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2,516 results for “Seri”
Kamchatka 2013 GNSS Time series
<p>GNSS time series presented in the article: "The 2013 slab-wide Kamchatka earthquake sequence"</p> <p>The columns of the files correspond to </p> <p>Year ; Month ; Day ; Hour ; Minute ; Second ; East position (mm) ; North position (mm) ; Up position (mm) ; East uncertainty (mm) ; North uncertainty (mm) ; Up uncertainty (mm) ;</p>
Training and validation data for artificial neural networks using three-dimensional partial convolutions to fill gaps in satellite image time series
<p>This dataset contains training and validation data for artificial neural networks using three-dimensional partial convolutions to fill gaps in satellite image time series. The data have been derived from Sentinel-5P total column carbon monoxide observations, using the offline processing stream.</p> <p><strong>Preprocessing</strong></p> <p>The following operations have been applied on the original S5P imagery:</p> <ol> <li>Images have been resampled to 0.1 by 0.1 degree spatial resolution</li> <li>Pixels with quality assessment value less than or equal to 0.5 have been set to NA</li> <li>Images have been aggregated by day of observation</li> <li>Images have been cropped to -60 to 60 degrees latitude</li> <li>Images have been devided into spatiotemporal blocks of size 128 x 128 pixels and 16 days</li> </ol> <p>Imagery has been recorded between 2021-01-01 and 2021-11-25. Notice that both the training and the validation blocks have been randomly sampled from all available blocks.</p> <p><br> <strong>Data Format and Naming Conventions</strong></p> <p>Input and output data blocks are stored as GeoTIFF files, where bands represent time. Notice the following file naming conventions:</p> <ul> <li>Files starting with <em>X</em> represent input measurements for training, where artificial gaps have been added.</li> <li>Files starting with <em>Y</em> represent true measurements without artificially added gaps (but still containing gaps in many cases).</li> <li>Binary masks of input data where all pixels with valid measurements are 1 and others 0 are stored in files whose name starts with <em>MASK</em></li> <li>Files starting with <em>VALMASK</em> contain a binary mask where only pixels that are available in Y but not in X are 1. The latter is used for validation on artificially removed pixels only.</li> </ul> <p>Numbers in filenames encode spatial and temporal block indexes.</p> <p>In addition, the dataset contains prediction of the validation blocks from different models in the `predictions` directory. The subfolders contain output from different models:</p> <ul> <li>mean refers to simple block-wise mean predictions.</li> <li>timeseries refers to simple linear time series interpolation.</li> <li>gapfill refers to the method proposed in [1].</li> <li>stmra refers to the method proposed in [2].</li> <li>STpconv refers to predictions passed on an artificial neural netowork with three-dimensional partial convolutions.</li> </ul> <p><strong>References</strong></p> <p>[1] Gerber, F., de Jong, R., Schaepman, M. E., Schaepman-Strub, G., & Furrer, R. (2018). Predicting missing values in spatio-temporal remote sensing data. IEEE Transactions on Geoscience and Remote Sensing, 56(5), 2841-2853.</p> <p>[2] Appel, M., & Pebesma, E. (2020). Spatiotemporal multi-resolution approximations for analyzing global environmental data. Spatial Statistics, 38, 100465.</p>
Model parameter time series of the Business Roadmap for sustainable development of the Mar Menor and surrounding Campo de Cartagena
<p>The Business Roadmap and Policy Recommendations (BRM) represents 14 solutions for sustainable development of the Mar Menor and surrounding Campo de Cartagena that were developed during an extensive co-design process (workshops, expert interviews, online questionnaires) with representatives from all relevant sectors involved. A full description of the BRM, its co-development, and the modelled impacts on Key Performance Indicators of sustainability can be found in<a href="http://doi.org/10.5281/zenodo.7142764"> Martínez-López et al (2022)</a>.</p> <p>The model parameter time-series in this dataset indicate if and when a solution is turned on or off between 1964 and 2070 based on preferences indicated by stakeholders. These time-series represent input parameters for the System Dynamics model of the socio-ecosystem of the Mar Menor-campo de Cartagena developed in the COASTAL project and that is used to quantify impacts on key performance indicators of sustainability. This System Dynamics based model, developed by Martínez-López et al (2022) can be consulted <a href="http://doi.org/10.5281/zenodo.7142764">here</a>.</p> <p>The Business Road Map and Policy Recommendations (BRM) consists of the following 4 milestones and related 14 solutions:</p> <p>(I) <strong>Rural ecotourism</strong>:</p> <p>1. The promotion of rural ecotourism activities.</p> <p>(II) <strong>Coastal ecotourism</strong>:</p> <p>2. The promotion of coastal ecotourism activities.</p> <p>(III) <strong>Sustainable agriculture</strong>:</p> <p>3. Implementation of nutrients, soil, and water retention measures</p> <p>4. Reduction in fertilizer use</p> <p>5. Denitrification of brine wastes from groundwater treated for irrigation</p> <p>6. Decrease in agricultural water demand per hectare (i.e. 10% of decrease by default in the model)</p> <p>(IV) <strong>Integrated sustainable management</strong>:</p> <p>7. Control of the extension of irrigated areas</p> <p>8. Promotion of environmental education</p> <p>9. Control of the number of groundwater wells (i.e. maximum 500 wells by default in the model)</p> <p>10. Promotion of small (<10MW) (agro)photovoltaic facilities</p> <p>11. Surface water pumping from the Albujón ephemeral stream</p> <p>12. Control of other point sources of pollution to the lagoon</p> <p>13. Groundwater pumping and treatment</p> <p>14. Increase in sea water desalination amount (twice the BAU value)</p>
Database for climate time series homogenization with metadata
<p>Usefulness of metadata in the automatic version of ACMANTv5 was tested.<br> A benchmark database has been developed, which consists of 41 datasets<br> of 20,500 networks of 170,000 synthetic monthly temperature time series<br> and the relating metadata dates. The research was supported by the<br> Catalan Meteorological Service. The research results will be published<br> in the open access MDPI journal Atmosphere. </p> <p>See more in the "Readme.txt" file of the dataset.</p>
South Pacific precipitation dataset: PACRAIN, TRMM, ERA5 and calibrated precipitation series.
<p>This dataset contains a set of stations located in the South Pacific region, obtained from the PACRAIN (Pacific Rainfall Database). Similarly, the TRMM (Tropical Rainfall Measuring Mission) satellite precipitation series and the ERA5 reanalysis precipitation series have been extracted for the aforementioned stations. For the stations corresponding to IDs NZ75400, NZ82400, NZ84317, NZ99701, SP00646, US14000 and US14690, the following <strong>daily</strong> variables are included:</p> <p> </p> <ul> <li>TRMM raw</li> <li>ERA5 raw</li> <li>PACRAIN </li> <li>Weather type associated</li> <li>TRMM calibrated (scaling) </li> <li>TRMM calibrated (empirical quantile mapping) </li> <li>TRMM calibrated (scaling conditioned) </li> <li>TRMM calibrated (empirical quantile mapping conditioned) </li> </ul> <p>where the last four are a consequence of the application of 4 different calibration methods. A summary of the stations is shown in the following table:</p> <table> <caption> </caption> <tbody> <tr> <td>Station Id</td> <td>Station Name</td> <td>Longitude</td> <td>Latitude</td> <td>Start</td> <td>End</td> <td>% Missing Data</td> <td>Altitude</td> </tr> <tr> <td>NZ75400</td> <td>Kolopelu (Wallis and Futuna)</td> <td>-178.12</td> <td>-14.32</td> <td>1998-01-01</td> <td>2012-01-01</td> <td>9.74</td> <td>36</td> </tr> <tr> <td>NZ82400</td> <td>Alofi (Niue)</td> <td>-163.93</td> <td>-19.07</td> <td>1998-01-01*</td> <td>2010-09-02</td> <td>2.68</td> <td>59</td> </tr> <tr> <td>NZ84317</td> <td>Rarotonga (Cook Islands)</td> <td>-159.8</td> <td>-21.2</td> <td>1999-09-28</td> <td>2012-01-12</td> <td>11.36</td> <td>4</td> </tr> <tr> <td>NZ99701</td> <td>Raoul Island (New Zealand)</td> <td>-177.93</td> <td>-29.23</td> <td>1998-01-01*</td> <td>2012-01-01</td> <td>0.72</td> <td>49</td> </tr> <tr> <td>SP00646</td> <td>Port Vila (Vanuatu)</td> <td>168.3</td> <td>-17.72</td> <td>2000-01-26</td> <td>2013-06-01</td> <td>18.13</td> <td>24</td> </tr> <tr> <td>US14000</td> <td>Aoloau (American Samoa)</td> <td>-170.77</td> <td>-14.3</td> <td>1998-01-01*</td> <td>2019-12-31*</td> <td>21.72</td> <td>408</td> </tr> <tr> <td>US14690</td> <td>Nu'uuli (American Samoa)</td> <td>-170.70</td> <td>-14.32</td> <td>1998-01-01*</td> <td>2019-12-31*</td> <td>0.037</td> <td>3</td> </tr> </tbody> </table> <p> </p>
Combined U-series and in situ U-Pb dating of fault-related carbonates for reconstructing a long-term history of fault activity in response to SE Tibetan Plateau brittle deformation
<p>Table S1. Analytical conditions for LA-ICP-MS U-Pb dating</p> <p>Table S2. Analytical conditions for LA-ICP-MS elemental mapping</p> <p>Table S3.<em> In situ </em>calcite LA-ICAPMS U-Pb dating data</p>
Outcome of severe COVID-19: spotlight on fatigue, fatiguability, multidomain complaints and pattern of cognitive deficits in a case series without prior brain dysfunction and without COVID-19-related stroke and/or cardiac arrest
<p>Outcome of severe COVID-19: spotlight on fatigue, fatiguability, multidomain complaints and pattern of cognitive deficits in a case series without prior brain dysfunction and without COVID-19-related stroke and/or cardiac arrest<br> Valérie Beaud1, Sonia Crottaz-Herbette1, Vincent Dunet2, Jean-François Knebel1, Pierre-Alexandre Bart3, Stephanie Clarke1<br> 1 Service of Neuropsychology and Neurorehabilitation, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland<br> 2 Service of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland<br> 3 Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland<br> ABSTRACT<br> Background: Cognitive deficits were often reported during the acute and post-acute stages of severe COVID-19 and were often, but not always, associated with signs of brain damage. Population-wide surveys highlighted the need for investigations into the nature, the severity and the evolution of cognitive, behavioural and psychiatric deficits.<br> Case presentation: We report the outcome at 12 months after severe COVID-19 involving intensive care unit stay and mechanical ventilation in six patients. None of the patients had history of prior brain dysfunction and none sustained stroke and/or cardiac arrest during COVID-19. A pervading mental and physical fatigue was consistently reported as well as numerous multidomain complaints, which affect to some extend everyday life, and for some of the patients a mental fatiguability, a certain degree of neurobehavioural (apathy) and/or psychiatric (anxiety) dysfunction. Standardized neuropsychological tests revealed for 4 of the 6 patients the occurrence relatively isolated of cognitive dysfunction or performance at the lower limit of the norm in some, but not all attentional, executive and/or working memory tests. Somatic scales highlighted the presence of dyspnoea, muscle weakness, olfactory disorder and/or minor sleep problems in some but not all patients.<br> Conclusion: Fatigue, fatiguability, multidomain complaints, which affect to some extend everyday life, cognitive dysfunction or performance at the lower limit of the norm and a certain degree of neurobehavioural and/or psychiatric and/or somatic dysfunction can occur in the aftermath of severe COVID-19 even in the absence of neurological antecedents or of COVID-19-related stroke and/or cardiac arrest.</p>
High resolution pictures of stone artefacts from Tunel Wielki Cave (southern Poland), sediments series II
<p>A dataset presenting high-resolution pictures of stone artefacts from Tunel Wielki Cave (southern Poland), sediments series II. Supplementary material to the paper: <em>Frontiers of the Lower Palaeolithic expansion in Europe: Tunel Wielki Cave (Poland).</em></p>
Datacubes of InSAR time series for active volcanoes
<p>Datacubes of InSAR time series for the 20 volcanoes (*) flagged in the paper "Large-scale demonstration of machine learning for the detection of volcanic deformation in Sentinel-1 satellite imagery" by Biggs et al. (Bull Volc, 2022).</p> <p>Each file contains the time series of cumulative displacements for one volcano in the *.nc format. There are four fields with "DATA" : cumulative LOS displacements (unit=meters), "lon" : longitude (unit=degrees), "lat" : latitude (unit=degrees) and "time" : number of days since the first date. The first date can be found in the attribute "units" of the variable "time".</p> <p>(*) The five volcanoes: Sierra Negra, Fernandina, Cerro Azul, Wolf and Alcedo volcanoes are contained in the single file "galapagos_128D_09016_110500.nc".</p>
InSAR time-series and FEM Model of the Post-seismic Surface Deformation following the 2013 Baluchistan Earthquake
<p>Subduction zone accretionary prisms are commonly modeled as elastic structures where permanent deformation is accommodated by faulting and folding of otherwise elastic materials, yet accretionary prisms may exhibit other deformation styles over relatively short time scales. In this study, we use 6.5-year (2014-2021) Sentinel-1 InSAR time-series of post-seismic deformation in the Makran accretionary prism of southeast Pakistan to characterize non-linear viscoelastic deformation within an active accretionary prism on short timescales (months to years). We constructed a series of 3-D finite-element models of the Makran subduction zone, including an accretionary prism, and constrained the elastic thickness of the upper wedge and the flow-law parameters (power-law exponent, activation enthalpy, and pre-exponential constant) of the lower wedge through forward model fits to the InSAR time-series. Our results show that the prism is elastically thin (8-12 km) and the non-linear viscoelastic relaxation of the deep portions of the prism alone can sufficiently explain the post-seismic surface deformation. Our best fitting flow-law parameters (<em>n</em> = 3.76±0.39, <em>Q</em> = 82.2±37.73 kJ mol<sup>-1</sup>, and <em>A</em> = 10<sup>-3.36±4.69</sup>) are consistent with triggering of low temperature dislocation creep within fluid-saturated siliciclastic rocks. We believe that the fluids necessary for this weakening originate from sedimentary underplating and/or the presence the hydrocarbons. The presence of power-law rheology within the lower wedge impacts the estimated plate coupling and the stress state in the subduction system, with respect to the conventional elastic wedge model, and hence need to be considered in future earthquake cycle models.</p>
Handshake - Ramadhan Series
The handshake is one of the habits that is carried out during Eid, forgiving each other's mistakes and establishing friendship Source: Objaverse 1.0 / Sketchfab
Ericsson AC100 Series "Skeletal" Desk Phone
Este es un modelado del telefono "skeletal" de la serie "AC100" No. 370 que se introdujo al mercado en el año 1890, se presume que fue diseñado por Lars Ericsson, para ese entonces, su empresa no era tan grande y se podía permitir una interacción directa en la elaboración de sus productos. Source: Objaverse 1.0 / Sketchfab
Silver sword ( Witcher series )
Witcher's silver sword. Made with Maya + Substance Painter. Feel free to use it. Source: Objaverse 1.0 / Sketchfab
Identifying knowledge gap -- Pergubi workshop series
<p>Choosing research topic and posing research questions can be hard. A good literature search and review are the two main ingredient to identify knowledge/research gap to build a good research question.</p> <p>The slides are available on Slideshare: https://www.slideshare.net/d_erwin_irawan/knowledge-gap-identification.</p> <p>I gave this talk on 06.10.2017 at Aston Braga Hotel, Bandung.</p> <p> </p>
Compounds with multi-target activity from X-ray structures, corresponding analog series, and associated scaffolds
<p>A total of 702 crystallographic ligands with activity against multiple targets from different protein families (multi-family ligands) were extracted from the Protein Data Bank (PDB). These ligands are made available as aromatic non-stereo SMILES strings together with their target information. A subset of these ligands were also found in the ChEMBL database yielding additional target annotations. Target and family assignments were made following the UniProt classification scheme. In addition, 133 analog-series-based (ASB) scaffolds were derived from series of PDB ligands and structural analogs identified in ChEMBL, which are also made available. For each ASB scaffold, the number of analogs, targets, and target families is provided (union of PDB and ChEMBL annotations).</p>
BIR-MicroED: selected area electron diffraction tilt series datasets used to determine representative structures of biotin, Cu(II)-serine, Zn(II)-methionine, Zn(II)-histidine, and Co(II)-porphyrin
<div> <div> </div> </div> <div> <p>This deposition contains a series zip files each containing electron diffraction datasets in .mrc file format (except for the data collected from Co(II) porphyrin, which are 300 kV data in .tvips file format). Each folder collects data acquired from crystals of a particular compound under the same conditions (electron energy, temperature), where the reduced data from each were merged to determine a single representative structure of the compound by microED. Zip files are named according to the format: <em>"CompoundName</em>_<em>AcceleratingVoltage</em>_<em>Temperature_</em>structuredatasets.zip"</p> <p>Diffraction datasets within each folder are named according to the format: <em>CompoundName</em>_structuretiltseries_<em>AcceleratingVoltage</em>_<em>Temperature</em>_crystal#.mrc (or .tvips).</p> <p>All 200 kV datasets were collected with a rotation speed of 1 degree/second and an effective frame rate of 1 frame/second, with the exception of two Zn(II) methionine datasets collected with a frame rate of 3 frames/second. These are noted by the presence of "3fps" in the file name.</p> <p>All 300 kV datasets were collected with a rotation speed of 0.03 degrees/second and a frame rate of 0.5 frames/second.</p> </div>
Data and model weights for a series of antibody language models
<p>This repo contains the sequence dataset for finetuning and model weights including pre-trained meta model and a series of finetuned antibody language models.</p> <p>The antibody language models were used in the paper "<em>Physics-driven structural docking and protein language models accelerate antibody screening and design for broad-spectrum antiviral therapy"</em> for antibody sequence embedding.</p>
Microdata on vector abundance and IRS quality assurance (Estimating the impact of indoor residual spraying on sandfly abundance and incidence of visceral leishmaniasis in India from 2016 to 2022: an interrupted time-series analysis and modelling study)
<p>This repository contains the microdata on vector abundance and quality assurance of indoor residual spraying (IRS) that was used to estimate the impact of IRS on sandfly abundance and incidence of visceral leishmaniasis (VL) in India, as described in the paper "Estimating the impact of indoor residual spraying on sandfly abundance and incidence of visceral leishmaniasis in India from 2016 to 2022: an interrupted time-series analysis and modelling study" by Coffeng et al (<a href="https://doi.org/10.1016/S1473-3099(24)00420-1">https://doi.org/10.1016/S1473-3099(24)00420-1</a>). These data were collected as part of a BMGF-funded project led by dr. Michael Coleman at the Liverpool School for Tropical Medicine, as described in an earlier paper by Deb et al (<a href="https://doi.org/10.1371/journal.pntd.0009101">https://doi.org/10.1371/journal.pntd.0009101</a>).</p> <p>This repository does not include microdata on VL cases as these are owned by India's National Center for Vector Borne Disease Control (NCVBDC, <a href="https://ncvbdc.mohfw.gov.in/" target="_blank" rel="nofollow noreferrer noopener">https://ncvbdc.mohfw.gov.in/</a>).</p>
Data from: Palaeoscolecids from the Ludlow Series of Leintwardine, Herefordshire (UK) – the latest occurrence of palaeoscolecids in the fossil record.
<p>The documentation of cuticular micro-ornament is vital for the taxonomic assignment of palaeoscolecids – vermiform lower Palaeozoic ecdysozoans interpreted as stem-group priapulans or early diverging panarthropods. This is due to the absence of the character-rich proboscis and tail hooks in palaeoscolecid material not from Burgess Shale-type Konservat-Lagerstätten. Here, the cuticular micro-ornamentation of palaeoscolecids from the upper Silurian (Ludlow) fauna of Leintwardine (Herefordshire, England), is described using scanning electron microscopy (SEM) and Reflectance Transformation Imaging (RTI). This material is taxonomically unstable as it was included in an effective wastebasket genus (Protoscolex) long before these imaging techniques were developed. This reveals the Leintwardine material is most closely comparable to a palaeoscolecid from the Darriwilian (Middle Ordovician) of the Builth-Llandrindod inlier, Powys, Wales and is transferred accordingly to Radnorscolex Botting et al. as Radnorscolex latus Bather. The Leintwardine fauna represents the uppermost stratigraphic occurrence of palaeoscolecids, constrained to the Saetograptus leintwardinensis Zone (lower Ludfordian), and the comparatively sparse Silurian palaeoscolecid record is subsequently discussed. It is hypothesised palaeoscolecids may have become extinct during the mid-Ludfordian Lau Event, the onset of which is recorded in the biozone immediately above the Leintwardine fauna (Bohemograptus Zone). Finally, the British palaeoscolecid fauna is summarised, including a new record from the Dapingian (Middle Ordovician) of Carmarthenshire, South Wales. --</p>
DEEPICE Stories Videos series - Insight into Ice & Climate - Videos with Italian subtitles
<p><em>DEEPICE Stories – Insights into Ice & Climate </em>is a series of 15 videos<em> </em>created in collaboration with the 15 PhD students of the European research project <a href="https://deepice.cnrs.fr/">DEEPICE</a>. These 3-minute educational video clips give an overview of scientific research on ice cores. <a href="https://deepice.cnrs.fr">https://deepice.cnrs.fr</a></p> <p><u>Credits</u></p> <p>Writing & presentation: Geunwoo Lee, Hanne Notø, Eirini Malegiannaki, Piers Larkman, Miguel Angel Sanchez Moreno, Lison Soussaintjean, Florian Painer, Niklas Kappelt, Lisa Ardoin, Inès Ollivier, Romilly Harris Stuart, Fyntan Shaw, Qinggang Gao, Ailsa Chung, Daniel Gunning</p> <p>Coordination : Marie Kazeroni (LSCE-CNRS)</p> <p>Direction: Dorothée Adam-Mazard (Inuaprod) & Marie Kazeroni (LSCE-CNRS)</p> <p>Editing: Thomas d’Aram</p> <p>Motion Design: Pauline Fuchs</p> <p>Co-production: DEEPICE & Inuaprod</p> <p>_____________________________________________</p> <p><em><span>DEEPICE Stories - Insights into Ice & Climate </span></em><span>è una serie di 15 video creati in collaborazione con i 15 dottorandi del progetto di ricerca europeo <a href="https://deepice.cnrs.fr/">DEEPICE</a>. Queste video didattici di 3 minuti, offrono una sintesi della ricerca scientifica sulle carote di ghiaccio. <a href="https://deepice.cnrs.fr">https://deepice.cnrs.fr</a></span></p> <p><span><span>Scrittura e presentazione : Geunwoo Lee, Hanne Notø, Eirini Malegiannaki, Piers Larkman, Miguel Angel Sanchez Moreno, Lison Soussaintjean, Florian Painer, Niklas Kappelt, Lisa Ardoin, Inès Ollivier, Romilly Harris Stuart, Fyntan Shaw, Qinggang Gao, Ailsa Chung, Daniel Gunning<br></span></span></p> <p><span><span>Coordinamento : Marie Kazeroni (LSCE-CNRS)</span></span></p> <p><span><span>Direzione : Dorothée Adam-Mazard (Inuaprod) & Marie Kazeroni (LSCE-CNRS)</span></span></p> <p><span><span>Montaggio : Thomas d’Aram</span></span></p> <p><span><span>Motion Design : Pauline Fuchs</span></span></p> <p>Coproduzione : <span><span>DEEPICE & Inuaprod</span></span></p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.