Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
725
datasets available to search
ShareScore release 0.9.0
Dataset results
725 results for “isoforms”
Comparative analysis of multiple human cell lines reveals distinct stability regulation of alternative polyadenylation isoforms and mitochondrial RNAs in neuronal cells
GEO Series GSE189899. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Compartment-specific and HuR-coordinated regulation of intronic polyadenylation isoforms by doxorubicin
GEO Series GSE180850. Homo sapiens. 78 samples. Type: Expression profiling by high throughput sequencing; Other.
Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals
<p>This record contains raw data related to the article "Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals"</p> <p><strong>Background:</strong> Circulating levels of soluble receptor for advanced glycation end products (sRAGE) and advanced glycation end products (AGEs) correlate with aging/cardiovascular risk, which is delayed in long-living individuals (LLIs). AGEs/sRAGE isoforms (cleaved RAGE [cRAGE] and secretory RAGE [esRAGE]) ratio is a valuable marker for disease risk. <strong>Results:</strong> We evaluated circulating sRAGE isoforms, and AGEs in LLIs (n = 95; 90-105 years) and controls (n = 94; 11-89 years). cRAGE decreased with age in controls and further declined in LLIs. esRAGE increased in LLIs. AGEs rose with age in controls and decreased in LLIs that were characterized by a lower AGEs/sRAGE ratio. Notably, cRAGE and AGE/esRAGE ratio better discriminated controls from LLIs. <strong>Conclusion:</strong> circulating cRAGE could be considered a reliable marker of chronological age while esRAGE a protective factor for longevity.</p>
: Dataset related to the article "Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study"
<p>This record contains raw data related to the article “Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study”.</p> <p><em><strong>Abstract</strong></em></p> <p><strong>Background: </strong>Advanced glycation end-products (AGEs) and their interaction with the receptor for advanced glycation end-products (RAGE) play a pivotal role in the development and progression of type 2 diabetes. In this retrospective cohort study, we explored the association of circulating levels of soluble RAGE (sRAGE) isoforms, i.e., endogenous secretory esRAGE and cleaved cRAGE, AGEs and their respective ratios with 15-year all-cause mortality in type 2 diabetes. <strong>Methods: </strong>Baseline AGEs and sRAGE isoforms concentration were measured by ELISA in 362 patients with type 2 diabetes and in 125 age- and gender-matched healthy control subjects (CTR). Independent predictors of mortality were determined using Cox proportional-hazards models and used to build and validate a nomogram for all-cause mortality prediction in type 2 diabetes. <strong>Results: </strong>AGEs, total sRAGE, cRAGE and the AGEs/sRAGE and AGEs/esRAGE ratios were significantly increased in patients with type 2 diabetes compared to CTR (p < 0.001). In CTR subjects, but not in type 2 diabetes patients, a significant negative correlation between cRAGE and age was confirmed (p = 0.003), whereas the AGEs/sRAGE (p = 0.032) and AGEs/cRAGE (p = 0.006) ratios were positively associated with age. At an average follow-up of 15 years (4,982 person-years), 130 deaths were observed. The increase in the AGEs/cRAGE ratio was accompanied by a higher risk of all-cause mortality in patients with type 2 diabetes (HR per each SD increment = 1.30, 95% CI 1.15-1.47; p < 0.001). Moreover, sRAGE was associated with the development of major adverse cardiovascular events (MACE) in type 2 diabetes patients without previous MACE (OR for each SD increase: 1.48, 95% CI 1.11-1.89). A nomogram based on age, sex, HbA1c, systolic blood pressure, and the AGEs/cRAGE ratio was built to predict 5-, 10- and 15-year survival in type 2 diabetes. Patients were categorized into quartiles of the monogram scores and Kaplan-Meier survival curves confirmed the prognostic accuracy of the model (log-rank p = 6.5 × 10<sup>- 13</sup>). <strong>Conclusions: </strong>The ratio between AGEs and the cRAGE isoform is predictive of 15-year survival in patients with type 2 diabetes. Our data support the assessment of circulating AGEs and soluble RAGE isoforms in patients with type 2 diabetes as predictors of MACE and all-cause mortality.</p> Enable Ginger<em>Cannot connect to Ginger</em> Check your internet connection<br> or reload the browserDisable in this text fieldRephraseRephrase current sentence<span class="ginger-floatingG-bar-tool-mistakes-count">26</span>Log in to edit with Ginger×
Fig. 2 in Study of two isoforms of lipoxygenase by kinetic assays, docking and molecular dynamics of a specialised metabolite isolated from the aerial portion of Lithrea caustica (Anacardiaceae) and its synthetic analogs
Fig. 2. Formation of tropylium ion with two phenolic –OH groups.
Fig. 3 in Study of two isoforms of lipoxygenase by kinetic assays, docking and molecular dynamics of a specialised metabolite isolated from the aerial portion of Lithrea caustica (Anacardiaceae) and its synthetic analogs
Fig. 3. (Z)-3-(pentadec-10′-enyl)-catechol structure.
Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma
GEO Series GSE284709. Homo sapiens. 65 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
Long-TUC-seq is a robust method for quantification of metabolically labeled full-length isoforms
GEO Series GSE149551. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
The divergent role of two PRDM1 isoforms during human naïve pluripotency reprogramming
GEO Series GSE255862. Homo sapiens. 59 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [CUT&Run]
GEO Series GSE299960. Homo sapiens. 70 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Development of micro RNA expression signatures for differential translation of protein isoforms.
GEO Series GSE56412. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by array.
Isoform-specific translational control is evolutionarily conserved in primates
GEO Series GSE230441. Pan troglodytes; Pongo abelii; Homo sapiens. 30 samples. Type: Other.
Transcript isoform switching occurs in the murine synaptic transcriptome during aging
GEO Series GSE146636. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Sacharomyces cerevisiae Transcript Isoform mapping (rrp6)
GEO Series GSE46140. Saccharomyces cerevisiae. 4 samples. Type: Expression profiling by high throughput sequencing.
DDX17-regulated alternative splicing that produced a novel oncogenic isoform of PXN-AS1 to promote HCC metastasis [Cells]
GEO Series GSE182787. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression perturbation upon over-expression of a new PPARG isoform
GEO Series GSE120466. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Interactome of different isoforms of RPL22L1 protein in human glioblastoma cells
GEO Series GSE180464. Homo sapiens. 3 samples. Type: Other.
Gene expression analysis after RNAi treatment of different isoforms of vab-3 in C.elegans
GEO Series GSE201211. Caenorhabditis elegans. 8 samples. Type: Expression profiling by high throughput sequencing.
Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance
GEO Series GSE153865. Homo sapiens. 59 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (DNAse I hypersensitivity)
GEO Series GSE153863. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.