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725
datasets available to search
ShareScore release 0.9.0
Dataset results
725 results for “isoforms”
A newly identified spliced isoform of metadherin differently regulates the global transcriptomic profile in human breast cancer cells
GEO Series GSE59058. Homo sapiens. 18 samples. Type: Expression profiling by array.
Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (RNA-Seq)
GEO Series GSE153864. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
Differentiation of human parthenogenetic pluripotent stem cells reveals multiple tissue and isoform specific imprinted transcripts
GEO Series GSE65002. Homo sapiens. 6 samples. Type: Expression profiling by array.
The divergent role of two PRDM1 isoforms during human naïve pluripotency reprogramming [RNA-seq]
GEO Series GSE255861. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin-lineage cells, generates a specific suite of brain, behavioral and molecular pathologies
GEO Series GSE231599. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ChIP-Seq)
GEO Series GSE153861. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression data in subcutaneous xenografts of Huh7 cells overexpressing or not insulin receptor isoform A
GEO Series GSE111707. Homo sapiens. 6 samples. Type: Expression profiling by array.
Simultaneous Genome-Wide Gene Expression and Transcript Isoform Profiling in P. falciaprum using Exon Arrays
GEO Series GSE86255. Plasmodium falciparum. 22 samples. Type: Expression profiling by array.
Developmentally regulated isoform of HNF4α reprograms the adult liver
GEO Series GSE231538. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene expression data from HEK293T cells stably expressing human TRAF7 wildtype or G536S mutant isoforms
GEO Series GSE136012. Homo sapiens. 3 samples. Type: Expression profiling by array.
Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ATAC-Seq)
GEO Series GSE153860. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression data from Periostin isoform 3 and 6 overexpressing oral cancer cells
GEO Series GSE125874. Homo sapiens. 3 samples. Type: Expression profiling by array.
Dataset related to the article "Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging"
<p>This record contains raw data related to the article "Modulation of soluble receptor for advanced glycation end-products (RAGE) isoforms and their ligands in healthy aging" </p> <p> The receptor for advanced glycation end-products (RAGE) recognizes several ligands involved in inflammatory diseases. Two circulating soluble isoforms exist: esRAGE derived from alternative splicing and cRAGE generated by the membrane-bound RAGE (FL-RAGE) proteolysis. Together, esRAGE and cRAGE constitute sRAGE and function as decoy receptors preventing FL-RAGE/ligands binding.</p> <p>We determined serum concentration of both, esRAGE and cRAGE, and their ligands AGEs, HMGB1 and S100A8/A9 in a healthy population of 169 subjects aged 20-90 years. cRAGE showed a negative (r=-0.375, P<0.0001) while AGEs (r=0.160, P=0.0384) and S100A8/A9 (r=0.207, P=0.0091) a positive correlation with age. esRAGE did not change during aging and inversely correlated with Hemoglobin, ALT, insulin, HOMA index, Waist-Hip ratio (W/H), Waist Circumference (WC) and positively with AGEs. cRAGE exhibited also an inverse correlation with WC, W/H, PAI-1, HMGB1, AGEs and S100A8/A9. Age, W/H, HMGB1, S100A8/A9 and AGEs are independent predictors of cRAGE, whereas W/H and AGEs associate with esRAGE. Treatment of cells with glycated albumin reduced cRAGE production and upregulated FL-RAGE<em>. </em></p> <p>These results indicate that in a healthy population cRAGE is a biomarker of aging while esRAGE represents a more reliable marker of obesity and insulin resistance. Hence, sRAGE isoforms levels could be differentially associated with age-related diseases risk factors.</p>
Data set from the article Massaccesi L, Galliera E, Galimberti D, Fenoglio C, Arcaro M, Goi G, Barassi A, Corsi Romanelli MM. Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform. Immun Ageing. 2019 Apr 1;16:7. doi: 10.1186/s12979-019-0147-x. PMID: 30984280; PMCID: PMC6444862.
<p>Data set from the article: Massaccesi L, Galliera E, Galimberti D, Fenoglio C, Arcaro M, Goi G, Barassi A, Corsi Romanelli MM. Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform. Immun Ageing. 2019 Apr 1;16:7. doi: 10.1186/s12979-019-0147-x. PMID: 30984280; PMCID: PMC6444862.</p> <p>This is the astract:</p> <p>In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's Disease (AD) development and recent evidence correlated oxidative stress with vascular lesion in the pathogenesis of AD, but the mechanism still need to be fully clarified. The etiology of AD is still not completely understood and is influenced by several factors including Apolipoprotein E (ApoE) genotype. In particular, the Apo ε4 isoform is considered a risk factor for AD development. This study was aimed to evaluate the possible relationship between three plasmatic OS marker and Apo ε4 carrier status. Plasmatic soluble receptor for advanced glycation end products (sRAGE) levels, plasma antioxidant total defenses (by lag-time method) and plasmatic Reactive Oxygen species (ROS) levels were evaluated in 25 AD patients and in 30 matched controls. ROS were significantly higher while plasma antioxidant total defenses and sRAGE levels were significantly lower in AD patients compared to controls. In AD patients lag-time values show a significant positive linear correlation with sRAGE levels and a (even not significant) negative correlation with ROS levels. Lag-time is significantly lower in ε4 carrier (<em>N</em> = 13) than in ε4 non-carrier (<em>N</em> = 12). Our result confirms the substantial OS in AD. Lag-time levels showed a significant positive correlation with sRAGE levels and a significant association with ε4 carrier status suggesting that plasmatic lag-time evaluation can be considered as a potential useful OS risk marker in AD.</p> <p> </p>
aSyn isoforms
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Alternatively-spliced isoforms of the cardiac Nav1.5 sodium channel modify channel activation by distinct structural mechanisms - Molecular dynamics results
<p>Output files associated with molecular dynamics simulations of the alternative splice variant of Nav1.5</p>
Inducible meiotic cDNA libraries for genome-wide studies of gene isoforms
GEO Series GSE174268. Saccharomyces cerevisiae; Escherichia coli. 175 samples. Type: Expression profiling by high throughput sequencing; Other.
Differential Gene Expression and Alternative Isoform Regulation in caper mutant embryos compared to wild-type
GEO Series GSE94565. Drosophila melanogaster. 6 samples. Type: Expression profiling by high throughput sequencing.
Analysis of p63-isoform specific direct target genes in primary murine keratinocytes
GEO Series GSE79449. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Evaluation of the synergistic potential of simultaneous pan- or isoform specific BET and SYK inhibition in B-cell lymphoma
GEO Series GSE207383. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.