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126,115 results for “Patients”
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 13
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 13 contains stitched image montages of a thin section through the lung of patient C03 which were acquired by scanning electron microscopy. The file “Data_set_13.tif” contains a montage of the entire thin section while the other files contain selected areas of the section recorded at higher resolution.</p>
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 01
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 01 contains a stitched image montage of the first and of the last semithin section from the analysis of patient C03, which was acquired by bright-field light microscopy.</p>
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 02
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 02 contains a stitched image montage of the first and of the last semithin section from the analysis of patient C04, which was acquired by bright-field light microscopy.</p>
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 03
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 03 contains a stitched image montage of the first and of the last semithin section from the analysis of patient C05, which was acquired by bright-field light microscopy.</p>
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 18
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 18 contains stitched image montages of a thin section through the lung of patient C08 which were acquired by scanning electron microscopy. The file “Data_set_18.tif” contains a montage of the entire thin section while the other files contain selected areas of the section recorded at higher resolution.</p>
A detailed ultrastructural examination of lung cryobiopsy samples from a COVID-19 patient case series – Data set 17
<p>We investigated six cryobiopsy samples from six deceased patients (patients C03 to C08 from Barisione et al. 2020 <a href="https://doi.org/10.1007/s00428-020-02934-1">doi.org/10.1007/s00428-020-02934-1</a>) by using thin section electron microscopy (Cortese et al. 2022 <a href="http://doi.org/10.1007/s00428-022-03308-5">doi.org/10.1007/s00428-022-03308-5</a>). A detailed description of the methods and the data set is provided in the download container.</p> <p>Data set 17 contains stitched image montages of a thin section through the lung of patient C07 which were acquired by scanning electron microscopy. The file “Data_set_17.tif” contains a montage of the entire thin section while the other files contain selected areas of the section recorded at higher resolution.</p> <p> </p>
Vancomycin-resistant enterococci and coagulase-negative staphylococci prevalence among patients attending at Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Ethiopia
<p>Background<br> Vancomycin resistant enterococci (VRE) and vancomycin resistance coagulase negative<br> staphylococci (VRCoNS) are common pathogens causing difficult to treat health care associated infections (HAI). Hence, the World Health Organization listed VRE as one of the high<br> priority pathogens for new antibiotic discovery and antimicrobial resistance surveillance.<br> Despite this, data on the prevalence of VRE and VRCoNS in Ethiopia is scarce. Thus, the<br> present study determined prevalence of VRE and VRCoNS among patients attending<br> Felege-Hiwot comprehensive specialized hospital, Ethiopia.<br> </p>
Blood Cell Transcriptomics and Proteomics of Axial Spondyloarthritis patients undergoing adalimumab treatment
<p>This study aims at identifying molecular biomarkers differentiating good responders and non-responders to treatment with TNF inhibitors (TNFi), among patients with axial spondyloarthritis (axSpA). Publication: <em>Biomolecules</em> <strong>2024</strong>, <em>14</em>(3), 382; <a href="https://doi.org/10.3390/biom14030382">https://doi.org/10.3390/biom14030382</a></p>
Psychological Characteristics of patients with Takotsubo Syndrome and patients with Acute Coronary Syndrome: an explorative study toward a better personalized care
<p>Database of the paper: Psychological Characteristics of patients with Takotsubo Syndrome and patients with Acute Coronary Syndrome: an explorative study toward a better personalized care</p>
Antibody level in Covid Patients
<p>Dataset incude code of patients and level of SARS-CoV-2 IgG antibodies. Antibodies level were mesured with Siemens ADVIA Centaur®<sup>*</sup> SARS-CoV-2 IgG (sCOVG).</p>
Nasopharyngeal virome analysis of COVID-19 patients during three different waves in Campania Region of Italy.
<p>From December 2019, SARS-CoV-2 infection has spread rapidly, leading to a global pandemic. Little is known about possible relationships between SARS-CoV-2 and other viruses in the respiratory system affecting patient prognosis and outcomes. This study aims to characterize respiratory virome profiles in association with SARS-CoV-2 infection and disease severity, through the analysis in 89 nasopharyngeal swabs collected in a patient’s cohort from the Campania region (Southern Italy).We found coinfections with viral species that belonged to <em>Coronaviridae, Retroviridae</em>, <em>Herpesviridae</em>, <em>Poxviridae</em>, <em>Pneumoviridae</em>, <em>Pandoraviridae,</em> and <em>Anelloviridae </em>families and only in 2% of cases (2/89) we identified respiratory viruses.</p>
Socioeconomic status affects the incidence of COVID-19 in Chilean multiple sclerosis patients
<p><span><b><span>Objective: </span></b>To investigate the frequency of coronavirus disease (COVID-19) in patients with multiple sclerosis (pwMSs) living in a high socioeconomic vulnerability area in Chile.<b> </b></span></p> <p><span><b><span>Methods:</span></b> In this prospective cohort study, we compared the frequency of COVID-19 in 52 Chilean pwMSs on disease-modifying treatments (DMTs), living in urban municipalities with low-income/high-poverty levels, with that previously reported in pwMSs living in municipalities with high-income/low-poverty rates in Santiago, Chile. Demographic and clinical features of the pwMSs were obtained from their last consultation between March 3, 2020, and August 29, 2020.<b> </b></span></p> <p><span><b><span>Results:</span></b> In the low-income pwMSs, the mean patient age was 34 years, 69% were women, mean disease duration was 3 years, and mean Expanded Disability Status Scale score was 1.6. Of these, 61.5% pwMSs (32/52) underwent quarantine during the study period. <span>COVID-19 diagnosis was confirmed by reverse transcriptase polymerase chain reaction in five patients (10%): two were on glatiramer acetate, one was on fingolimod, and two were on alemtuzumab. All pwMSs with COVID-19 recovered fully. </span>The previously reported frequency of confirmed COVID-19 in middle‒upper income pwMSs living in Santiago was 1%. The frequency of COVID-19 among pwMSs in the low- and middle‒high income inhabitants of Santiago differed significantly (z = -4.3235, p < 0.00001; one-tailed Fisher exact test, p < 0.01).</span></p> <p><span><b>Conclusion: </b>The frequency of COVID-19 in the low-income/high-poverty cohort in Santiago, Chile, was markedly high. Accordingly, high socioeconomic vulnerability should be considered as an important risk factor for COVID-19 in pwMSs.</span></p>
Data from: Combined analysis of micro RNA and proteomic profiles and interactions in patients with primary lung adenocarcinoma and lung adenocarcinoma brain metastases
<p>We carried out an analysis of miRNAs expression profiles and protein spectrums of non-metastatic primary lung adenocarcinoma (LP) and patients with brain metastases (BM) to better explore the molecular basis of BM. Files containing raw data of miRNA expression and proteomic profiles in the manuscript "Combined analysis of micro RNA and proteomic profiles and interactions in patients with primary lung adenocarcinoma and lung adenocarcinoma brain metastases".</p>
Comparative analysis of patient-specific aortic dissections through computational fluid dynamics suggests increased likelihood of degeneration in partially thrombosed aorta
<p>Aortic dissection is a life-threatening cardiovascular disease associated with high rates of morbidity and mortality, especially in medically under-served communities. It compromises the hemodynamics of the arteries that originate from the aorta, and its outcomes include visceral ischemia and aortic rupture in the acute phase and aneurysmatic degeneration in the chronic phase. Understanding patients’ blood flow patterns is pivotal for non-invasive evidence-based treatment as they greatly influence both the disease onset and its outcome. In this paper, we combine diagnostic imaging techniques and computational fluid dynamics to analyze the flow patterns of three aorta dissections (fully perfused, partially thrombosed, and fully thrombosed), and compare them to a healthy aorta. Besides flow kinematics, we focus on time averaged wall shear stress and oscillatory shear index that are recognized risk factors for aneurysm and rupture. Our analysis shows that partially thrombosed dissection is the most prone to false lumen degeneration. In all dissections, the arteries connected to the false lumen are generally poorly supplied with blood. Further, both true and false lumens present higher turbulence levels than the healthy aorta, and critical stagnation points. Mesh sensitivity and a thorough comparison against literature data together support the methodology robustness.</p>
A scoping review of patient safety research carried out in the Republic of Ireland [dataset]
<p>This is an example search strategy (supplemental materials 1) and the charting form data (supplemental materials 2) from each of the 31 included papers included in the scoping research.</p> <p><strong>Background.</strong> Maintaining the highest levels of patient safety is a priority of healthcare organisations. However, although considerable resources are invested in improving safety, patients still suffer avoidable harm.</p> <p><strong>Aims.</strong> (1) To examine the extent, range, and nature of patient safety research activities carried out in the RoI; (2) make recommendations for future research; and (3) consider how these recommendations align with the Health Service Executive’s (HSE) patient safety strategy.</p> <p><strong>Methods.</strong> A five-stage scoping review methodology was used to synthesise the published research literature on patient safety carried out in the RoI: (1) identify the research question; (2) identify relevant studies; (3) study selection; (4) chart the data; and (5) collate, summarising, and reporting the results. Electronic searches were conducted across five electronic databases.</p> <p><strong>Results.</strong> A total of 31 papers met the inclusion criteria. Of the 24 papers concerned with measuring and monitoring safety, 12 (50%) assessed past harm, 4 (16.7%) the reliability of safety systems, 4 (16.7%) sensitivity to operations, 9 (37.5%) anticipation and preparedness, and 2 (8.3%) integration and learning. Of the six intervention papers, three (50%) were concerned with education and training, two (33.3%) with simplification and standardisation, and one (16.7%) with checklists. One paper was concerned with identifying potential safety interventions.</p> <p><strong>Conclusions.</strong> There is a modest, but growing, body of patient safety research conducted in the RoI. It is hoped that this review will provide direction to researchers, healthcare practitioners, and health service managers, in how to build upon existing research in order to improve patient safety.</p>
DATASET RELATED TO ARTICLE "Brain Tumor Resection in Elderly Patients Potential Factors of Postoperative Worsening in a Predictive Outcome Model"
<p><span>clinical database including information on patients included in the study at title</span></p>
Patient breast MRI images and computational breast phantom data for research in patient-derived realistic breast modelling
<p>The data is comprised of two parts: 1) patient DICOM MRI images and 2) 3D matrix of a computational breast phantom.</p> <ol> <li>The DICOM images are anonymised patient breast MRI images of a female patient diagnosed with invasive ductal carcinoma. The obtaining of the patients’ DICOM images is approved by the Ethics Committee of Medical University of Varna. The acquisition was performed with GE Signa HDxt MRI scanner. The images are from a T1-weigthed Axial multi-phase VIBRANT (3-phase) sequence and with voxel size of 0.7 mm x 0.7 mm x 0.8 mm. Contrast agent is present. The image set can be opened with any standard DICOM reader.</li> <li>The computational breast phantom is derived from the above mentioned dataset. The phantom is in the form of a 3D matrix saved as a MATLAB data file (.mat file). Each voxel has an assigned Hounsfield Unit value depending on its classification: air = 0, adipose tissue = -152, glandular tissue = 42, tumour = 64, skin = 108. The data file can be opened with MATLAB or Octave.</li> </ol>
Expression of CDCA2 in hepatocellular carcinoma by immunohistochemistry and patients' information
<p>Cohort of hepatocellular carcinoma patients enrolled in the study entitled "Cell division cycle associated 2 (CDCA2) upregulation promotes the progression of hepatocellular carcinoma in a p53-dependant mannar". CDCA2 expression in paraffin-embedded liver cancer tissue sections was evaluated by immunohistochemistry. Patients' clinicopathological information was collected.</p>
Patient-reported outcomes among people living with HIV on single- versus multi-tablet regimens
<p><strong>Background: </strong>Single-tablet regimens (STR) have become the golden standard in antiretroviral therapy. However, there are calls to reintroduce (generic) components as multi-tablet regimens (MTR) because of cost-savings. Patient-reported outcome measures (PROs) are an important touchstone to support or to renounce this proposal. As such, our aim was to compare PROs of people living with HIV taking an STR versus a MTR in a real world setting.</p> <p><strong>Materials and methods: </strong>188 people living with HIV participated in a longitudinal study. 132 remained on their MTR and 56 switched to an STR. At baseline, months 1-3-6-12-18 and 24, participants filled in questionnaires on health-related quality of life (HRQoL), depressive symptoms, HIV symptoms, neurocognitive complaints (NCC) treatment satisfaction and adherence. Generalized linear mixed models and generalized estimation equations mixed models were built.</p> <p><strong>Results: </strong>At baseline, the two groups did not differ in clinical parameters and PROs. The mixed models revealed differences among the groups regarding neurocognitive complaints and treatment satisfaction. The odds of having NCC increased by 4,1% per month in the STR-group as compared to the MTR-group (p=0.035). Nonetheless, treatment satisfaction also increased in the STR-group: at month 6, median change score was highly positive: 24 (IQR 7,5-29). Treatment satisfaction showed a significantly different evolution in the groups: the estimated state score increased by 3,3 in the STR-group while it decreased by 0,2 in the MTR-group (p=0.003). HRQoL measures, HIV symptoms, depressive symptoms and adherence did not differ between the groups over time.</p> <p><strong>Conclusions: </strong>Neurocognitive complaints and treatment satisfaction differed between the two groups. More people on an STR reported NCC over time compared to the MTR-group. Contrarily, treatment satisfaction in the STR-group increased significantly over time. It should be further investigated to which extent treatment satisfaction is a predictor for long-term treatment persistence and health outcomes.</p>
Content Validity and Reliability of the Italian Language Version of the US National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE®)
<p><strong>ABSTRACT </strong></p> <p><strong>Introduction: </strong>The US National Cancer Institute’s (NCI) Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE<sup>®</sup>) is a library of 78 symptom terms and 124 items enabling patient reporting of symptomatic adverse events in cancer trials. This multicenter study used mixed methods to develop an Italian language version of this widely accepted measure, and evaluate content validity and reliability in a diverse sample of Italian-speaking patients.</p> <p><strong>Methods: </strong>All PRO-CTCAE items were translated in accordance with international guidelines. Subsequently, the content validity of the PRO-CTCAE-Italian was examined and iteratively refined through cognitive debriefing interviews. Participants (n=96; 52% male; median age 64 years; 26% older adults; 18% lower educational attainment) completed a PRO-CTCAE survey and participated in a semi-structured interview to determine if the translation captured the concepts of the original English language PRO-CTCAE, and to evaluate comprehension, clarity and ease of judgement. Test-retest reliability of the finalized measure was evaluated in a second sample (n=135).</p> <p><strong>Results: </strong>Four rounds of cognitive debriefing interviews were conducted. The majority of PRO-CTCAE symptom terms, attributes and associated response choices were well-understood, and respondents found the items easy to judge. To improve comprehension and clarity, the symptom terms for nausea and pain were rephrased and retested in subsequent interview rounds. Test-retest reliability was excellent for 41/49 items (84%); the median intraclass correlation coefficient was 0.83 (range 0.64-0.94).</p> <p><strong>Discussion: </strong>Results support the semantic, conceptual and pragmatic equivalence of PRO-CTCAE-Italian to the original English version, and provide preliminary evidence of content validity and reliability.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.