Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7,327
datasets available to search
ShareScore release 0.9.0
Dataset results
7,327 results for “Pathway”
Data associated to the study entitled:"Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI"
<p>Parkinson’s disease is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta. The 6-hydroxydopamine (6-OHDA) rat model has been used to study neurodegeneration in the nigro-striatal dopaminergic system. The goal of this study was to evaluate the reliability of diffusion MRI and resting-state functional MRI biomarkers in monitoring neurodegeneration in the 6-OHDA rat model assessed by quantitative histology.</p> <p>We performed a unilateral injection of 6-OHDA in the striatum of Sprague Dawley rats to produce retrograde degeneration of the dopamine neurons in the substantia nigra pars compacta. We carried out a longitudinal study with a multi-modal approach combining structural and functional MRI together with quantitative histological validation to follow the effects of the lesion. Functional and structural connectivity were assessed in the brain of 6-OHDA rats and sham rats (NaCl injection) at 3 and 6 weeks post-lesioning using resting-state functional MRI and diffusion-weighted.</p> <p>The shared datafile corresponds to the MRI biomarkers extracted from diffusion and functional acquisitions as well as from histological mesaurements within striatum and substantia nigria.</p>
Figure 5. Development pathways since 1970 in Summary for policymakers of the global assessment report on biodiversity and ecosystem services - unedited advance version
Figure 5. Development pathways since 1970 for selected key indicators of human-environment interactions, which show a large increase in the scale of global economic growth and its impacts on nature, with strong contrasts across developed, developing, and least developed countries. Countries are classified according to the UN World Economic Situation and Prospects (www.un.org). Global gross domestic product has risen 4-fold in real terms with the vast majority of growth occurring in developed and developing countries (A). Extraction of living biomass (e.g. crops, fisheries) to meet the demand for domestic consumption and for export is highest in developing countries and rising rapidly (B). Material consumption per capita within each country (from imports and domestic production), however, is highest in developed countries (C). Overall protection of Key Biodiversity
Genomic Alterations of the Metabolic Pathways Across 32 Cancer Types and Their Clinical Significance
<p>Supplementary Information for the thesis chapter: Genomic Alterations of the Metabolic Pathways Across 32 Cancer Types and Their Clinical Significance </p>
Progenitors of Type IIb Supernovae: I. Evolutionary Pathways and Rates
<p>Mesa templates and data associated with <a href="https://ui.adsabs.harvard.edu/abs/2018arXiv180807580S/abstract">Sravan et al. (2018)</a>. MESA version 9575.</p> <p>Each tar.xz contains one set of simulations, with files marked as binaries_* and singles_* corresponding to binary star, and single star simulations. Files ending in *high_Z.tar.xz and *low_Z.tar.xz correspond to the high and low metallicity simulations in the paper. for binary runs, the three digits indicate the mass transfer efficiency with 001, 010, 050 and 100 corresponding to efficiencies of 0.01, 0.10, 0.50 and 1.00.</p> <p>Within the files, simulation results are contained in individual folders, that also include all necessary MESA files to recreate the simulation. For single star simulations, the folder name indicates the value of log10(M_ZAMS/Msun), so for example, the folder named "1.6000" represents a star with ZAMS mass of 39.81 Msun. For binary systems, data is arranged such that, for example, the folder "1.400/0.825_3.000" represents a binary system with a primary mass at ZAMS of log10(M_1,ZAMS/Msun)=1.4, mass ratio q=M_2,ZAMS/M_1,ZAMS=0.825 and initial orbital period log P_i/days=3.</p> <p>All MESA output files have been post-processed to reduce their size. within each folder, the files named "last_prof*.data.s" contain the structure of the models at the end of a simulation. Files "LOGS/history.data.s", "LOGS1/history.data.s" and "LOGS2/history.data.s" contain information that can be represented by a single number at each timestep, such as the age, luminosity and effective temperature of the star. "LOGS/history.data.s" is used in single star simulations, while "LOGS1/history.data.s" and "LOGS2/history.data.s" correspond to each star in a binary run.</p> <p>MESA templates are available in the file IIb_progenitors_MESA_templates.zip.</p>
Fig. 3 in A dragonfly in the desert: genetic pathways of the widespread Trithemis arteriosa (Odonata: Libellulidae) suggest male-biased dispersal
Fig. 3 Bayesian analysis of the nuclear genetic structure of T. arteriosa populations based on eight microsatellite loci. Each vertical bar represents an individual and is partitioned into one to three coloured segments indicating the individual membership in the three genetic
Data used in "Fire Weather Compromises Forestation-reliant Climate Mitigation Pathways" (Jaeger et al. 2024a)
Open the record for dataset details and reuse information.
Pathways to a net zero building sector in Colombia: insights from a circular economy perspective
<p>This dataset contains the input data and core results of the RECC v2.5 model for the analysis of circular economy strategies in the Colombian residential sector. For details about the RECC model, see DOI <a href="https://doi.org/10.1111/jiec.13023" target="_blank" rel="noopener">https://doi.org/10.1111/jiec.13023</a> and the RECC model landing page: <a href="https://www.industrialecology.uni-freiburg.de/odym-recc" target="_blank" rel="noopener">https://www.industrialecology.uni-freiburg.de/odym-recc</a></p> <p>The following data are included in this dataset:</p> <ul> <li>The entire model input database (120 model parameters)</li> <li>The parameters for the sensitivity analysis (8 parameters)</li> <li>The 70 folders with the core results</li> <li>The master classification file RECC_Classifications_Master_V2.0.xlsx</li> <li>The model config file RECC_Config.xlsx</li> <li>The list of scenario configurations RECC_ModelConfig_List.xlsx</li> <li>The result compilation and exporting configuration file RECCv2.5_EXPORT_Combine_Select.xlsx</li> <li>The main result summary file (extracted from the 70 result folders) Results_Extracted_RECCv2.5_10Regs_sep.xlsx</li> <li>The results of the sensitivity analysis</li> </ul> <p> </p> <p>The model itself is available as Python code from <a href="https://github.com/IndEcol/RECC-ODYM" target="_blank" rel="noopener">https://github.com/IndEcol/RECC-ODYM</a></p>
vanBeest iScience 2024: The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions.
<p>Data for the paper 'The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions.' by van Beest et al. 2024, iScience: https://doi.org/10.1016/j.isci.2024.110753</p> <p>Code to analyze data is available via https://github.com/EnnyvanBeest/vanBeest_iScience2024.</p> <p> </p> <p> </p>
Structural Model of OSM-OSMRβ-gp130 Ternary Complex Reveals the Pathways of Allosteric Communication in OSM Signaling
Open the record for dataset details and reuse information.
Transcriptome profiling associated with CARD11 overexpres-sion in Colorectal Cancer implicates a potential role for Tumour Immune Microenvironment and Cancer pathways modulation via NF-κB
<p>Images for CARD11 study in IJMS</p>
Single-cell RNA sequencing reveals immunosuppressive pathways associated with metastatic breast cancer
Open the record for dataset details and reuse information.
Numerical source data for the manuscript Stimulus duration encoding occurs early in the moth olfactory pathway
<p>Numerical source data for the manuscript Stimulus duration encoding occurs early in the<br>moth olfactory pathway published in Communications Biology</p>
Ocean Alkalinity Enhancement in deep water formation regions under low and high emission pathways
<p>The dataset includes the minimum data required to reproduce the findings of Nagwekar et al. (2024). The output of the global ocean biogeochemical model FESOM2.1-REcoM3 implementing Ocean Alkalinity Enhancement (OAE) is provided. In particular it contains: a) model grid, b)Water Mass Transformation and Formation rates in the subduction regions of the Southern Ocean (SO), Northwest Atlantic (NWA) and Norwegian-Barents Sea (NBS) region, c) annual mean time-series (2015-2100) for the increase in oceanic CO2 uptake, long-term and short-term OAE efficiencies, surface alkalinity, depth and area integrated Dissolved Inorganic carbon (DIC), diatom productivity, small phytoplankton productivity, and total Net Primary Production (NPP), d) seasonal time-series averaged over 2090-2099 for the increase in oceanic CO2 uptake, mixed layer depth, amount of olivine added, surface alkalinity, DIC accumulation, and total NPP for the subduction regions in the SO, NWA, NBS, and e) data for spatial maps averaged over 2090-2099 for oceanic CO2 uptake, alkalinity, calcification and NPP. The data is available for the SSP1-2.6 and SSP3-7.0 emission sceanrio. </p>
Synthetic ECG Database of Antegrade Accessory Pathway Locations and Timings in Wolff-Parkinson-White syndrome
<p>A synthetic database of 12 lead electrocardiograms (ECGs) was generated by varying locations and timings of antegrade accessory pathways (APs) within Wolff-Parkinson-White syndrome. The ECGs were generated within a <a href="https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.907190/full">virtual model of whole-heart electrophysiology</a> of a single male patient that had been previously personalized to a clinical 12 lead ECG under normal sinus rhythm. The dataset consists of a total of 9271 ECGs, each corresponding to an APs sampled throughout both ventricles. The database is split into LV ( 4678 ECGs ) and RV (4593 ECGs) datasets for subsequent processing. Sampling CSV files are provided for both LV and RV datasets. </p>
Relative abundance tables for bacterial species, pathways, ARGs, and VFGs in "Gut Microbial Community Structure, Metabolic Signature, and Resistome in Dyslipidemia: Insights from Metagenomic Sequencing"
<p>Dyslipidemia, characterized by abnormal blood lipid levels, is a significant risk factor for cardiovascular disease. Emerging evidence suggests that the gut microbiota plays a role in lipid metabolism, although findings across studies have varied. In this study, we analyzed the gut microbiota, metabolic pathways, predicted gut metabolites, and resistome in 1384 participants (895 with dyslipidemia cases and 489 controls) using shotgun metagenomic sequencing. Our results revealed that Bacteroides caccae was enriched in dyslipidemia cases, potentially contributing to inflammation and altered lipid metabolism, while Coprococcus eutactus and Coprococcus catus, known producers of short-chain fatty acids (SCFAs) in lipid regulation, and Blautia obeum, known to be positively impacted by SCFAs, were more abundant in controls. We also identified an enrichment of the dTDP-beta-D-fucofuranose biosynthesis pathway gene family, which is linked to bacterial pathogenicity, in dyslipidemia cases, with Bacteroides stercoris contributing strongly. Dyslipidemia cases exhibited depleted glycogen and peptidoglycan biosynthesis pathways, potentially impairing energy storage and immune function, alongside distinct metabolic profiles, including decreased pseudouridine, which may affect RNA metabolism. Furthermore, we observed a higher abundance of antibiotic-resistance genes, particularly tetQ, in dyslipidemia cases, suggesting a link between gut resistome and metabolic disorders. These findings provide new insights into how dysbiosis of the gut microbiota may contribute to the pathophysiology of dyslipidemia, offering potential avenues for microbiome-based interventions in personalized medicine.</p>
Time series transcriptomes resolve metabolic pathways underlying crocin's anti-cancer activity: Control FASTQ sequencing reads
<p><span>Natural products like saffron show promise in treating hepatocellular carcinoma (HCC), but their mechanisms remain unclear. Here, we used time-series transcriptomics to elucidate crocin's anti-cancer mechanisms in HCC cells. We treated HepG2 cells with 1 and 2 mM crocin for 2, 6, 12, and 24 hours and analyzed transcriptomic profiles at each timepoint. The strongest transcriptional response occurred at 2 hours with 1 mM crocin, with diminishing effects at later timepoints. We observed upregulation of metabolic-, adhesion-, and endocytosis-related genes across all timepoints. Pathway analysis revealed activation of DNA damage checkpoints and senescence while proliferation pathways were suppressed. Notably, 52 genes involved in non-alcoholic fatty liver disease were downregulated at 24 hours (FDR p = 8 × 10⁻⁸), suggesting reversal of carcinogenic pathways. Strikingly, crocin consistently downregulated spliceosomal machinery genes across all timepoints while upregulating senescence and autophagy pathways. This spliceosome targeting represents a clinically relevant mechanism, as aberrant splicing drives oncogenesis in more than 90% of cancers. The transcription factor PAX5 was significantly upregulated while oncogenic ELK1 targets were downregulated. Our findings show that crocin treatment is accompanied by HCC cell senescence induction through coordinated spliceosome disruption and metabolic reprogramming, providing novel therapeutic targets for hepatocellular carcinoma.</span></p> <p><strong><span>Keywords: </span></strong><span>Hepatocellular carcinoma (HCC), crocin, transcriptomics, spliceosome, senescence, natural anti-cancer compounds</span></p>
Analysis of mitochondrial respiratory pathway and coupling control by substrate-uncoupler-inhibitor titration reference protocols
Open the record for dataset details and reuse information.
Source data related to the manuscript by Zhou et al (2024), entitled "Impaired Functional Connectivity of Cortico-Amygdala Pathway Can Drive Social Behavior Deficits in Synucleinopathies"
Open the record for dataset details and reuse information.
Raw data for "Kitaev Interactions Through Extended~Superexchange Pathways in the jeff = 1/2 Ru3+ Honeycomb Magnet RuP3SiO11"
<p>Magnetization, specific heat, powder X-ray diffraction, and linear spin wave theory grid data for the manuscript "Kitaev Interactions Through Extended~Superexchange Pathways in the jeff = 1/2 Ru3+ Honeycomb Magnet RuP3SiO11".</p>
Supplementary tables for the paper: "Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer."
<p><strong>Authors</strong>:<br>Thomas Jaylet, Vinita Chauhan, Laura Mezquita, <em>Nadia Boroumand</em><em>, </em>Olivier Laurent, <em>Karine Elihn</em><em>, Lovisa Lundholm</em><em>, </em>Olivier Armant, Karine Audouze</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.