: 1. Publications: 0.
Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
ClinicalTrials.gov study NCT00376948. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.