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Dataset results
674 results for “brain disease”
Gene expression changes in multiple brain regions of a mouse MPTP model of Parkinson's disease
GEO Series GSE7707. Mus musculus. 18 samples. Type: Expression profiling by array.
Loss of adaptive DNA breaks in Alzheimer’s disease brains
GEO Series GSE294102. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Integrative analysis of altered genes expressed in human Alzheimer’s disease brain
GEO Series GSE173954. Homo sapiens. 18 samples. Type: Expression profiling by array.
A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease
GEO Series GSE198226. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
Molecular signatures and spatial distribution of disease-associated cellular populations in early-onset Alzheimer's disease mouse brain
GEO Series GSE253570. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Transcriptional profiling of brain tissues from a Q130 Long Evans Knock-in rat model of Huntington’s disease at 2-, 6-, 10-, 12-, 19- and 24-months of age
GEO Series GSE169388. Rattus norvegicus. 397 samples. Type: Expression profiling by high throughput sequencing.
Methionine restriction alleviate cognitive dysfunction in Alzheimer’s disease: the mediating roles of gut microbiota-brain axis
GEO Series GSE164618. Mus musculus. 85 samples. Type: Expression profiling by high throughput sequencing.
Profiling of post-mortem brain microRNA in Alzheimer’s disease
GEO Series GSE157239. synthetic construct; Homo sapiens. 16 samples. Type: Non-coding RNA profiling by array.
Brain pathology and cerebellar Purkinje cell loss in a mouse model of chronic neuronopathic Gaucher disease
GEO Series GSE157992. Mus musculus. 35 samples. Type: Expression profiling by high throughput sequencing.
Data set from Varga A, Di Leo G, Banga PV, Csobay-Novák C, Kolossváry M, Maurovich-Horvat P, Hüttl K. Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. Eur Radiol. 2019 Jan;29(1):46-56. doi: 10.1007/s00330-018-5577-x. Epub 2018 Jun 19. PMID: 29922933; PMCID: PMC6291432.
<p>Data set from the article Data set from Varga A, Di Leo G, Banga PV, Csobay-Novák C, Kolossváry M, Maurovich-Horvat P, Hüttl K. Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. Eur Radiol. 2019 Jan;29(1):46-56. doi: 10.1007/s00330-018-5577-x. Epub 2018 Jun 19. PMID: 29922933; PMCID: PMC6291432.</p> <p>This is the abstract</p> <p><strong>Purpose: </strong> (1) to estimate the prevalence of Circle of Willis (CoW) variants in patients undergoing carotid endarterectomy, (2) to correlate these variants to controls and (3) cerebral ischemia depicted by computed tomography (CT).</p> <p><strong>Materials and methods: </strong> After Institutional Review Board approval, data of 544 carotid endarterectomy patients (331 males, mean age 69±8 years) and 196 controls (117 males, mean age 66±11 years) who underwent brain CT and carotid CT angiography (CTA) were retrospectively analysed. Two observers independently classified each CoW segment as normal, hypoplastic (diameter <0.8 mm) or non-visualized. Four groups of CoW variants based on the number of hypoplastic/non-visualized segments were correlated with clinical data (ANOVA, χ<sup>2</sup> and multivariate logistic regression analysis). Intra- and inter-observer agreement was estimated using Cohen κ statistics.</p> <p><strong>Results: </strong> High prevalence of CoW variants (97%) and compromised CoW (81%) was observed in the study group and significant difference was found in the distribution of CoW variants compared to controls (p<0.001), internal carotid artery (ICA) stenosis being the only independent predictor of CoW morphology (p<0.001). Significant correlation was found between CoW configuration and brain ischemia in the study group (p=0.002). ICA stenosis of ≥90% was associated to higher rate of ipsilateral A1 hypoplasia/non-visualization (p<0.001). Intra- and inter-observer agreement was from substantial to almost perfect (Cohen κ=0.75-1.0).</p> <p><strong>Conclusion: </strong> Highly variable CoW morphology was demonstrated in patients undergoing endarterectomy compared to controls. Likely compromised CoW in relation to cerebral ischemia was observed in a large cohort of carotid endarterectomy subjects.</p> <p><strong>Key points: </strong> • CoW variant distribution significantly differed in the study and control groups (p<0.001). • ICA stenosis was the only independent predictor of CoW morphology (p<0.001). • Severely compromised CoW configuration showed significant association with brain ischemia (p=0.002).</p>
MicroRNA (miRNA) expression profiling of blood leukocytes of Parkinson's disease (PD) patients pre- and post-deep brain stimulation treatment and of healthy control volunteers
GEO Series GSE38385. synthetic construct; Homo sapiens. 13 samples. Type: Non-coding RNA profiling by array.
Datase related to article "NOVEL DEEP INTRONIC MUTATION IN PLA2G6 CAUSING EARLY-ONSET PARKINSON'S DISEASE WITH BRAIN IRON ACCUMULATION THROUGH PSEUDO-EXON ACTIVATION"
<p>The database contains the sequencing data included in the article at title</p>
CXCR4/CXCR7-SDF1 Axis-Based Targeting Treatment of Huntington’s Disease with Blood-Brain Barrier Permeable Neural Stem Cell-Derived Nanovesicles Reinforced by Biomimetic Nanozymes
GEO Series GSE284476. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
CXCR4/CXCR7-SDF1 Axis-Based Targeting Treatment of Huntington’s Disease with Blood-Brain Barrier Permeable Neural Stem Cell-Derived Nanovesicles Reinforced by Biomimetic Nanozymes
GEO Series GSE284688. Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.