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7,327 results for “Pathway”
Original Western Blot Images_Papers "The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K/Akt Pathways"
<p>Original Western Blot Images_Papers "The PIK3CA H1047R Mutation Confers Resistance to BRAF and MEK Inhibitors in A375 Melanoma Cells through the Cross-Activation of MAPK and PI3K/Akt Pathways" which is submitted to Pharmaceutics Journal for publication.</p>
H2 partial pressure switches autotrophic pathways in an anaerobic bacterium
<p>proteomics.xlsx: Full proteome expression data for Table S6</p> <p>*.tab files: Initial sequence sets as downloaded from UniProtKB.</p> <p>*_cluster.fa: Sequences clustered to an identity of 95%</p> <p>*_cluster.fa.clstr: Clustering information</p> <p>*_cluster_homo.fa: Sequences not homologous to the <em>A. degensii</em> enzymes removed</p> <p>*_mafft.fa: Alignments</p> <p>*_mafft_fasttree: Tree files in nexus format</p>
Overexpression of miR-155-5p can upregulate antigen processing and presentation pathway via targeting tapasin
<p><strong>Background </strong>Dysregulation of major histocompatibility complex (MHC) class I antigen processing and presentation machinery (APM) components in the tumor as one main molecular mechanism of immune escape leading to deactivation of T cell immune surveillance could be due to post-transcriptional regulation via immune-modulatory microRNAs (miRNA). It is now well established from a variety of studies that several miRNAs could effectively modulate the expression of some MHC class I APM components in tumors. Tapasin is an important APM molecule involved in the association of MHC class I with transporter associated with antigen processing (TAP) and peptide loading. Since so far no detailed investigation of the posttranscriptional regulation of tapasin exists, the aim of this study is to identify and functionally characterize miRNAs targeting tapasin in melanoma.</p> <p><strong>Methods </strong>Using miRNA trapping by RNA <em>in vitro</em> affinity purification (miTRAP) and <em>in silico </em>as well as small RNA sequencing, miRNAs will be identified, which bind to the 3'untranslated region (3' UTR) of tapasin. Dual luciferase assays will be performed to determine binding of the miRNA. <em>In silico</em> analysis was performed to predict the effect of miRNAs on the survival of melanoma patients in correlation to tapasin. RT-qPCR, Western blot, flow cytometry and other functional assays were performed after transfecting miRNA mimics in three melanoma cell lines.</p> <p><strong>Results </strong>Using the combination strategy of miTRAP and RNA seq we identified miR-155-5p to bind to the 3’UTR of tapasin, which was further confirmed by <em>in silico analysis</em> and dual luciferase reporter assay. Transfection of miR-155-5p mimics demonstrated that miR-155-5p upregulate tapasin protein level, which was accompanied by an upregulation of the MHC class I (HLA-ABC) surface expression. Simultaneously, in several different types of cancer, including melanoma, the expression of miR-155-5p is significantly positively correlated with the patient's survival and HLA-A protein.</p>
Kids First: Craniofacial Microsomia: Genetic Causes and Pathway Discovery
Namespace hosted on the Kids First DRC FHIR services at fhir.kidsfirstdrc.org
PATHway dataset
<p>Depth maps from kinect streams</p>
Aerobic Exercise Increases Autophagic Flux in Brain Cells of APP/PS1 Mice by Activating the APN–AdipoR1 Signaling Pathway
<p>Raw data and pictures</p>
Data from: Brassinosteroids act as positive regulators of autophagy pathways in response to chilling stress in tomato
Autophagy, a highly conserved and regulated catabolic process involved in the degradation of protein aggregates, plays critical roles in eukaryotes. In plants, autophagy has been well studied in stress responses including nutrient deficiency, salt and drought stress. Whilst, multiple molecular processes can induce or suppress autophagy, however, the mechanism of its regulation by phytohormones is little known. Brassinosteroids (BRs) are steroid phytohormones which play crucial roles in plant response to stresses. We used diverse techniques, including transcriptional suppression, CRISPR/Cas9, histochemical and cytochemical methodologies and gene transcript analysis, to investigate the role of BRs in autophagy in response to chilling stress in tomato. Here, we show that BRs and their signaling element BZR1 induce autophagy in tomato under chilling stress. Cold increased the stability of BZR1, which was promoted by BRs. Cold- and BR-induced BZR1 stability activates the transcription of several ATG genes by directly binding to the promoters of those genes, resulting in autophagy formation. Furthermore, silencing of these ATGs compromised BR-induced cold tolerance with increased accumulation of several functional proteins and reduced accumulation of oxidative proteins. These results strongly suggest that BRs regulate autophagy by BZR1-dependent manner in response to chilling stress in tomato.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.