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Dataset results
702 results for “Longitudinal study”
A longitudinal study of female and male mice to identify DNA methylation signatures of frailty beyond age
GEO Series GSE316651. Mus musculus. 315 samples. Type: Methylation profiling by genome tiling array.
Longitudinal Mult-omics Study of Palbociclib Resistance in Hormone Receptor (HR) Positive/Human Epidermal Growth Factor Receptor (HER) 2 Negative Metastatic Breast Cancer (MBC)
GEO Series GSE186901. Homo sapiens. 90 samples. Type: Expression profiling by high throughput sequencing.
T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination - 2009
GEO Series GSE58943. Homo sapiens. 72 samples. Type: Expression profiling by array.
T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination - 2012
GEO Series GSE64514. Homo sapiens. 71 samples. Type: Expression profiling by array.
Dataset related to article "Morphometric vertebral fractures in patients with castration-resistant prostate cancer undergoing treatment with radium-223: a longitudinal study in the real-life clinical practice"
<p>This record contains data related to article "Morphometric vertebral fractures in patients with castration-resistant prostate cancer undergoing treatment with radium-223: a longitudinal study in the real-life clinical practice"</p> <p><strong>Abstract</strong></p> <p><strong>Purpose: </strong>Radium-223 was associated with high incidence of non-vertebral fractures in patients with castration-resistant prostate cancer (CRPC). However, it is still unclear whether radium-223 may induce skeletal fragility regardless of other therapies for CRPC. We aimed at evaluating the prevalence, incidence, and determinants of vertebral fractures (VFs), i.e., the most frequent complication of skeletal fragility, in CRCP patients undergoing radium-223 therapy in the real-life clinical practice.</p> <p><strong>Methods: </strong>We retrospectively reviewed 49 CRPC patients with symptomatic bone metastases treated with radium-223. Patients received median number of four radium-223 doses (range: 2-6) and were followed-up for a median period of 11 months (range: 6-44). VFs were assessed by a quantitative morphometry using lateral images of spine 11C-Choline PET/CT, excluding from the analysis the vertebral bodies affected by bone metastases.</p> <p><strong>Results: </strong>Before radium-223 administration, 24 patients (49%) had VFs significantly associated with duration of androgen deprivation therapy (ADT; odds ratio 1.29) and previous abiraterone therapy (odds ratio 3.80). During radium-223 therapy, incident VFs occurred in 25% of patients, in relationship with prevalent VFs (hazard ratio 6.89) and change in serum total alkaline phosphatase values (hazard ratio 0.97), whereas the correlations with ADT and abiraterone therapy were lost. Noteworthy, the risk of VFs did not correlate with the therapeutic end points of radium-223.</p> <p><strong>Conclusions: </strong>This study provides a first evidence that in real-life clinical practice, radium-223 therapy may induce skeletal fragility with high risk of VFs, likely by inhibition of bone formation and independently of ADT and abiraterone therapy.</p>
Longitudinal study of hospitalized COVID-19 patients: RNA-seq dataset
<p>Upon request, RNA-seq data are available (n = 82). Longitudinal design: (1) samples collected on 1-2 days of hospitalization; (2) samples collected 4-5 weeks post-hospitalization; (3) samples collected 3-4 months post-hospitalization. Readily available files are 1) read counts for genes in each sample; 2) total read counts per library, QC metrics, etc., and phenotype (sex, age, bmi) in the metadata file. Raw data will be made available through EGA-archive.org in December 2025, ensuring the safe sharing of human genetic RNA sequences and promoting the principles of FAIR data.<br> </p>
Dateset related to article "Spinocerebellar Ataxia Type 1: One‑Year Longitudinal Study to Identify Clinical and MRI Measures of Disease Progression in Patients and Presymptomatic Carriers "
<p>This dataset contains clinical information (neuropsychological evaluations, structural MRI measures, etc.) on patients with Spinocerebellar Ataxia included in the study reported at title</p>
Dataset related to article "Xpert Bladder Cancer Monitor May Avoid Cystoscopies in Patients Under "Active Surveillance" for Recurrent Bladder Cancer (BIAS Project): Longitudinal Cohort Study "
<p>This record contains raw data related to article “Xpert Bladder Cancer Monitor May Avoid Cystoscopies in Patients Under "Active Surveillance" for Recurrent Bladder Cancer (BIAS Project): Longitudinal Cohort Study"</p> <p>Abstract</p> <p><strong>Objectives: </strong> To test the hypothesis that patients under active surveillance (AS) for Non-muscle Invasive Bladder Cancer (NMIBC) who were negative on longitudinal re-testing by the Xpert<sup>®</sup> Bladder Cancer Monitor (Xpert BC Monitor) assay may avoid unnecessary cystoscopies and urine cytology (UC).</p> <p><strong>Subjects/patients or materials and methods: </strong> This is a prospective cohort study of patients enrolled in the AS protocol for recurrent NMIBC (Bladder Cancer Italian Active Surveillance, BIAS project), whose urine samples were analyzed by Xpert BC Monitor upon entry in the study (T0). Patients who had a negative Xpert test and did not fail AS, underwent additional Xpert tests after 4 (T1), 8 (T2), and 12 (T3) months. The clinical utility of Xpert was assessed by determining the number of cystoscopies and UC that could be avoided within 1 year.</p> <p><strong>Results: </strong> Overall, 139 patients were tested with Xpert at T0. Median follow-up was 23 (IQR 17-27) months. Sixty-eight (48.9%) patients failed AS, 65 (46.7%) are currently on AS, and 6 (4.3%) were lost at follow-up. At T0 57 (41.0%) patients had a negative test and 36 (63.2%) are still in AS. In patients with 2 consecutives negative Xpert tests, we could have avoided 73.9% of unnecessary cystoscopies, missing 26.4% failure, up to avoid all cystoscopies with 4 negative tests missing only 12% of failure. All the patients with negative Xpert had negative UC. Failure-free-survival at median follow-up (23 month) stratified for having 0, 1, or ≥2 negative tests was 67.0, 55.1. and 84.1, respectively.</p> <p><strong>Conclusion: </strong> Our findings suggest that Xpert BC Monitor assay, when it is longitudinally repeated, could significantly reduce the number of unnecessary cystoscopies and UC during their follow-up.</p> <p> </p>
Datasets of the paper Monitoring cognitive and psychological alterations in COVID-19 patients: A longitudinal neuropsychological study by Diana et al. 2022
<p>Datasets of the paper "Monitoring cognitive and psychological alterations in COVID-19 patients: A longitudinal neuropsychological study" by Diana et al. 2022</p>
Longitudinal Study of Cortisol and Pulmonary Function
ClinicalTrials.gov study NCT00005370. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Longitudinal Study of Neighborhood Predictors of CVD
ClinicalTrials.gov study NCT00046657. IPD Sharing: Not stated. Countries: 0. Publications: 0.
T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination
GEO Series GSE58970. Homo sapiens. 147 samples. Type: Expression profiling by array.
Trajectories of Health-Related Quality of Life, Health Literacy, and Self-Efficacy in Curatively-Treated Patients with Esophageal Cancer: A Longitudinal Single-Center Study in Italy
<p>Dataset from Trajectories of Health-Related Quality of Life, Health Literacy, and Self-Efficacy in Curatively-Treated Patients with Esophageal Cancer: A Longitudinal Single-Center Study in Italy <a href="https://journals.sagepub.com/doi/full/10.1177/23743735211060769">Arianna Magon</a>, RN, MSN, PhD, <a href="https://journals.sagepub.com/doi/full/10.1177/23743735211060769">Rosario Caruso</a>, PhD, <a href="https://journals.sagepub.com/doi/full/10.1177/23743735211060769">Andrea Sironi</a>, MD, <a href="https://journals.sagepub.com/doi/full/10.1177/23743735211060769">Sabrina Mirabella</a>, RN, MSN, <a href="https://journals.sagepub.com/doi/full/10.1177/23743735211060769">Federica Dellafiore</a>, PhD, RN, <a href="https://journals.sagepub.com/doi/full/10.1177/23743735211060769">Cristina Arrigoni</a>, RN, MSc, <a href="https://journals.sagepub.com/doi/full/10.1177/23743735211060769">Luigi Bonavina</a>, MD, FACS <a href="https://doi.org/10.1177%2F23743735211060769">https://doi.org/10.1177/23743735211060769</a> </p> <p>Abstract</p> <p>This prospective longitudinal study aimed to describe the trajectories of HRQoL, health literacy, and self-efficacy in patients with esophageal cancer, which have been thus far poorly described. Data were collected at baseline (preoperative phase) and in the postoperative period (two weeks, and one, two, and three months after esophagectomy). The study hypothesis was that health literacy and self-efficacy might predict better health status and quality of life over time. Forty-five patients were enrolled between 2018 and 2019. HRQoL, health literacy, and self-efficacy were assessed using validated scales. The ability to analyze information to exert greater control over life events critically (critical health literacy) (η<sup>2</sup><em>p</em> =&thinsp;0.660) and the individual's confidence in dealing with challenging tasks (self-efficacy) (η<sup>2</sup><em>p</em> =&thinsp;0.501) strongly predicted the scores of general health status over time. Overall, the functional status improved at 3 months after surgery, and this trend paralleled the decline of cancer-specific and surgery-related symptoms. In conclusion, researchers and clinicians should pay greater attention to optimizing baseline health literacy and self-efficacy levels. Future educational and motivational interventions should be further tested and possibly integrated into the prehabilitation programs.</p>
Studying in Challenging Times (SICT) – A Longitudinal Study on Social Work Students' Situations During the Covid-19 Pandemic
<p>The aim of this quantitative study was to examine challenges and attitudes towards studying, social support, and personal lives of social work students during the Covid-19 pandemic, and to analyze how their situations have changed over the past few semesters under pandemic conditions. Drawing on a longitudinal research design, 99 students enrolled in the bachelor’s and master’s programs of social work at the Eastern Switzerland University of Applied Sciences (OST) were surveyed over four points in time, starting in the spring semester 2020 and ending in the fall semester 2021. The SICT dataset is available on demand.</p>
BINAURAL BEATS ON PARKINSON DISEASE: A LONGITUDINAL STUDY
<p>File structure description:</p> <ul> <li><strong>Patient data:</strong> Excel file with the most relevant patient data.</li> <li><strong>RAW:</strong> Contains the raw data in the appropriate format to be processed in BRAINSTORM. These are the records of all patients (ID 5,14, 16, 23, 30, 33, 33, 35, 38, 39, 40, 64, 65) in the pre-stimulation (PRE) and post-stimulation (POST) condition in each of the sessions (Session 1, 2, 3).</li> <li><strong>Theta power:</strong> This folder contains the Excel files with the results of the relative power of the theta band obtained in Brainstorm, conveniently ordered to later generate the .mat files with the patients to be analyzed. The files are sorted by session (S1, S2, S3) and in turn by condition (PRE, POST).</li> <li><strong>Matlab scripts:</strong> Folder containing the .txt scripts that generate the heads of the figures in the paper.</li> <li><strong>Matlab Functions:</strong> Contains the necessary functions to obtain the heads of the figures in the paper, including the .mat files with the relative powers of the theta band of the 8 patients analyzed. It includes the FieldTrip software, since the scripts call some functions of this program, some of them have been modified for this particular study. FieldTrip is the MATLAB software toolbox for MEG, EEG and iEEG analysis, which is released free of charge as open source software under the GNU general public license. Fieldtrip version 20160222 was used for this study, although the updated version can be downloaded at https://www.fieldtriptoolbox.org/download/.</li> </ul> <p> </p>
Longitudinal bibliometric investigation of trending orthodontic research topics, study designs and outcomes: are we reporting patient-focused outcomes?
Open the record for dataset details and reuse information.
Prognostic relevance of quantitative and longitudinal MOG antibody testing in patients with MOGAD: a multicentre retrospective study
<p><strong>Introduction. </strong>The database contains information regarding patients with myelin oligodendrocyte glycoprotein associated disorders (MOGAD), including demographic, clinical presentation and course, neuroradiological data, laboratory data, treatment and outcome data and data regarding antibody titres over time.</p> <p><strong>Methods. </strong>In this retrospective multicentre Italian cohort study, we recruited patients with MOGAD and available longitudinal samples (at least one >3 months after disease onset) and tested them with a live cell-based assay with endpoint titration (1:160 cut-off). Samples were classified as ’attack’ (within 30 days since a disease attack (n=59, 17%)) and ’remission’ (≥31 days after attack (n=295, 83%)).</p> <p><strong>Results . </strong>We included 102 patients with MOGAD (57% adult and 43% paediatric) with a total of 354 samples (83% from remission and 17% from attack). Median titres were higher during attacks (1:1280 vs 1:640, p=0.001). Median onset titres did not correlate with attack-related disability, age or relapses. Remission titres were higher in relapsing patients (p=0.02). When considering the first remission sample available for each patient, titres >1:2560 were predictors of relapsing course in survival (log rank, p<0.001) and multivariate analysis (p<0.001, HR: 10.9, 95% CI 3.4 to 35.2). MOG-IgG seroconversion to negative was associated with a 95% relapse incidence rate reduction (incidence rate ratio: 0.05, p<0.001). Persistent MOG-IgG positivity and high remission titres are associated with an increased relapse risk. Longitudinal MOG-IgG titres could be useful to stratify patients to be treated with long term immunosuppression.</p>
Maternal pandemic-related stress during pregnancy associates with infants' socio-cognitive development at 12 months: a longitudinal multi-centric study
<p><strong>Introduction.</strong> This database includes the raw data linked with the paper “Maternal pandemic-related stress during pregnancy associates with infants’ socio-cognitive development at 12 months: A longitudinal multi-centric study”. This study is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” research project. In this study, we report on the effects of maternal prenatal stress related to the COVID-19 pandemic on 12-month-old infants’ behavioral markers of socio-cognitive development.</p> <p><strong>Methods.</strong> Ninety infants and their mothers provided complete longitudinal data from birth to 12 months. At birth, mothers reported on pandemic-related stress (PRS) during pregnancy through an ad-hoc scale (attached). At infants’ 12-month-age, a remote mother-infant interaction was videotaped: after an initial 2-min face-to-face episode, the experimenter remotely played a series of four auditory stimuli. Infants’ orienting, communication, and pointing toward the auditory source was micro-analytically coded.</p> <p><strong>Analytical plan.</strong> Two principal component analyses (PCA) were used to reduce the infant behavioral data. The first PCA yielded 3 principal components (Orienting; Communication; Pointing), while the second PCA showed the presence of an over-arching socio-cognitive score. Separate independent-sample t-tests were used to assess the presence of statistically significant differences in maternal prenatal PRS between infants who showed or not each of the socio-cognitive behavior. Separate hierarchical regression models were used to further test the effect of PRS on infants’ socio-cognitive development continuous measures.</p> <p><strong>Results in brief.</strong> Mothers who reported greater prenatal pandemic-related stress had infants with higher probability of showing no communication or pointing after the auditory stimuli. A significant and negative linear association was found between maternal prenatal PRS and infants’ SCS at 12 months, while adjusting for potential confounders.</p>
Data from: "What is the actual relationship between neutrophil extracellular traps and COVID-19 severity? A longitudinal study".
<p>Data supporting the manuscript titled: "<strong>What is the actual relationship between neutrophil extracellular traps and COVID-19 severity? A longitudinal study?</strong></p>
Long-term stability of orthodontically treated patients with a deep curve of Spee: a retrospective longitudinal study
<p>Dataset for all analyses. Initially, the dataset will be made available to the editor and reviewers for the peer-review phase. After acceptance, the dataset will be made openly available to anyone.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.